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公开(公告)号：US08426137B2
公开(公告)日：2013-04-23
申请号：US13176626
申请日：2011-07-05
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
CPC分类号： C12Q1/689 , C12Q1/14 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166 , G01N2333/195 , G01N2333/31
摘要： Compositions and methods for the detection of vancomycin-resistant pathogens using primers and/or probes to the vanA and vanB genes.
摘要翻译： 使用引物和/或探针对vanA和vanB基因检测万古霉素抗性病原体的组合物和方法。
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2.发明申请Highly conserved genes and their use to generate probes and primers for detection of microorganisms 有权高度保守的基因及其用于产生用于检测微生物的探针和引物公开(公告)号：US20090068641A1
公开(公告)日：2009-03-12
申请号：US11236785
申请日：2005-09-27
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/6893 , C12Q2600/156 , C12Q2600/16 , Y02A50/55
摘要： Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention.
摘要翻译： 四个高度保守的基因，编码翻译延伸因子Tu，翻译延伸因子G，质子转位ATP酶的催化亚基和RecA重组酶，用于产生物种特异性，属特异性，家族特异性，群体特异性和通用性 核酸探针和扩增引物，从临床标本中快速检测和鉴定藻类，古细菌，细菌，真菌和寄生虫病原体进行诊断。 相关的抗微生物剂抗性和毒素基因的检测也在本发明的范围内。
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3.发明申请公开(公告)号：US20120058487A1
公开(公告)日：2012-03-08
申请号：US11842141
申请日：2007-08-21
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/6893 , C12Q2600/156 , C12Q2600/16 , Y02A50/55
摘要： Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention.
摘要翻译： 四个高度保守的基因，编码翻译延伸因子Tu，翻译延伸因子G，质子转位ATP酶的催化亚基和RecA重组酶，用于产生物种特异性，属特异性，家族特异性，群体特异性和通用性 核酸探针和扩增引物，从临床标本中快速检测和鉴定藻类，古细菌，细菌，真菌和寄生虫病原体进行诊断。 相关的抗微生物剂抗性和毒素基因的检测也在本发明的范围内。
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4.发明申请Highly conserved genes and their use to generate probes and primers for detection of microorganisms 审中-公开高度保守的基因及其用于产生用于检测微生物的探针和引物公开(公告)号：US20100267012A1
公开(公告)日：2010-10-21
申请号：US11522253
申请日：2006-09-14
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois Picard , Paul H. Roy
CPC分类号： C12Q1/689 , C12Q1/14 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166 , G01N2333/195 , G01N2333/31
摘要： Compositions and methods for the detection of vancomycin-resistant pathogens using primers and/or probes to the vanA and vanB genes.
摘要翻译： 使用引物和/或探针对vanA和vanB基因检测万古霉素抗性病原体的组合物和方法。
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5.发明授权Highly conserved genes and their use to generate probes and primers for detection of microorganisms 有权高度保守的基因及其用于产生用于检测微生物的探针和引物公开(公告)号：US08114601B2
公开(公告)日：2012-02-14
申请号：US11236785
申请日：2005-09-27
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Ménard , Marc Ouellette , François J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Ménard , Marc Ouellette , François J. Picard , Paul H. Roy
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/6893 , C12Q2600/156 , C12Q2600/16 , Y02A50/55
摘要： Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention.
摘要翻译： 四个高度保守的基因，编码翻译延伸因子Tu，翻译延伸因子G，质子转位ATP酶的催化亚基和RecA重组酶，用于产生物种特异性，属特异性，家族特异性，群体特异性和通用性 核酸探针和扩增引物，从临床标本中快速检测和鉴定藻类，古细菌，细菌，真菌和寄生虫病原体进行诊断。 相关的抗微生物剂抗性和毒素基因的检测也在本发明的范围内。
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公开(公告)号：US08182996B2
公开(公告)日：2012-05-22
申请号：US11842141
申请日：2007-08-21
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Ménard , Marc Ouellette , François J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Ménard , Marc Ouellette , François J. Picard , Paul H. Roy
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/6893 , C12Q2600/156 , C12Q2600/16 , Y02A50/55
摘要： Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention.
摘要翻译： 四个高度保守的基因，编码翻译延伸因子Tu，翻译延伸因子G，质子转位ATP酶的催化亚基和RecA重组酶，用于产生物种特异性，属特异性，家族特异性，群体特异性和通用性 核酸探针和扩增引物，从临床标本中快速检测和鉴定藻类，古细菌，细菌，真菌和寄生虫病原体进行诊断。 相关的抗微生物剂抗性和毒素基因的检测也在本发明的范围内。
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7.发明授权Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 有权物种特异性，属特异性和通用DNA探针和扩增引物，用于快速检测和鉴定临床标本中常见的细菌和真菌病原体及相关抗生素抗性基因，用于诊断微生物实验室公开(公告)号：US08034588B2
公开(公告)日：2011-10-11
申请号：US10753169
申请日：2004-01-07
CPC分类号： C12Q1/6895 , C12Q1/6844 , C12Q1/689 , C12Q2600/16
摘要： Provided herein are methods and kits for the specific and ubiquitous detection of Streptococcus agalactiae.
摘要翻译： 本文提供了用于特异性和无处不在检测无乳链球菌的方法和试剂盒。
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8.发明授权Probes and primers for detection of bacterial pathogens and antibiotic resistance genes 有权用于检测细菌病原体和抗生素抗性基因的探针和底物公开(公告)号：US07943346B2
公开(公告)日：2011-05-17
申请号：US11416499
申请日：2006-05-01
申请人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
发明人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
CPC分类号： C07K14/315 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/3156 , C12Q1/689 , C12Q1/6895 , C12Q2600/16
摘要： The present invention relates to methods for universal bacterial detection, for specific detection of the common bacterial pathogens, and for specific detection of commonly encountered and clinically relevant bacterial antibiotic resistance genes directly from clinical specimens or, alternatively, from a bacterial colony. The core of this invention consists primarily of the DNA sequences from all species-specific genomic DNA fragments selected by hybridization from genomic libraries or, alternatively, selected from data banks as well as any oligonucleotide sequences derived from these sequences which can be used as probes or amplification primers for PCR or any other nucleic acid amplification methods. This invention also includes DNA sequences from the selected clinically relevant antibiotic resistance genes. Diagnostic kits comprising such primers and probes are also provided.
摘要翻译： 本发明涉及通用细菌检测方法，用于特异性检测常见细菌病原体，以及直接从临床标本或细菌菌落特异性检测常见且临床相关的细菌抗生素抗性基因。 本发明的核心主要由来自基因组文库杂交选择的所有物种特异性基因组DNA片段的DNA序列组成，或者选自数据库，以及衍生自可用作探针的这些序列的任何寡核苷酸序列， 用于PCR的扩增引物或任何其它核酸扩增方法。 本发明还包括来自所选择的临床相关抗生素抗性基因的DNA序列。 还提供了包括这种引物和探针的诊断试剂盒。
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9.发明授权Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories 失效物种特异性和通用DNA探针和扩增引物，用于快速检测和鉴定临床标本中常见的细菌病原体和相关抗生素抗性基因，用于微生物实验室的常规诊断
公开(公告)号：US6001564A
公开(公告)日：1999-12-14
申请号：US526840
申请日：1995-09-11
申请人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
发明人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
IPC分类号： C12N15/09 , C07K14/195 , C07K14/21 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C12N15/65 , C12Q1/06 , C12Q1/68 , C12R1/46 , C12P19/34
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12N15/65 , C12Q2600/16
摘要： The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection of commonly encountered and clinically relevant bacterial antibiotic resistance genes directly from clinical specimens or, alternatively, from a bacterial colony. The above bacterial species can account for as much as 80% of bacterial pathogens isolated in routine microbiology laboratories.
摘要翻译： 本发明涉及用于通用细菌检测的基于DNA的方法，用于特异性检测常见细菌病原体大肠杆菌，肺炎克雷伯杆菌，绿脓假单胞菌，奇异变形杆菌，肺炎链球菌，金黄色葡萄球菌，表皮葡萄球菌，粪肠球菌，腐生葡萄球菌，链球菌 化脓性链球菌，流感嗜血杆菌和卡他莫拉菌，以及直接从临床标本或细菌菌落特异性检测常见和临床相关的细菌抗生素抗性基因。 上述细菌种类可以在常规微生物实验室中分离出多达80％的细菌病原体。
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10.发明申请SPECIFIC AND UNIVERSAL PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL PATHOGENS AND ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES 审中-公开特异性和通用探针和放大引物，用于快速检测和鉴定临床样本中常见细菌病原体和抗生素基因，用于微生物实验室中的常规诊断公开(公告)号：US20090053703A1
公开(公告)日：2009-02-26
申请号：US11842080
申请日：2007-08-20
申请人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
发明人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
IPC分类号： C12Q1/68
CPC分类号： C07K14/315 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/3156 , C12Q1/689 , C12Q1/6895 , C12Q2600/16
摘要： The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection of commonly encountered and clinically relevant bacterial antibiotic resistance genes directly from clinical specimens or, alternatively, from a bacterial colony.
摘要翻译： 本发明涉及用于通用细菌检测的基于DNA的方法，用于特异性检测常见细菌病原体大肠杆菌，肺炎克雷伯杆菌，绿脓假单胞菌，奇异变形杆菌，肺炎链球菌，金黄色葡萄球菌，表皮葡萄球菌，粪肠球菌，腐生葡萄球菌，链球菌 化脓性链球菌，流感嗜血杆菌和卡他莫拉菌，以及直接从临床标本或细菌菌落特异性检测常见和临床相关的细菌抗生素抗性基因。
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