Fine platy kaolin composition
    7.
    发明申请
    Fine platy kaolin composition 有权
    精细高岭土组成

    公开(公告)号:US20060124033A1

    公开(公告)日:2006-06-15

    申请号:US10531257

    申请日:2003-12-15

    IPC分类号: C04B14/04

    摘要: The present invention relates to a kaolin composition having improved physical properties, for example, for use in the production of paper products. The composition can comprise kaolin having a shape factor of at least about 20. The kaolin can have a particle size distribution such that at least about 94% by weight of the kaolin can have an esd of less than about 2 μm and/or at least about 80% by weight of the kaolin can have an esd of less than 1 μm. The amount of the kaolin having an esd of less than about 0.25 μm can range from about 25% to about 60% by weight. The Hercules viscosity of the kaolin product is less than 4000 rpm at 18 dynes at 63% solids and less than 1500 rpm at 18 dynes at 69% solids when measured using the “A” bob. The present invention also relates to an improved method for making the kaolin product from sedimentary kaolin.

    摘要翻译: 本发明涉及具有改善的物理性能的高岭土组合物,例如用于生产纸制品。 该组合物可以包含具有至少约20的形状因子的高岭土。高岭土可以具有使得高岭土的至少约94重量%的esd可以具有小于约2μm的esd和/或至少 约80重量%的高岭土可以具有小于1m的esd。 具有小于约0.25μm的esd的高岭土的量可以为约25重量%至约60重量%。 高岭土产品的Hercules粘度在18达因数时为63%固体,小于1500转/分钟,18达因时为69%固体,当使用“A”鲍伯测量时。 本发明还涉及一种由沉淀高岭土制备高岭土产品的改进方法。

    Effective reductive bleaching of mineral slurries
    8.
    发明申请
    Effective reductive bleaching of mineral slurries 有权
    有效还原漂白矿浆

    公开(公告)号:US20070194276A1

    公开(公告)日:2007-08-23

    申请号:US10592142

    申请日:2005-03-22

    IPC分类号: C01B3/00

    摘要: Disclosed herein are a method of reductively bleaching a mineral slurry comprising adding in the mineral slurry an effective amount of a formamidine sulfinic acid (FAS) and an effective amount of a borohydride to reductively bleach the mineral slurry, compositions comprising a mineral slurry, a FAS, and a borohydride, and final products comprising a mineral obtained by the method disclosed herein.

    摘要翻译: 本文公开了一种还原性漂白矿物浆料的方法,包括在矿物浆料中加入有效量的甲脒亚磺酸(FAS)和有效量的硼氢化物以还原性漂白矿物浆料,包含矿物浆料,FAS 和硼氢化物,以及包含通过本文公开的方法获得的矿物的最终产品。

    Bioconjugates of synthetic apelin polypeptides
    10.
    发明授权
    Bioconjugates of synthetic apelin polypeptides 有权
    合成apelin多肽的生物缀合物

    公开(公告)号:US09340582B2

    公开(公告)日:2016-05-17

    申请号:US14336290

    申请日:2014-07-21

    摘要: The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

    摘要翻译: 本发明提供包含式I'(SEQ ID NO:1)的合成多肽的生物缀合物或其酰胺,其酯或其盐,其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,X 8,X 9 ,X10,X11,X12和X13在本文中定义并且半衰期延长部分,其中肽和半衰期延长部分任选地经由连接体共价连接或融合。 多肽是APJ受体的激动剂。 本发明还涉及本发明的生物缀合物的制备方法及其治疗用途,例如治疗或预防急性失代偿性心力衰竭(ADHF),慢性心力衰竭,肺动脉高压,心房颤动,布鲁加达综合征,室性心动过速,动脉粥样硬化 ,高血压,再狭窄,缺血性心血管疾病,心肌病,心脏纤维化,心律失常,保水,糖尿病(包括妊娠糖尿病),肥胖,外周动脉疾病,脑血管意外,短暂性脑缺血发作,创伤性脑损伤,肌萎缩性侧索硬化,烧伤( 包括晒伤)和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。