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    Ischemia detection systems for paced-patients using beat-type dependent baseline datasets
    4.
    发明授权
    Ischemia detection systems for paced-patients using beat-type dependent baseline datasets 有权
    使用节拍型依赖基线数据集的针对患者的缺血检测系统

    公开(公告)号：US08805498B1

    公开(公告)日：2014-08-12

    申请号：US12624515

    申请日：2009-11-24

    申请人： David R. Fischell ,  Michael Sasha John ,  David Keenan

    发明人： David R. Fischell ,  Michael Sasha John ,  David Keenan

    IPC分类号： A61N1/362

    CPC分类号： A61N1/37247 ,  A61N1/056 ,  A61N1/36592

    摘要： A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to distinguish between two different heart beats types such as ventricularly paced beats and supraventricular beats. The processor collects separate reference data for each beat type indicative of the normal values of a cardiac feature associated with these beat types. The processor performs an ischemia test by separately comparing present values of the cardiac feature for each beat type with the reference values for the corresponding beat type.

    摘要翻译： 公开了一种用于检测心脏缺血的装置。 该装置包括处理器，其被配置为区分两种不同的心跳类型，例如心室起搏节拍和室上搏动。 处理器针对指示与这些节拍类型相关联的心脏特征的正常值的每个节拍类型收集单独的参考数据。 处理器通过将每个节拍类型的心脏特征的当前值与相应节拍类型的参考值分开比较来执行缺血测试。

    Medical accessory proximity testing, detection, and alerting system
    6.
    发明授权
    Medical accessory proximity testing, detection, and alerting system 有权
    医疗附件接近测试，检测和警报系统

    公开(公告)号：US08855782B2

    公开(公告)日：2014-10-07

    申请号：US12817506

    申请日：2010-06-17

    申请人： David Keenan ,  Michael Sasha John

    发明人： David Keenan ,  Michael Sasha John

    IPC分类号： A61N1/00 ,  G06F19/00 ,  A61B5/055 ,  A61B5/00 ,  A61N1/372

    CPC分类号： A61B5/0432 ,  A61B5/0031 ,  A61B5/055 ,  A61B5/7221 ,  A61B5/742 ,  A61B2560/0271 ,  A61N1/37252 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/63

    摘要： Disclosed is a system having an implanted component and external component which are configured to provide a test of wireless communication in order to assess the success or failure of such communication and to store attributes related to such test in a memory log. To provide the communication test the implantable and external components can attempt wireless communication according to communication test parameters which relate to number of times to retry communication, duration of sending communication test signals, durations of waiting for communication test signals and the schedule of the communication tests. The schedule of tests may be periodic or may change over time in order to become more or less frequent according to a programmable schedule that may also decrease if the communication tests are successful and indicate patient compliance in keeping the external components close by. The communication tests can assist in determining if the patient is maintaining external components within a suggested proximity (e.g. 6 feet) of the patient and may assist to determine if transmission or reception difficulties are the source of communication failure. A physician programmer can provide for programming, conducting, summarizing and assessing the results of communication tests.

    摘要翻译： 公开了一种具有植入部件和外部部件的系统，其被配置为提供无线通信的测试，以便评估这种通信的成功或失败并且将与这种测试相关的属性存储在存储器日志中。 为了提供通信测试，可植入和外部组件可以根据与重试通信次数相关的通信测试参数，发送通信测试信号的持续时间，等待通信测试信号的持续时间和通信测试的进度来尝试无线通信 。 测试时间表可能是周期性的，也可能随着时间的推移而变化，以便根据可编程的时间表变得或多或少是频繁的，如果通信测试成功并且指示患者遵守以保持外部组件靠近，也可能减少。 通信测试可以帮助确定患者是否将外部组件维持在患者的建议接近度（例如6英尺）内，并且可以帮助确定传输或接收困难是否是通信故障的来源。 医生程序员可以提供编程，进行，总结和评估通信测试的结果。

    Baseline processing for the detection of cardiac events
    7.
    发明授权
    Baseline processing for the detection of cardiac events 有权
    检测心脏事件的基线处理

    公开(公告)号：US08170653B2

    公开(公告)日：2012-05-01

    申请号：US12367155

    申请日：2009-02-06

    申请人： David R. Fischell ,  Jonathan Harwood ,  Steven R. Johnson ,  David Keenan

    发明人： David R. Fischell ,  Jonathan Harwood ,  Steven R. Johnson ,  David Keenan

    IPC分类号： A61N1/00

    CPC分类号： A61B5/02455 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/746 ,  A61B5/7465 ,  A61B2560/0209

    摘要： A system for the detection of cardiac events occurring in a human patient is provided. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal and a patient alarm means is further provided and electrically coupled to the electrical signal processor. The electrical signal is acquired in the form of electrogram segments, which are categorized according to heart rate, ST segment shift and type heart rhythm (normal or abnormal). Baseline electrogram segments are tracked over time.

    摘要翻译： 提供了一种用于检测在人类患者中发生的心脏事件的系统。 系统中包括至少两个电极，以从患者的心脏获得电信号。 电信号处理器电耦合到电极以处理电信号，并且还提供患者报警装置并电耦合到电信号处理器。 电信号是以心律，ST段移位和心律（正常或异常）分为心电图段的形式获得的。 基线电描绘片段随时间跟踪。

    Ischemia detection systems for paced-patients having three different detection modes
    8.
    发明授权
    Ischemia detection systems for paced-patients having three different detection modes 有权
    具有三种不同检测模式的起搏患者的缺血检测系统

    公开(公告)号：US08452404B1

    公开(公告)日：2013-05-28

    申请号：US12624506

    申请日：2009-11-24

    申请人： David R. Fischell ,  Michael Sasha John ,  David Keenan

    发明人： David R. Fischell ,  Michael Sasha John ,  David Keenan

    IPC分类号： A61N1/00 ,  A61B5/0402

    CPC分类号： A61B5/04525 ,  A61B5/0031 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/1112 ,  A61N1/368

    摘要： A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to operate in three different modes according to relative frequency of different beat types. If beats of a first beat type, such as ventricularly paced beats, are predominant, the processor ignores other beat types and performs ischemia detection only on ventricularly paced beats. Conversely, if beats of a second beat type, such as sinus or atrially paced beats, are predominant, the processor ignores ventricularly paced beats and performs ischemia detection only on sinus or atrially paced beats. If there is a mixture of beat types such that neither predominates, the processor performs ischemia detection on both beat types.

    摘要翻译： 公开了一种用于检测心脏缺血的装置。 该装置包括处理器，其配置为根据不同拍子类型的相对频率在三种不同模式下操作。 如果头部节拍类型（例如心室起搏节拍）占优势，则处理器忽略其他节拍类型，仅针对心室起搏节拍进行缺血检测。 相反，如果第二节拍类型的节拍（例如窦性或高发性节拍）是主要的，则处理器忽略心室起搏节拍，并且仅对窦性或心率起搏节拍进行缺血检测。 如果没有优势的节拍类型的混合，则处理器对两种节拍类型执行缺血检测。

    Method and system for producing documents in a structured format
    9.
    发明授权
    Method and system for producing documents in a structured format 失效
    以结构化格式生成文档的方法和系统

    公开(公告)号：US06490603B1

    公开(公告)日：2002-12-03

    申请号：US09272291

    申请日：1999-03-19

    申请人： David Keenan ,  Anthony Joseph Donnelly

    发明人： David Keenan ,  Anthony Joseph Donnelly

    IPC分类号： G06F1721

    CPC分类号： G06F17/24 ,  G06F17/218 ,  G06F17/2247 ,  G06F17/2264 ,  G06F17/2276 ,  G06F17/2725

    摘要： Structured-format documents are produced in a process in which a file in a particular word processing format (input A) or in any other format (Input B) are converted (2) to a particular word processor format. The system loads a parameter activation table which sets document parameter values to allow DTDs to be automatically implemented. The document is cleaned (5) and tagged (6). The tagging provides an important link to allow automatic conversion at a later stage in the process. There is copy-editing (7) followed by validation of the file preparation stage. The involves automatic validation of tags, including validation of their order and nesting arrangement. Automatic conversion to SGML is performed in sequence of symbol/character conversion (20), tag conversion (21), equation processing(22), and floating element processing (23). Final validation (24) is then performed.

    摘要翻译： 在特定字处理格式（输入A）或任何其他格式（输入B）的文件被转换为特定的文字处理器格式的过程中产生结构化格式文档。 系统加载参数激活表，设置文档参数值以允许DTD自动实现。 文件清理（5）并标记（6）。 标记提供了一个重要的链接，允许在过程的后期自动转换。 有复制编辑（7），然后验证文件准备阶段。 涉及标签的自动验证，包括验证其顺序和嵌套排列。 符号/字符转换（20），标签转换（21），方程式处理（22）和浮动元素处理（23）的顺序自动转换为SGML。 然后执行最终验证（24）。

    Apparatus for producing a pharmaceutical product
    10.
    发明授权
    Apparatus for producing a pharmaceutical product 失效
    用于生产药物的装置

    公开(公告)号：US6092567A

    公开(公告)日：2000-07-25

    申请号：US189869

    申请日：1998-11-12

    申请人： David Keenan ,  Padraig Somers

    发明人： David Keenan ,  Padraig Somers

    IPC分类号： A61K9/14 ,  B01J2/16 ,  A61K9/16

    CPC分类号： B01J2/16 ,  A61K9/14

    摘要： A method and apparatus for producing a pharmaceutical product in a micronised form. The pharmaceutical product is delivered at a predetermined flow rate from a gravimetric feeding device into a delivery line. An air compressor generates an air stream which is delivered along an airline into which the pharmaceutical product delivery line is discharged for delivering the product to a microniser which micronises the product to a desired size range. The micronised product is delivered through a cyclone filter apparatus from which the micronised product is collected through an outlet valve to a storage drum.

    摘要翻译： 一种用于生产微粉化形式的药物产品的方法和装置。 药物产品以预定的流速从重量给药装置输送到输送管线中。 空气压缩机产生沿着航空公司输送的空气流，药物产品输送管线排放到该空气流中，以将产品输送到微粉化器，微粉化机将产品微粉化至期望的尺寸范围。 微粉化产品通过旋风过滤装置输送，微粉化产物通过旋风过滤装置通过出口阀收集到储存鼓中。