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1.发明授权6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade 失效可用于选择性抑制凝血级联的6元杂环化合物公开(公告)号：US06969715B2
公开(公告)日：2005-11-29
申请号：US10263637
申请日：2002-10-03
申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
IPC分类号： C07D249/12 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/513 , A61K31/53 , A61K31/535 , A61K45/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07C257/18 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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公开(公告)号：US07105559B2
公开(公告)日：2006-09-12
申请号：US10263936
申请日：2002-10-03
申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
IPC分类号： C07D23/10 , A61K31/415
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D207/46 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
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3.发明授权Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶公开(公告)号：US06828338B2
公开(公告)日：2004-12-07
申请号：US10465125
申请日：2003-06-19
申请人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
发明人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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公开(公告)号：US06624180B2
公开(公告)日：2003-09-23
申请号：US09989634
申请日：2001-11-20
申请人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
发明人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
IPC分类号： C07D21306
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
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5.发明授权Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和异齿酰基吡嗪酮公开(公告)号：US07119094B1
公开(公告)日：2006-10-10
申请号：US10276174
申请日：2000-11-20
申请人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney
发明人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney
IPC分类号： A61K31/4965 , C07D241/02
CPC分类号： C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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6.发明授权Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮公开(公告)号：US06664255B1
公开(公告)日：2003-12-16
申请号：US09574752
申请日：2000-05-18
申请人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
发明人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
IPC分类号： C07D24120
CPC分类号： C07D417/12 , A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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7.发明授权Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮公开(公告)号：US06908919B2
公开(公告)日：2005-06-21
申请号：US10195573
申请日：2002-07-15
申请人： Michael S. South , Brenda L. Case , Thomas A. Dice , Ricky L. Fenton , Gary W. Franklin , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , Carrie L. Kusturin , Richard J. Lindmark , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney , John J. Parlow , Melvin L. Rueppel
发明人： Michael S. South , Brenda L. Case , Thomas A. Dice , Ricky L. Fenton , Gary W. Franklin , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , Carrie L. Kusturin , Richard J. Lindmark , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney , John J. Parlow , Melvin L. Rueppel
IPC分类号： A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/495 , A61P7/02
CPC分类号： C07D401/12 , A61K38/00 , C04B35/632 , C07D241/20 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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公开(公告)号：US08393026B2
公开(公告)日：2013-03-12
申请号：US13118037
申请日：2011-05-27
申请人： Jean-Paul Dionne , David Kim Soui Wan Fong , David T. Becker , Christopher J. Hopper , Michael J. Hayes , Richard C. Mayoras, Jr.
发明人： Jean-Paul Dionne , David Kim Soui Wan Fong , David T. Becker , Christopher J. Hopper , Michael J. Hayes , Richard C. Mayoras, Jr.
CPC分类号： B60T7/085 , A61G7/005 , A61G7/012 , A61G7/015 , A61G7/018 , A61G7/05 , A61G7/0506 , A61G7/0507 , A61G7/0509 , A61G7/0514 , A61G7/0516 , A61G7/052 , A61G7/0524 , A61G7/0527 , A61G7/0528 , A61G7/08 , A61G7/1046 , A61G2203/16 , A61G2203/20 , A61G2203/32 , A61G2203/36 , A61G2203/42 , A61G2203/44 , A61G2203/46 , A61G2210/50 , A61M5/1415 , B60T17/22 , G16H40/63
摘要： A patient support apparatus includes a deck, a plurality of side rails, a control panel, and a plurality of subsystems, such as a bed exit system that detects when a patient may exit from the support apparatus, or a lifting mechanism to raise and lower the deck. A controller is in communication with the control panel and is adapted to monitor conditions regarding the side rails and/or the other subsystems. At least one lamp is also provided on the patient support apparatus that is adapted to be illuminated in a first manner when a plurality of monitored conditions remain in a desired state, and in a second manner when at least one of the plurality of monitored conditions changes to an undesired state.
摘要翻译： 患者支撑装置包括甲板，多个侧轨，控制面板和多个子系统，例如检测病人什么时候可能从支撑装置退出的床出口系统，或提升机构升高和降低 甲板。 控制器与控制面板通信，并且适于监测关于侧轨和/或其他子系统的状况。 至少一个灯还设置在患者支撑装置上，当多个监视条件保持在期望状态时，适于以第一方式照亮，并且当多个监视条件中的至少一个变化时，第二种方式 到不期望的状态。
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公开(公告)号：US20110277242A1
公开(公告)日：2011-11-17
申请号：US13118037
申请日：2011-05-27
申请人： Jean-Paul Dionne , David Kim Soui Wan Fong , David T. Becker , Christopher J. Hopper , Michael J. Hayes , Richard C. Mayoras, JR.
发明人： Jean-Paul Dionne , David Kim Soui Wan Fong , David T. Becker , Christopher J. Hopper , Michael J. Hayes , Richard C. Mayoras, JR.
CPC分类号： B60T7/085 , A61G7/005 , A61G7/012 , A61G7/015 , A61G7/018 , A61G7/05 , A61G7/0506 , A61G7/0507 , A61G7/0509 , A61G7/0514 , A61G7/0516 , A61G7/052 , A61G7/0524 , A61G7/0527 , A61G7/0528 , A61G7/08 , A61G7/1046 , A61G2203/16 , A61G2203/20 , A61G2203/32 , A61G2203/36 , A61G2203/42 , A61G2203/44 , A61G2203/46 , A61G2210/50 , A61M5/1415 , B60T17/22 , G16H40/63
摘要： A patient support apparatus includes a deck, a plurality of side rails, a control panel, and a plurality of subsystems, such as a bed exit system that detects when a patient may exit from the support apparatus, or a lifting mechanism to raise and lower the deck. A controller is in communication with the control panel and is adapted to monitor conditions regarding the side rails and/or the other subsystems. At least one lamp is also provided on the patient support apparatus that is adapted to be illuminated in a first manner when a plurality of monitored conditions remain in a desired state, and in a second manner when at least one of the plurality of monitored conditions changes to an undesired state.
摘要翻译： 患者支撑装置包括甲板，多个侧轨，控制面板和多个子系统，例如检测病人什么时候可能从支撑装置退出的床出口系统，或提升机构升高和降低 甲板。 控制器与控制面板通信，并且适于监测关于侧轨和/或其他子系统的状况。 至少一个灯还设置在患者支撑装置上，当多个监视条件保持在期望状态时，适于以第一方式照亮，并且当多个监视条件中的至少一个变化时，第二种方式 到不期望的状态。
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公开(公告)号：US08840573B2
公开(公告)日：2014-09-23
申请号：US12229764
申请日：2008-08-27
CPC分类号： A61N1/205 , A61H23/0263 , A61H2201/165 , A61H2201/5058 , A61N1/328 , Y10S5/94
摘要： An apparatus for the prevention of decubitus ulcers includes an overlay and a plurality of stimulation segments disposed throughout the overlay, wherein the stimulation segments provide stimulation. At least one sensor is disposed within at least one of the plurality of stimulation segments. A controller is electrically connected to the at least one sensor, wherein the controller gathers data from the sensor, processes the data, and transmits instructions to the stimulation segments.
摘要翻译： 用于预防褥疮溃疡的装置包括覆盖层和遍及覆盖层设置的多个刺激段，其中刺激段提供刺激。 至少一个传感器设置在所述多个刺激段中的至少一个中。 控制器电连接到所述至少一个传感器，其中所述控制器从所述传感器收集数据，处理所述数据并将指令发送到所述刺激段。
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