摘要:
Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要:
Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要:
Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要:
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
摘要:
Provided is a priming mechanism for priming a biofluid drop ejection device having a drop ejection opening leading to an ejection reservoir. The priming mechanism includes a vacuum unit which generates a vacuum force, connected to a vacuum nozzle. The vacuum nozzle is located over the drop ejection opening. A disposable sleeve or tubing is attached to the vacuum nozzle and is placed in operational contact with the drop ejection opening. A fluid height detection sensor is positioned to sense a fluid height within at least one of the disposable tubing and the vacuum nozzle. Upon sensing a predetermined fluid height, by the fluid height detection sensor, the priming operation is completed, and the primer mechanism is removed from the operational contact with the drop ejection opening.
摘要:
A method of forming and moving ink drops across a gap between a print head and a print medium, or intermediate print medium, in a marking device includes generating an electric field, forming the ink drops adjacent the print head and controlling the electric field. The electric field is generated to extend across the gap. The ink drops are formed in an area adjacent the print head. The electric field is controlled such that an electrical attraction force exerted on the formed ink drops by the electric field is the greatest force acting on the ink drops. The marking device may be incorporated into a transfuse printing system having an intermediate print medium made of one or more materials that allow for lateral dissipation of electrical charge from the incident ink drops.
摘要:
A number of architectures of switch compensation networks are described for the provision of a compensation current which ensures the maintaining of a desired switching ratio in an acoustic printhead. The described architectures include those which provide column compensation, row compensation, and row and column compensation to a transducer switching matrix. Control of the switching ratio by the compensation networks, is used in consideration of the dissipation of heat energy through expulsion of a heated drop, to provide a precisely controlled balance.
摘要:
In AIP printheads, misfunction after printing a number of prints, due to the accumulation of ink and dust around orifices in the orifice plate may occur. In order to clean the printheads, the dirty printhead is first capped and the ink pressure in the printhead increase significantly to allow ink to escape through the orifices and completely fill a small gap inside the cap portion. After letting the orifices soak for a predetermined time to dissolve the dried ink and loosen dust debris which may be found on the printheads, the cap drainhole is opened to drain the ink while keeping the ink pressure inside the head at an intermediate higher level. This higher pressure prevents the ink still remaining inside the bore of each orifice hole from reentering the printhead. The dirty ink remaining inside the orifice bore is removed using a wiping station in separate steps.
摘要:
A droplet emitter with an array of droplet emitting devices constructed such that a flowing liquid used create the droplets can flow through the droplet emitter at higher flow rates. The higher flow rates prevent excess heat absorption during the droplet emission process and allow for excess heat generated by control electronics to be transferred to the flowing liquid after droplet emission but before it leaves the droplet emitter. This prevents excess heat build-up within the droplet emitter and allows for higher more accurate droplet emission.
摘要:
This invention provides systems for analyzing substrates. Also provided by the invention are improved optical systems for enhanced multiplex illumination, optical systems with compact multi-wavelength illumination architectures, optical systems for enhanced detection of optical signals, and optical systems for reduced autofluorescence background noise.