公开(公告)号：US4531056A

公开(公告)日：1985-07-23

申请号：US486645

申请日：1983-04-20

申请人： Michael J. Labowsky ,  John B. Fenn ,  Masamichi Yamashita

发明人： Michael J. Labowsky ,  John B. Fenn ,  Masamichi Yamashita

IPC分类号： B01D59/44 ,  G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC分类号： H01J49/165 ,  B01D59/44 ,  H01J49/044 ,  H01J49/0477 ,  G01N30/7273 ,  G01N30/7293

摘要： An electrospray ion source for a mass spectrometer capable of generating ions from samples dissolved in a solution comprises a capillary tube through which the said solution is pumped into a first chamber maintained substantially at atmospheric pressure and in which an inert gas is flowing in a direction counter to the flow of the solution, and a small orifice in the end wall of the chamber opposite to and aligned with the capillary. A high potential difference is applied between the capillary and the end wall so that the solution is electrosprayed into the chamber and ions characteristic of the sample are formed. These ions are desolvated to a controllable extent by the inert gas, which may also be heated to improve the efficiency of the process and increase the maximum permissible flow rate of solution. The ions so formed pass through the small orifice into a second chamber maintained at a reduced pressure, and into a mass spectrometer. Alternatively an additional pressure reduction stage can be included, so that the ions pass into a third chamber maintained at a still lower pressure in which the mass spectrometer is situated through a conventional nozzle and skimmer arrangement. The ion source is particularly effective for the production of unfragmented and unsolvated ions from thermally unstable or involatile samples, and may be used as a liquid chromatograph--mass spectrometer interface.

摘要翻译： 用于能够从溶解在溶液中的样品产生离子的质谱仪的电喷雾离子源包括毛细管，所述溶液通过该毛细管被泵入保持基本上处于大气压的第一室，并且惰性气体沿反方向流动 到溶液的流动，以及在腔室的端壁中与毛细管相对并与毛细管对准的小孔口。 在毛细管和端壁之间施加高电位差，使得溶液电喷雾到室中并形成样品的特征。 这些离子通过惰性气体被解吸到可控程度，惰性气体也可被加热以提高过程的效率并增加溶液的最大允许流速。 如此形成的离子通过小孔进入保持在减压下的第二室，并进入质谱仪。 或者，可以包括另外的减压阶段，使得离子进入维持在更低压力的第三室中，在该压力下质谱仪通过常规喷嘴和分离器排列设置。 离子源对于从热不稳定或非挥发性样品生产未分散和未溶解的离子特别有效，并且可以用作液相色谱 - 质谱仪界面。

公开(公告)号：US5635713A

公开(公告)日：1997-06-03

申请号：US491261

申请日：1995-06-16

申请人： Michael J. Labowsky

发明人： Michael J. Labowsky

IPC分类号： H01J49/02 ,  H01J49/04

CPC分类号： H01J49/0027

摘要： A method for analyzing chemical species and determining the molecular weight of a parent molecule. Multiply charged ions are produced from the parent molecule by adding adduct ions thereto. A mass analysis is conducted of the multiply charged ions to generate mass/charge data. The molecular weight is calculated by using a deconvolution procedure in which the adduct ion mass and the molecular weight of the parent molecule are both treated as unknowns. Alternatively, a modified deconvolution procedure in which the adduct ion mass is treated as a known value is used.

摘要翻译： 用于分析化学物质并测定母体分子的分子量的方法。 通过向母体分子中加入加成离子而产生带负电荷的离子。 对多电荷离子进行质量分析以产生质量/电荷数据。 通过使用其中加合离子质量和母体分子的分子量都被作为未知物处理的去卷积方法来计算分子量。 或者，使用其中将加合离子质量作为已知值处理的改进的去卷积方法。

公开(公告)号：US06787763B2

公开(公告)日：2004-09-07

申请号：US10286672

申请日：2002-11-01

申请人： Juan Fernandez De La Mora ,  Michael J. Labowsky

发明人： Juan Fernandez De La Mora ,  Michael J. Labowsky

IPC分类号： H01J4940

CPC分类号： H01J49/40 ,  G01N27/62

摘要： A differential mobility analyzer (DMA) for separating charged particles or ions suspended in a gas and a method of using the DMA for separating such particles. The invention includes various means for increasing the resolution of the DMA by stabilizing the laminar flow within the DMA and by allowing unusually large flow velocities.

摘要翻译： 用于分离悬浮在气体中的带电粒子或离子的差分迁移率分析仪（DMA）和使用DMA分离这些颗粒的方法。 本发明包括通过稳定DMA内的层流并且允许非常大的流速来提高DMA分辨率的各种手段。

公开(公告)号：US07161143B2

公开(公告)日：2007-01-09

申请号：US10923623

申请日：2004-08-20

申请人： Juan Fernandez De La Mora ,  Michael J. Labowsky ,  Jerome J. Schmitt, III ,  G. Wayne Neilson

发明人： Juan Fernandez De La Mora ,  Michael J. Labowsky ,  Jerome J. Schmitt, III ,  G. Wayne Neilson

IPC分类号： H01J49/40 ,  G01N27/60

CPC分类号： H01J49/40 ,  G01N27/62

摘要： A differential mobility analyzer (DMA) for separating charged particles or ions suspended in a gas and a method of using the DMA for separating such particles. The invention includes various means for increasing the resolution of the DMA by stabilizing the laminar flow within the DMA and by allowing unusually large flow velocities.

摘要翻译： 用于分离悬浮在气体中的带电粒子或离子的差分迁移率分析仪（DMA）和使用DMA分离这些颗粒的方法。 本发明包括通过稳定DMA内的层流并且允许非常大的流速来提高DMA分辨率的各种手段。

公开(公告)号：US07626161B2

公开(公告)日：2009-12-01

申请号：US10556521

申请日：2004-02-21

申请人： Michael J. Labowsky ,  Juan Fernandez de la Mora

发明人： Michael J. Labowsky ,  Juan Fernandez de la Mora

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： G01N27/622 ,  G01N15/0266

摘要： The invention describes a system and method to separate ions (and charged particles) suspended in gas based on their ion electrical mobility. Most common ion mobility analyzers involve two parallel plate (or concentric cylinder) elements (electrodes) between which is imposed an electrical field perpendicular to a sheath gas flow field between the cylinders. Separation occurs because high mobility ions tend to follow the electrical field while low mobility ions tend to follow the flow field. This invention describes various configurations of electrical elements and sheath gas flow fields for ion mobility separation devices with unique performance characteristics. These characteristics include devices in which: the ion inlet and outlet are on the same element; the inlet and outlet are at the same voltage; the outlet is upstream from the inlet; the outlet is on the axis; the inlet is on the axis; and the ions are focused on the outlet.

摘要翻译： 本发明描述了基于其离子电迁移率分离悬浮在气体中的离子（和带电粒子）的系统和方法。 最常见的离子迁移率分析仪涉及两个平行板（或同心圆筒）元件（电极），其间施加垂直于气缸之间的鞘气流场的电场。 发生分离，因为高迁移率离子倾向于跟随电场，而低迁移率离子倾向于跟随流场。 本发明描述了具有独特性能特征的离子迁移率分离装置的电气元件和鞘气流场的各种配置。 这些特征包括：离子入口和出口在同一元件上的装置; 入口和出口处于相同的电压; 出口在入口的上游; 出口在轴上; 入口在轴上; 并且离子聚焦在出口上。

公开(公告)号：US5440119A

公开(公告)日：1995-08-08

申请号：US220369

申请日：1994-03-30

申请人： Michael J. Labowsky

发明人： Michael J. Labowsky

IPC分类号： H01J49/02 ,  H01J49/04 ,  B01D59/44

CPC分类号： H01J49/0027

摘要： The invention comprises a method of analyzing the results obtained from the mass analysis of an ensemble or population of multiply charged ions comprising large polyatomic molecules of which is attached a plurality of charges. These molecules can be charged either by the attachment of charged mass or by the loss of charged mass. The charged mass is referred to as the "adduct" ion mass. The measured mass spectrum for such a population of ions generally comprises a sequence of peaks for each distinct polyatomic molecular species, the ions of each peak differing from those of adjacent peaks in the sequence by only a single charge. The method of analysis taught by the invention produces a deconvoluted spectrum in which there is only one peak for each distinct molecular species, the magnitude of that single peak containing contributions from each of the multiplicity of peaks for that species in the measured spectrum. A unique feature of the method taught by the invention is the use of special signal filters and enhancer and averaging techniques which eliminate noise and artifact peaks and make the final spectrum easier to understand and to interpret.

摘要翻译： 本发明包括一种分析从多重电荷离子的组合或群体的质量分析获得的结果的方法，其包括附加多个电荷的大的多原子分子。 这些分子可以通过带电物质的附着或带电质量的损失而被带电。 带电量称为“加合物”离子质量。 对于这样的离子群体的测量质谱通常包含每个不同的多原子分子物种的一系列峰，每个峰的离子与序列中的相邻峰的离子仅通过单次电荷而不同。 本发明教导的分析方法产生解卷积光谱，其中对于每个不同的分子物种仅存在一个峰，该单峰的量值包含来自测定光谱中该物种的多个峰的每个峰的贡献。 本发明教导的方法的独特特征是使用特殊的信号滤波器和增强器和平均技术来消除噪声和伪像峰值，并使最终频谱更容易理解和解释。

公开(公告)号：US5300771A

公开(公告)日：1994-04-05

申请号：US892113

申请日：1992-06-02

申请人： Michael J. Labowsky

发明人： Michael J. Labowsky

IPC分类号： H01J49/02 ,  H01J49/04 ,  B01D59/44

CPC分类号： H01J49/0027

摘要： The invention comprises a method of analyzing the results obtained from the mass analysis of an ensemble or population of multiply charged ions comprising large polyatomic molecules to each of which is attached a plurality of charges. These molecules can be charged either by the attachment of charged mass or by the loss of charged mass. The charged mass is referred to as the "adduct" ion mass. The measured mass spectrum for such a population of ions generally comprises a sequence of peaks for each distinct polyatomic molecular species, the ions of each peak differing from those of adjacent peaks in the sequence by only a single charge. The method of analysis taught by the invention produces a deconvoluted spectrum in which there is only one peak for each distinct molecular species, the magnitude of that single peak containing contributions from each of the multiplicity of peaks for that species in the measured spectrum. A unique feature of the method taught by the invention is that the deconvoluted spectrum becomes a three dimensional surface in which the three coordinates of the single peak for a particular species represent respectively the molecular weight Mr of the parent polyatomic molecular species, the effective mass ma of the adduct ion charges, and the relative abundance of the ions of the polyatomic molecular species in the population of ions that gave rise to the measured spectrum. Consequently, there is no need to assume a priori a particular value for the mass of the adduct ion.

摘要翻译： 本发明包括一种分析从包含大多原子分子的多重带电离子的集合或群体的质量分析获得的结果的方法，每个多原子分子连接多个电荷。 这些分子可以通过带电物质的附着或带电质量的损失而被带电。 带电量称为“加合物”离子质量。 对于这样的离子群体的测量质谱通常包含每个不同的多原子分子物种的一系列峰，每个峰的离子与序列中的相邻峰的离子仅通过单次电荷而不同。 本发明教导的分析方法产生解卷积光谱，其中对于每个不同的分子物种仅存在一个峰，该单峰的量值包含来自测定光谱中该物种的多个峰的每个峰的贡献。 本发明教导的方法的独特之处在于，解卷积光谱成为三维表面，其中特定物种的单峰的三个坐标分别表示母体多原子分子种类的分子量Mr，有效质量ma 的加合离子电荷，以及多原子分子物种在离子群中产生测量光谱的相对丰度。 因此，不需要假定加合物质量的特定值。