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1.发明申请公开(公告)号：US20080095847A1
公开(公告)日：2008-04-24
申请号：US11550740
申请日：2006-10-18
IPC分类号： A61K9/14
CPC分类号： A61K9/0009 , A61K9/0019 , C08L53/005
摘要： Compositions, methods of fabrication and methods of treatment for the controlled release of a therapeutic substance to a treatment region are disclosed herein. In some embodiments, block copolymer-based release platforms (modified or unmodified) can be used to deliver a therapeutic substance to an inflamed site in, for example, the coronary tree or the kidney glomeri. The platforms can be carriers of at least one therapeutic substance. An external “trigger”, or stimulus, such as radiation, ultrasound, temperature, a magnetic field, a change in pH, a change in ionic strength or release of an enzyme, can be used to destabilize the platform in order to release its payload in a controlled manner once at a treatment site. Delivery devices can include a syringe, an infusion catheter, a porous balloon catheter, a double balloon catheter and the like.
摘要翻译： 本文公开了将治疗物质控制释放到治疗区域的组合物，制造方法和治疗方法。 在一些实施方案中，基于嵌段共聚物的释放平台（经修饰或未修饰）可用于将治疗物质递送至例如冠状动脉树或肾小球中的发炎部位。 平台可以是至少一种治疗物质的载体。 可以使用外部“触发”或刺激，例如辐射，超声，温度，磁场，pH变化，离子强度的变化或酶的释放，以破坏平台的稳定性，以释放其有效载荷 以受控的方式一次在治疗部位。 输送装置可包括注射器，输注导管，多孔气囊导管，双气囊导管等。
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公开(公告)号：US08293367B2
公开(公告)日：2012-10-23
申请号：US13184406
申请日：2011-07-15
IPC分类号： B32B5/16
CPC分类号： A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
摘要： Nano-constructscomprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供纳米结构的纳米壳和使用纳米结构物治疗或改善医学病症的方法。
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3.发明申请公开(公告)号：US20110184384A1
公开(公告)日：2011-07-28
申请号：US13079239
申请日：2011-04-04
申请人： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
发明人： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
CPC分类号： A61K9/0019 , A61F2/95 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61M25/0084 , A61M25/104 , A61M2025/105
摘要： This invention relates to methods of enhancing the permeability of blood vessels to therapeutic agents.
摘要翻译： 本发明涉及增强血管对治疗剂的渗透性的方法。
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公开(公告)号：US08017237B2
公开(公告)日：2011-09-13
申请号：US11473822
申请日：2006-06-23
IPC分类号： B32B5/16
CPC分类号： A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
摘要： Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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5.发明申请公开(公告)号：US20110196474A1
公开(公告)日：2011-08-11
申请号：US12704136
申请日：2010-02-11
申请人： Dariush Davalian , Syed Faiyaz Ahmed Hossainy , Rachel Bright , Jinping Wan , Florian Niklas Ludwig
发明人： Dariush Davalian , Syed Faiyaz Ahmed Hossainy , Rachel Bright , Jinping Wan , Florian Niklas Ludwig
CPC分类号： A61K31/436 , A61K9/0009 , A61K9/0019 , A61K9/19 , A61K9/5094
摘要： Compositions of matter comprising a magnetically sensitive drug carrier and a related drug as well as methods for administering these compositions and causing them to localize within the patient using an internal or external magnetic field are described.
摘要翻译： 描述了包含磁敏感药物载体和相关药物的物质组合物以及用于施用这些组合物并使其使用内部或外部磁场定位在患者体内的方法。
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公开(公告)号：US20070298257A1
公开(公告)日：2007-12-27
申请号：US11473822
申请日：2006-06-23
CPC分类号： A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
摘要： Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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7.发明授权公开(公告)号：US08870847B2
公开(公告)日：2014-10-28
申请号：US13079239
申请日：2011-04-04
申请人： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
发明人： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
CPC分类号： A61K9/0019 , A61F2/95 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61M25/0084 , A61M25/104 , A61M2025/105
摘要： This invention is directed to a method of treating a vascular disease involving administration to a patient by means of an angioplasty balloon a composition comprising a permeability-enhancing substance and a therapeutic agent.
摘要翻译： 本发明涉及一种治疗血管疾病的方法，所述血管疾病涉及通过血管成形术球囊向患者施用包含渗透性增强物质和治疗剂的组合物。
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8.发明申请Regional delivery of therapeutic agents for the treatment of vascular diseases 审中-公开用于治疗血管疾病的治疗剂的区域递送公开(公告)号：US20080146489A1
公开(公告)日：2008-06-19
申请号：US11639512
申请日：2006-12-15
申请人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
发明人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译： 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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公开(公告)号：US09242005B1
公开(公告)日：2016-01-26
申请号：US11507860
申请日：2006-08-21
申请人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
发明人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1273 , A61M5/178 , A61M25/104 , A61M31/00 , A61M2025/0087 , A61M2025/105 , A61M2025/1052
摘要： Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.
摘要翻译： 本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。 在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。 在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。 在一些应用中，前修复剂可以帮助恢复内皮功能。 制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。
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公开(公告)号：US09456983B1
公开(公告)日：2016-10-04
申请号：US11636092
申请日：2006-12-08
CPC分类号： A61K9/10 , A61K9/0019 , A61K9/1629 , A61K9/1641 , A61K9/513 , A61K31/00
摘要： A composition that includes a bioactive agent-containing polymeric nanoparticle and a polymeric non-spherical microparticle, and methods of using such a composition to treat a vascular disease are disclosed.
摘要翻译： 公开了包含含有生物活性剂的聚合物纳米颗粒和聚合物非球形微粒的组合物，以及使用这种组合物治疗血管疾病的方法。
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