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    Device for administering substances such as an inhalation preparation
    1.
    发明授权
    Device for administering substances such as an inhalation preparation 失效
    用于施用诸如吸入制剂的物质的装置

    公开(公告)号：US5878917A

    公开(公告)日：1999-03-09

    申请号：US678857

    申请日：1996-07-12

    申请人： Michael Reinhard ,  Ralf Bouffleur ,  Michael Spallek ,  Andreas Geiger

    发明人： Michael Reinhard ,  Ralf Bouffleur ,  Michael Spallek ,  Andreas Geiger

    IPC分类号： B65D83/14 ,  A61M11/00 ,  A61M15/00 ,  B65D23/08 ,  B65D25/20 ,  B65D25/34 ,  B67D5/64

    CPC分类号： A61M15/009

    摘要： The invention relates to a device for administering substances at overpressure. The device includes a pressure vessel made of glass and containing a substance to be discharged from the pressure vessel and at least one propellent. The pressure vessel has an opening and an actuable discharge element mounted on the pressure vessel in the opening for releasing the substance from the pressure vessel. A self-supporting housing encloses the pressure vessel and at least a portion of the discharge element to prevent splinters of glass and the discharge element from being propelled away from the device in the event that the pressure vessel bursts. The self-supporting housing has a lower portion made of transparent plastic to facilitate viewing the substance in the pressure vessel.

    摘要翻译： 本发明涉及一种用于在超压下给药物质的装置。 该装置包括由玻璃制成并包含要从压力容器排出的物质和至少一个推进剂的压力容器。 压力容器具有安装在开口中的压力容器上的开口和可致动的排放元件，用于将物质从压力容器释放。 在压力容器爆裂的情况下，自支撑壳体包围压力容器和排放元件的至少一部分，以防止玻璃碎片和排放元件被推离远离装置。 自支撑壳体具有由透明塑料制成的下部，以便于观察压力容器中的物质。

    Glass bottle with a sprayed on synthetic coating, its production process and device necessary for its production
    3.
    发明授权
    Glass bottle with a sprayed on synthetic coating, its production process and device necessary for its production 失效
    玻璃瓶喷涂在合成涂料上，其生产工艺和装置生产所需

    公开(公告)号：US5979714A

    公开(公告)日：1999-11-09

    申请号：US905937

    申请日：1997-08-05

    申请人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

    发明人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

    IPC分类号： B29C45/14 ,  B65D23/08 ,  B65D83/00

    CPC分类号： B65D23/0807 ,  B29C45/14778 ,  B29C2045/14163 ,  B29C2045/14877 ,  B29C45/14065 ,  B29K2709/08 ,  B29L2031/7158

    摘要： A glass bottle (1) fitted with a narrowed neck (2) which can be filled under pressure with chiefly a medically active substance sprayable by aerosol and with a propellant and which exhibits an opening which may be closed using a dosage valve (5). This glass bottle (1) has a sprayed-on synthetic coating (4) to protect it against shattering and splintering, preventing the user from being injured by the broken bottle. To substantially enhance this safety, the neck (2) of the bottle (1) has been fitted with a bulge like edge (3) at the opening which is also coated with the synthetic material (4) and onto which the dosage valve (5) is mechanically attached by turning. Furthermore, the coating (4) consists of an elastic synthetic material with pronounced increased shrinkage properties used for the summoning of pre-stressing force on the glass body (1) and it exhibits several hole-like pressure relieving openings (7) permitting rapid pressure release in case of shattering.

    摘要翻译： 玻璃瓶（1）装有狭窄的颈部（2），其可以在压力下被填充，主要是由气溶胶和推进剂喷射的医疗活性物质，并且其表现出可以使用剂量阀（5）封闭的开口。 该玻璃瓶（1）具有喷涂合成涂层（4），以防止其破碎和碎裂，从而防止使用者被破瓶损坏。 为了大大提高这种安全性，瓶（1）的颈部（2）在开口处已经装有类似凸起的边缘（3），该开口也涂覆有合成材料（4），并且向其上添加剂量阀 ）通过转动机械连接。 此外，涂层（4）由具有明显增加的收缩性质的弹性合成材料组成，用于召集玻璃体（1）上的预应力，并且其表现出几个孔状缓冲开口（7），允许快速压力 释放时发生破裂。

    Glass bottle with a sprayed on synthetic coating, its production process and device necessary for its production
    4.
    发明授权
    Glass bottle with a sprayed on synthetic coating, its production process and device necessary for its production 有权
    玻璃瓶喷涂在合成涂料上，其生产工艺和装置生产所需

    公开(公告)号：US06216922B1

    公开(公告)日：2001-04-17

    申请号：US09397119

    申请日：1999-09-16

    申请人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

    发明人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

    IPC分类号： B65D8300

    CPC分类号： B65D23/0807 ,  B29C45/14065 ,  B29C45/14778 ,  B29C2045/14163 ,  B29C2045/14877 ,  B29K2709/08 ,  B29L2031/7158

    摘要： The invention consists of a glass bottle (1) fitted with a narrowed neck (2) which can be filled under pressure with chiefly a medically active substance sprayable by aerosol and with a propellant and which exhibits an opening which may be closed using a dosage valve (5). This glass bottle (1) has a sprayed on synthetic coating (4) to protect it against shattering and splintering, preventing the user from being injured by the broken bottle. To substantially enhance this safety, the neck (2) of the bottle (1) has been fitted with a bulge like edge (3) at the opening which is also coated with the synthetic material (4) and onto which the dosage valve (5) is mechanically attached by turning. Furthermore, the coating (4) consists of an elastic synthetic material with pronounced increased shrinkage properties used for the summoning of pre-stressing force on the glass body (1) and it exhibits several hole like pressure relieving openings (7) permitting rapid pressure release in case of shattering.

    摘要翻译： 本发明包括一个玻璃瓶（1），它装有一个狭窄的颈部（2），该瓶子可以在压力下被填充，主要是由气溶胶和推进剂喷射的医疗活性物质，并且其表现出可以使用剂量阀 （5）。 该玻璃瓶（1）喷洒在合成涂层（4）上，以防止其破碎和碎裂，从而防止使用者受到破碎的瓶子的伤害。为了大大提高安全性，瓶子（1）的颈部（2） ）在开口处已经装有凸起状的边缘（3），该开口也涂覆有合成材料（4），并且通过转动机械地附接剂量阀（5）。 此外，涂层（4）由弹性合成材料组成，具有明显增加的收缩性能，用于召集玻璃体（1）上的预应力，并且其具有几个孔状缓冲开口（7），允许快速释放压力 在破碎的情况下。

    Gripping strip for prefilled disposable syringes
    5.
    发明授权
    Gripping strip for prefilled disposable syringes 失效
    预填充一次性注射器的夹带

    公开(公告)号：US5897532A

    公开(公告)日：1999-04-27

    申请号：US92287

    申请日：1998-06-05

    申请人： Michael Spallek ,  Andreas Geiger ,  John W. Pellow

    发明人： Michael Spallek ,  Andreas Geiger ,  John W. Pellow

    IPC分类号： A61M5/31 ,  A61M5/00

    CPC分类号： A61M5/3135 ,  A61M2005/3139

    摘要： A gripping strip for prefilled disposable syringes having a syringe cylinder. The gripping strip has a gripping strip element formed as a separate synthetic plastic part fixedly mountable on the syringe cylinder, a plate-shaped abutment provided on the gripping strip element and having a hollow cylindrical receptacle with an outer diameter which is adapted to be smaller than an inner diameter of the syringe cylinder, arresting elements provided in a region of an outer surface of the gripping strip element for mounting with the syringe cylinder in a complimentary inner undercut of the syringe cylinder, a safety ring insertable in an interior of the receptacle for maintaining a working connection, the safety ring being connected with the interior of the receptacle of one piece through locations of desired breakage in an unsecured position, so that during placing the syringe cylinder over the receptacle it is displaceable into a securing position. The receptacle has an outer surface which is formed of peripheral portions with gaps therebetween, the arresting elements being arranged in the gaps for a form-locking operative connection with the inner undercut of the syringe cylinder.

    摘要翻译： 用于具有注射器筒的预填充一次性注射器的夹持条。 夹持条具有形成为可固定地安装在注射器筒上的单独的合成塑料部分的夹持条状元件，设置在抓持条形元件上的板状邻接件，并且具有中空圆柱形容器，其外径适于小于 注射器筒的内径，设置在夹持条元件的外表面区域中的止动元件，用于将注射器筒安装在注射器筒的互补的内切口中;安全环，可插入到容器的内部， 保持工作连接，安全环通过一个片段的容器的内部连接到处于不安全位置的期望的断裂的位置，使得在将注射器筒放置在容器上方时，其可移位到固定位置。 该容器具有外表面，该外表面由其间具有间隙的周边部分形成，止动元件布置在间隙中，用于与注射器筒的内底切割操作连接。

    Glass container for medicinal purposes
    6.
    发明授权
    Glass container for medicinal purposes 有权
    用于药用的玻璃容器

    公开(公告)号：US06599594B1

    公开(公告)日：2003-07-29

    申请号：US09564758

    申请日：2000-05-04

    申请人： Marten Walther ,  Andreas Geiger ,  Petra Auchter-Krummel ,  Michael Spallek

    发明人： Marten Walther ,  Andreas Geiger ,  Petra Auchter-Krummel ,  Michael Spallek

    IPC分类号： B65D2302

    CPC分类号： C23C16/045 ,  C03C17/22 ,  C03C17/30 ,  C03C2217/282 ,  C03C2218/153 ,  Y10S215/03 ,  Y10T428/1317 ,  Y10T428/1321

    摘要： The glass container stores and preserves pharmaceutical or diagnostic solutions for medicinal purposes. So that the container is free of silicones and other residues, it is provided with an amorphous, transparent anti-adherent coating (4) over its entire interior surface from its bottom over the wall (3) to the closure device (2). This anti-adherent coating (4) is free of heavy metals, free of silicones, is stable after autoclaving at about 120° C. for about 20 min or hot air sterilization for 30 min at 300° C., has a contact angle for wetting with water of ≧80°, contains silicon, oxygen, carbon, fluorine and hydrogen and is deposited by a PECVD method, especially a PICVD method. If the coating contains less than 0.1% by weight fluorine, then it contains greater than or equal to 10% by weight carbon, but if it contains greater than or equal to 0.1% fluorine then it contains greater than or equal to 5% by weight carbon.

    摘要翻译： 玻璃容器储存并保存用于药用目的的药物或诊断溶液。 为了使容器不含有机硅和其他残留物，在其整个内表面上从其底部（3）到封闭装置（2）的底部提供无定形透明的抗粘附涂层（4）。 这种抗粘附涂层（4）不含重金属，不含硅氧烷，在约120℃下高压灭菌约20分钟或在300℃热空气灭菌30分钟后是稳定的，具有接触角 用> = 80°的水润湿，含有硅，氧，碳，氟和氢，并通过PECVD法，特别是PICVD法沉积。 如果涂层含有少于0.1重量％的氟，则其含有大于或等于10重量％的碳，但如果其含有大于或等于0.1％的氟，则其含有大于或等于5重量％ 碳。

    Prefilled, low particle, sterile disposable syringe for injecting preparations and procedure for manufacture
    8.
    发明授权
    Prefilled, low particle, sterile disposable syringe for injecting preparations and procedure for manufacture 失效
    预填充，低颗粒，无菌的一次性注射器，用于注射制剂和制造程序

    公开(公告)号：US06331174B1

    公开(公告)日：2001-12-18

    申请号：US08529195

    申请日：1995-09-15

    申请人： Michael Reinhard ,  Michael Spallek

    发明人： Michael Reinhard ,  Michael Spallek

    IPC分类号： A61M500

    CPC分类号： B65B55/02 ,  A61M5/28 ,  A61M5/3129 ,  A61M5/343 ,  A61M5/349 ,  A61M2005/3131 ,  A61M2207/00 ,  B65B3/003

    摘要： Prefilled, disposable syringes for injecting preparations with a fill volume of less than 5 ml are typically made of glass. The disposable syringe in this invention avoids the use of glass as a construction material. The body of the syringe with barrel, grip and nozzle is made of transparent, glass-like plastic with a very low gas permeability and is designed to be resistant to gamma rays and/or ethylene oxide gas, whereby the hypodermic needle is directly integrated within the plastic nozzle.

    摘要翻译： 用于注射填充体积小于5ml的制剂的预填充的一次性注射器通常由玻璃制成。 本发明的一次性注射器避免使用玻璃作为建筑材料。 具有桶，把手和喷嘴的注射器的主体由透气的玻璃状塑料制成，具有非常低的透气性，并且被设计为耐γ射线和/或环氧乙烷气体，由此将皮下注射针直接集成在 塑料喷嘴。

    Container for storing and dispensing injection, infusion and diagnostic preparations
    9.
    发明授权
    Container for storing and dispensing injection, infusion and diagnostic preparations 失效
    用于储存和分配注射，输液和诊断准备的容器

    公开(公告)号：US06280418B1

    公开(公告)日：2001-08-28

    申请号：US08921665

    申请日：1997-09-02

    申请人： Michael Reinhard ,  Michael Spallek

    发明人： Michael Reinhard ,  Michael Spallek

    IPC分类号： A61M500

    CPC分类号： A61M5/28 ,  A61M5/344 ,  A61M5/347 ,  A61M5/348 ,  A61M2005/3104 ,  A61M2005/3139

    摘要： The invention concerns a container for injection, infusion, and diagnostic preparations, serving, on the one hand, as a long-term storage container, and, on the other, as a device for directly dispensing the preparations. The container has a glass barrel with a glass headpiece with a connector cone that acts as a nozzle. This is molded onto a glass barrel, thereby forming a single unit. A separate plastic, threaded section of an interlocking, conical joint is mounted onto the connector cone, accommodating a secured sealing cap that can be removed from the connector cone. The other opening of the glass barrel is sealed by a plunger that has a connection spot for a plunger rod. Furthermore, the container has a plastic grip mounted onto the inner wall of the glass barrel. Since the container, including the external profile, is, on the whole, designed to resemble a standard syringe, it ensures that the invented container can be accommodated by all current syringe pumps.

    摘要翻译： 本发明涉及用于注射，输注和诊断制剂的容器，一方面用作长期储存容器，另一方面，作为用于直接分配制剂的装置。 该容器具有玻璃管，玻璃管具有作为喷嘴的连接锥体的玻璃头。 将其模制在玻璃筒上，从而形成单个单元。 联接锥形接头的单独的塑料螺纹部分安装在连接器锥体上，容纳可从连接锥体移除的固定的密封盖。 玻璃筒的另一个开口由具有用于柱塞杆的连接点的柱塞密封。 此外，容器具有安装在玻璃筒的内壁上的塑料手柄。 由于包括外部轮廓在内的容器总体上被设计成类似于标准注射器，所以确保了本发明的容器可以由所有当前的注射泵容纳。