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    Cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents, immunosuppressants, drugs, cosmetics, foods and food materials
    1.
    发明授权
    Cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents, immunosuppressants, drugs, cosmetics, foods and food materials 失效
    细胞因子产生抑制剂，保护和促进肝功能的药物，抗炎剂，免疫抑制剂，药物，化妆品，食品和食品材料

    公开(公告)号：US06992068B2

    公开(公告)日：2006-01-31

    申请号：US10311136

    申请日：2001-06-13

    申请人： Minoru Yoshida ,  Toshihiro Nakayama ,  Hiroichi Nagai ,  Munekazu Iinuma

    发明人： Minoru Yoshida ,  Toshihiro Nakayama ,  Hiroichi Nagai ,  Munekazu Iinuma

    IPC分类号： A61K31/70

    CPC分类号： A61Q19/00 ,  A23L33/105 ,  A61K8/63 ,  A61K8/97 ,  A61K31/70 ,  A61K36/48

    摘要： Highly safe cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents and immunosuppressants. Brazilian licorice extract and periandrins, which are constituents thereof, have excellent characteristics of showing effects of inhibiting cytokine production and protecting and promoting liver function, an anti-inflammatory effect and an immunosuppressive effect without any harmful side effects. Thus use of Brazilian licorice extract or periandrins as cytokine production inhibitors makes it possible to inhibit inflammations in various diseases such as rheumatoid arthritis. These substances are also usable as agents for protecting and promoting liver function, anti-inflammatory agents and immunosuppressants. Moreover, foods, cosmetics, sweeteners and food materials containing Brazilian licorice extract exert the effects as described above.

    摘要翻译： 高度安全的细胞因子产生抑制剂，保护和促进肝功能的药物，抗炎药和免疫抑制剂。 作为其成分的巴西甘草提取物和周质蛋白具有显示抑制细胞因子产生的作用，保护和促进肝功能，抗炎作用和免疫抑制作用而没有任何有害副作用的优异特征。 因此，使用巴西甘草提取物或周质蛋白作为细胞因子产生抑制剂可以抑制各种疾病如类风湿性关节炎的炎症。 这些物质也可用作保护和促进肝功能，抗炎剂和免疫抑制剂的药剂。 此外，含有巴西甘草提取物的食品，化妆品，甜味剂和食物材料发挥如上所述的效果。

    AGENT HAVING NEUROTROPHIC FACTOR-LIKE ACTIVITY
    7.
    发明申请
    AGENT HAVING NEUROTROPHIC FACTOR-LIKE ACTIVITY 审中-公开
    具有神经营养因子活性的药剂

    公开(公告)号：US20100204498A1

    公开(公告)日：2010-08-12

    申请号：US12678671

    申请日：2008-09-18

    申请人： Munekazu Iinuma ,  Shoei Furukawa

    发明人： Munekazu Iinuma ,  Shoei Furukawa

    IPC分类号： C07C59/185

    CPC分类号： A61K31/20 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231

    摘要： The present invention provides a pharmaceutical agent having high safety and a neurotrophic factor-like activity, which contains, as an active ingredient, any one compound included in fatty acids each having 8 carbon atoms (C8) or having 10 carbon atoms (C10) to 12 carbon atoms (C12) or fatty acid esters thereof, such as 3,7-dimethyloctanoic acid ethyl ester, geranic acid ethyl ester, and the like, each of which has 8 carbon atoms (C8), decanoic acid methyl ester, trans-2-decenoic acid, trans-2-decenoic acid methyl ester, trans-2-decenoic acid ethyl ester, trans-2-decenoic acid-2-decenyl ester, trans-2-decenoic acid cyclohexyl ester, trans-2-decenoic acid isopropyl ester, trans-3-decenoic acid methyl ester, trans-9-decenoic acid methyl ester, and the like, each of which has 10 carbon atoms (C10), trans-10-undecenoic acid methyl ester, trans-10-undecenoic acid ethyl ester, and the like, each of which has 11 carbon atoms (C11), and dodecanoic acid, and the like, each of which has 12 carbon atoms (C12), or salts thereof or prodrugs thereof.

    摘要翻译： 本发明提供一种具有高安全性和神经营养因子样活性的药剂，其含有作为活性成分的包含在各自具有8个碳原子（C8）或10个碳原子（C10）的脂肪酸中的任何一种化合物， 12个碳原子（C12）或其脂肪酸酯，例如3,7-二甲基辛酸乙酯，香叶酸乙酯等，它们各自具有8个碳原子（C8），癸酸甲酯， 2-癸烯酸，反式-2-癸烯酸甲酯，反式-2-癸烯酸乙酯，反式-2-癸烯-2-癸烯基酯，反式-2-癸烯酸环己酯，反式-2-癸烯酸 异丙酯，反式-3-癸烯酸甲酯，反式-9-癸烯酸甲酯等，各自具有10个碳原子（C10），反式-10-十一碳烯酸甲酯，反式-10-十一碳烯酸 酸性乙酯等，各自具有11个碳原子（C11）和十二烷酸等，其各自具有12个碳原子 原子（C12）或其盐或其前药。

    PPARs AGONIST ACTIVITY ENHANCING DRUG
    9.
    发明申请
    PPARs AGONIST ACTIVITY ENHANCING DRUG 有权
    PPARs AGONIST活动增强药物

    公开(公告)号：US20160374986A1

    公开(公告)日：2016-12-29

    申请号：US15260434

    申请日：2016-09-09

    申请人： Munekazu Iinuma ,  Tsujimoto Chemical Co., Ltd.

    发明人： Munekazu Iinuma

    IPC分类号： A61K31/366 ,  A61K9/00

    CPC分类号： A61K31/366 ,  A61K9/0053 ,  C07D309/32

    摘要： A lifestyle disease improving drug is disclosed that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons. Methods for enhancing PPARα, γ and δ agonist activities in vertebrates or medically treating a vertebrate are disclosed. The methods include providing a composition of an active ingredient, the lifestyle disease improving drug, in a biologically acceptable medium and administering an effective amount of the composition to a vertebrate.

    摘要翻译： 公开了一种生活方式改善药物，其增强PPARα，δ和γ激动剂活性，其包括具有根据化学式6-烷基-5,6-二氢-2H-吡喃-2-酮的内酯结构的化合物，烷基 含有4个，5个或6个碳。 公开了增强脊椎动物中PPARα，γ和δ激动剂活性或医学治疗脊椎动物的方法。 所述方法包括在生物可接受的培养基中提供活性成分的组合物，生活方式改善药物，并向脊椎动物施用有效量的组合物。

    PPARs AGONIST ACTIVITY ENHANCING DRUG
    10.
    发明申请
    PPARs AGONIST ACTIVITY ENHANCING DRUG 审中-公开
    PPARs AGONIST活动增强药物

    公开(公告)号：US20150087846A1

    公开(公告)日：2015-03-26

    申请号：US14388012

    申请日：2013-03-21

    申请人： Munekazu Iinuma ,  Tsujimoto Chemical Co., Ltd.

    发明人： Munekazu Iinuma

    IPC分类号： C07D309/32

    CPC分类号： A61K31/366 ,  A61K9/0053 ,  C07D309/32

    摘要： A lifestyle disease improving drug that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons, and a method for synthesizing the compound. The method includes adding, stepwise, a butyllithium-hexane solution to a diisopropylamine-tetrahydrofuran solution, and then a 6-alkyltetrahydro-2H-pyran-2-one-tetrahydrofuran solution, wherein the alkyl contains 4, 5, or 6 carbons, adding a phenylselenyl choloride-tetrahydrofuran solution to produce a reaction mixture with a phenylselenide, extracting and purifying the phenylselenide, preparing a phenylselenide-tetrahydrofuran solution with the purified phenylselenide, and adding sodium bicarbonate and an aqueous hydrogen peroxide solution to the phenylselenide-tetrahydrofuran solution to produce a reaction mixture including the compound.

    摘要翻译： 一种增强PPARα，δ和γ激动剂活性的生活方式改善药物，其包括具有根据化学式6-烷基-5,6-二氢-2H-吡喃-2-酮的内酯结构的化合物，含有4个 ，5或6个碳原子，以及合成该化合物的方法。 该方法包括将丁基锂 - 己烷溶液逐步加入到二异丙胺 - 四氢呋喃溶液中，然后加入6-烷基四氢-2H-吡喃-2-酮 - 四氢呋喃溶液，其中烷基含有4,5或6个碳，加入 苯基烯基氯化物 - 四氢呋喃溶液，以产生与苯基硒化物的反应混合物，萃取和纯化苯基硒化物，用纯化的苯基硒化物制备苯基硒化物 - 四氢呋喃溶液，并将碳酸氢钠和过氧化氢水溶液加入到苯基硒化物 - 四氢呋喃溶液中以产生 包括该化合物的反应混合物。