公开(公告)号：US20060188904A1

公开(公告)日：2006-08-24

申请号：US11331161

申请日：2006-01-13

申请人： Mihrimah Ozkan ,  Cengiz Ozkan ,  Mo Yang ,  Xuan Zhang ,  Shalini Prasad

发明人： Mihrimah Ozkan ,  Cengiz Ozkan ,  Mo Yang ,  Xuan Zhang ,  Shalini Prasad

IPC分类号： C12Q1/68 ,  G01N33/554 ,  C12M1/34 ,  G01N33/543 ,  G01N33/569

CPC分类号： G01N33/552 ,  C12Q1/6825 ,  G01N33/543 ,  C12Q2565/507

摘要： Disclosed herein are single reactant components immobilized over single electrodes and methods of making and using thereof. Devices, such as biosensors, comprising the single reactant components immobilized over single electrodes are also disclosed. Assays using the single reactant components immobilized over single electrodes are disclosed as well as databases comprising signature pattern vectors for reactant components.

摘要翻译： 本文公开了固定在单个电极上的单一反应物组分及其制备和使用方法。 还公开了包含固定在单个电极上的单个反应物组分的装置，例如生物传感器。 公开了使用固定在单个电极上的单个反应物组分的测定以及包含反应物组分的标记图案载体的数据库。

公开(公告)号：US20050003396A1

公开(公告)日：2005-01-06

申请号：US10820108

申请日：2004-04-08

申请人： Mihrimah Ozkan ,  Cengiz Ozkan ,  Mo Yang ,  Xuan Zhang ,  Shalini Prasad

发明人： Mihrimah Ozkan ,  Cengiz Ozkan ,  Mo Yang ,  Xuan Zhang ,  Shalini Prasad

IPC分类号： C12Q1/68 ,  G01N33/543 ,  G01N33/552 ,  C12Q1/04 ,  G01N33/53

CPC分类号： G01N33/552 ,  C12Q1/6825 ,  G01N33/543 ,  C12Q2565/507

摘要： Disclosed herein are single reactant components immobilized over single electrodes and methods of making and using thereof. Devices, such as biosensors, comprising the single reactant components immobilized over single electrodes are also disclosed. Assays using the single reactant components immobilized over single electrodes are disclosed as well as databases comprising signature pattern vectors for reactant components.

摘要翻译： 本文公开了固定在单个电极上的单一反应物组分及其制备和使用方法。 还公开了包含固定在单个电极上的单个反应物组分的装置，例如生物传感器。 公开了使用固定在单个电极上的单个反应物组分的测定以及包含反应物组分的标记图案载体的数据库。

公开(公告)号：US20070141721A1

公开(公告)日：2007-06-21

申请号：US10422776

申请日：2003-04-25

申请人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert Haddon ,  Abdul-Rahim Khaled ,  Mo Yang

发明人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert Haddon ,  Abdul-Rahim Khaled ,  Mo Yang

IPC分类号： G01N33/543

CPC分类号： G01N33/54373 ,  B82Y30/00

摘要： Disclosed herein are microcantilevers having structural shapes that are less sensitive to turbulence and drift effects yet provide greater deflections due to analyte concentration. The structural shapes include a C-shaped microcantilever, an E-shaped microcantilever, an L-shaped microcantilever, a double microcantilever, a slit microcantilever, a tapered microcantilever, and a triangular microcantilever. The microcantilevers may be piezoresistive microcantilevers. Also disclosed are microsensors, microfludic devices, and biochips that comprise the microcantilevers as well as methods of using the microcantilevers to detect analytes in a fluid sample.

摘要翻译： 本文公开了具有对湍流和漂移效应较不敏感但具有由于分析物浓度引起的更大偏转的结构形状的微悬臂梁。 结构形状包括C形微悬臂梁，E形微悬臂梁，L形微悬臂梁，双微悬臂梁，狭缝微悬臂梁，锥形微悬臂梁和三角形微悬臂梁。 微悬臂梁可以是压阻微型悬臂梁。 还公开了包含微悬臂梁的微传感器，微流体装置和生物芯片以及使用微悬臂梁来检测流体样品中的分析物的方法。

公开(公告)号：US07695951B2

公开(公告)日：2010-04-13

申请号：US11764523

申请日：2007-06-18

申请人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert C. Haddon ,  Adbul Rahim A. Khaled ,  Mo Yang

发明人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert C. Haddon ,  Adbul Rahim A. Khaled ,  Mo Yang

IPC分类号： C12M1/34

CPC分类号： G01N33/54373 ,  B82Y30/00

摘要： Disclosed herein are microcantilevers having structural shapes that are less sensitive to turbulence and drift effects yet provide greater deflections due to analyte concentration. The structural shapes include a C-shaped microcantilever, an E-shaped microcantilever, an L-shaped microcantilever, a double microcantilever, a slit microcantilever, a tapered microcantilever, and a triangular microcantilever. The microcantilevers may be piezoresistive microcantilevers. Also disclosed are microsensors, microfluidic devices, and biochips that comprise the microcantilevers as well as methods of using the microcantilevers to detect analytes in a fluid sample.

摘要翻译： 本文公开了具有对湍流和漂移效应较不敏感但具有由于分析物浓度引起的更大偏转的结构形状的微悬臂梁。 结构形状包括C形微悬臂梁，E形微悬臂梁，L形微悬臂梁，双微悬臂梁，狭缝微悬臂梁，锥形微悬臂梁和三角形微悬臂梁。 微悬臂梁可以是压阻微型悬臂梁。 还公开了包含微悬臂梁的微传感器，微流体装置和生物芯片，以及使用微悬臂梁来检测流体样品中的分析物的方法。

公开(公告)号：US20070287185A1

公开(公告)日：2007-12-13

申请号：US11764523

申请日：2007-06-18

申请人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert Haddon ,  Abdul-Rahim Khaled ,  Mo Yang

发明人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert Haddon ,  Abdul-Rahim Khaled ,  Mo Yang

IPC分类号： G01N33/00 ,  C12M1/00

CPC分类号： G01N33/54373 ,  B82Y30/00

摘要： Disclosed herein are microcantilevers having structural shapes that are less sensitive to turbulence and drift effects yet provide greater deflections due to analyte concentration. The structural shapes include a C-shaped microcantilever, an E-shaped microcantilever, an L-shaped microcantilever, a double microcantilever, a slit microcantilever, a tapered microcantilever, and a triangular microcantilever. The microcantilevers may be piezoresistive microcantilevers. Also disclosed are microsensors, microfluidic devices, and biochips that comprise the microcantilevers as well as methods of using the microcantilevers to detect analytes in a fluid sample.

摘要翻译： 本文公开了具有对湍流和漂移效应较不敏感但具有由于分析物浓度引起的更大偏转的结构形状的微悬臂梁。 结构形状包括C形微悬臂梁，E形微悬臂梁，L形微悬臂梁，双微悬臂梁，狭缝微悬臂梁，锥形微悬臂梁和三角形微悬臂梁。 微悬臂梁可以是压阻微型悬臂梁。 还公开了包含微悬臂梁的微传感器，微流体装置和生物芯片，以及使用微悬臂梁来检测流体样品中的分析物的方法。

公开(公告)号：US07288404B2

公开(公告)日：2007-10-30

申请号：US10422776

申请日：2003-04-25

申请人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert C. Haddon ,  Abdul-Rahim A. Khaled ,  Mo Yang

发明人： Kambiz Vafai ,  Cengiz Ozkan ,  Robert C. Haddon ,  Abdul-Rahim A. Khaled ,  Mo Yang

IPC分类号： C12M1/34

CPC分类号： G01N33/54373 ,  B82Y30/00

摘要： Disclosed herein are microcantilevers having structural shapes that are less sensitive to turbulence and drift effects yet provide greater deflections due to analyte concentration. The structural shapes include a C-shaped microcantilever, an E-shaped microcantilever, an L-shaped microcantilever, a double microcantilever, a slit microcantilever, a tapered microcantilever, and a triangular microcantilever. The microcantilevers may be piezoresistive microcantilevers. Also disclosed are microsensors, microfludic devices, and biochips that comprise the microcantilevers as well as methods of using the microcantilevers to detect analytes in a fluid sample.

摘要翻译： 本文公开了具有对湍流和漂移效应较不敏感但具有由于分析物浓度引起的更大偏转的结构形状的微悬臂梁。 结构形状包括C形微悬臂梁，E形微悬臂梁，L形微悬臂梁，双微悬臂梁，狭缝微悬臂梁，锥形微悬臂梁和三角形微悬臂梁。 微悬臂梁可以是压阻微型悬臂梁。 还公开了包含微悬臂梁的微传感器，微流体装置和生物芯片以及使用微悬臂梁来检测流体样品中的分析物的方法。

公开(公告)号：US20140339423A1

公开(公告)日：2014-11-20

申请号：US14125436

申请日：2011-12-16

申请人： Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

发明人： Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

IPC分类号： H01J49/16

CPC分类号： H01J49/161 ,  H01J49/0022 ,  H01J49/08 ,  H01J49/424 ,  Y10T29/49826

摘要： The present invention relates to an ultraviolet diode and an atomic mass analysis ionization source collecting device using an MCP. In the manufacturing of a portable atomic mass analyzer, an object of the present invention is to use an MCP electron multiplier plate, whereby ultraviolet photons emitted from an ultraviolet diode are irradiated on a front surface plate of the MCP electron multiplier plate to induce primary electrons, an amplified electron beam is collected from the electrons, and an electron beam is generated at a low temperature and low power and having a discharge time that is accurately controlled. The atomic mass analysis ionization source collecting device using an ultraviolet diode and an MCP according to the present invention comprises: an ultraviolet diode emitting ultraviolet rays by means of supplied power; an MCP electron multiplier plate inducing and amplifying primary electron discharge from ultraviolet photons from the ultraviolet diode, and collecting a large amount of electron beams from an MCP reverse surface plate; an electron condenser lens condensing the electron beam amplified through the MCP electron multiplier plate; an ion trap atomic mass separator ionizing gas sample molecules by means of an electron beam injected through the electron condenser lens; and an ion detector performing detection of ions separated from the ion trap atomic mass separator, by means of an atomic mass spectrum.

摘要翻译： 本发明涉及使用MCP的紫外二极管和原子质量分析电离源收集装置。 在便携式原子质量分析仪的制造中，本发明的目的是使用MCP电子倍增器板，其中从紫外二极管发射的紫外光子照射在MCP电子倍增器板的前表面板上以诱导一次电子 从电子收集放大的电子束，并且在低温和低功率下产生电子束，并且具有被精确控制的放电时间。 根据本发明的使用紫外二极管和MCP的原子质量分析电离源收集装置包括：通过供电的电源发射紫外线的紫外二极管; MCP电子倍增器板从紫外二极管的紫外光子中诱发和放大一次电子放电，并从MCP反面板收集大量的电子束; 电子聚光透镜，聚合通过MCP电子倍增器板放大的电子束; 离子阱原子质量分离器通过通过电子聚光透镜注入的电子束离子化气体样品分子; 以及离子检测器，其通过原子质谱进行离子阱原子质量分离器分离的离子的检测。

公开(公告)号：US08981289B2

公开(公告)日：2015-03-17

申请号：US14125436

申请日：2011-12-16

申请人： Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

发明人： Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

IPC分类号： H01J49/10 ,  H01J49/06 ,  H01J49/26 ,  H01J49/16 ,  H01J49/00 ,  H01J49/08 ,  H01J49/42

CPC分类号： H01J49/161 ,  H01J49/0022 ,  H01J49/08 ,  H01J49/424 ,  Y10T29/49826

摘要： The present invention relates to an ultraviolet diode and an atomic mass analysis ionization source collecting device using an MCP. In the manufacturing of a portable atomic mass analyzer, an object of the present invention is to use an MCP electron multiplier plate, whereby ultraviolet photons emitted from an ultraviolet diode are irradiated on a front surface plate of the MCP electron multiplier plate to induce primary electrons, an amplified electron beam is collected from the electrons, and an electron beam is generated at a low temperature and low power and having a discharge time that is accurately controlled. The atomic mass analysis ionization source collecting device using an ultraviolet diode and an MCP according to the present invention comprises: an ultraviolet diode emitting ultraviolet rays by means of supplied power; an MCP electron multiplier plate inducing and amplifying primary electron discharge from ultraviolet photons from the ultraviolet diode, and collecting a large amount of electron beams from an MCP reverse surface plate; an electron condenser lens condensing the electron beam amplified through the MCP electron multiplier plate; an ion trap atomic mass separator ionizing gas sample molecules by means of an electron beam injected through the electron condenser lens; and an ion detector performing detection of ions separated from the ion trap atomic mass separator, by means of an atomic mass spectrum.

摘要翻译： 本发明涉及使用MCP的紫外二极管和原子质量分析电离源收集装置。 在便携式原子质量分析仪的制造中，本发明的目的是使用MCP电子倍增器板，其中从紫外二极管发射的紫外光子照射在MCP电子倍增器板的前表面板上以诱导一次电子 从电子收集放大的电子束，并且在低温和低功率下产生电子束，并且具有被精确控制的放电时间。 根据本发明的使用紫外二极管和MCP的原子质量分析电离源收集装置包括：通过供电的电源发射紫外线的紫外二极管; MCP电子倍增器板从紫外二极管的紫外光子中诱发和放大一次电子放电，并从MCP反面板收集大量的电子束; 电子聚光透镜，聚合通过MCP电子倍增器板放大的电子束; 离子阱原子质量分离器通过通过电子聚光透镜注入的电子束离子化气体样品分子; 以及离子检测器，其通过原子质谱进行离子阱原子质量分离器分离的离子的检测。

公开(公告)号：US20140124662A1

公开(公告)日：2014-05-08

申请号：US14125491

申请日：2011-12-16

申请人： Mo Yang ,  Seung Yong Kim ,  Hyun Sik Kim

发明人： Mo Yang ,  Seung Yong Kim ,  Hyun Sik Kim

IPC分类号： H01J49/10

CPC分类号： H01J49/10 ,  H01J49/0022 ,  H01J49/08 ,  H01J49/424

摘要： The present invention relates to a device for obtaining the ion source of a mass spectrometer using an ultraviolet diode and a CEM module, having the purpose of inducing initial electron emission using a CEM module and by radiating ultraviolet photons emitted from the ultraviolet diode to the entrance of the CEM module to obtain a large amount of amplified electron beams from the exit and to produce electron beams the emission times of which are accurately controlled at low temperature and at low power. The present invention is characterized by a device for obtaining the ion source of a mass spectrometer using an ultraviolet diode and a CEM module, the device consisting essentially of: an ultraviolet diode emitting ultraviolet rays by means of supplied power; an electron multiplier inducing and amplifying the initial electron emission of ultraviolet photons from the ultraviolet diode and obtaining a large amount of electron beams from the exit; an electron condenser lens condensing the electron beams amplified by the electron multiplier; an ion trap mass separator ionizing gas sample molecules by the electron beams injected through the electron xondensing lens; and an ion detector detecting ions separated from the ion trap mass separator by mass spectrum, wherein the electron multiplier is a CEM module.

摘要翻译： 本发明涉及一种使用紫外二极管和CEM模块获得质谱仪的离子源的装置，其目的是使用CEM模块诱发初始电子发射，并将从紫外线二极管发射的紫外光子辐射到入口 的CEM模块，以从出口获得大量的放大电子束，并产生其发射时间在低温和低功率下精确控制的电子束。 本发明的特征在于一种用于使用紫外二极管和CEM模块获得质谱仪的离子源的装置，该装置基本上由以下部分组成：紫外线二极管，通过供电供给紫外线; 电子倍增器，从紫外二极管感应并放大紫外光子的初始电子发射，并从出口获得大量的电子束; 电子聚光透镜，聚合由电子倍增器放大的电子束; 离子阱质量分离器通过电子透射透镜注入的电子束离子化气体样品分子; 以及离子检测器，通过质谱检测离子阱质量分离器分离的离子，其中电子倍增器是CEM模块。

公开(公告)号：US20140312255A1

公开(公告)日：2014-10-23

申请号：US14358859

申请日：2011-11-18

申请人： Mo Yang ,  Seung Yong Kim ,  Hyun Sik Kim

发明人： Mo Yang ,  Seung Yong Kim ,  Hyun Sik Kim

IPC分类号： F16K31/06

CPC分类号： F16K31/0658 ,  F16K11/207 ,  F16K11/24 ,  H01J49/0422 ,  H01J49/0495

摘要： The present invention relates to a gaseous sample injection valve. The gaseous sample injection valve includes a middle body injecting a fixed amount of a gaseous sample into the vacuum chamber of a mass spectrometer, the middle body being constituted by a gaseous sample injection tube, a gaseous sample discharge tube, a storage part, and a vacuum chamber connection tube; an upper body accommodating a first solenoid coil, a first plunger, and a first packing; and a lower body accommodating a second solenoid coil, a second plunger, and a second packing. The gaseous sample injection valve according to the present invention may be miniaturized to utilize a lightweight portable mass spectrometer. Also, the vacuum pump may be reduced in load to extend the operation life-cycle of the vacuum pump. In addition, when the gaseous sample is analyzed by using the mass spectrometer, a uniform mass spectrum with respect to the gaseous sample may be obtained.

摘要翻译： 本发明涉及一种气态样品注入阀。 气态样品注入阀包括将固定量的气态样品注入质谱仪的真空室中的中间体，中间体由气体样品注入管，气体样品放电管，存储部和 真空室连接管; 容纳第一螺线管线圈的上体，第一柱塞和第一填料; 以及容纳第二电磁线圈，第二柱塞和第二填料的下体。 根据本发明的气态样品注射阀可以被小型化以利用轻便的便携式质谱仪。 此外，真空泵可以减小负载以延长真空泵的操作寿命。 此外，当通过使用质谱仪分析气态样品时，可以获得相对于气态样品的均匀质谱。