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公开(公告)号：US08614318B2
公开(公告)日：2013-12-24
申请号：US11491851
申请日：2006-07-24
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander R. Shoemaker , Michael J. Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander R. Shoemaker , Michael J. Mitten
IPC分类号： C07D211/06 , C07D413/02
CPC分类号： C07D233/06 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/36 , C07D277/74 , C07D295/155 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号：US20100240715A1
公开(公告)日：2010-09-23
申请号：US12800702
申请日：2010-05-19
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
IPC分类号： A61K31/4192 , C07C311/15 , A61K31/18 , C07C311/19 , C07D235/06 , A61K31/4184 , C07D249/18 , A61P35/00
CPC分类号： C07D295/155 , C07D207/24 , C07D211/20 , C07D211/26 , C07D211/48 , C07D211/70 , C07D211/72 , C07D213/38 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/12 , C07D257/04 , C07D277/36 , C07D295/185 , C07D295/30 , C07D307/22 , C07D309/20 , C07D333/20 , C07D333/34 , C07D401/12 , C07D403/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号：US08354404B2
公开(公告)日：2013-01-15
申请号：US13093753
申请日：2011-04-25
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号： C07D241/04 , A61K31/496
CPC分类号： C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号：US20100022773A1
公开(公告)日：2010-01-28
申请号：US12390945
申请日：2009-02-23
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Noah Tu , Xilu Wang , Michael Wendt
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Noah Tu , Xilu Wang , Michael Wendt
IPC分类号： C07D241/04
CPC分类号： C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号：US08173811B2
公开(公告)日：2012-05-08
申请号：US12800702
申请日：2010-05-19
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
IPC分类号： C07D235/02
CPC分类号： C07D295/155 , C07D207/24 , C07D211/20 , C07D211/26 , C07D211/48 , C07D211/70 , C07D211/72 , C07D213/38 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/12 , C07D257/04 , C07D277/36 , C07D295/185 , C07D295/30 , C07D307/22 , C07D309/20 , C07D333/20 , C07D333/34 , C07D401/12 , C07D403/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号：US20110256129A1
公开(公告)日：2011-10-20
申请号：US13093753
申请日：2011-04-25
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号： A61K31/635 , A61K39/395 , A61K31/7048 , A61P35/00 , A61K31/495 , A61K31/63 , A61K31/497 , A61K31/675 , A61K31/704
CPC分类号： C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号：US07973161B2
公开(公告)日：2011-07-05
申请号：US11600445
申请日：2006-11-16
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号： C07D241/02 , C07D403/02
CPC分类号： C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有化合物的组合物和化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号：US07767684B2
公开(公告)日：2010-08-03
申请号：US11127940
申请日：2005-05-12
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07D295/155 , C07D207/24 , C07D211/20 , C07D211/26 , C07D211/48 , C07D211/70 , C07D211/72 , C07D213/38 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/12 , C07D257/04 , C07D277/36 , C07D295/185 , C07D295/30 , C07D307/22 , C07D309/20 , C07D333/20 , C07D333/34 , C07D401/12 , C07D403/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号：US07642260B2
公开(公告)日：2010-01-05
申请号：US11202827
申请日：2005-08-12
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号： A61K31/496 , C07D241/04
CPC分类号： C07D207/24 , C07D211/20 , C07D211/26 , C07D211/48 , C07D211/70 , C07D211/72 , C07D213/38 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/12 , C07D257/04 , C07D277/36 , C07D295/155 , C07D295/185 , C07D295/30 , C07D307/22 , C07D309/20 , C07D333/20 , C07D333/34 , C07D401/12 , C07D403/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号：US08084607B2
公开(公告)日：2011-12-27
申请号：US12390945
申请日：2009-02-23
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol-min Park , Andrew M. Petros , Xiaohong Song , Noah P. Tu , Xilu Wang , Michael D. Wendt
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol-min Park , Andrew M. Petros , Xiaohong Song , Noah P. Tu , Xilu Wang , Michael D. Wendt
IPC分类号： C07D241/04 , C07D295/00
CPC分类号： C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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