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113 条记录 (耗时 0.036 秒)

    Antidiabetic Bicyclic Compounds
    2.
    发明申请
    Antidiabetic Bicyclic Compounds 审中-公开
    抗糖尿病双环化合物

    公开(公告)号：US20080090865A1

    公开(公告)日：2008-04-17

    申请号：US11794591

    申请日：2006-01-24

    申请人： Min Ge ,  Lihu Yang ,  Changyou Zhou ,  Songnian Lin ,  Eric Cline

    发明人： Min Ge ,  Lihu Yang ,  Changyou Zhou ,  Songnian Lin ,  Eric Cline

    IPC分类号： A61K31/47 ,  A61K31/435 ,  A61P3/10 ,  C07D215/00 ,  C07D221/02

    CPC分类号： C07D413/12 ,  C07D215/20 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12

    摘要： Bicyclic compounds containing a fused pyridine ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

    摘要翻译： 含有稠合吡啶环的双环化合物，包括其药学上可接受的盐和前体药物，是G蛋白偶联受体40（GPR40）的激动剂，可用作治疗性化合物，特别是治疗2型糖尿病， 通常与该疾病有关，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症。

    2,6-disubstituted piperiddines as modulators
    5.
    发明授权
    2,6-disubstituted piperiddines as modulators 失效
    2,6-二取代的哌啶作为调节剂

    公开(公告)号：US07410961B2

    公开(公告)日：2008-08-12

    申请号：US10586765

    申请日：2005-01-14

    申请人： Lihu Yang ,  Sander G. Mills ,  Changyou Zhou ,  Stephen D. Goble ,  Alexander Pasternak

    发明人： Lihu Yang ,  Sander G. Mills ,  Changyou Zhou ,  Stephen D. Goble ,  Alexander Pasternak

    IPC分类号： C07D401/00 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D421/00 ,  C07D223/16 ,  A01N43/00 ,  A61K31/553 ,  A61K31/554

    CPC分类号： C07D519/00 ,  C07D451/02 ,  C07D451/04 ,  C07D451/06

    摘要： The present invention is further directed to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R16, R17, R18, R19, R20, R21 and R22 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

    摘要翻译： 本发明还涉及式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， R 10，R 16，R 17，R 18，R 19，R 16， R 20，R 21，R 22和R 22如本文所定义），其是趋化因子受体活性的调节剂，并且可用于 预防或治疗某些炎性和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫病态如类风湿性关节炎和动脉粥样硬化。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及趋化因子受体的疾病中的用途。

    Amino heterocyclic modulators of chemokine receptor activity
    7.
    发明授权
    Amino heterocyclic modulators of chemokine receptor activity 失效
    趋化因子受体活性的氨基杂环调节剂

    公开(公告)号：US07700772B2

    公开(公告)日：2010-04-20

    申请号：US10589406

    申请日：2005-02-08

    申请人： Lihu Yang ,  Alexander Pasternak ,  Sander G. Mills

    发明人： Lihu Yang ,  Alexander Pasternak ,  Sander G. Mills

    IPC分类号： C07D401/04 ,  C07D407/04 ,  A61K31/445 ,  A61K31/438

    CPC分类号： C07D307/24 ,  C07D207/16 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04

    摘要： Compounds of Formula I and Formula II: (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R33, R34, R35, R36, R37, R38, A, j, k, m, n, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

    摘要翻译： 式I和式II化合物（其中n，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R15，R16，R17，R18，R19，R24，R25，R26， R28，R29，R30，R33，R34，R35，R36，R37，R38，A，j，k，m，n，X，Y和Z如本文所定义），其是趋化因子受体活性的调节剂， 预防或治疗某些炎性和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫性病态如类风湿性关节炎和动脉粥样硬化。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及趋化因子受体的疾病中的用途。

    3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
    9.
    发明授权
    3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity 失效
    趋化因子受体活性的3,3-二取代四氢吡喃基环戊基酰胺调节剂

    公开(公告)号：US07566726B2

    公开(公告)日：2009-07-28

    申请号：US11587448

    申请日：2005-04-22

    申请人： Lihu Yang ,  Sander G. Mills ,  Kothandaraman Shankaran

    发明人： Lihu Yang ,  Sander G. Mills ,  Kothandaraman Shankaran

    IPC分类号： C07D217/02 ,  C07D471/02 ,  A61K31/4375

    CPC分类号： C07D471/04

    摘要： (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, Y and Z are defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

    摘要翻译： （其中n，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 15，R 16，R 17，R 18，Y和Z在本文中定义），其是趋化因子受体活性的调节剂， 预防或治疗某些炎性和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫病态如类风湿性关节炎和动脉粥样硬化。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及趋化因子受体的疾病中的用途。