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1.发明授权Amide derivatives as positive allosteric modulators and methods of use thereof 有权酰胺衍生物作为正变构调节剂及其使用方法公开(公告)号：US07994223B2
公开(公告)日：2011-08-09
申请号：US12841547
申请日：2010-07-22
IPC分类号： A61K31/166
CPC分类号： C07C323/62 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D205/04 , C07D207/325 , C07D207/327 , C07D207/38 , C07D209/14 , C07D215/12 , C07D233/61 , C07D243/08 , C07D295/112 , C07D295/135 , C07D307/52 , C07D309/14 , C07D333/20
摘要： The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的正变构调节剂的新型酰胺衍生物，包含该酰胺衍生物的组合物，其制备方法以及使用这些化合物和组合物的方法。
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2.发明申请AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF 有权作为阳性调节剂的酰胺衍生物及其使用方法公开(公告)号：US20100286109A1
公开(公告)日：2010-11-11
申请号：US12841547
申请日：2010-07-22
IPC分类号： A61K31/166 , C07D207/325 , A61K31/402 , C07D211/14 , C07D207/06 , A61K31/451 , C07D243/14 , A61K31/5513 , C07C323/63 , C07D233/61 , A61K31/4164 , C07D205/02 , A61K31/397 , A61K31/27 , C07D215/14 , A61K31/47 , A61P29/00 , A61P25/28 , A61P25/18 , A61P25/24 , A61P25/34 , A61P25/00 , G01N33/53
CPC分类号： C07C323/62 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D205/04 , C07D207/325 , C07D207/327 , C07D207/38 , C07D209/14 , C07D215/12 , C07D233/61 , C07D243/08 , C07D295/112 , C07D295/135 , C07D307/52 , C07D309/14 , C07D333/20
摘要： The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的正变构调节剂的新型酰胺衍生物，包含该酰胺衍生物的组合物，其制备方法以及使用这些化合物和组合物的方法。
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3.发明申请AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF 有权作为阳性调节剂的酰胺衍生物及其使用方法公开(公告)号：US20090253670A1
公开(公告)日：2009-10-08
申请号：US12412110
申请日：2009-03-26
IPC分类号： A61K31/40 , C07D207/323 , C07D211/26 , C07D243/08 , A61K31/445 , A61K31/551 , A61K31/397 , C12Q1/02 , A61P25/00
CPC分类号： C07C323/62 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D205/04 , C07D207/325 , C07D207/327 , C07D207/38 , C07D209/14 , C07D215/12 , C07D233/61 , C07D243/08 , C07D295/112 , C07D295/135 , C07D307/52 , C07D309/14 , C07D333/20
摘要： The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的正变构调节剂的新型酰胺衍生物，包含该酰胺衍生物的组合物，其制备方法以及使用这些化合物和组合物的方法。
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4.发明授权Amide derivatives as positive allosteric modulators and methods of use thereof 有权酰胺衍生物作为正变构调节剂及其使用方法公开(公告)号：US07786171B2
公开(公告)日：2010-08-31
申请号：US12412110
申请日：2009-03-26
IPC分类号： A61K31/166 , C07C323/09
CPC分类号： C07C323/62 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D205/04 , C07D207/325 , C07D207/327 , C07D207/38 , C07D209/14 , C07D215/12 , C07D233/61 , C07D243/08 , C07D295/112 , C07D295/135 , C07D307/52 , C07D309/14 , C07D333/20
摘要： The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的正变构调节剂的新型酰胺衍生物，包含该酰胺衍生物的组合物，其制备方法以及使用这些化合物和组合物的方法。
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公开(公告)号：US09625475B2
公开(公告)日：2017-04-18
申请号：US12727723
申请日：2010-03-19
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/55 , C07D487/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , G01N33/68 , C07D471/18 , C07D487/10 , G01N33/50
CPC分类号： G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
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6.发明授权Amide derivatives as positive allosteric modulators and methods of use thereof 有权酰胺衍生物作为正变构调节剂及其使用方法公开(公告)号：US08536221B2
公开(公告)日：2013-09-17
申请号：US12367096
申请日：2009-02-06
申请人： Kathleen H. Mortell , Diana L. Nersesian , Michael R. Schrimpf , Chih-Hung Lee , Murali Gopalakrishnan
发明人： Kathleen H. Mortell , Diana L. Nersesian , Michael R. Schrimpf , Chih-Hung Lee , Murali Gopalakrishnan
IPC分类号： A01N43/30 , A61K31/36 , C07D209/44
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D471/04
摘要： The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的PAM的新型酰胺衍生物，包含该酰胺衍生物的组合物，其制备方法以及使用这些化合物和组合物的方法。
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公开(公告)号：US09063126B2
公开(公告)日：2015-06-23
申请号：US12568085
申请日：2009-09-28
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/439 , C07D471/08 , G01N33/50 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/68
CPC分类号： G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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公开(公告)号：US20100249105A1
公开(公告)日：2010-09-30
申请号：US12727723
申请日：2010-03-19
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/55 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/02 , C07D487/04 , A61K31/439 , C07D471/00
CPC分类号： G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
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公开(公告)号：US20100087471A1
公开(公告)日：2010-04-08
申请号：US12568085
申请日：2009-09-28
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/439 , C12Q1/02 , C07D471/08
CPC分类号： G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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10.发明申请AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF 有权作为阳性调节剂的酰胺衍生物及其使用方法公开(公告)号：US20090270408A1
公开(公告)日：2009-10-29
申请号：US12367096
申请日：2009-02-06
申请人： Kathleen H. Mortell , Diana L. Nersesian , Michael R. Schrimpf , Chih-Hung Lee , Murali Gopalakrishnan
发明人： Kathleen H. Mortell , Diana L. Nersesian , Michael R. Schrimpf , Chih-Hung Lee , Murali Gopalakrishnan
IPC分类号： A61K31/501 , C12Q1/02 , A61K31/47 , C07D401/12 , A61K31/404 , A61P25/28 , C07D215/14 , A61K31/4439 , C07D209/18
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D471/04
摘要： The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的PAM的新型酰胺衍生物，包含该酰胺衍生物的组合物，其制备方法以及使用这些化合物和组合物的方法。
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