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    Site-specific aminoglycoside derivatives for use in immunodiagnostic assays
    5.
    发明授权
    Site-specific aminoglycoside derivatives for use in immunodiagnostic assays 有权
    用于免疫诊断测定的位点特异性氨基糖苷衍生物

    公开(公告)号：US07781570B2

    公开(公告)日：2010-08-24

    申请号：US11675216

    申请日：2007-02-15

    申请人： Mitali Ghoshal ,  Salvatore J. Salamone

    发明人： Mitali Ghoshal ,  Salvatore J. Salamone

    IPC分类号： C07K16/00 ,  C07K1/04

    CPC分类号： C07H5/06 ,  A61K31/7008 ,  C07H3/06 ,  C07K16/44 ,  G01N33/9446 ,  Y02P20/55 ,  Y10S435/81 ,  Y10S435/968 ,  Y10S436/815 ,  Y10S530/807 ,  Y10T436/13

    摘要： A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and regents.

    摘要翻译： 制备衍生化的氨基糖苷的方法包括在非质子溶剂中将氨基糖苷与至少2当量的二价金属离子反应以使两个相邻的氨基和羟基对复合; 使非络合氨基与保护试剂反应以提供保护基团; 除去二价金属离子以提供两个未保护的氨基; 使一个未保护的氨基与含有接头，载体或标记的反应性物质反应; 并除去保护基。 该方法可用于生产新型化合物和试剂。

    Site-specific aminoglycoside derivatives for use in immunodiagnostic assays
    8.
    发明授权
    Site-specific aminoglycoside derivatives for use in immunodiagnostic assays 有权
    用于免疫诊断测定的位点特异性氨基糖苷衍生物

    公开(公告)号：US07235370B2

    公开(公告)日：2007-06-26

    申请号：US10624822

    申请日：2003-07-22

    申请人： Mitali Ghoshal ,  Salvatore J. Salamone

    发明人： Mitali Ghoshal ,  Salvatore J. Salamone

    IPC分类号： G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N33/534 ,  C07H5/06

    CPC分类号： C07H5/06 ,  A61K31/7008 ,  C07H3/06 ,  C07K16/44 ,  G01N33/9446 ,  Y02P20/55 ,  Y10S435/81 ,  Y10S435/968 ,  Y10S436/815 ,  Y10S530/807 ,  Y10T436/13

    摘要： A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and reagents.

    摘要翻译： 制备衍生化的氨基糖苷的方法包括在非质子溶剂中将氨基糖苷与至少2当量的二价金属离子反应以使两个相邻的氨基和羟基对复合; 使非络合氨基与保护试剂反应以提供保护基团; 除去二价金属离子以提供两个未保护的氨基; 使一个未保护的氨基与含有接头，载体或标记的反应性物质反应; 并除去保护基。 该方法可用于生产新型化合物和试剂。

    Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
    9.
    发明授权
    Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays 有权
    位点特异性氨基糖苷衍生物及其在免疫诊断测定中的应用

    公开(公告)号：US06653456B2

    公开(公告)日：2003-11-25

    申请号：US09920402

    申请日：2001-07-31

    申请人： Mitali Ghoshal ,  Salvatore J. Salamone

    发明人： Mitali Ghoshal ,  Salvatore J. Salamone

    IPC分类号： C08B3700

    CPC分类号： C07H5/06 ,  A61K31/7008 ,  C07H3/06 ,  C07K16/44 ,  G01N33/9446 ,  Y02P20/55 ,  Y10S435/81 ,  Y10S435/968 ,  Y10S436/815 ,  Y10S530/807 ,  Y10T436/13

    摘要： A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and reagents.

    摘要翻译： 制备衍生化的氨基糖苷的方法包括在非质子溶剂中将氨基糖苷与至少2当量的二价金属离子反应以使两个相邻的氨基和羟基对复合; 使非络合氨基与保护试剂反应以提供保护基团; 除去二价金属离子以提供两个未保护的氨基; 使一个未保护的氨基与含有接头，载体或标记的反应性物质反应; 并除去保护基。 该方法可用于生产新型化合物和试剂。