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公开(公告)号：US08534319B2
公开(公告)日：2013-09-17
申请号：US12529199
申请日：2008-03-03
申请人： Michel G. Bergeron , Regis Peytavi , Horacio Kido , Marc Madou
发明人： Michel G. Bergeron , Regis Peytavi , Horacio Kido , Marc Madou
IPC分类号： E03B1/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2200/0621 , B01L2300/0803 , B01L2300/0861 , B01L2400/0409 , B01L2400/0688 , F16K99/0021 , F16K99/0063 , F16K2099/0074 , F16K2099/0084 , G01N21/07 , Y10T137/0753 , Y10T137/0989 , Y10T137/218 , Y10T137/2911 , Y10T137/86928 , Y10T137/87917
摘要： Methods and devices using a co-radial arrangement of serial siphon structures composed of siphon valves each separated by a capillary valve to save radial space in a fluidic system. Such serial siphon valves allow to sequentially distribute liquids in a fluidic system upon application of successive centripetal accelerations and decelerations applied to a rotary platform.
摘要翻译： 使用由虹吸阀组成的串联虹吸结构的共同径向排列的方法和装置，每个虹吸管由毛细管阀分开，以节省流体系统中的径向空间。 这种串联虹吸阀允许在施加连续的向心加速度和施加到旋转平台的减速时，在流体系统中顺序地分配液体。
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2.发明申请公开(公告)号：US20120058487A1
公开(公告)日：2012-03-08
申请号：US11842141
申请日：2007-08-21
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/6893 , C12Q2600/156 , C12Q2600/16 , Y02A50/55
摘要： Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention.
摘要翻译： 四个高度保守的基因，编码翻译延伸因子Tu，翻译延伸因子G，质子转位ATP酶的催化亚基和RecA重组酶，用于产生物种特异性，属特异性，家族特异性，群体特异性和通用性 核酸探针和扩增引物，从临床标本中快速检测和鉴定藻类，古细菌，细菌，真菌和寄生虫病原体进行诊断。 相关的抗微生物剂抗性和毒素基因的检测也在本发明的范围内。
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3.发明申请NUCLEIC ACID SEQUENCES FOR THE AMPLIFICATION AND DETECTION OF RESPIRATORY VIRUSES 审中-公开用于扩增和检测呼吸道病毒的核酸序列公开(公告)号：US20100279273A1
公开(公告)日：2010-11-04
申请号：US12669272
申请日：2008-07-17
申请人： Michel G. Bergeron , Johanne Frenette , Maurice Boissinot , Eric Leblanc , Guy Boivin , Natasha Dionne
发明人： Michel G. Bergeron , Johanne Frenette , Maurice Boissinot , Eric Leblanc , Guy Boivin , Natasha Dionne
CPC分类号： C40B40/06 , C07B2200/11 , C12N7/00 , C12N2710/10322 , C12N2760/16122 , C12N2760/16222 , C12N2760/18322 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , C12N2770/20022 , C12N2770/32322 , C12N2770/32722 , C12Q1/701 , C40B30/04
摘要： The present invention relates to methods of detection, as well as assays, reagents and kits for the specific detection of 15 clinically important respiratory viruses including influenza A and B viruses, human respiratory syncytial viruses, human metapneumoviruses, human enteroviruses, all serotypes of rhinoviruses, 7 serotypes of adenoviruses, parainfluenza viruses types 1, 2, 3, and 4, as well as coronaviruses NL, 229E, OC43, and SARS-CoV. The present invention allows for the detection of each of these respiratory viruses in a single assay.
摘要翻译： 本发明涉及检测方法，以及用于特异性检测15种临床重要呼吸道病毒（包括甲型和乙型流感病毒），人呼吸道合胞病毒，人类偏肺病毒，人肠道病毒，所有鼻病毒血清型的试剂和试剂盒， 7型血清型腺病毒，副流感病毒1,2,3型和4型，以及冠状病毒NL，229E，OC43和SARS-CoV。 本发明允许在单次测定中检测这些呼吸道病毒中的每一种。
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4.发明申请Highly conserved genes and their use to generate probes and primers for detection of microorganisms 审中-公开高度保守的基因及其用于产生用于检测微生物的探针和引物公开(公告)号：US20100267012A1
公开(公告)日：2010-10-21
申请号：US11522253
申请日：2006-09-14
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois Picard , Paul H. Roy
CPC分类号： C12Q1/689 , C12Q1/14 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166 , G01N2333/195 , G01N2333/31
摘要： Compositions and methods for the detection of vancomycin-resistant pathogens using primers and/or probes to the vanA and vanB genes.
摘要翻译： 使用引物和/或探针对vanA和vanB基因检测万古霉素抗性病原体的组合物和方法。
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5.发明授权公开(公告)号：US07465295B2
公开(公告)日：2008-12-16
申请号：US10190393
申请日：2002-07-05
IPC分类号： A61M31/00
CPC分类号： A61M31/00 , A61M2210/1067 , A61M2210/1475
摘要： This invention relates to a vaginal/ano-rectal applicator for the uniform delivery of any topical formulations to treat and/or prevent any infection and/or abnormal conditions of mucosa cavity caused by any pathogen and/or disease. The present applicator comprises a longitudinally extending body that has proximal and distal ends. The proximal end is located close to the external site of a mucosal cavity accessible to a user. The body has external perforations, made as a series of slots or holes, for uniform distribution of any formulation to be delivered to the user's mucosal cavity. Upon insertion of the applicator and expulsion of the formulation in the mucosal cavity, the formulation, which is contained in a reservoir, travels through a diffusion channel having a small volume, prior to being expelled through the perforations.
摘要翻译： 本发明涉及用于均匀递送任何局部制剂以治疗和/或预防由任何病原体和/或疾病引起的粘膜腔的任何感染和/或异常状况的阴道/非直肠施用器。 本涂抹器包括具有近端和远端的纵向延伸体。 近端位于使用者可接近的粘膜腔的外部位置附近。 身体具有外部穿孔，制成一系列狭槽或孔，用于均匀分配要输送到使用者的粘膜腔的任何制剂。 在插入施用器并将制剂排出到粘膜腔中时，容纳在储存器中的制剂在通过穿孔排出之前通过具有小体积的扩散通道。
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6.发明授权Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories 失效物种特异性和通用DNA探针和扩增引物，用于快速检测和鉴定临床标本中常见的细菌病原体和相关抗生素抗性基因，用于微生物实验室的常规诊断
公开(公告)号：US6001564A
公开(公告)日：1999-12-14
申请号：US526840
申请日：1995-09-11
申请人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
发明人： Michel G. Bergeron , Marc Ouellette , Paul H. Roy
IPC分类号： C12N15/09 , C07K14/195 , C07K14/21 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C12N15/65 , C12Q1/06 , C12Q1/68 , C12R1/46 , C12P19/34
CPC分类号： C12Q1/689 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/245 , C07K14/26 , C07K14/285 , C07K14/31 , C07K14/315 , C07K14/3156 , C12N15/65 , C12Q2600/16
摘要： The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection of commonly encountered and clinically relevant bacterial antibiotic resistance genes directly from clinical specimens or, alternatively, from a bacterial colony. The above bacterial species can account for as much as 80% of bacterial pathogens isolated in routine microbiology laboratories.
摘要翻译： 本发明涉及用于通用细菌检测的基于DNA的方法，用于特异性检测常见细菌病原体大肠杆菌，肺炎克雷伯杆菌，绿脓假单胞菌，奇异变形杆菌，肺炎链球菌，金黄色葡萄球菌，表皮葡萄球菌，粪肠球菌，腐生葡萄球菌，链球菌 化脓性链球菌，流感嗜血杆菌和卡他莫拉菌，以及直接从临床标本或细菌菌落特异性检测常见和临床相关的细菌抗生素抗性基因。 上述细菌种类可以在常规微生物实验室中分离出多达80％的细菌病原体。
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公开(公告)号：US5773027A
公开(公告)日：1998-06-30
申请号：US538457
申请日：1995-10-03
IPC分类号： A61K9/127 , A61K31/47 , A61K31/4725 , A61K31/52 , A61K31/66 , A61K31/70 , A61K31/7056 , A61P31/12 , A61P31/18 , C07H31/70
CPC分类号： A61K31/662 , A61K31/4725 , A61K31/522 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K9/127 , A61K9/1271 , Y10S514/934
摘要： A method is disclosed for the treatment of viral diseases comprising the administration of antiviral agents encapsulated in liposomes. Also provided are formulations of liposomes for the treatment of viral diseases and more particularly for the treatment of infections caused by viruses like human immunodeficiency virus (HIV) and cytomegalovirus (CMV). These formulations of liposomes are composed of specific classes of lipid components and contain an entrapped drug effective against the viral disease. These liposomal formulations of antiviral drugs allow high cellular penetration in different cell lines, good in vitro antiviral efficacy against HIV and CMV replication, efficient in vivo targeting of HIV reservoirs and a marked improvement of the pharmacokinetics of drugs.
摘要翻译： 公开了用于治疗病毒性疾病的方法，其包括施用包封在脂质体中的抗病毒剂。 还提供了用于治疗病毒性疾病的脂质体的制剂，更特别是用于治疗由病毒如人类免疫缺陷病毒（HIV）和巨细胞病毒（CMV）引起的感染的治疗。 脂质体的这些制剂由特定类型的脂质组分组成，并且含有对病毒性疾病有效的包埋药物。 抗病毒药物的这些脂质体制剂允许不同细胞系中的高细胞穿透，对HIV和CMV复制的良好的体外抗病毒效能，HIV储库的有效的体内靶向以及药物的药代动力学的显着改善。
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公开(公告)号：USD714458S1
公开(公告)日：2014-09-30
申请号：US29429959
申请日：2012-08-20
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公开(公告)号：US08426137B2
公开(公告)日：2013-04-23
申请号：US13176626
申请日：2011-07-05
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
CPC分类号： C12Q1/689 , C12Q1/14 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166 , G01N2333/195 , G01N2333/31
摘要： Compositions and methods for the detection of vancomycin-resistant pathogens using primers and/or probes to the vanA and vanB genes.
摘要翻译： 使用引物和/或探针对vanA和vanB基因检测万古霉素抗性病原体的组合物和方法。
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10.发明申请Highly conserved genes and their use to generate probes and primers for detection of microorganisms 有权高度保守的基因及其用于产生用于检测微生物的探针和引物公开(公告)号：US20090068641A1
公开(公告)日：2009-03-12
申请号：US11236785
申请日：2005-09-27
申请人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
发明人： Michel G. Bergeron , Maurice Boissinot , Ann Huletsky , Christian Menard , Marc Ouellette , Francois J. Picard , Paul H. Roy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/6893 , C12Q2600/156 , C12Q2600/16 , Y02A50/55
摘要： Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention.
摘要翻译： 四个高度保守的基因，编码翻译延伸因子Tu，翻译延伸因子G，质子转位ATP酶的催化亚基和RecA重组酶，用于产生物种特异性，属特异性，家族特异性，群体特异性和通用性 核酸探针和扩增引物，从临床标本中快速检测和鉴定藻类，古细菌，细菌，真菌和寄生虫病原体进行诊断。 相关的抗微生物剂抗性和毒素基因的检测也在本发明的范围内。
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