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    Integrated droplet actuator for gel; electrophoresis and molecular analysis
    1.
    发明授权
    Integrated droplet actuator for gel; electrophoresis and molecular analysis 有权
    凝胶液滴致动器 电泳和分子分析

    公开(公告)号：US09091649B2

    公开(公告)日：2015-07-28

    申请号：US13508300

    申请日：2010-11-08

    申请人： Michael G. Pollack ,  Vijay Srinivasan ,  Zhishan Hua ,  Hon Lung Chu ,  Michael Hauser ,  Allen Eckhardt

    发明人： Michael G. Pollack ,  Vijay Srinivasan ,  Zhishan Hua ,  Hon Lung Chu ,  Michael Hauser ,  Allen Eckhardt

    IPC分类号： G01N27/447 ,  B01L7/00 ,  B01L3/00

    CPC分类号： G01N27/44743 ,  B01L3/502715 ,  B01L3/502792 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0457 ,  B01L2400/046 ,  G01N27/44791

    摘要： The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and liquid handling operations on a single integrated device. The integrated liquid handling operations may be used to prepare and deliver samples to the electrophoresis gel, capture and subsequently process products of the electrophoresis gel or perform additional assays on the same sample materials which are analyzed by gel electrophoresis. In one embodiment, one or more molecular assays, such as nucleic acid (e.g., DNA) quantification by real-time PCR, and one or more sample processing operations such as sample dilution is performed on a droplet actuator integrated with an electrophoresis gel. In one embodiment, an electrophoresis gel may be integrated on the top substrate of the droplet actuator.

    摘要翻译： 本发明涉及液滴致动器装置以及用于将凝胶电泳分析与分析前样品或分析后处理以及其它分子分析方法相集成的方法。 使用数字微流体技术，液滴致动器装置和本发明的方法提供了在单个集成装置上执行凝胶电泳和液体处理操作的能力。 集成的液体处理操作可以用于制备并将样品递送到电泳凝胶，捕获并随后处理电泳凝胶的产物，或在通过凝胶电泳分析的相同样品材料上进行附加测定。 在一个实施方案中，在与电泳凝胶结合的液滴致动器上进行一个或多个分子测定，例如通过实时PCR的核酸（例如DNA）定量和一个或多个样品处理操作，例如样品稀释。 在一个实施方案中，电泳凝胶可以集成在液滴致动器的顶部基底上。

    Integrated Droplet Actuator for Gel; Electrophoresis and Molecular Analysis
    2.
    发明申请
    Integrated Droplet Actuator for Gel; Electrophoresis and Molecular Analysis 有权
    集成液滴执行器凝胶; 电泳和分子分析

    公开(公告)号：US20130059366A1

    公开(公告)日：2013-03-07

    申请号：US13508300

    申请日：2010-11-08

    申请人： Michael G. Pollack ,  Vijay Srinivasan ,  Zhishan Hua ,  Hon Lung Chu ,  Michael Hauser ,  Allen Eckhardt

    发明人： Michael G. Pollack ,  Vijay Srinivasan ,  Zhishan Hua ,  Hon Lung Chu ,  Michael Hauser ,  Allen Eckhardt

    IPC分类号： C12M1/40

    CPC分类号： G01N27/44743 ,  B01L3/502715 ,  B01L3/502792 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0457 ,  B01L2400/046 ,  G01N27/44791

    摘要： The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and liquid handling operations on a single integrated device. The integrated liquid handling operations may be used to prepare and deliver samples to the electrophoresis gel, capture and subsequently process products of the electrophoresis gel or perform additional assays on the same sample materials which are analyzed by gel electrophoresis. In one embodiment, one or more molecular assays, such as nucleic acid (e.g., DNA) quantification by real-time PCR, and one or more sample processing operations such as sample dilution is performed on a droplet actuator integrated with an electrophoresis gel. In one embodiment, an electrophoresis gel may be integrated on the top substrate of the droplet actuator.

    摘要翻译： 本发明涉及液滴致动器装置以及用于将凝胶电泳分析与分析前样品或分析后处理以及其它分子分析方法相集成的方法。 使用数字微流体技术，液滴致动器装置和本发明的方法提供了在单个集成装置上执行凝胶电泳和液体处理操作的能力。 集成的液体处理操作可以用于制备并将样品递送到电泳凝胶，捕获并随后处理电泳凝胶的产物，或在通过凝胶电泳分析的相同样品材料上进行附加测定。 在一个实施方案中，在与电泳凝胶结合的液滴致动器上进行一个或多个分子测定，例如通过实时PCR的核酸（例如DNA）定量和一个或多个样品处理操作，例如样品稀释。 在一个实施方案中，电泳凝胶可以集成在液滴致动器的顶部基底上。

    Peripheral Reticular Pigmentary Change and Age-Related Macular Degeneration
    4.
    发明申请
    Peripheral Reticular Pigmentary Change and Age-Related Macular Degeneration 审中-公开
    周围网状色素变化和年龄相关性黄斑变性

    公开(公告)号：US20100145223A1

    公开(公告)日：2010-06-10

    申请号：US12617256

    申请日：2009-11-12

    申请人： Eric A. Postel ,  R. Keith Shuler ,  Jennifer Vaughn Caldwell ,  Michael Hauser ,  Silke Schmidt

    发明人： Eric A. Postel ,  R. Keith Shuler ,  Jennifer Vaughn Caldwell ,  Michael Hauser ,  Silke Schmidt

    IPC分类号： A61B3/14 ,  A61F9/00 ,  A61B3/10

    CPC分类号： A61K31/00

    摘要： Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmentary change. AMD phenotypes of 796 carriers of the CFH Y402H variant were compared to the AMD phenotypes of 160 non-carriers. Of 34 phenotypic features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant (P-value 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose-response fashion. The association of CFH Y402H polymorphism with PRPC suggests that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula; peripheral retinal changes should also be included in grading methods. PRPC may be used as a surrogate of a high-risk genotype and may be used for diagnostic, therapeutic, and research purposes.

    摘要翻译： 检查956例年龄相关性黄斑变性病例显示，补体因子H变体（Y402H，C等位基因rs1061170）增加了外周网状色素变化的发展风险。 将CF9Y402H变体的796个载体的AMD表型与160个非载体的AMD表型进行比较。 在分析的34个表型特征中，只有周围网状色素变化（PRPC）与该CFH变体相关（P值0.0006）。 AMD病例与PRPC的比例与剂量反应方式与CFH风险C等位基因数量相关。 CFH Y402H多态性与PRPC的关联表明AMD的变化并不局限于黄斑。 目前AMD分级方法仅评估黄斑; 周边视网膜变化也应包括在分级方法中。 PRPC可以用作高风险基因型的替代物，并且可以用于诊断，治疗和研究目的。

    ON DEMAND CIRCUIT FUNCTION EXECUTION EMPLOYING OPTICAL SENSING
    5.
    发明申请
    ON DEMAND CIRCUIT FUNCTION EXECUTION EMPLOYING OPTICAL SENSING 失效
    使用光电传感器的需求电路功能执行

    公开(公告)号：US20070127172A1

    公开(公告)日：2007-06-07

    申请号：US11275058

    申请日：2005-12-06

    申请人： Wagdi Abadeer ,  James Adkisson ,  Jeffrey Brown ,  Kiran Chatty ,  Robert Gauthier ,  Michael Hauser ,  Jed Rankin ,  William Tonti

    发明人： Wagdi Abadeer ,  James Adkisson ,  Jeffrey Brown ,  Kiran Chatty ,  Robert Gauthier ,  Michael Hauser ,  Jed Rankin ,  William Tonti

    IPC分类号： H02H9/00

    CPC分类号： H01L23/5256 ,  H01L23/525 ,  H01L27/14609 ,  H01L2924/0002 ,  H01L2924/00

    摘要： Disclosed is a method of executing an electrical function, such as a fusing operation, by activation through a chip embedded photodiode through spectrally selected external light activation, and corresponding structure and circuit. The present invention is based on having incident light with specific intensity/wave length characteristics, in conjunction with additional circuit elements to an integrated circuit, perform the implementation of repairs, i.e., replacing failing circuit elements with redundant ones for yield and/or reliability. Also to perform disconnection of ESD protection device from input pad once the packaged chip is placed in system. No additional pins on the package are necessary.

    摘要翻译： 公开了通过光谱选择的外部光激活通过芯片嵌入式光电二极管的激活以及相应的结构和电路来执行诸如定影操作之类的电功能的方法。 本发明基于将具有特定强度/波长特性的入射光结合到集成电路的附加电路元件，执行维修的实现，即用冗余电路替换故障电路元件以获得和/或可靠性。 一旦封装的芯片放置在系统中，也可以将ESD保护装置从输入焊盘断开。 不需要额外的引脚。

    DEVICE FOR LUBRICATING CONTRA-SLIDING PARTS
    9.
    发明申请
    DEVICE FOR LUBRICATING CONTRA-SLIDING PARTS 审中-公开
    用于润滑防滑部件的装置

    公开(公告)号：US20070295558A1

    公开(公告)日：2007-12-27

    申请号：US11743731

    申请日：2007-05-03

    申请人： Ralf Lottgen ,  Michael Hauser ,  Jens Thing

    发明人： Ralf Lottgen ,  Michael Hauser ,  Jens Thing

    IPC分类号： F16C1/24 ,  F16N3/00

    CPC分类号： B23Q11/124

    摘要： A device for lubricating contra-sliding parts of a tool device having a drive for effecting the sliding operation, wherein the device has a lubricant dispensing device for the moving parts, which lubricant dispensing device can be actuated by means of the same drive. A method for lubricating contra-sliding parts of a tool device having a drive for effecting the sliding operation, wherein a lubricating pulse is triggered by the following method steps: measuring of the path covered in the operating phase of the sliding parts, recording of the individual path lengths by means of a counter, comparison of the total actual path length with a total path length after which a lubricating pulse is intended to be triggered, and triggering of a lubricating pulse by the same drive for the sliding parts after the cumulative total path length has been reached.

    摘要翻译： 一种用于润滑具有用于进行滑动操作的驱动器的工具装置的反滑部件的装置，其中所述装置具有用于所述运动部件的润滑剂分配装置，所述润滑剂分配装置可以通过相同的驱动器来致动。 一种用于润滑具有用于进行滑动操作的驱动装置的工具装置的反滑动部件的方法，其中通过以下方法步骤触发润滑脉冲：测量滑动部件的操作阶段所覆盖的路径，记录 通过计数器的单个路径长度，总实际路径长度与旨在触发润滑脉冲的总路径长度的比较，以及在累积总数之后通过相同的驱动器触发滑动部件的润滑脉冲 路径长度已达到。