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497 条记录 (耗时 0.043 秒)

    Therapeutic agent for intractable vasculitis
    1.
    发明授权
    Therapeutic agent for intractable vasculitis 失效
    难治性血管炎治疗剂

    公开(公告)号：US06251929B1

    公开(公告)日：2001-06-26

    申请号：US09434494

    申请日：1999-11-05

    申请人： Mitsuru Naiki ,  Takumi Numazawa ,  Tomoyuki Okada ,  Kazuharu Ienaga ,  Kazuyoshi Sawada

    发明人： Mitsuru Naiki ,  Takumi Numazawa ,  Tomoyuki Okada ,  Kazuharu Ienaga ,  Kazuyoshi Sawada

    IPC分类号： A64K31415

    CPC分类号： A61K31/4166

    摘要： A highly safe therapeutic agent for intractable vasculitis such as malignant rheumatoid arthritis contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: wherein each of R1, and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, a hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group. The hydantoin derivatives significantly suppress the generation of arthritis and arteritis (cutaneous ulcer and auricular infarcted necrosis) which are naturally developed in model animals (MRL/lpr), and further significantly elongate the survival rate of MRL/lpr mice. Consequently, the hydantoin derivatives, having low toxicity and little side effects are very useful as highly safe therapeutic agents for intractable vasculitis such as malignant rheumatoid arthritis.

    摘要翻译： 用于顽固性血管炎的恶性类风湿性关节炎的高度安全的治疗剂含有式（I）表示的乙内酰脲衍生物或其药学上可接受的盐作为有效成分：其中R1和R2可以相同或不同 表示氢，烷基或环烷基; X和Y各自可以相同或不同，表示氢，羟基，烷基或烷氧基，或X和Y一起表示氧代基。 乙内酰脲衍生物显着抑制模型动物（MRL / lpr）中天然发育的关节炎和动脉炎（皮肤溃疡和耳廓梗塞坏死）的产生，并进一步显着延长MRL / lpr小鼠的存活率。 因此，具有低毒性和少量副作用的乙内酰脲衍生物作为难治性血管炎如恶性类风湿性关节炎的高度安全的治疗剂是非常有用的。

    ANALGESIC
    2.
    发明申请
    ANALGESIC 审中-公开

    公开(公告)号：US20130296426A1

    公开(公告)日：2013-11-07

    申请号：US13979723

    申请日：2012-01-30

    申请人： Munekazu Iinuma ,  Shoei Furukawa ,  Mitsuru Naiki ,  Tomoyuki Okada ,  Tomonori Matsumoto ,  Kazuyoshi Sawada

    发明人： Munekazu Iinuma ,  Shoei Furukawa ,  Mitsuru Naiki ,  Tomoyuki Okada ,  Tomonori Matsumoto ,  Kazuyoshi Sawada

    IPC分类号： A61K31/23 ,  A61K31/231

    CPC分类号： A61K31/23 ,  A61K31/231

    摘要： An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing an ester of C10 fatty acid as an active ingredient. The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis) or by demyelinating diseases such as multiple sclerosis or Guillain-Bareé syndrome.

    摘要翻译： 本发明的目的是提供一种有效预防或治疗各种疼痛疾病的止​​痛剂。 本发明提供一种含有C10脂肪酸的酯作为活性成分的止痛剂。 含有该化合物作为活性成分的本发明的止痛剂作为各种疼痛疾病例如由骨关节炎（例如膝关节骨性关节炎和髋关节骨性关节炎）引起的疼痛或脱髓鞘性疾病如多发性硬化症的预防或治疗剂是非常有用的 或吉兰 - 巴雷综合征。

    Method for study, determination or evaluation by gene expression analysis
    4.
    发明申请
    Method for study, determination or evaluation by gene expression analysis 审中-公开
    通过基因表达分析进行研究，测定或评估的方法

    公开(公告)号：US20100048408A1

    公开(公告)日：2010-02-25

    申请号：US12310623

    申请日：2007-09-05

    申请人： Mitsuru Naiki ,  Tomoyuki Okada

    发明人： Mitsuru Naiki ,  Tomoyuki Okada

    IPC分类号： C40B30/00 ,  C12Q1/68 ,  A61K35/12 ,  A01K67/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/50

    摘要： There is provided a method for study, determination or evaluation of a disease condition due to SART stressing or a pharmacological activity, for example an analgesic activity, an autonomic imbalance-ameliorating activity or an anti-stress activity, of a test substance at the gene level. It is a method for study, determination or evaluation of a pharmacological activity of a test substance, especially an analgesic activity, an autonomic imbalance-ameliorating activity, or an anti-stress activity at the gene level by comprehensively analyzing the change in gene expression in a neural tissue after administration of a test substance in a SART-stressed animal. The method enables exploration of the substance that is effective against painful diseases, stress-related diseases, autonomic-imbalance or the like, determination and evaluation of efficacy of the substance, or analysis of a target gene of the substance

    摘要翻译： 提供了一种用于研究，测定或评估由于SART应激或药理学活性引起的疾病状况的方法，例如在基因上测试物质的止痛活性，自主失调 - 改善活性或抗应激​​活性 水平。 它是通过综合分析基因表达变化来研究，测定或评估测试物质的药理活性，特别是镇痛活性，自主神经不平衡改善活性或基因水平的抗应激活性的方法 在SART受压动物中施用测试物质后的神经组织。 该方法能够探索对抗痛性疾病，应激相关疾病，自主神经不平衡等有效的物质，物质的功效的测定和评估，或物质的靶基因的分析

    Recording medium, program, and reproduction method
    6.
    发明授权
    Recording medium, program, and reproduction method 有权
    记录介质，程序和再现方法

    公开(公告)号：US08655145B2

    公开(公告)日：2014-02-18

    申请号：US13094106

    申请日：2011-04-26

    申请人： Hiroshi Yahata ,  Tomoyuki Okada

    发明人： Hiroshi Yahata ,  Tomoyuki Okada

    IPC分类号： H04N9/80 ,  H04N5/93

    CPC分类号： G11B27/105 ,  G11B27/322 ,  G11B2220/2537 ,  G11B2220/2541 ,  G11B2220/412

    摘要： ABD-ROM 100 and a local storage 200 contain dynamic scenarios (programs) such as a Java application and a Movie Object. A dynamic scenario reads profile information from PSR 31 of the playback apparatus and judges whether or not the playback apparatus is an audio-only type. If it is judged that the playback apparatus is not the audio-only type, an interactive screen is displayed to perform a control to play back a digital stream according to an operation made onto the interactive screen. If it is judged that the playback apparatus is the audio-only type, a control is performed to play back a digital stream according to an operation that is made without use of the interactive screen.

    摘要翻译： ABD-ROM 100和本地存储器200包含诸如Java应用程序和Movie Object之类的动态场景（程序）。 动态方案从重放装置的PSR 31读取简档信息，并判断播放装置是否是音频类型。 如果判断回放装置不是仅音频类型，则显示交互式屏幕，以根据对交互式屏幕的操作进行数字流播放的控制。 如果判断回放装置是仅音频类型，则执行根据不使用交互式屏幕的操作来播放数字流的控制。

    Recording medium, playback apparatus and method, recording method, and computer-readable program implementing stream model information showing whether graphics stream is multiplexed or non-multiplexed with video system
    9.
    发明授权
    Recording medium, playback apparatus and method, recording method, and computer-readable program implementing stream model information showing whether graphics stream is multiplexed or non-multiplexed with video system 有权
    记录介质，播放装置和方法，记录方法和实现流模型信息的计算机可读程序，显示图形流是否与视频系统复用或非复用

    公开(公告)号：US08490017B2

    公开(公告)日：2013-07-16

    申请号：US12607744

    申请日：2009-10-28

    申请人： Joseph McCrossan ,  Tomoyuki Okada ,  Masayuki Kozuka

    发明人： Joseph McCrossan ,  Tomoyuki Okada ,  Masayuki Kozuka

    IPC分类号： G06F3/00 ,  H04N5/92 ,  H04N5/93 ,  H04N9/74

    CPC分类号： G11B27/105 ,  G11B27/3027 ,  G11B27/309 ,  G11B27/34 ,  G11B2220/2541 ,  G11B2220/2562

    摘要： A BD-ROM stores a video stream and a graphics stream. The video stream represents a moving picture. The graphics stream is used for overlaying a multi-page menu on the moving picture, and includes interactive control information (ICS) and graphics data (ODS) used for generating the multi page menu. A PTS attached to a PES packet containing the interactive control information shows timing for the first presentation of a main page the multi-page menu in accordance with the proceeding of the video stream playback. In addition, the interactive control information includes information (selection_time_out_pts) showing a timeout upon which a button on a page of the multi-page menu is automatically activated, and information (user_time_out_duration) showing a timeout upon which a sub-page of the multi-page menu is automatically removed.

    摘要翻译： BD-ROM存储视频流和图形流。 视频流表示运动图像。 图形流用于在运动图像上叠加多页菜单，并且包括用于生成多页菜单的交互式控制信息（ICS）和图形数据（ODS）。 附加到包含交互式控制信息的PES包的PTS表示根据视频流回放的进行，主页首次呈现多页菜单的定时。 此外，交互式控制信息包括表示多页菜单的页面上的按钮被自动激活的超时的信息（selection_time_out_pts）以及表示多页菜单的子页面的超时的信息（user_time_out_duration） 页面菜单被自动删除。

    Recording medium, reproduction apparatus, recording method, program, and reproduction method
    10.
    发明授权
    Recording medium, reproduction apparatus, recording method, program, and reproduction method 有权
    记录介质，再现装置，记录方法，程序和再现方法

    公开(公告)号：US08463107B2

    公开(公告)日：2013-06-11

    申请号：US12757128

    申请日：2010-04-09

    申请人： Wataru Ikeda ,  Tomoyuki Okada ,  Yasushi Uesaka ,  Masayuki Kozuka

    发明人： Wataru Ikeda ,  Tomoyuki Okada ,  Yasushi Uesaka ,  Masayuki Kozuka

    IPC分类号： H04N5/917

    CPC分类号： G11B27/34 ,  G11B27/034 ,  G11B27/10 ,  G11B27/105 ,  G11B27/3027 ,  G11B27/3036 ,  G11B2220/2541 ,  H04N5/775 ,  H04N5/781 ,  H04N5/85 ,  H04N5/907 ,  H04N5/9205 ,  H04N9/8042 ,  H04N9/8063 ,  H04N9/8205 ,  H04N9/8715

    摘要： On a BD-ROM, there is recorded is a digital stream into which video and audio streams are multiplexed. The video stream is composed of a plurality of pictures that together represent video. The graphics stream includes a PES packet storing state control information (ICS) and PES packets containing graphics data (ODSs). The graphics data constructs an interactive display. The state control information defines the control so as to change the states of buttons presented on the interactive display according to the reproduction proceeding and user operations.The ICS is attached with a PTS showing the display timing of a picture to be synchronized with the interactive display. The ODS is attached with a PTS showing the timing for decoding the graphics data. The timing shown in the ODS is prior to the display timing.

    摘要翻译： 在BD-ROM中，记录有视频和音频流被多路复用的数字流。 视频流由一起表示视频的多个图像组成。 图形流包括存储状态控制信息（ICS）的PES分组和包含图形数据（ODS）的PES分组。 图形数据构成交互式显示。 状态控制信息定义控制，以便根据再现进行和用户操作来改变呈现在交互式显示器上的按钮的状态。 ICS附有PTS，显示要与交互式显示同步的图片的显示时间。 ODS附带有显示解码图形数据的时间的PTS。 ODS显示的时间在显示时间之前。