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    Method of and device for forming X-ray images
    1.
    发明授权
    Method of and device for forming X-ray images 失效
    用于形成X射线图像的方法和装置

    公开(公告)号：US06438194B2

    公开(公告)日：2002-08-20

    申请号：US09761250

    申请日：2001-01-16

    申请人： Michael Grass ,  Geerd Richard Kemkers

    发明人： Michael Grass ,  Geerd Richard Kemkers

    IPC分类号： A61B603

    CPC分类号： G06T3/4053 ,  A61B6/027 ,  G06T7/32 ,  G06T2207/30004

    摘要： The invention relates to a method of forming X-ray images (B) from at least two series of projection data sets (P1, P2) successively acquired along different trajectories (T1, T2), a respective 3D data set (S1, S2) being formed from each series of projection data sets (P1, P2). In order to neutralize motions of the patient between the acquisition of the individual series of projection data sets upon combination of the 3D data sets so as to form X-ray images which are as free from artefacts as possible, the invention proposes to determine a transformation rule (F) describing the location in space of the 3D data sets (S1, S2) relative to one another in such a manner that voxels are selected in a 3D data set (S1) and their location in the other 3D data set (S2) is determined by means of a suitable similarity measure, after which X-ray images (B) are formed from the 3D data sets (S1, S2) combined by means of the transformation rule (F). Consequently, it is possible to dispense with phantom members that are to be reproduced for fine adjustment of the individual 3D data sets as well as with manual fine adjustment steps. The invention also relates to an X-ray device constructed for this purpose.

    摘要翻译： 本发明涉及从沿着不同轨迹（T1，T2）连续获取的至少两个系列的投影数据集（P1，P2），相应的3D数据集（S1，S2）形成X射线图像（B）的方法， 由每一系列投影数据组（P1，P2）形成。 为了在组合3D数据组之后，在获取单个系列的投影数据集之间中和患者的运动，从而形成尽可能不含人工制品的X射线图像，本发明提出确定转换 规则（F）以3D数据集（S1）中选择的体素和其他3D数据集（S2）中的位置的方式相对于彼此描述3D数据集（S1，S2）的空间中的位置 ）通过合适的相似度测量来确定，之后，通过变换规则（F）组合的3D数据集（S1，S2）形成X射线图像（B）。 因此，可以省略要被再现的幻影成员以精细调整各个3D数据集以及手动微调步骤。 本发明还涉及为此而构造的X射线装置。

    Dynamic perfusion imaging
    2.
    发明授权
    Dynamic perfusion imaging 有权

    公开(公告)号：US09848843B2

    公开(公告)日：2017-12-26

    申请号：US14112047

    申请日：2012-04-17

    申请人： Michael Grass ,  Holger Schmitt

    发明人： Michael Grass ,  Holger Schmitt

    IPC分类号： A61B6/00

    CPC分类号： A61B6/481 ,  A61B6/00 ,  A61B6/486 ,  A61B6/503 ,  A61B6/507 ,  A61B6/5217 ,  A61B6/542 ,  A61B6/545 ,  F04C2270/0421

    摘要： A method includes scanning a region of interest, during a contrast agent based perfusion scan, at a predetermined temporal sampling rate during contrast agent uptake in the region of interest, and generating time frame data indicative of the scanned region of interest. The method further includes identifying a predetermined change in an amount of the contrast agent in the region of interest from the time frame data. The method further includes scanning the region of interest at a lower temporal sampling rate, which is lower than the temporal sampling rate during the contrast agent uptake, in response to identifying the predetermined change in the amount of the contrast agent in the region of interest.

    Perfusion imaging
    3.
    发明授权
    Perfusion imaging 有权

    公开(公告)号：US09597042B2

    公开(公告)日：2017-03-21

    申请号：US13266556

    申请日：2010-04-09

    申请人： Roland Proksa ,  Michael Grass

    发明人： Roland Proksa ,  Michael Grass

    IPC分类号： G06K9/00 ,  A61B6/03 ,  A61B6/00

    CPC分类号： A61B6/032 ,  A61B6/481 ,  A61B6/482 ,  A61B6/486 ,  A61B6/504 ,  A61B6/507

    摘要： A method is disclosed that includes decomposing, with a decomposer, agent-based time series projection data for an object or a subject into at least an agent based component. A projection data decomposer includes a time series decomposer that determines agent-based projection data based on agent-based time series projection data based on at least two energy dependent components. A computer readable storage medium containing instructions which, when executed by a computer, cause the computer to perform the act of determining an agent-based component of agent-based time series projection data utilizing at least two components of the agent-based time series projection is provided.

    Reconstruction for cone-beam computed tomography imaging with off-center flat panel detector
    5.
    发明授权
    Reconstruction for cone-beam computed tomography imaging with off-center flat panel detector 有权
    用偏心平板检测器进行锥束计算机断层扫描成像的重建

    公开(公告)号：US09087404B2

    公开(公告)日：2015-07-21

    申请号：US13697445

    申请日：2011-04-25

    申请人： Eberhard S. Hansis ,  Dirk Schaefer ,  Michael Grass

    发明人： Eberhard S. Hansis ,  Dirk Schaefer ,  Michael Grass

    IPC分类号： G01N23/04 ,  G06T1/00 ,  G06T11/00

    CPC分类号： G06T11/008 ,  G06T11/006 ,  G06T2211/432

    摘要： Computed tomography (CT) reconstruction includes reconstructing an axially extended reconstructed image from a measured cone beam x-ray projection data set (Pm), optionally having an off-center geometry. The reconstructing is performed for an extended volume (eFOV) comprising a reconstructable volume (rFOV) of the measured cone beam x ray data set that is extended along the axial direction. The projection data set may be weighted in the volume domain. Iterative reconstruction may be used, including initializing a constant volume and performing one or more iterations employing a first iterative update followed by one or more iterations employing a second, different iterative update. Alternatively, backprojection filtration (BPF) reconstruction may be used, including transforming the projection data set to a new geometry including finite differences between neighboring projection views and performing BPF using Hilbert filtering along a plurality of different directions and averaging the resultant reconstructed images to generate the final reconstructed image.

    摘要翻译： 计算机断层摄影（CT）重建包括从测量的锥形束X射线投影数据集（Pm）重建轴向延伸的重建图像，可选地具有偏心几何。 对包括沿轴向延伸的测量的锥形束x射线数据集的可重建体积（rFOV）的扩展体积（eFOV）进行重建。 投影数据集可以在体积域中加权。 可以使用迭代重建，包括初始化恒定体积并且使用第一迭代更新执行一个或多个迭代，随后使用第二，不同迭代更新的一个或多个迭代。 或者，可以使用反投影过滤（BPF）重建，包括将投影数据集变换为包括相邻投影视图之间的有限差异的新几何，并且使用沿着多个不同方向的希尔伯特滤波来执行BPF，并平均所得到的重建图像以产生 最终重建图像。

    Image data registration for dynamic perfusion CT
    6.
    发明授权
    Image data registration for dynamic perfusion CT 有权
    用于动态灌注CT的图像数据注册

    公开(公告)号：US09002089B2

    公开(公告)日：2015-04-07

    申请号：US13643167

    申请日：2011-04-12

    申请人： Michael Grass ,  Alfonso Agatino Isola

    发明人： Michael Grass ,  Alfonso Agatino Isola

    IPC分类号： G06K9/00 ,  G06T7/00 ,  A61B6/00

    CPC分类号： G06T7/0026 ,  A61B6/507 ,  G06T7/32 ,  G06T2207/10076 ,  G06T2207/30104

    摘要： A method of registering a 4D contrast enhanced image data set, wherein the 4D contrast enhanced image data set includes image data of the same volume of interest acquired at different timeframes with changing contrast enhancement, the volume of interest includes moving structure, and the different timeframes correspond to a predetermined motion phase of interest in different motion cycles of the moving structure, the method, comprising: registering image data corresponding to a plurality of the different timeframes with reference image from one of the timeframes.

    摘要翻译： 一种注册4D对比度增强图像数据集的方法，其中所述4D对比度增强图像数据集包括在改变对比度增强的不同时间帧处获取的相同感兴趣体积的图像数据，所述感兴趣的体积包括移动结构和不同的时间帧 对应于移动结构的不同运动周期中的感兴趣的预定运动相位，该方法包括：将与多个不同时间帧对应的图像数据与来自其中一个时间帧的参考图像进行对应。

    Method for continuous catalytic hydrogenation
    10.
    发明授权
    Method for continuous catalytic hydrogenation 有权
    连续催化氢化方法

    公开(公告)号：US08586784B2

    公开(公告)日：2013-11-19

    申请号：US11320409

    申请日：2005-12-29

    申请人： Michael Grass ,  Burkhard Reeken ,  Axel Tuchlenski ,  Alfred Kaizik

    发明人： Michael Grass ,  Burkhard Reeken ,  Axel Tuchlenski ,  Alfred Kaizik

    IPC分类号： C07C61/00

    CPC分类号： C07C67/303 ,  Y02P20/582 ,  C07C69/75

    摘要： The invention relates to the preparation of alicyclic carboxylic acids or their derivatives by selective hydrogenation of the corresponding aromatic carboxylic acid (derivatives) in at least two series-connected reactors, at least one reactor being operated in loop operating mode. The catalyst volumes in the method are set in such a manner that the catalyst volume required, based on the conversion rate, is as low as possible.

    摘要翻译： 本发明涉及通过在至少两个串联连接的反应器中选择性氢化相应的芳族羧酸（衍生物）来制备脂环族羧酸或其衍生物，至少一个反应器以循环操作模式操作。 该方法中的催化剂体积设定为使得基于转化率所需的催化剂体积尽可能低。