利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

92 条记录 (耗时 0.031 秒)

    Methods and apparatuses for coating a lesion
    3.
    发明申请
    Methods and apparatuses for coating a lesion 失效
    用于涂覆病变的方法和装置

    公开(公告)号：US20090005849A1

    公开(公告)日：2009-01-01

    申请号：US11726647

    申请日：2007-03-21

    申请人： Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Thierry Glauser ,  Yiwen Eveleen Tang ,  Eugene T. Michal

    发明人： Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Thierry Glauser ,  Yiwen Eveleen Tang ,  Eugene T. Michal

    IPC分类号： A61K31/337 ,  A61M25/10 ,  A61F2/82 ,  A61F2/84 ,  A61P9/00

    CPC分类号： A61L31/043 ,  A61L2430/36

    摘要： A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.

    摘要翻译： 描述了一种处理容器区域的方法和装置。 将蛋白质弹性蛋白基聚合物从装置中释放出来，作为主要疗法或辅助治疗来涂覆血管衬里，随着具有或不具有药物涂层的支架的递送和展开。 基于蛋白质弹性蛋白的聚合物可以包括具有弹性蛋白五肽作为侧翼嵌段的三嵌段结构和作为中间嵌段的五肽的亲水性变体。 可以改变侧面和中间嵌段以改变聚合物的结构和化学性质。 特别地，基于蛋白质弹性蛋白的聚合物适于执行控制治疗剂释放，刺激内皮细胞生长和稳定易损斑块中的至少一种，以防止脆弱斑块的破裂。

    STIMULUS-RELEASE CARRIER, METHODS OF MANUFACTURE AND METHODS OF TREATMENT
    6.
    发明申请
    STIMULUS-RELEASE CARRIER, METHODS OF MANUFACTURE AND METHODS OF TREATMENT 审中-公开
    刺激释放载体，制造方法和治疗方法

    公开(公告)号：US20080095847A1

    公开(公告)日：2008-04-24

    申请号：US11550740

    申请日：2006-10-18

    申请人： Thierry Glauser ,  Dariush Davalian ,  Florian Niklas Ludwig ,  Mikael Trollsas

    发明人： Thierry Glauser ,  Dariush Davalian ,  Florian Niklas Ludwig ,  Mikael Trollsas

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0009 ,  A61K9/0019 ,  C08L53/005

    摘要： Compositions, methods of fabrication and methods of treatment for the controlled release of a therapeutic substance to a treatment region are disclosed herein. In some embodiments, block copolymer-based release platforms (modified or unmodified) can be used to deliver a therapeutic substance to an inflamed site in, for example, the coronary tree or the kidney glomeri. The platforms can be carriers of at least one therapeutic substance. An external “trigger”, or stimulus, such as radiation, ultrasound, temperature, a magnetic field, a change in pH, a change in ionic strength or release of an enzyme, can be used to destabilize the platform in order to release its payload in a controlled manner once at a treatment site. Delivery devices can include a syringe, an infusion catheter, a porous balloon catheter, a double balloon catheter and the like.

    摘要翻译： 本文公开了将治疗物质控制释放到治疗区域的组合物，制造方法和治疗方法。 在一些实施方案中，基于嵌段共聚物的释放平台（经修饰或未修饰）可用于将治疗物质递送至例如冠状动脉树或肾小球中的发炎部位。 平台可以是至少一种治疗物质的载体。 可以使用外部“触发”或刺激，例如辐射，超声，温度，磁场，pH变化，离子强度的变化或酶的释放，以破坏平台的稳定性，以释放其有效载荷 以受控的方式一次在治疗部位。 输送装置可包括注射器，输注导管，多孔气囊导管，双气囊导管等。