公开(公告)号：US6130351A

公开(公告)日：2000-10-10

申请号：US373106

申请日：1999-08-12

申请人： Michael K. Stern ,  Todd J. Johnson ,  Amy L. Jorgenson ,  Michael D. Rogers ,  Thaddeus S. Franczyk, II

发明人： Michael K. Stern ,  Todd J. Johnson ,  Amy L. Jorgenson ,  Michael D. Rogers ,  Thaddeus S. Franczyk, II

IPC分类号： B01J20/26 ,  B01J20/34 ,  B01J31/20 ,  B01J31/40 ,  B01J38/00 ,  C07B61/00 ,  C07C233/47 ,  C07D241/08 ,  C07F9/38

CPC分类号： C07D241/08 ,  C07C233/47 ,  C07F9/3808

摘要： A process for the production of N-(phosphonomethyl)iminodiacetic acid. N-(acetyl)iminodiacetic acid is formed in a amidocarboxymethylation reactor system, into which a source of each of the following is continuously fed: (1) acetamide or an acetamide derivative, (2) formaldehyde or a formaldehyde generator or derivative, (3) a carbonylation catalyst, (4) carbon monoxide, and optionally (5) hydrogen. In turn, an amidocarboxymethylation reaction product stream, which contains N-(acetyl)iminodiacetic acid and the carbonylation catalyst, is withdrawn from the amidocarboxymethylation reactor system. The carbonylation catalyst is separated from the amidocarboxymethylation reaction product stream to recover the carbonylation catalyst and form a catalyst depleted product stream which contains N-(acetyl)iminodiacetic acid. The separated carbonylation catalyst is returned to the amidocarboxymethylation reactor system, and the N-(acetyl)iminodiacetic acid in the catalyst depleted product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. Either way, the N-(phosphonomethyl)iminodiacetic acid is precipitated from the phosphonomethylation reaction product stream in the presence of acetic acid, and the precipitate is recovered to form a filtrate stream.

摘要翻译： 一种生产N-（膦酰基甲基）亚氨基二乙酸的方法。 在酰胺羧甲基化反应器系统中形成N-（乙酰基）亚氨基二乙酸，其中连续供给以下各项的源：（1）乙酰胺或乙酰胺衍生物，（2）甲醛或甲醛发生剂或衍生物，（3 ）羰基化催化剂，（4）一氧化碳和任选的（5）氢。 反过来，含有N-（乙酰基）亚氨基二乙酸和羰基化催化剂的酰胺甲基甲基化反应产物流从酰胺羧甲基化反应器系统中排出。 从酰胺羧甲基化反应产物流中分离羰基化催化剂以回收羰基化催化剂并形成含有N-（乙酰基）亚氨基二乙酸的催化剂贫化产物流。 将分离的羰基化催化剂返回到酰胺羧甲基化反应器系统中，催化剂贫化产物流中的N-（乙酰基）亚氨基二乙酸是：（1）在酸存在下与磷源和甲醛源反应 以形成含有N-（膦酰基甲基）亚氨基二乙酸和乙酸的膦酰基甲基化反应产物流; 或（2）脱酰基并环化形成2,5-二酮哌嗪，然后在酸存在下与磷源和甲醛源反应，形成含有N-（膦酰基甲基）亚氨基二乙酸的膦酰基甲基化反应产物流 和乙酸。 无论哪种方式，在乙酸存在下，从膦酰基甲基化反应产物流中沉淀N-（膦酰基甲基）亚氨基二乙酸，并回收沉淀物以形成滤液流。

公开(公告)号：US06278017B1

公开(公告)日：2001-08-21

申请号：US09612705

申请日：2000-07-10

申请人： Michael K. Stern ,  Todd J. Johnson ,  Amy L. Jorgenson ,  Michael D. Rogers ,  Thaddeus S. Franczyk, II

发明人： Michael K. Stern ,  Todd J. Johnson ,  Amy L. Jorgenson ,  Michael D. Rogers ,  Thaddeus S. Franczyk, II

IPC分类号： C07F938

CPC分类号： C07D241/08 ,  C07C233/47 ,  C07F9/3808

摘要： A process for the continuous production of N-(phosphonomethyl)glycine is provided. In the process, N-(acetyl)iminodiacetic acid is formed in an amidocarboxymethylation reactor system. The N-(acetyl)iminodiacetic acid product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. In either case, the N-(phosphonomethyl)iminodiacetic acid product is recovered and converted to N-(phosphonomethyl)glycine.

摘要翻译： 提供了连续生产N-（膦酰基甲基）甘氨酸的方法。 在此过程中，N-（乙酰基）亚氨基二乙酸在酰胺羧甲基化反应器体系中形成。 N-（乙酰基）亚氨基二乙酸产物流是：（1）在酸存在下与磷源和甲醛源反应，形成含有N-（膦酰基甲基）亚氨基二乙酸和乙酸的膦酰基甲基化反应产物流 酸; 或（2）脱酰基并环化形成2,5-二酮哌嗪，然后在酸存在下与磷源和甲醛源反应，形成含有N-（膦酰基甲基）亚氨基二乙酸的膦酰基甲基化反应产物流 和乙酸。 在任一种情况下，N-（膦酰基甲基）亚氨基二乙酸产物被回收并转化成N-（膦酰基甲基）甘氨酸。

公开(公告)号：US06265605B1

公开(公告)日：2001-07-24

申请号：US09499699

申请日：2000-02-07

申请人： Todd J. Johnson ,  Michael K. Stern ,  David A. Morgenstern ,  Michael D. Rogers ,  Yvette M. Fobian ,  Jeffrey A. Levine

发明人： Todd J. Johnson ,  Michael K. Stern ,  David A. Morgenstern ,  Michael D. Rogers ,  Yvette M. Fobian ,  Jeffrey A. Levine

IPC分类号： C07F938

CPC分类号： C07F9/3813 ,  C07C227/00 ,  C07C275/16 ,  C07D241/18 ,  C07D251/04 ,  C07D251/14

摘要： Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.

摘要翻译： 新型化合物，N，N'-双（膦酰基甲基）-N，N'-双（羟基羰基甲基）脲和N，N，N'，N'-四（羟基羰基甲基）脲，适用于制备N-酰基氨基羧酸 可以容易地转化成N-（膦酰基甲基）甘氨酸。 这些化合物可以通过在羧甲基化催化剂前体和溶剂的存在下分别与双 - （phosophonomethyl）脲或脲与一氧化碳和甲醛的反应形成。

公开(公告)号：US6153753A

公开(公告)日：2000-11-28

申请号：US22967

申请日：1998-02-12

申请人： Todd J. Johnson ,  Michael K. Stern ,  David A. Morgenstern ,  Michael D. Rogers ,  Yvette M. Fobian ,  Jeffrey A. Levine

发明人： Todd J. Johnson ,  Michael K. Stern ,  David A. Morgenstern ,  Michael D. Rogers ,  Yvette M. Fobian ,  Jeffrey A. Levine

IPC分类号： B01J31/24 ,  B01J31/20 ,  C07B61/00 ,  C07C227/00 ,  C07C227/20 ,  C07C229/16 ,  C07C231/08 ,  C07C233/36 ,  C07C233/47 ,  C07C273/18 ,  C07C275/16 ,  C07D241/08 ,  C07D241/18 ,  C07D251/04 ,  C07D251/14 ,  C07F9/38 ,  C07F9/40 ,  C07F9/6509

CPC分类号： C07F9/3813 ,  C07C227/00 ,  C07C275/16 ,  C07D241/18 ,  C07D251/04 ,  C07D251/14

摘要： Process for the preparation of an N-acyl amino carboxylic acid by means of a carboxymethylation reaction. In this reaction, a reaction mixture is formed which contains a base pair, carbon monoxide, hydrogen and an aldehyde with the base pair comprising a carbamoyl compound and a carboxymethylation catalyst precursor. In a preferred embodiment, the carbamoyl compound and aldehyde are selected to yield an N-acyl amino carboxylic acid which is readily converted to N-(phosphonomethyl)glycine, or a salt or ester thereof.

摘要翻译： 通过羧甲基化反应制备N-酰基氨基羧酸的方法。 在该反应中，形成含有碱基对，一氧化碳，氢和醛的反应混合物，碱基对包含氨基甲酰基化合物和羧甲基化催化剂前体。 在优选的实施方案中，选择氨基甲酰基化合物和醛以产生N-酰基氨基羧酸，其易于转化为N-（膦酰基甲基）甘氨酸或其盐或酯。

公开(公告)号：US08735345B2

公开(公告)日：2014-05-27

申请号：US12713497

申请日：2010-02-26

申请人： Steven B. Porter ,  Williamson Ziegler Bradford ,  Patrick F. Smith ,  Ellen S. Yetzer ,  Abel De La Rosa ,  Michael D. Rogers ,  William T. Symonds

发明人： Steven B. Porter ,  Williamson Ziegler Bradford ,  Patrick F. Smith ,  Ellen S. Yetzer ,  Abel De La Rosa ,  Michael D. Rogers ,  William T. Symonds

IPC分类号： A61K38/06 ,  A61K38/12

CPC分类号： A61K31/395 ,  A61K31/4709 ,  A61K31/7068 ,  A61K2300/00

摘要： Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

摘要翻译： 本申请中公开的实施方案涉及可以包括丙型肝炎病毒聚合酶抑制剂或其药学上可接受的盐或前药以及丙型肝炎病毒蛋白酶抑制剂或其药学上可接受的盐或前药的组合物。 所公开的其它实施方案涉及用丙型肝炎病毒聚合酶抑制剂或其药学上可接受的盐或前药和丙型肝炎病毒蛋白酶抑制剂治疗疾病状况如丙型肝炎病毒感染，肝纤维化和/或肝功能受损的方法， 或其药学上可接受的盐或前药。

公开(公告)号：US4964895A

公开(公告)日：1990-10-23

申请号：US471686

申请日：1990-01-30

申请人： Kurt Moedritzer ,  Michael D. Rogers

发明人： Kurt Moedritzer ,  Michael D. Rogers

IPC分类号： A01N43/56 ,  C07D231/22 ,  C07D231/30 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D521/00 ,  C07F7/08 ,  C07F9/6503

CPC分类号： C07F9/65037 ,  A01N43/56 ,  C07D231/12 ,  C07D231/22 ,  C07D231/30 ,  C07D231/56 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07F7/0812 ,  C07F9/65033

摘要： The present invention relates to certain novel substituted 3-(4-nitrophenoxy)pyrazoles and their use as herbicides.

摘要翻译： 本发明涉及某些新的取代的3-（4-硝基苯氧基）吡唑及其作为除草剂的用途。

公开(公告)号：US07629871B2

公开(公告)日：2009-12-08

申请号：US11701643

申请日：2007-02-01

申请人： Allan E. Schrum ,  Michael D. Rogers

发明人： Allan E. Schrum ,  Michael D. Rogers

IPC分类号： H01C10/00

CPC分类号： H01C10/12 ,  H01C10/06 ,  H01C10/305 ,  H01C10/38 ,  Y10T29/49082 ,  Y10T29/49085 ,  Y10T29/49101 ,  Y10T29/49117

摘要： A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor. The straight resistance component increases or decreases as the distance between the first contact location and the second contact location increases or decrease, respectively. The parallel path resistance component has preset desired characteristics based on selected first and second contact locations and selected first and second contact areas. The first and second contact locations and first and second contact areas can be selected such that the change in the resistance between the first and second contact locations is at least substantially equal to the change in the straight resistance component or the change in the parallel path resistance component.

摘要翻译： 可变电阻装置包括具有电阻弹性材料的电阻构件。 第一导体被配置为在第一接触区域上的第一接触位置处与电阻构件电耦合。 第二导体被配置为在第二接触区域上的第二接触位置处与电阻构件电耦合。 第一接触位置和第二接触位置彼此间隔一定距离。 在第一接触位置处的第一导体与第二接触位置处的第二导体之间的电阻等于直电阻分量和平行路径电阻分量的和。 改变第一位置，第二位置，第一接触区域和第二接触区域中的至少一个，以产生第一导体和第二导体之间的电阻变化。 直电阻分量随着第一接触位置和第二接触位置之间的距离分别增加或减小而增加或减小。 平行路径电阻分量基于所选择的第一和第二接触位置以及所选择的第一和第二接触区域来预设期望的特性。 可以选择第一和第二接触位置以及第一和第二接触区域，使得第一和第二接触位置之间的电阻的变化至少基本上等于直线电阻分量的变化或平行路径电阻的变化 零件。

公开(公告)号：US07190251B2

公开(公告)日：2007-03-13

申请号：US10188513

申请日：2002-07-03

申请人： Allan E. Schrum ,  Michael D. Rogers

发明人： Allan E. Schrum ,  Michael D. Rogers

IPC分类号： H01C10/06

CPC分类号： H01C10/12 ,  H01C10/06 ,  H01C10/305 ,  H01C10/38 ,  Y10T29/49082 ,  Y10T29/49085 ,  Y10T29/49101 ,  Y10T29/49117

摘要： A method of providing a variable resistance from a resistive member including a resistive resilient material comprises electrically coupling a first conductor with the resistive member at a first contact location over a first contact area; and electrically coupling a second conductor with the resistive member at a movable second contact location over a second contact area. The second contact location is movable relative to the resistive member to change the second contact location between the second conductor and the resistive member, the first contact location and the movable second contact location being spaced from one another by a distance. The method further comprises changing at least one of the first location, the second location, the first contact area, and the second contact area to produce a change in resistance in the resistive member, measured between the first conductor at the first contact location and the second conductor at the second contact location, as the resistive member deforms along the second conductor.

摘要翻译： 从包括电阻弹性材料的电阻构件提供可变电阻的方法包括在第一接触区域上的第一接触位置电耦合第一导体与电阻构件; 以及在第二接触区域上的可移动的第二接触位置处将第二导体与所述电阻构件电耦合。 第二接触位置可相对于电阻构件移动以改变第二导体和电阻构件之间的第二接触位置，第一接触位置和可动第二接触位置彼此间隔一定距离。 该方法还包括改变第一位置，第二位置，第一接触区域和第二接触区域中的至少一个，以在第一接触位置处的第一导体与第一接触位置之间测量的电阻构件中的电阻变化， 第二导体在第二接触位置处，因为电阻构件沿着第二导体变形。

公开(公告)号：US5530126A

公开(公告)日：1996-06-25

申请号：US189337

申请日：1994-01-31

申请人： Scott S. Woodard ,  Bruce C. Hamper ,  Kurt Moedritzer ,  Michael D. Rogers ,  Deborah A. Mischke ,  Gerard A. Dutra

发明人： Scott S. Woodard ,  Bruce C. Hamper ,  Kurt Moedritzer ,  Michael D. Rogers ,  Deborah A. Mischke ,  Gerard A. Dutra

IPC分类号： A01N43/56 ,  A01N43/78 ,  A01P7/04 ,  C07C45/29 ,  C07C45/45 ,  C07C49/80 ,  C07C49/835 ,  C07D231/12 ,  C07D231/16 ,  C07D231/18 ,  C07D231/22 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D409/10 ,  C07D409/12 ,  C07D411/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D498/04 ,  C07D521/00 ,  C07D417/10

CPC分类号： C07D231/12 ,  C07C45/292 ,  C07C45/455 ,  C07C49/80 ,  C07C49/835 ,  C07D231/16 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D411/04 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04

摘要： The disclosure herein relates to a process for the preparation of compounds according to Formula N ##STR1## which comprises using a compound of Formula M ##STR2## as starting material for alkylation to said compounds of Formula N in an inert solvent at temperatures within the range of 0.degree.-200.degree. C. whereinR.sub.1 is C.sub.1-5 alkyl;R.sub.2 is C.sub.1-5 haloalkyl;R.sub.3 is halogen;R.sub.5 is hydrogen or halogen;q is 0-2;R.sub.28 and R.sub.30 are independently an alkyl, alkenyl or alkynyl radical having up to 5 carbon atoms or said radicals substituted with a ##STR3## radical; X is O, S(O).sub.m, NR.sub.19 or CR.sub.20 R.sub.21 ;Y is O, S(O).sub.m or NR.sub.22 ;m is 0-2 andR.sub.13 and R.sub.19 -R.sub.22 are hydrogen or an R.sub.28 member.The above compounds are useful as herbicides.

摘要翻译： 本文的公开内容涉及制备根据式N的式M化合物的方法，其为在惰性溶剂中在0℃-200℃范围内的烷基化作用的式N化合物的起始原料。 其中R1是C1-5烷基; R2是C1-5卤代烷基; R3是卤素; R5是氢或卤素; q为0-2; R 28和R 30独立地为具有至多5个碳原子的烷基，烯基或炔基或所述基团被一个或多个基团取代; X为O，S（O）m，NR 19或CR 20 R 21; Y是O，S（O）m或NR 22; m为0-2，R 13和R 19 -R 22为氢或R 28成员。 上述化合物可用作除草剂。

公开(公告)号：US20100221217A1

公开(公告)日：2010-09-02

申请号：US12713497

申请日：2010-02-26

申请人： Steven B. Porter ,  Williamson Ziegler Bradford ,  Patrick F. Smith ,  Ellen S. Yetzer ,  Abel De La Rosa ,  Michael D. Rogers ,  William T. Symonds

发明人： Steven B. Porter ,  Williamson Ziegler Bradford ,  Patrick F. Smith ,  Ellen S. Yetzer ,  Abel De La Rosa ,  Michael D. Rogers ,  William T. Symonds

IPC分类号： A61K38/21 ,  A61P31/12 ,  A61K38/16 ,  A61K31/70 ,  A61K31/4965 ,  A61K31/505 ,  A61P1/16

CPC分类号： A61K31/395 ,  A61K31/4709 ,  A61K31/7068 ,  A61K2300/00

摘要： Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

摘要翻译： 本申请中公开的实施方案涉及可以包括丙型肝炎病毒聚合酶抑制剂或其药学上可接受的盐或前药以及丙型肝炎病毒蛋白酶抑制剂或其药学上可接受的盐或前药的组合物。 所公开的其它实施方案涉及用丙型肝炎病毒聚合酶抑制剂或其药学上可接受的盐或前药和丙型肝炎病毒蛋白酶抑制剂治疗疾病状况如丙型肝炎病毒感染，肝纤维化和/或肝功能受损的方法， 或其药学上可接受的盐或前药。