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    Dental root implant
    1.
    发明授权
    Dental root implant 失效
    牙根种植体

    公开(公告)号：US5762499A

    公开(公告)日：1998-06-09

    申请号：US667516

    申请日：1996-06-21

    申请人： Michel Dard ,  Gerard De Witte ,  Philippe Rouvre

    发明人： Michel Dard ,  Gerard De Witte ,  Philippe Rouvre

    IPC分类号： A61C8/00

    CPC分类号： A61C8/0018 ,  A61C8/0089

    摘要： A dental root implant has a metal implant body which has transverse openings near its rounded lower end. The implant body has a shape which tapers downwards. Circumferential grooves are arranged parallel and mutually separated in its outer face, the grooves being rounded at their bases and at the junctions with neighboring outer face sections.

    摘要翻译： 牙根种植体具有金属植入体，其在其圆形下端附近具有横向开口。 植入体具有向下变细的形状。 环形槽在其外表面上平行并相互分离，凹槽在其基部处和与相邻外表面部分的接合部处是圆形的。

    Peptide and peptide mimetic conjugates with integrin-inhibitor properties
    3.
    发明授权
    Peptide and peptide mimetic conjugates with integrin-inhibitor properties 有权
    具有整合素抑制剂性质的肽和肽模拟物缀合物

    公开(公告)号：US07655624B2

    公开(公告)日：2010-02-02

    申请号：US10344669

    申请日：2001-08-02

    申请人： Joerg Meyer ,  Berthold Nies ,  Michel Dard ,  Guenter Hoelzemann ,  Horst Kessler ,  Martin Kantlehner ,  Ulrich Hersel ,  Christoph Gibson ,  Gabor Sulyok

    发明人： Joerg Meyer ,  Berthold Nies ,  Michel Dard ,  Guenter Hoelzemann ,  Horst Kessler ,  Martin Kantlehner ,  Ulrich Hersel ,  Christoph Gibson ,  Gabor Sulyok

    IPC分类号： A61K38/12 ,  A61F2/02

    CPC分类号： A61K47/6435 ,  A61K47/6425

    摘要： The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule, selected from the group Lys-(CO—CH2—(CH2)n—PO3H2)2(I), -Lys-[-Lys-(CO—CH2—(CH2)a—PO3H2)2]2(ii) or -Lys-(Lys[-Lys-(CO—CH2—(CH2)n—PO3H2]2 (iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.

    摘要翻译： 本发明涉及式（1）B-Q-X1的化合物，其中B是生物活性细胞粘附介导分子。 Q不存在或是无机间隔分子，X1是选自Lys-（CO-CH 2 - （CH 2）n -PO 3 H 2）2（I），-Lys - [ - Lys-（CO-CH 2） - （CH 2）a-PO 3 H 2）2] 2（ⅱ）或-Lys-（Lys [-Lys-（CO-CH 2 - （CH 2）n -PO 3 H 2] 2（ⅲ），n独立地表示0,1,2 或3，其中B族的游离氨基以间隔分子Q或锚分子X1的游离羧基形式连接，或者基团Q的游离氨基以肽形式连接至游离氨基 本发明还涉及其盐。本发明化合物可用作整联蛋白抑制剂，用于治疗由植入物引起的疾病，缺血性和溶骨性疾病如骨质疏松症，血栓形成，心肌梗塞和动脉硬化 ，除了加速和加强植入物或组织中生物相容性表面的整合过程。

    Abutment with a hydroxylated surface
    4.
    发明授权
    Abutment with a hydroxylated surface 有权
    具有羟基化表面的基台

    公开(公告)号：US08029283B2

    公开(公告)日：2011-10-04

    申请号：US11680042

    申请日：2007-02-28

    申请人： Frank Schwarz ,  Jürgen Becker ,  Marco Wieland ,  Michel Dard

    发明人： Frank Schwarz ,  Jürgen Becker ,  Marco Wieland ,  Michel Dard

    IPC分类号： A61C8/00

    CPC分类号： A61C8/0012 ,  A61C8/0013 ,  A61C8/0015 ,  A61C8/005 ,  A61C8/006 ,  A61C8/0066 ,  A61C8/0069

    摘要： Abutment of a dental implant system, having at the top a support region intended for receiving a prosthetic build-up construction and at the bottom an implant contact region intended for insertion into a receiving hole of an implant, and wherein the abutment has between the support region and the implant contact region a soft tissue contact surface. The soft tissue contact surface is at least partially hydroxylated or silanated.

    摘要翻译： 牙科植入物系统的基座，其顶部具有用于接纳假体积聚构造的支撑区域，并且在底部具有用于插入到植入物的接收孔中的植入物接触区域，并且其中所述支座具有在支撑件 区域和植入物接触区域是软组织接触表面。 软组织接触表面至少部分羟基化或硅烷化。

    Peptide and peptide mimetic derivatives with integrin-inhibitors properties II
    5.
    发明授权
    Peptide and peptide mimetic derivatives with integrin-inhibitors properties II 有权
    具有整合蛋白抑制剂性质的肽和肽模拟衍生物II

    公开(公告)号：US07276482B2

    公开(公告)日：2007-10-02

    申请号：US10344668

    申请日：2001-08-02

    申请人： Joerg Meyer ,  Berthold Nies ,  Michel Dard ,  Guenter Hoelzemann ,  Horst Kessler ,  Martin Kantlehner ,  Ulrich Hersel ,  Christoph Gibson ,  Gabor Sulyok

    发明人： Joerg Meyer ,  Berthold Nies ,  Michel Dard ,  Guenter Hoelzemann ,  Horst Kessler ,  Martin Kantlehner ,  Ulrich Hersel ,  Christoph Gibson ,  Gabor Sulyok

    IPC分类号： A61K38/10

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/78 ,  Y02P20/125

    摘要： The invention relates to compounds of formula (I) B-Q-X1, wherein B is a bioactive, cell adhesive mediating molecule, selected from the group (i) and Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 1) (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 2) (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 3) (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (SEQ ID NO: 4) (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (SEQ ID NO: 5) (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (SEQ ID NO: 6) (vii), wherein (i) X, Y, Z, R2, R3, R4, A, Ar, Hal, Het, Het1, n, m, o, p, q, s, t have the meanings cited in claim 1, Q is absent or is an organic spacer molecule, X1 is an anchor molecule selected from the group cited in claim 1, and the salts thereof, which can be used as integrin inhibitors particularly for treatment of illness, deficiencies and inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.

    摘要翻译： 本发明涉及式（I）BQX 1的化合物，其中B是选自（i）和Thr-Trp-Tyr-Lys-Ile-Ala的生物活性的细胞粘附介导分子 -Ph-Gln-Arg-Asn-Arg-Lys（SEQ ID NO：1）（ii），Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys（SEQ ID NO： ）（iii），Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys（SEQ ID NO：3）（iv），Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln -Arg-Asn-Arg（SEQ ID NO：4）（v），Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn（SEQ ID NO：5）（vi） -Tyr-Lys-Ile-Ala-Phe-Gln-Arg（SEQ ID NO：6）（vii），其中（i）X，Y，Z，R 2，R 3 A，Ar，Hal，Het，Het 1，n，m，o，p，q，s，t具有引用的含义 在权利要求1中，Q不存在或是有机间隔分子，X 1是选自权利要求1所述的基团的锚定分子及其盐，其可以用作整联蛋白抑制剂，特别是用于 治疗由植入物和溶骨性疾病引起的疾病，缺陷和炎症 例如骨质疏松症，血栓形成，心肌梗死和动脉硬化，以及植入物或组织中生物相容性表面的整合过程的加速和加强。

    Abutment with a Hydroxylated Surface
    7.
    发明申请
    Abutment with a Hydroxylated Surface 有权
    羟基化表面的基台

    公开(公告)号：US20070202462A1

    公开(公告)日：2007-08-30

    申请号：US11680042

    申请日：2007-02-28

    申请人： Frank Schwarz ,  Jurgen Becker ,  Marco Wieland ,  Michel Dard

    发明人： Frank Schwarz ,  Jurgen Becker ,  Marco Wieland ,  Michel Dard

    IPC分类号： A61C13/225

    CPC分类号： A61C8/0012 ,  A61C8/0013 ,  A61C8/0015 ,  A61C8/005 ,  A61C8/006 ,  A61C8/0066 ,  A61C8/0069

    摘要： Abutment of a dental implant system, having at the top a support region intended for receiving a prosthetic build-up construction and at the bottom an implant contact region intended for insertion into a receiving hole of an implant, and wherein the abutment has between the support region and the implant contact region a soft tissue contact surface. Said soft tissue contact surface is at least partially hydroxylated or silanated.

    摘要翻译： 牙科植入物系统的基座，其顶部具有用于接纳假体积聚构造的支撑区域，并且在底部具有用于插入到植入物的接收孔中的植入物接触区域，并且其中所述支座具有在支撑件 区域和植入物接触区域是软组织接触表面。 所述软组织接触表面至少部分羟基化或硅烷化。

    ENAMEL MATRIX DERIVATIVE FRACTION C
    9.
    发明申请
    ENAMEL MATRIX DERIVATIVE FRACTION C 审中-公开
    ENAMEL矩阵衍生分类C

    公开(公告)号：US20110312891A1

    公开(公告)日：2011-12-22

    申请号：US13000130

    申请日：2009-06-29

    申请人： Stina Gestrelius ,  Michel Dard ,  Ruzica Ranevski ,  S. Petter Lyngstadaas ,  Corinna Mauth

    发明人： Stina Gestrelius ,  Michel Dard ,  Ruzica Ranevski ,  S. Petter Lyngstadaas ,  Corinna Mauth

    IPC分类号： A61K38/17 ,  A61P19/08 ,  C12N5/0775 ,  C07K14/47 ,  C12N5/071

    CPC分类号： C07K14/78

    摘要： Isolated active compound of a naturally occurring fraction of Enamel Matrix Derivatives (EMD), having at least one of each two N-terminal polypeptide fragments of amelogenin, which are at least 95% identical to an amino acid sequence as shown in SEQ. ID. No:1 and/or 2. The invention relates to the use of said isolated active compound of a fraction and/or of the fraction itself, and/or the at least one of each two polypeptide fragments for use as a medicament and/or for the manufacture of a pharmaceutical composition for a variety of different medical indications such as inducing and/or promoting cementogenesis, bone growth and/or binding between parts of living mineralised tissue, for bonding of a piece of living mineralised tissue to a bonding site on a piece of other living tissue, for endorsing binding between hard tissues, for inducing regeneration of dentin, and/or for filling a mineralized wound cavity and/or tissue defect following from a procedure and/or trauma.

    摘要翻译： 具有至少与氨基酸序列至少95％相同的釉质蛋白的两个N末端多肽片段中至少一个的釉质基质衍生物（EMD）的天然存在部分的分离的活性化合物。 ID。 本发明涉及所述分离的活性成分和/或级分本身的分离活性化合物和/或每两种多肽片段中的至少一种用作药物和/或 用于制造用于各种不同医学适应症的药物组合物，例如诱导和/或促进活的矿化组织的部分之间的骨水泥生成，骨生长和/或结合，用于将一块活的矿化组织粘合到粘合部位上 用于在手术和/或创伤之后识别硬组织之间的结合，用于诱导牙质的再生和/或用于填充矿化的伤口腔和/或组织缺损的一块其它活组织。

    One-Part Implant with a Hydroxylated Soft Tissue Contact Surface
    10.
    发明申请
    One-Part Implant with a Hydroxylated Soft Tissue Contact Surface 审中-公开
    一部分植入与羟化软组织接触表面

    公开(公告)号：US20070202464A1

    公开(公告)日：2007-08-30

    申请号：US11680048

    申请日：2007-02-28

    申请人： Frank Schwarz ,  Jurgen Becker ,  Marco Wieland ,  Michel Dard

    发明人： Frank Schwarz ,  Jurgen Becker ,  Marco Wieland ,  Michel Dard

    IPC分类号： A61C8/00

    CPC分类号： A61C8/0012 ,  A61C8/0013 ,  A61C8/0015 ,  A61C8/0075

    摘要： One-part implant for attachment of artificial teeth comprising an anchoring part and a mounting part, wherein the anchoring part and the mounting part are configured in one piece. The anchoring part of the one-part implant has a bone contact surface B and a soft tissue contact surface S. The soft tissue contact surface S is at least partially hydroxylated or silanated, which results in an improved soft tissue integration.

    摘要翻译： 包括锚定部件和安装部件的用于附接人造牙齿的一部分植入物，其中所述锚固部件和所述安装部件被构造成一体。 一部分植入物的锚定部分具有骨接触表面B和软组织接触表面S.软组织接触表面S至少部分羟基化或硅烷化，这导致改善的软组织整合。