公开(公告)号：US08705042B2

公开(公告)日：2014-04-22

申请号：US13479453

申请日：2012-05-24

申请人： Michael Haisch ,  Christoph Hauger ,  Harmut Wolf ,  Joachim Hug ,  Brigitta Schwarz ,  Gerhard Gaida ,  Andreas Raabe

发明人： Michael Haisch ,  Christoph Hauger ,  Harmut Wolf ,  Joachim Hug ,  Brigitta Schwarz ,  Gerhard Gaida ,  Andreas Raabe

IPC分类号： G01J3/45

CPC分类号： G02B27/0172 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0086 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1782 ,  G01N2021/6421 ,  G02B7/002 ,  G02B21/16 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B21/368 ,  G02B2027/0134 ,  G02B2027/0138 ,  G02B2027/014

摘要： A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series.

摘要翻译： 提供显微镜系统和显微镜方法来观察积聚在组织中的荧光物质。 显微镜系统包括允许在可见光和荧光的同时观察组织的过滤器。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。

公开(公告)号：US08810907B2

公开(公告)日：2014-08-19

申请号：US13193759

申请日：2011-07-29

申请人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

发明人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

IPC分类号： G02B21/06

CPC分类号： G02B27/0172 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0086 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1782 ,  G01N2021/6421 ,  G02B7/002 ,  G02B21/16 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B21/368 ,  G02B2027/0134 ,  G02B2027/0138 ,  G02B2027/014

摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

摘要翻译： 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

公开(公告)号：US20100097618A1

公开(公告)日：2010-04-22

申请号：US12380286

申请日：2009-02-25

申请人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

发明人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

IPC分类号： G01B9/02 ,  G01B11/06 ,  H04N7/18

CPC分类号： G02B27/0172 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0086 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1782 ,  G01N2021/6421 ,  G02B7/002 ,  G02B21/16 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B21/368 ,  G02B2027/0134 ,  G02B2027/0138 ,  G02B2027/014

摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

摘要翻译： 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

公开(公告)号：US08189201B2

公开(公告)日：2012-05-29

申请号：US12380286

申请日：2009-02-25

申请人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

发明人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

IPC分类号： G01B11/02

CPC分类号： G02B27/0172 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0086 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1782 ,  G01N2021/6421 ,  G02B7/002 ,  G02B21/16 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B21/368 ,  G02B2027/0134 ,  G02B2027/0138 ,  G02B2027/014

摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

摘要翻译： 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

公开(公告)号：US20080013166A1

公开(公告)日：2008-01-17

申请号：US11901764

申请日：2007-09-19

申请人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

发明人： Michael Haisch ,  Christoph Hauger ,  Hartmut Wolf ,  Joachim Hug ,  Schwarz Brigitta ,  Gerhard Gaida ,  Andreas Raabe

IPC分类号： G02B21/06 ,  G02B21/36

CPC分类号： G02B27/0172 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0086 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1782 ,  G01N2021/6421 ,  G02B7/002 ,  G02B21/16 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B21/368 ,  G02B2027/0134 ,  G02B2027/0138 ,  G02B2027/014

摘要： A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

摘要翻译： 提供显微镜系统和显微镜方法来观察积聚在组织中的荧光物质。 显微镜系统包括允许在可见光和荧光的同时观察组织的过滤器。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

公开(公告)号：US08300309B2

公开(公告)日：2012-10-30

申请号：US13072840

申请日：2011-03-28

申请人： Michael Haisch ,  Christoph Hauger ,  Harmut Wolf ,  Joachim Hug ,  Schwarz Brigitta

发明人： Michael Haisch ,  Christoph Hauger ,  Harmut Wolf ,  Joachim Hug ,  Schwarz Brigitta

IPC分类号： G02B21/06

CPC分类号： G02B27/0172 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0086 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1782 ,  G01N2021/6421 ,  G02B7/002 ,  G02B21/16 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B21/368 ,  G02B2027/0134 ,  G02B2027/0138 ,  G02B2027/014

摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

摘要翻译： 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

公开(公告)号：US07580185B2

公开(公告)日：2009-08-25

申请号：US10650038

申请日：2003-08-28

申请人： Michael Haisch ,  Christoph Hauger ,  Gerhard Gaida ,  Andreas Raabe

发明人： Michael Haisch ,  Christoph Hauger ,  Gerhard Gaida ,  Andreas Raabe

IPC分类号： G02B21/06

CPC分类号： G02B27/0172 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0086 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1782 ,  G01N2021/6421 ,  G02B7/002 ,  G02B21/16 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B21/368 ,  G02B2027/0134 ,  G02B2027/0138 ,  G02B2027/014

摘要： A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

摘要翻译： 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。

公开(公告)号：US20100238541A1

公开(公告)日：2010-09-23

申请号：US12790522

申请日：2010-05-28

申请人： Christoph Hauger ,  Michael Haisch ,  Andreas Obrebski

发明人： Christoph Hauger ,  Michael Haisch ,  Andreas Obrebski

IPC分类号： G02B21/22

CPC分类号： G02B21/22

摘要： A stereo-examination system including an objective arrangement configured to receive an object-side beam bundle emanating from the object plane and to convert the object-side beam bundle into an image-side beam bundle and a selection arrangement configured to select at least one pair of partial beam bundles from the image side beam bundle. The system also includes an image transmission apparatus configured to generate stereoscopic images of an object positionable in the object plane from the at least one pair of partial beam bundles and an illumination arrangement. The illumination arrangement includes a light source, a beam coupler to superpose a beam cross-section of the illumination beam with the image-side beam bundle, and a field of a plurality of state-changing elements. The elements are selectively switchable between a first state directed and a second state in which light of the illumination beam is and is not directed to the object plane.

摘要翻译： 一种立体检查系统，包括被配置为接收从物体平面发出的物体侧束束并将物体侧束束转换为图像侧束束的物镜布置，以及配置为选择至少一对的选择装置 的来自图像侧束束的部分束束。 该系统还包括图像传输装置，被配置为从至少一对部分束束和照明装置生成可在物平面中定位的物体的立体图像。 照明装置包括光源，用于将照明光束的横截面与图像侧光束叠加的光束耦合器，以及多个状态变化元件的场。 元件可以在第一状态指示和第二状态之间选择性地切换，其中照明光束的光并未被引导到物体平面。

公开(公告)号：US20070127115A1

公开(公告)日：2007-06-07

申请号：US11699175

申请日：2007-01-29

申请人： Christoph Hauger ,  Michael Haisch ,  Andreas Obrebski

发明人： Christoph Hauger ,  Michael Haisch ,  Andreas Obrebski

IPC分类号： G02B21/22

CPC分类号： G02B21/22

摘要： A stereo-examination system for imaging an object 8 is proposed, comprising an objective arrangement 3 having an optical axis 5 and an object plane 7 for positioning the object 8 to be imaged, wherein the objective arrangement 3 receives an object-side beam bundle 11 emanating from the object plane 7 into a solid angle region 9 and converts the same into an image-side beam bundle 13, a selection arrangement for selecting at least a pair of partial beam bundles 19, 20 from the image-side beam bundle 13, and an image transmission apparatus 51, 52 for generating a representation of images of the object 8 provided by the partial beam bundles 19, 20. The stereo-examination system is distinguished in that the selection arrangement is provided for displacing a beam cross-section of at least one of the two partial beam bundles 19, 20 relative to a beam cross-section of the image-side beam bundle 13, a controller 49 being provided for controlling the selection arrangement to displace the beam cross-section of the at least one partial beam bundle 19, 20 in circumferential direction about the optical axis 5.

公开(公告)号：US07180660B2

公开(公告)日：2007-02-20

申请号：US10357260

申请日：2003-02-03

申请人： Christoph Hauger ,  Michael Haisch ,  Andreas Obrebski

发明人： Christoph Hauger ,  Michael Haisch ,  Andreas Obrebski

IPC分类号： G02B21/22

CPC分类号： G02B21/22

摘要： A stereo-examination system for imaging an object 8 is proposed, comprising an objective arrangement 3 having an optical axis 5 and an object plane 7 for positioning the object 8 to be imaged, wherein the objective arrangement 3 receives an object-side beam bundle 11 emanating from the object plane 7 into a solid angle region 9 and converts the same into an image-side beam bundle 13, a selection arrangement for selecting at least a pair of partial beam bundles 19, 20 from the image-side beam bundle 13, and an image transmission apparatus 51, 52 for generating a representation of images of the object 8 provided by the partial beam bundles 19, 20. The stereo-examination system is distinguished in that the selection arrangement is provided for displacing a beam cross-section of at least one of the two partial beam bundles 19, 20 relative to a beam cross-section of the image-side beam bundle 13, a controller 49 being provided for controlling the selection arrangement to displace the beam cross-section of the at least one partial beam bundle 19, 20 in circumferential direction about the optical axis 5.

摘要翻译： 提出了一种用于对物体8成像的立体检查系统，其包括具有光轴5的物镜装置3和用于定位待成像物体8的物平面7，其中物镜装置3接收物体侧束束11 从物体面7发射成立体角区域9并将其转换为图像侧束束13，用于从图像侧束束13中选择至少一对部分束束19,20的选择装置， 以及用于产生由部分束束19,20提供的物体8的图像的表示的图像传输装置51,52。该立体检查系统的区别在于，提供选择装置用于使梁的横截面 两个部分光束束19,20中的至少一个相对于图像侧束束13的光束横截面，设置有控制器49，用于控制选择装置以使bea 所述至少一个部分光束束19,20的周向的横截面围绕光轴5。