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26 条记录 (耗时 0.053 秒)

    Polynucleotides encoding .alpha.2-3 neuraminidase
    8.
    发明授权
    Polynucleotides encoding .alpha.2-3 neuraminidase 失效
    编码α2-3神经氨酸酶的多核苷酸

    公开(公告)号：US5591839A

    公开(公告)日：1997-01-07

    申请号：US294477

    申请日：1994-08-18

    申请人： Harvey I. Miller ,  John C. Klock ,  Christopher M. Starr

    发明人： Harvey I. Miller ,  John C. Klock ,  Christopher M. Starr

    IPC分类号： C12N9/24 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Y302/01018 ,  C12N9/2402

    摘要： Polynucleotide sequences encoding enzymes that possess .alpha.2-3 neuraminidase activity are provided. Of particular interest are polynucleotide sequences encoding an enzyme having .alpha.2-3 neuraminidase activity and naturally produced by the bacteria Streptococcus pneumoniae. Recombinant DNA expression of enzymes possessing .alpha.2-3 specific neuraminidase activity is also described, including methods, recombinant host cells and a genetic construction. The invention also provides a purified enzyme having .alpha.2-3 neuraminidase activity from Streptococcus pneumoniae, wherein the enzyme is isolated from S. pneumoniea cultures. Another aspect of this invention is to provide methods of isolating genes encoding enzymes having neuraminidase activity, particularly .alpha.2-3 neuraminidase activity. The gene isolation methods of the invention comprise the step of labeling a hybridization probe derived from the neuraminidase coding portion of plasmid pND-1. The hybridization probe may then be used to isolate homologous genes encoding enzymes having the desired enzymatic activity.

    摘要翻译： 提供了编码具有α2-3神经氨酸酶活性的酶的多核苷酸序列。 特别感兴趣的是编码具有α2-3神经氨酸酶活性并由细菌肺炎链球菌天然产生的酶的多核苷酸序列。 还描述了具有α2-3特异性神经氨酸酶活性的酶的重组DNA表达，包括方法，重组宿主细胞和遗传构建。 本发明还提供了具有来自肺炎链球菌的α2-3神经氨酸酶活性的纯化酶，其中所述酶从肺炎链球菌培养物中分离。 本发明的另一方面是提供分离编码具有神经氨酸酶活性的酶的基因，特别是α2-3神经氨酸酶活性的方法。 本发明的基因分离方法包括标记衍生自质粒pND-1的神经氨酸酶编码部分的杂交探针的步骤。 然后可以使用杂交探针来分离编码具有所需酶活性的酶的同源基因。

    Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof
    9.
    发明授权
    Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof 有权
    包含对LRP2特异的受体相关蛋白（RAP）变体的组合物及其用途

    公开(公告)号：US08877714B2

    公开(公告)日：2014-11-04

    申请号：US11576506

    申请日：2006-06-14

    申请人： Christopher M. Starr ,  Todd C. Zankel

    发明人： Christopher M. Starr ,  Todd C. Zankel

    IPC分类号： C07K14/705 ,  A61K38/17 ,  A61K38/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions for therapeutic purposes. The invention also relates to antibodies that bind to one or a small subset of CR-containing proteins.

    摘要翻译： 本发明一般涉及低密度脂蛋白受体相关蛋白（RAP）的受体选择性变体及其组合物，产生这些变体的方法和使用这种受体选择性RAP变体组合物用于治疗目的的方法。 本发明还涉及结合至含有CR的蛋白质的一个或一小组的抗体。