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    Test cartridge holder for blood samples
    1.
    发明授权
    Test cartridge holder for blood samples 有权
    用于血液样品的测试盒支架

    公开(公告)号：US07294312B2

    公开(公告)日：2007-11-13

    申请号：US10371351

    申请日：2003-02-20

    申请人： Michael M. Green ,  Douglas D. Nippoldt ,  William D. Zillmann ,  Brent E. Wallace ,  Jeff N. Rejent

    发明人： Michael M. Green ,  Douglas D. Nippoldt ,  William D. Zillmann ,  Brent E. Wallace ,  Jeff N. Rejent

    IPC分类号： G01N1/10 ,  B01L9/00

    CPC分类号： B01L9/00 ,  B01L3/0293 ,  B01L3/508 ,  B01L2200/026 ,  B01L2300/0654 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： Improved methods and apparatus that make more accurate and reduces risk of filling reaction chambers of cartridge cells with blood samples to conduct blood coagulation tests of the type employing the plunger technique are disclosed. A cartridge holder is provided that secures a test cartridge in a fixed upright position and deflects the plunger flag of each cartridge cell to enable manual insertion of a blood dispenser deeply into the reaction chamber to fill the reaction chamber and avoid contamination of surfaces of the cartridge outside the reaction chamber. Preferably, the cartridge holder provides illumination of the reaction chamber during filling, so that the user can judge when the reaction chamber is properly filled with blood dispensed from the blood dispenser. The cartridge holder may incorporate image magnification to facilitate viewing of the reaction chamber as it is filled.

    摘要翻译： 公开了改进的方法和装置，其使得更准确并降低了使用血液样品填充细胞的反应室的风险以进行使用柱塞技术的类型的凝血试验。 提供了一种盒式存储器，其将测试盒固定在固定的直立位置，并使每个盒式电池的柱塞标志偏转，使得血液分配器可以深入人工插入反应室以填充反应室，并避免对盒的表面的污染 在反应室外。 优选地，盒保持器在填充期间提供反应室的照明，使得用户可以判断反应室何时被适当地填充从血液分配器分配的血液。 墨盒保持器可以包括图像放大率以便于在填充反应室时观察反应室。

    Test cartridge holder for blood samples
    2.
    发明授权
    Test cartridge holder for blood samples 有权
    用于血液样品的测试盒支架

    公开(公告)号：US08333938B2

    公开(公告)日：2012-12-18

    申请号：US11752743

    申请日：2007-05-23

    申请人： Michael M. Green ,  Douglas D. Nippoldt ,  William D. Zillmann ,  Brent E. Wallace ,  Jeff N. Rejent

    发明人： Michael M. Green ,  Douglas D. Nippoldt ,  William D. Zillmann ,  Brent E. Wallace ,  Jeff N. Rejent

    IPC分类号： B01L9/00

    CPC分类号： B01L9/00 ,  B01L3/0293 ,  B01L3/508 ,  B01L2200/026 ,  B01L2300/0654 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： Improved methods and apparatus that make more accurate and reduces risk of filling reaction chambers of cartridge cells with blood samples to conduct blood coagulation tests of the type employing the plunger technique are disclosed. A cartridge holder is provided that secures a test cartridge in a fixed upright position and deflects the plunger flag of each cartridge cell to enable manual insertion of a blood dispenser deeply into the reaction chamber to fill the reaction chamber and avoid contamination of surfaces of the cartridge outside the reaction chamber. Preferably, the cartridge holder provides illumination of the reaction chamber during filling, so that the user can judge when the reaction chamber is properly filled with blood dispensed from the blood dispenser. The cartridge holder may incorporate image magnification to facilitate viewing of the reaction chamber as it is filled.

    摘要翻译： 公开了改进的方法和装置，其使得更准确并降低了使用血液样品填充细胞的反应室的风险以进行使用柱塞技术的类型的凝血试验。 提供了一种盒式存储器，其将测试盒固定在固定的直立位置，并使每个盒式电池的柱塞标志偏转，使得血液分配器可以深入人工插入反应室以填充反应室，并避免对盒的表面的污染 在反应室外。 优选地，盒保持器在填充期间提供反应室的照明，使得用户可以判断反应室何时被适当地填充从血液分配器分配的血液。 墨盒保持器可以包括图像放大率以便于在填充反应室时观察反应室。

    Conformal antenna for implantable medical device and implantable medical device with such antenna
    3.
    发明授权
    Conformal antenna for implantable medical device and implantable medical device with such antenna 有权
    用于可植入医疗设备的保形天线和具有这种天线的可植入医疗设备

    公开(公告)号：US08903497B2

    公开(公告)日：2014-12-02

    申请号：US12895083

    申请日：2010-09-30

    申请人： Clark B. Norgaard ,  Michael W. Barror ,  Douglas D. Nippoldt ,  Tony A. Ulrich

    发明人： Clark B. Norgaard ,  Michael W. Barror ,  Douglas D. Nippoldt ,  Tony A. Ulrich

    IPC分类号： A61N1/372 ,  A61B5/00 ,  H01F5/02

    CPC分类号： A61N1/37229 ,  A61B5/0031 ,  A61N1/37205 ,  H01F5/02 ,  Y10T29/49016

    摘要： System and method for making an antenna. An implantable medical device has a housing, a bobbin and a coil. The housing has an interior generally tubular cross-section with a longitudinal axis, the housing having a lateral portion of a segment of the tubular cross-section along the longitudinal axis. The bobbin has a first side nearest to the interior of the housing and a second side opposite the first side. The coil, wound around the bobbin on a winding axis orthogonal to the longitudinal axis of the tubular cross-section, has a greater number of complete turns proximate the second side of the bobbin than proximate the first side of the bobbin, with the coil having a cross-sectional shape selected for a space between the bobbin and the interior of the housing in the lateral portion of the segment of the tubular cross-section along the longitudinal axis of the housing.

    摘要翻译： 制造天线的系统和方法。 可植入医疗装置具有壳体，线轴和线圈。 壳体具有内部具有纵向轴线的大致管状的横截面，壳体具有沿着纵向轴线的管状横截面的一部分的横向部分。 线轴具有最靠近壳体内部的第一侧和与第一侧相对的第二侧。 线圈缠绕在与管状横截面的纵向轴线正交的绕线轴上的线轴上，靠近线轴第二侧的完整匝数比靠近线轴的第一侧更多，线圈具有 所述截面形状被选择为所述筒管和所述壳体内部之间的空间，所述横截面形状沿着所述壳体的纵向轴线在所述管状横截面的所述段的横向部分的横向部分中。

    Blood coagulation test cartridge, system, and method
    4.
    发明授权
    Blood coagulation test cartridge, system, and method 失效
    血液凝固试验盒，系统和方法

    公开(公告)号：US07439069B2

    公开(公告)日：2008-10-21

    申请号：US11047026

    申请日：2005-01-31

    申请人： Douglas D. Nippoldt ,  Cynthia T. Clague ,  Daniel G. Ericson

    发明人： Douglas D. Nippoldt ,  Cynthia T. Clague ,  Daniel G. Ericson

    IPC分类号： G01N33/86

    CPC分类号： G01N33/86 ,  G01N33/4905 ,  Y10T436/2575

    摘要： A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood receptacle that is open to the atmosphere into which a blood sample is to be deposited, a vacuum port that is open to atmosphere, and a spiral capillary within the test cartridge having a capillary length and cross-section area, a first capillary end of the spiral capillary open to the blood receptacle and a second capillary end of the spiral capillary open to the vacuum port, whereby the spiral capillary is closed to atmosphere. When a blood sample is deposited in the blood receptacle, a vacuum is drawn through the vacuum port and the blood is drawn through the spiral capillary until coagulation occurs. A pressure change is detected, and the coagulation time is measured.

    摘要翻译： 公开了一种用于确定沉积在测试盒中的血液样品的凝固时间，例如凝血酶时间，PT，aPTT和ACT的系统和方法。 测试盒包括对要沉积血液样本的大气开放的血液容器，对大气开放的真空端口以及具有毛细管长度和横截面面积的测试盒内的螺旋毛细管， 螺旋毛细管的第一毛细管端部通向血液容器，并且螺旋毛细管的第二毛细管端部通向真空端口，由此螺旋毛细管关闭到大气。 当血液样本沉积在血液容器中时，真空通过真空口抽出，血液通过螺旋毛细管吸入，直到发生凝血。 检测到压力变化，并测量凝固时间。

    Blood coagulation test cartridge, system, and method
    6.
    发明授权
    Blood coagulation test cartridge, system, and method 有权
    血液凝固试验盒，系统和方法

    公开(公告)号：US07422905B2

    公开(公告)日：2008-09-09

    申请号：US10826994

    申请日：2004-04-19

    申请人： Cynthia T. Clague ,  Daniel S. Cheek ,  Douglas D. Nippoldt

    发明人： Cynthia T. Clague ,  Daniel S. Cheek ,  Douglas D. Nippoldt

    IPC分类号： G01N33/86

    CPC分类号： G01N11/162 ,  G01N11/14 ,  G01N15/042 ,  G01N15/05 ,  G01N33/4905 ,  G01N2015/0092 ,  Y10T436/111666

    摘要： A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chamber pivot element and is provided with a cartridge port for introducing a test sample into the test chamber. Ferromagnetic agitator vane leaflets extend from an agitator pivot element supported by the test chamber pivot element intermediate the upper and lower major sides for rotational motion. The agitator vane leaflets can be swept, in response to an external magnetic field, through the test sample in the absence of coagulation. A timer is started when the agitator movement is commenced whereupon the agitator moves freely. Resistance to agitator movement due to coagulation is detected, and the coagulation time is measured.

    摘要翻译： 公开了一种用于确定沉积在测试盒中的测试样品的凝固时间（例如TT，PT，aPTT和ACT）的系统和方法。 具有上下侧和下侧壁的盒壳体包围具有测试室枢转元件的测试室，并且设置有用于将测试样品引入测试室的盒端口。 铁磁搅拌器叶片叶片从由测试室枢转元件支撑的搅拌器枢轴元件延伸，位于上，下三个主要侧面以用于旋转运动。 在不存在凝结的情况下，搅拌器叶片叶片可以响应于外部磁场扫过测试样品。 当搅拌器运动开始时，搅拌器自由移动，启动定时器。 检测到由于凝结而产生的搅拌器运动阻力，测定凝固时间。

    ROBUST HIGH POWER AND LOW POWER CARDIAC LEADS HAVING INTEGRATED SENSORS
    8.
    发明申请
    ROBUST HIGH POWER AND LOW POWER CARDIAC LEADS HAVING INTEGRATED SENSORS 审中-公开
    具有集成传感器的稳定的高功率和低功率电源引线

    公开(公告)号：US20090248117A1

    公开(公告)日：2009-10-01

    申请号：US12411058

    申请日：2009-03-25

    申请人： Douglas D. Nippoldt ,  Thomas D. Brostrom ,  Richard J. O'Brien ,  Michael A. Schugt ,  Scott J. Davis ,  Yaling Fan

    发明人： Douglas D. Nippoldt ,  Thomas D. Brostrom ,  Richard J. O'Brien ,  Michael A. Schugt ,  Scott J. Davis ,  Yaling Fan

    IPC分类号： A61N1/08 ,  A61N1/05

    CPC分类号： A61N1/056 ,  A61B5/02152 ,  A61B5/02158 ,  A61B2562/0247 ,  A61B2562/187

    摘要： A lead of an implantable medical device system having an elongated lead body and a sensor coupled to the lead body and extending from a proximal end to a distal end. The sensor includes a first portion extending from a top to a bottom, and from a proximal end to a distal end and a second portion engaged against the first portion and extending from a top to a bottom, the top of the second portion extending from a proximal end to a distal end. A first flange extends proximally relative to the proximal end of the top of the second portion to a first flange end, and a second flange extends distally relative to the distal end of the top of the second portion to a second flange end, wherein the first flange end is aligned with the proximal end of the first portion and the second flange end is aligned with the distal end of the first portion.

    摘要翻译： 可植入医疗装置系统的引线，其具有细长的引线主体和耦合到引线主体并从近端延伸到远端的传感器。 传感器包括从顶部延伸到底部以及从近端延伸到远端的第一部分和与第一部分接合并且从顶部延伸到底部的第二部分，第二部分的顶部从 近端到远端。 第一凸缘相对于第二部分的顶部的近端向近侧延伸到第一凸缘端，并且第二凸缘相对于第二部分的顶部的远端向远侧延伸到第二凸缘端，其中第一凸缘 凸缘端与第一部分的近端对准，第二凸缘端与第一部分的远端对准。