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1.&agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰脲衍生物公开(公告)号:US06683648B2
公开(公告)日:2004-01-27
申请号:US10138534
申请日:2002-05-06
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07D40302
CPC分类号: C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要: &agr;-and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰脲衍生物化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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2.
公开(公告)号:US06515024B2
公开(公告)日:2003-02-04
申请号:US10011778
申请日:2001-12-11
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: A61K3118
CPC分类号: C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要: Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号:US5482947A
公开(公告)日:1996-01-09
申请号:US152934
申请日:1993-11-15
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/28 , C07C269/06 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C04B35/632 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/06 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07B2200/07 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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4.Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟基氨基磺酰脲衍生物公开(公告)号:US06337398B1
公开(公告)日:2002-01-08
申请号:US08542861
申请日:1995-10-13
申请人: Michael L Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07D29515
CPC分类号: C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要: Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 下式的琥珀酰氨基羟基氨基磺酰脲衍生物:其中取代基如说明书中所定义,作为逆转录病毒蛋白酶抑制剂,特别是作为HIV蛋白酶抑制剂是有效的。
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5.α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰脲衍生物公开(公告)号:US07232817B2
公开(公告)日:2007-06-19
申请号:US11235524
申请日:2005-09-27
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: A61K31/535 , A61K31/50 , C07D31/535 , C07D403/02 , C07D471/02
CPC分类号: C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要: α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰脲衍生物化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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6.Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 用作逆转录病毒蛋白酶抑制剂的磺酰基烷酰基氨基羟基乙基氨基磺酰脲衍生物公开(公告)号:US5756498A
公开(公告)日:1998-05-26
申请号:US589563
申请日:1996-01-11
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07C311/44 , C07D213/40 , C07D213/75 , C07D233/64 , C07D307/66 , C07D333/36 , C07D521/00 , C07D211/28 , A61K31/38 , C07D265/30
CPC分类号: C07D213/40 , C07C311/44 , C07D213/75 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/66 , C07D333/36
摘要: Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. In accordance with the present invention, compounds of Formula (I) are disclosed ##STR1## wherein the substituents are as defined in the specification.
摘要翻译: 磺酰基烷酰基氨基羟基乙基氨基磺酰脲衍生物化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。 根据本发明,公开了式(I)化合物,其中取代基如说明书中所定义。
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公开(公告)号:US5610190A
公开(公告)日:1997-03-11
申请号:US476009
申请日:1995-06-07
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/28 , C07C269/06 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C04B35/632 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/06 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07B2200/07 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV Protease.
摘要翻译: 含尿素的羟胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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8.Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors 失效
标题翻译: 用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟基氨基氨基磺酸衍生物公开(公告)号:US5602119A
公开(公告)日:1997-02-11
申请号:US379573
申请日:1995-01-31
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07C307/06 , C07D207/48 , C07D211/96 , C07D295/26 , C07C307/02 , A61K31/18 , A61K31/40 , A61K31/535
CPC分类号: C07D295/26 , C07C307/06 , C07D207/48 , C07D211/96
摘要: Succinoylamino hydroxyethylamino sulfamic acid derivative compounds which are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: PCT No.PCT / US93 / 10460 Sec。 371日期1995年1月31日 102(e)日期1995年1月31日PCT 1993年10月29日提交了作为逆转录病毒蛋白酶抑制剂,特别是作为HIV蛋白酶抑制剂的琥珀酰氨基羟基氨基氨基磺酸衍生化合物。
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9.α- and β-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基氨基磺酸衍生物公开(公告)号:US07202258B2
公开(公告)日:2007-04-10
申请号:US11167164
申请日:2005-06-28
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: A61K31/47 , A61K215/38
CPC分类号: C07D295/26 , A61K38/00 , C07C307/06 , C07C2601/14 , C07D215/48 , C07D303/36 , C07D401/12 , C07K5/06026 , C07K5/06139
摘要: Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors:
摘要翻译: 由下式表示的某些α-和β-氨基酸羟乙氨基氨基磺酸衍生物可用作逆转录病毒蛋白酶抑制剂:
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10.
公开(公告)号:US07030161B2
公开(公告)日:2006-04-18
申请号:US10689513
申请日:2003-10-21
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: A61K31/18 , C07C309/24
CPC分类号: C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要: α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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