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1.发明授权Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基嘧啶酮公开(公告)号：US06750342B1
公开(公告)日：2004-06-15
申请号：US09574739
申请日：2000-05-18
IPC分类号： C07D23954
CPC分类号： C07D239/47 , C07D253/07 , C07D401/04 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基嘧啶酮化合物，以及用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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2.发明授权Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基1,2,4-三嗪酮公开(公告)号：US07015223B1
公开(公告)日：2006-03-21
申请号：US10275856
申请日：2000-11-20
申请人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
发明人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
IPC分类号： C07D253/07 , C07D413/02 , A61K31/53 , A61P7/02
CPC分类号： C07D401/04
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基嘧啶酮化合物，以及用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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3.发明授权Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基嘧啶酮公开(公告)号：US06653316B1
公开(公告)日：2003-11-25
申请号：US09716951
申请日：2000-11-20
申请人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
发明人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
IPC分类号： C07D23948
CPC分类号： C07D239/47 , C07D253/07 , C07D401/04 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代多环芳基和杂芳基嘧啶酮化合物，以及用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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4.发明授权Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮公开(公告)号：US06664255B1
公开(公告)日：2003-12-16
申请号：US09574752
申请日：2000-05-18
申请人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
发明人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
IPC分类号： C07D24120
CPC分类号： C07D417/12 , A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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5.发明授权Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants 失效用作抗凝剂的取代的多环芳基和杂芳基1,2,4 - 三嗪酮公开(公告)号：US06906068B1
公开(公告)日：2005-06-14
申请号：US10009447
申请日：2000-05-17
IPC分类号： A61K31/513 , A61K31/53 , A61P7/02 , C07D239/02 , C07D239/46 , C07D253/065 , C07D253/07 , C07D401/04
CPC分类号： C07D239/47 , C07D253/07 , C07D401/04
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基嘧啶酮化合物，以及用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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6.发明授权6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade 失效可用于选择性抑制凝血级联的6元杂环化合物公开(公告)号：US06969715B2
公开(公告)日：2005-11-29
申请号：US10263637
申请日：2002-10-03
申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
IPC分类号： C07D249/12 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/513 , A61K31/53 , A61K31/535 , A61K45/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07C257/18 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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7.发明授权Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和异齿酰基吡嗪酮公开(公告)号：US07119094B1
公开(公告)日：2006-10-10
申请号：US10276174
申请日：2000-11-20
申请人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney
发明人： Michael S. South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Rick Fenton , Gary W. Franklin , Horng-Chih Huang , Wei Huang , Carrie Kusturin , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney
IPC分类号： A61K31/4965 , C07D241/02
CPC分类号： C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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公开(公告)号：US07105559B2
公开(公告)日：2006-09-12
申请号：US10263936
申请日：2002-10-03
申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
IPC分类号： C07D23/10 , A61K31/415
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D207/46 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
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9.发明授权Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮公开(公告)号：US06908919B2
公开(公告)日：2005-06-21
申请号：US10195573
申请日：2002-07-15
申请人： Michael S. South , Brenda L. Case , Thomas A. Dice , Ricky L. Fenton , Gary W. Franklin , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , Carrie L. Kusturin , Richard J. Lindmark , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney , John J. Parlow , Melvin L. Rueppel
发明人： Michael S. South , Brenda L. Case , Thomas A. Dice , Ricky L. Fenton , Gary W. Franklin , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , Carrie L. Kusturin , Richard J. Lindmark , Scott A. Long , William L. Neumann , David B. Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew W. Mahoney , John J. Parlow , Melvin L. Rueppel
IPC分类号： A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/495 , A61P7/02
CPC分类号： C07D401/12 , A61K38/00 , C04B35/632 , C07D241/20 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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10.发明授权Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶公开(公告)号：US06828338B2
公开(公告)日：2004-12-07
申请号：US10465125
申请日：2003-06-19
申请人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
发明人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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