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公开(公告)号：US07856985B2
公开(公告)日：2010-12-28
申请号：US11347672
申请日：2006-02-03
IPC分类号： A61B19/00
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00011 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61B2018/2211 , G02B5/1885
摘要： Methods and apparatus for treatment, such as skin rejuvenation treatment, using non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:YAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a non-uniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the target tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production). A large area of tissue, preferably 7-10 mm in diameter, can be treated simultaneously, while minimizing the risk of burning or other damage to the skin.In one embodiment, the invention uses a fiber bundle to provide a non-uniform energy output beam. In another embodiment, the invention uses a diffractive lens array to produce the non-uniform output beam. A cooling system can also be integrated with the laser treatment system.
摘要翻译： 治疗方法和设备，如皮肤嫩肤治疗，使用不均匀的激光辐射。 激光辐射的高强度部分导致处理区域的选定部分内的胶原蛋白破坏和收缩，而辐射的较低强度部分引起成纤维细胞刺激，导致治疗区域的其它部分的胶原产生。 来自激光源（例如Nd：YAG激光器）的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，该光束由多个高强度区域 被处理梁内的低强度区域包围。 较高强度区域将目标组织的部分热量选择为足以进行第一次处理（例如胶原收缩）的温度，而较低强度区域为第二次处理提供足够的能量（例如刺激的胶原产生）。 可以同时治疗大面积的组织，优选直径为7-10mm，同时最小化对皮肤的燃烧或其它损伤的风险。 在一个实施例中，本发明使用纤维束来提供不均匀的能量输出束。 在另一个实施例中，本发明使用衍射透镜阵列来产生不均匀的输出光束。 冷却系统也可以与激光治疗系统集成。
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2.发明授权公开(公告)号：US08322348B2
公开(公告)日：2012-12-04
申请号：US12947310
申请日：2010-11-16
IPC分类号： A61B19/00
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00011 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61B2018/2211 , G02B5/1885
摘要： Methods and apparatus for treatment, such as skin rejuvenation treatment, using non-uniform laser radiation. An output beam from a laser source is coupled into an optical system that modifies the beam to provide a large-diameter beam having a non-uniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. A large area of tissue, preferably 7-10 mm in diameter, can be treated simultaneously, while minimizing the risk of burning or other damage to the skin.
摘要翻译： 治疗方法和设备，如皮肤嫩肤治疗，使用不均匀的激光辐射。 来自激光源的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，所述大直径光束由处理中的较低强度区域包围的多个高强度区域组成 光束。 可以同时治疗大面积的组织，优选直径为7-10mm，同时最小化对皮肤的燃烧或其它损伤的风险。
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公开(公告)号：US10245107B2
公开(公告)日：2019-04-02
申请号：US14340961
申请日：2014-07-25
IPC分类号： H01S3/094 , A61B18/20 , A61N5/06 , H01S3/06 , H01S3/11 , H01S3/08 , H01S3/102 , H01S3/093 , H01S3/107 , H01S3/16 , H01S3/00 , A61N5/067 , A61B18/00
摘要： Methods, systems and apparatus are disclosed for delivery of pulsed treatment radiation by employing a pump radiation source generating picosecond pulses at a first wavelength, and a frequency-shifting resonator having a lasing medium and resonant cavity configured to receive the picosecond pulses from the pump source at the first wavelength and to emit radiation at a second wavelength in response thereto, wherein the resonant cavity of the frequency-shifting resonator has a round trip time shorter than the duration of the picosecond pulses generated by the pump radiation source. Methods, systems and apparatus are also disclosed for providing beam uniformity and a sub-harmonic resonator.
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公开(公告)号：US20140321484A1
公开(公告)日：2014-10-30
申请号：US14216353
申请日：2014-03-17
申请人： Rafael Armando Sierra , John Robertson , Daniel Hohm , Christian Hoffman , Mirko Georgiev Mirkov
发明人： Rafael Armando Sierra , John Robertson , Daniel Hohm , Christian Hoffman , Mirko Georgiev Mirkov
CPC分类号： A61B18/203 , A61B2018/0047 , A61N5/0616 , A61N2005/067 , H01S3/0092 , H01S3/0627 , H01S3/08018 , H01S3/08054 , H01S3/093 , H01S3/094038 , H01S3/094076 , H01S3/094084 , H01S3/1024 , H01S3/107 , H01S3/1106 , H01S3/1109 , H01S3/1121 , H01S3/1611 , H01S3/1623 , H01S3/1633 , H01S3/1643 , H01S3/1673
摘要： Methods, systems and apparatus are disclosed for delivery of pulsed treatment radiation by employing a pump radiation source generating picosecond pulses at a first wavelength, and a frequency-shifting resonator having a lasing medium and resonant cavity configured to receive the picosecond pulses from the pump source at the first wavelength and to emit radiation at a second wavelength in response thereto, wherein the resonant cavity of the frequency-shifting resonator has a round trip time shorter than the duration of the picosecond pulses generated by the pump radiation source. Methods, systems and apparatus are also disclosed for providing beam uniformity and a sub-harmonic resonator.
摘要翻译： 公开了用于通过采用产生第一波长的皮秒脉冲的泵浦辐射源来递送脉冲处理辐射的方法，系统和装置，以及具有激光介质和谐振腔的频移谐振器，其配置成从泵浦源接收皮秒脉冲 并且响应于第二波长发射第二波长的辐射，其中所述频移谐振器的谐振腔具有比由泵浦辐射源产生的皮秒脉冲的持续时间短的往返时间。 还公开了用于提供光束均匀性和次谐波谐振器的方法，系统和装置。
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5.发明申请公开(公告)号：US20130178917A1
公开(公告)日：2013-07-11
申请号：US13685199
申请日：2012-11-26
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00011 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61B2018/2211 , G02B5/1885
摘要： Disclosed herein are methods and systems for treatment, such as skin rejuvenation treatment, use non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:NAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a nonuniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the tar et tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production).
摘要翻译： 本文公开了用于治疗的方法和系统，例如皮肤年轻化治疗，使用不均匀的激光辐射。 激光辐射的高强度部分导致处理区域的选定部分内的胶原蛋白破坏和收缩，而辐射的较低强度部分引起成纤维细胞刺激，导致治疗区域的其它部分的胶原产生。 来自诸如Nd：NAG激光器的激光源的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，所述大直径光束包括被包围的多个高强度区域 处理梁内的较低强度区域。 较高强度区域将焦油和组织的部分热量选择为足以进行第一次处理（例如胶原收缩）的温度，而较低强度区域提供足够的能量进行第二次处理（例如刺激胶原产生）。
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公开(公告)号：US20130096546A1
公开(公告)日：2013-04-18
申请号：US13508293
申请日：2010-03-05
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B18/22 , A61B2018/00452 , A61B2018/1807 , A61B2018/2211 , A61B2018/2294 , A61N5/06 , A61N5/0616 , A61N2005/0652 , A61N2005/067
摘要： An apparatus is disclosed including: an incoherent light source that generates a treatment beam having a non-uniform energy profile, the non-uniform energy profile being included of regions of relatively high energy per unit area within a substantially uniform background region of relatively low energy per unit area.
摘要翻译： 公开了一种装置，其包括：非相干光源，其产生具有不均匀能量分布的处理束，所述非均匀能量分布包括在相对较低能量的基本上均匀的背景区域内的每单位面积相对较高能量的区域 每单位面积。
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公开(公告)号：US20130035675A1
公开(公告)日：2013-02-07
申请号：US13566306
申请日：2012-08-03
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/0047
摘要： This application provides a consumer device for aesthetic applications, and methods for titrating doses of therapeutic light output from the device in the form of a non-uniform beam, in connection with dermal rejuvenation and cosmetic applications.
摘要翻译： 该应用提供了美学应用的消费者设备，以及用于以与非皮肤复原和化妆品应用相结合的非均匀束的形式滴定从该装置输出的治疗光剂量的方法。
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公开(公告)号：US20140371730A1
公开(公告)日：2014-12-18
申请号：US14340961
申请日：2014-07-25
CPC分类号： A61B18/203 , A61B2018/0047 , A61N5/0616 , A61N2005/067 , H01S3/0092 , H01S3/0627 , H01S3/08018 , H01S3/08054 , H01S3/093 , H01S3/094038 , H01S3/094076 , H01S3/094084 , H01S3/1024 , H01S3/107 , H01S3/1106 , H01S3/1109 , H01S3/1121 , H01S3/1611 , H01S3/1623 , H01S3/1633 , H01S3/1643 , H01S3/1673
摘要： Methods, systems and apparatus are disclosed for delivery of pulsed treatment radiation by employing a pump radiation source generating picosecond pulses at a first wavelength, and a frequency-shifting resonator having a lasing medium and resonant cavity configured to receive the picosecond pulses from the pump source at the first wavelength and to emit radiation at a second wavelength in response thereto, wherein the resonant cavity of the frequency-shifting resonator has a round trip time shorter than the duration of the picosecond pulses generated by the pump radiation source. Methods, systems and apparatus are also disclosed for providing beam uniformity and a sub-harmonic resonator.
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9.发明申请公开(公告)号：US20110152847A1
公开(公告)日：2011-06-23
申请号：US12947310
申请日：2010-11-16
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00011 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61B2018/2211 , G02B5/1885
摘要： Methods and apparatus for treatment, such as skin rejuvenation treatment, using non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:YAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a non-uniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the target tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production). A large area of tissue, preferably 7-10 mm in diameter, can be treated simultaneously, while minimizing the risk of burning or other damage to the skin.In one embodiment, the invention uses a fiber bundle to provide a non-uniform energy output beam. In another embodiment, the invention uses a diffractive lens array to produce the non-uniform output beam. A cooling system can also be integrated with the laser treatment system.
摘要翻译： 治疗方法和设备，如皮肤嫩肤治疗，使用不均匀的激光辐射。 激光辐射的高强度部分导致处理区域的选定部分内的胶原蛋白破坏和收缩，而辐射的较低强度部分引起成纤维细胞刺激，导致治疗区域的其它部分的胶原产生。 来自激光源（例如Nd：YAG激光器）的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，该光束由多个高强度区域 被处理梁内的低强度区域包围。 较高强度区域将目标组织的部分热量选择为足以进行第一次处理（例如胶原收缩）的温度，而较低强度区域为第二次处理提供足够的能量（例如刺激的胶原产生）。 可以同时治疗大面积的组织，优选直径为7-10mm，同时最小化对皮肤的燃烧或其它损伤的风险。 在一个实施例中，本发明使用纤维束来提供不均匀的能量输出束。 在另一个实施例中，本发明使用衍射透镜阵列来产生不均匀的输出光束。 冷却系统也可以与激光治疗系统集成。
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10.发明申请公开(公告)号：US20100217248A1
公开(公告)日：2010-08-26
申请号：US12635295
申请日：2009-12-10
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00011 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61B2018/2211 , G02B5/1885
摘要： Disclosed herein are methods and systems for treatment, such as skin rejuvenation treatment, use non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:YAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a nonuniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the target tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production).
摘要翻译： 本文公开了用于治疗的方法和系统，例如皮肤年轻化治疗，使用不均匀的激光辐射。 激光辐射的高强度部分导致处理区域的选定部分内的胶原蛋白破坏和收缩，而辐射的较低强度部分引起成纤维细胞刺激，导致治疗区域的其它部分的胶原产生。 来自诸如Nd：YAG激光器的激光源的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，所述大直径光束包括被包围的多个高强度区域 处理梁内的较低强度区域。 较高强度区域将目标组织的部分热量选择为足以进行第一次处理（例如胶原收缩）的温度，而较低强度区域为第二次处理提供足够的能量（例如刺激的胶原产生）。
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