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    ANTIMICROBIAL MATERIAL AND METHOD FOR MAKING THE SAME
    1.
    发明申请
    ANTIMICROBIAL MATERIAL AND METHOD FOR MAKING THE SAME 有权
    抗微生物材料及其制备方法

    公开(公告)号：US20120150095A1

    公开(公告)日：2012-06-14

    申请号：US13402336

    申请日：2012-02-22

    申请人： Michael Szycher

    发明人： Michael Szycher

    IPC分类号： A61L29/16 ,  A61L31/16 ,  C08L75/04

    CPC分类号： A61K31/28 ,  A61K31/63 ,  A61K33/38 ,  A61K45/06 ,  A61L29/049 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  C08L75/04 ,  C08L31/04 ,  A61K2300/00

    摘要： This invention provides a modified catheter/indwelling device biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA) as an option, a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation. Alternatively, the sparsely soluble silver salt can be silver iodate and is combined with silver sulfadiazine. Chlorhexidine can also be included in the material.

    摘要翻译： 本发明提供了一种修改的导管/留置装置生物材料，其对其他抗生素抗性微生物菌株提供立即和长期的杀微生物作用。 对于医疗器械具有良好的机械性能特性的材料由疏水性聚氨酯（PU），亲水性聚乙烯乙酸乙烯酯（PEVA），可溶性银盐和稀溶银盐构成。 疏水性聚氨酯提供良好的物理性能，PEVA具有允许一些水进入导管所需的亲水性，即时爆发作用的可溶性银盐以及在植入后多个月持续释放的稀溶溶性银盐。 或者，稀溶银银可以是碘酸银，并且与磺胺嘧啶银组合。 氯己定也可以包括在材料中。

    Extrudable polyurethane for prosthetic devices prepared from a diisocyanate, a polytetramethylene ether polyol, and 1,4-butane diol
    3.
    发明授权
    Extrudable polyurethane for prosthetic devices prepared from a diisocyanate, a polytetramethylene ether polyol, and 1,4-butane diol 失效
    由二异氰酸酯，聚四亚甲基醚多元醇和1,4-丁二醇制备的用于假体装置的可挤出聚氨酯

    公开(公告)号：US4523005A

    公开(公告)日：1985-06-11

    申请号：US600568

    申请日：1984-04-17

    申请人： Michael Szycher

    发明人： Michael Szycher

    IPC分类号： C08G18/48 ,  C08G18/66 ,  C08G18/73 ,  C08G18/75 ,  C08G18/30

    CPC分类号： C08G18/6674 ,  C08G18/4854 ,  C08G18/6607 ,  C08G18/73 ,  C08G18/75

    摘要： Reaction product of an aliphatic organic diisocyanate, a high molecular weight polyether polyol (poly tetra methylene ether glycol) and 1,4 butane diol. The resulting polymers have thromboresistant properties, a long flexural life and are extrudable. The polyurethane polymer is ideal for forming transvenous cardiac pacemaker leads, blood bags, intravenous and intra-arterial catheters and tubing, and other shaped devices which must be formed of a blood compatible material.

    摘要翻译： 脂肪族有机二异氰酸酯，高分子量聚醚多元醇（聚四亚甲基醚二醇）和1,4-丁二醇的反应产物。 所得聚合物具有抗血栓性，长的弯曲寿命并且是可挤压的。 聚氨酯聚合物是形成经静脉心脏起搏器引线，血袋，静脉内和动脉内导管和管道以及必须由血液相容材料形成的其它成形装置的理想选择。

    Antimicrobial material and method for making the same
    4.
    发明授权
    Antimicrobial material and method for making the same 有权
    抗微生物材料及其制造方法

    公开(公告)号：US08173151B2

    公开(公告)日：2012-05-08

    申请号：US13178002

    申请日：2011-07-07

    申请人： Michael Szycher

    发明人： Michael Szycher

    IPC分类号： A61F2/00

    CPC分类号： A61K31/28 ,  A61K33/38 ,  A61L29/049 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/404 ,  C08L75/04 ,  C08L31/04

    摘要： This invention provides a modified catheter biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA), a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation.

    摘要翻译： 本发明提供了一种改良的导管生物材料，其对其他抗生素抗性微生物菌株提供立即和长期的杀微生物作用。 对于医疗器械具有良好机械性能的材料由疏水性聚氨酯（PU），亲水性聚乙烯乙酸乙烯酯（PEVA），可溶性银盐和稀溶银盐构成。 疏水性聚氨酯提供良好的物理性能，PEVA具有允许一些水进入导管所需的亲水性，即时爆发作用的可溶性银盐以及在植入后多个月持续释放的稀溶溶性银盐。

    Spyrosorbent wound dressings for exudate management
    5.
    发明授权
    Spyrosorbent wound dressings for exudate management 失效
    用于渗出物管理的吸收性伤口敷料

    公开(公告)号：US5653699A

    公开(公告)日：1997-08-05

    申请号：US305273

    申请日：1994-09-13

    申请人： Andrew M. Reed ,  Jon M. Potter ,  Michael Szycher

    发明人： Andrew M. Reed ,  Jon M. Potter ,  Michael Szycher

    IPC分类号： A61F13/00 ,  A61F13/02

    CPC分类号： A61F13/023 ,  A61F2013/0074 ,  A61F2013/00748 ,  A61F2013/00876

    摘要： A sheet-form composite suitable as a spyrosorbent wound dressing and exhibiting differential moisture vapor transport rate properties is disclosed. The sheet-form composite includes a hydrophilic, monolithic film layer characterized by having a differential ratio of wet to dry moisture transport rate greater than 1 and a dry moisture transport rate greater than about 2,600 g/m.sup.2 /24 hrs. This film layer is laminated to a hydrophilic exudate transport layer. The exudate transport layer can itself be, or can further include, a hydrophilic pressure sensitive adhesive applied in a continuous or discontinuous pattern. The sheet-form composite has a moisture vapor transport rate of greater than 2,000 g/m.sup.2 /24 hrs when dry, and a wet to dry moisture vapor transport rate ratio in the range of about 1.5 to about 10.

    摘要翻译： 公开了一种适合作为间接吸收剂伤口敷料并呈现差别水汽输送速率性质的片状复合材料。 片状复合材料包括亲水的整体膜层，其特征在于具有大于1的湿湿干燥输送速率的差异比率以及大于约2,600g / m 2/24小时的干燥水分输送速率。 将该膜层层合到亲水性渗出物输送层上。 渗出物输送层本身可以是或可以进一步包括以连续或不连续图案施加的亲水性压敏粘合剂。 片状复合材料在干燥时具有大于2,000g / m 2/24小时的湿气输送速率，以及在约1.5至约10的范围内的湿湿蒸汽输送速率比。

    Drug dispensing wound dressing
    6.
    发明授权
    Drug dispensing wound dressing 失效
    药物分配伤口敷料

    公开(公告)号：US4614787A

    公开(公告)日：1986-09-30

    申请号：US670810

    申请日：1984-11-13

    申请人： Michael Szycher ,  Donald J. Dempsey ,  Jonathan L. Rolfe

    发明人： Michael Szycher ,  Donald J. Dempsey ,  Jonathan L. Rolfe

    IPC分类号： A61F13/15 ,  A61L15/26 ,  A61L15/44 ,  C08G18/10 ,  A61F13/00

    CPC分类号： A61L15/44 ,  A61L15/26 ,  A61F2013/530007 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/418

    摘要： The disclosed wound dressings have a drug dispersed throughout a polyurethane matrix that is the reaction product of: (A) An isocyante terminated prepolymer formed by reaction of isophorone diisocyanate and a macroglycol and (B) a monomer containing hydroxyl and vinyl groups. The reaction product is a vinyl terminated polyurethane oligomer which is liquid at room temperature and which may be readily admixed with a pharmacoactive substance and a photosensitizer, formed into a film and cured by exposure to UV light without release of heat.In the most preferred embodiments the foregoing oligomer is codissolved in an organic solvent with a polyurethane polymer which is the reaction product of:dicyclohexyl methane diisocyanate;a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 daltons; and1,4-butane diol.That solution is then admixed with the pharmacoactive agent, formed into a film and cured.

    摘要翻译： 所公开的伤口敷料具有分散在整个聚氨酯基质中的药物，其是以下物质的反应产物：（A）通过异佛尔酮二异氰酸酯和大分子二醇反应形成的异氰酸酯封端的预聚物和（B）含有羟基和乙烯基的单体。 反应产物是在室温下为液体的乙烯基封端的聚氨酯低聚物，其可以容易地与药物活性物质和光敏剂混合，形成膜并通过暴露于UV光而不释放热而固化。 在最优选的实施方案中，上述低聚物与聚氨酯聚合物共同存在于有机溶剂中，所述聚氨酯聚合物是以下物质的反应产物：二环己基甲烷二异氰酸酯; 分子量为1000-3000道尔顿的聚四亚甲基醚多元醇; 和1,4-丁二醇。 然后将该溶液与药物活性剂混合，形成膜并固化。

    Biostable polyurethane products
    10.
    发明授权
    Biostable polyurethane products 失效
    生物稳定聚氨酯产品

    公开(公告)号：US5254662A

    公开(公告)日：1993-10-19

    申请号：US885927

    申请日：1992-05-18

    申请人： Michael Szycher ,  Andrew M. Reed

    发明人： Michael Szycher ,  Andrew M. Reed

    IPC分类号： A61L27/18 ,  C08G18/10 ,  C08G18/44 ,  C08G18/42

    CPC分类号： C08G18/44 ,  A61L27/18 ,  C08G18/10

    摘要： Polyurethane products having long-term biostability in combination with a low modulus of elasticity and a high ultimate tensile strength and other desireable mechanical properties which are particularly useful as leads for implantable pacemakers, as vascular grafts, as mammary prostheses, and as other products which are intended to be placed within the body of a mammal for extended periods with no substantial degradation of the product. The polyurethanes are prepared from the reaction of an organic diisocyanate, preferably an aliphatic or cycloaliphatic diisocyanate with polycarbonate glycol chained extended with diol, diamine or a mixture of diamine and alkanolamine.

    摘要翻译： 具有长期生物稳定性和低弹性模量以及高极限拉伸强度和其它期望的机械性能的聚氨酯产品，其特别用作植入式起搏器的导线，作为血管移植物，作为乳房假体，以及其它产品 意在长期放置在哺乳动物的体内，没有产品的显着降解。 聚氨酯由有机二异氰酸酯，优选脂肪族或脂环族二异氰酸酯与与二醇链接的聚碳酸酯二醇或二胺和链烷醇胺的混合物反应制备。