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公开(公告)号:US3949023A
公开(公告)日:1976-04-06
申请号:US422388
申请日:1973-12-06
申请人: Mitsuru Sasaki , Isao Ohno , Hisami Takeda , Takeo Satomi , Kunio Mukai
发明人: Mitsuru Sasaki , Isao Ohno , Hisami Takeda , Takeo Satomi , Kunio Mukai
IPC分类号: A01N57/12 , A01N57/10 , A01N57/14 , C07F9/165 , C07F9/59 , A01N9/36 , C07D211/08 , C07D317/14
CPC分类号: C07F9/1657 , A01N57/10
摘要: Oximino-phosphorothiolate derivatives represented by the formula, ##EQU1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter defined, which are useful as a controlling agent for agricultural pests containing the oximino-phosphorothiolate derivatives as active ingredients, as well as processes for preparing the compounds and the composition are disclosed.
摘要翻译: 由下式表示的肟基 - 硫代磷酸酯衍生物,其中R 1,R 2,R 3和R 4如下文所定义,其可用作含有肟基 - 硫代磷酸酯的农业害虫的控制剂 衍生物作为活性成分,以及制备化合物和组合物的方法。
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公开(公告)号:US3932459A
公开(公告)日:1976-01-13
申请号:US491636
申请日:1974-07-25
申请人: Yoshitoshi Okuno , Masachika Hirano , Isao Ohno , Hisami Takeda , Osamu Magara , Nobushige Itaya , Toshio Nishioka , Toshio Mizutani , Nobuo Ohno , Takashi Matsuo
发明人: Yoshitoshi Okuno , Masachika Hirano , Isao Ohno , Hisami Takeda , Osamu Magara , Nobushige Itaya , Toshio Nishioka , Toshio Mizutani , Nobuo Ohno , Takashi Matsuo
IPC分类号: C07C69/747 , A01N53/04 , A01N53/06 , C07C67/00 , C07C253/00 , C07C255/39 , C07D307/45 , C07D307/56 , C07D317/54 , C07D333/16 , C07D333/24 , C07D333/78
CPC分类号: C07D333/16 , C07D333/78
摘要: A new cyclopropanecarboxylic acid ester represented by the formula, ##SPC1##Wherein R.sub.1 is alkyl having up to four carbon atoms, alkenyl having up to five carbon atoms, cycloalkenyl having up to six carbon atoms, alkenyl having up to five carbon atoms, benzyl, phenoxy or halogen; R.sub.2 and R.sub.3 are hydrogen, halogen or methyl; and any adjacent two of R.sub.1, R.sub.2 and R.sub.3 may combine to form polymethylene, which is useful as insecticides and acaricides having a strong insecticidal activity but a low toxicity to mammals, in agriculture, horticulture as well as public health.
摘要翻译: 由下式表示的新的环丙烷羧酸酯WHEREIN R1是具有至多4个碳原子的烷基,具有至多5个碳原子的烯基,具有至多6个碳原子的环烯基,具有至多5个碳原子的链烯基,苄基,苯氧基或卤素 ; R2和R3是氢,卤素或甲基; 并且R 1,R 2和R 3中的任何相邻的两个可以结合形成多亚甲基,其可用作具有强的杀虫活性但对哺乳动物毒性低,在农业,园艺以及公共卫生中的杀虫剂和杀螨剂。
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公开(公告)号:US4309439A
公开(公告)日:1982-01-05
申请号:US882155
申请日:1978-02-28
申请人: Nobuo Ohno , Isao Ohno , Toshio Nishioka , Hisami Takeda , Kiyoshi Kasamatsu
发明人: Nobuo Ohno , Isao Ohno , Toshio Nishioka , Hisami Takeda , Kiyoshi Kasamatsu
IPC分类号: C07C69/612 , A01N37/00 , A01N37/10 , A01N37/38 , A01N37/42 , A01N37/48 , A01N43/06 , A01N43/08 , A01N43/12 , A01N43/30 , A01N43/32 , A01N43/90 , C07C51/00 , C07C59/46 , C07C59/48 , C07C67/00 , C07C69/62 , C07C69/73 , C07C69/76 , C07C69/767 , C07C69/95 , C07C201/00 , C07C205/56 , C07C253/00 , C07C255/50 , C07C255/57 , C07C313/00 , C07C323/62 , C07D307/00 , C07D307/40 , C07D307/54 , C07D307/79 , C07D307/80 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07D333/78 , C08K5/34 , A61K31/235 , A61K31/60 , C07C69/614 , C07D323/02
CPC分类号: C07D307/79 , C07C205/56 , C07C323/00 , C07C67/14 , C07C69/65 , C07D307/54 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60
摘要: A novel substituted-arylacetic acid ester of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or a halogen atom, a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxy, cyano, nitro, methylthio, C.sub.1 -C.sub.4 alkanoyl, C.sub.1 -C.sub.4 alkanoyloxy, or C.sub.1 -C.sub.4 alkoxycarbonyl group, or R.sub.1 and R.sub.2, taken together, may form methylenedioxy, a C.sub.3 -C.sub.5 alkylene or butadienylene (--CH.dbd.CH--CH.dbd.CH--) ring; R.sub.3 is a C.sub.2 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, propargyl, C.sub.3 -C.sub.6 cycloalkyl or cyclopropylmethyl group; R.sub.4 is hydrogen or a halogen atom, methyl or ethyl group; R.sub.5 is allyl, propargyl, 3-butenyl, 3-butynyl, phenyl or benzyl group; and A is oxygen or sulfur atom or --CH.dbd.CH-- group, which possesses various useful insecticidal and acaricidal activities and can be prepared by reacting a substituted-arylacetic acid of the formula: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and A are each as defined above, or a reactive derivative thereof with an alcohol, or halide or sulfonate thereof of the formula, ##STR3## wherein R.sub.4 and R.sub.5 are each as defined above and X is hydroxy group, a halogen atom, alkylsulfonyloxy or arylsulfonyloxy group.
摘要翻译: 一种新颖的下式的取代芳基乙酸酯,其中R 1和R 2各自为氢或卤原子,C 1 -C 4烷基,C 2 -C 4烯基,C 1 -C 4烷氧基,氰基,硝基,甲硫基 ,C 1 -C 4烷酰基,C 1 -C 4烷酰氧基或C 1 -C 4烷氧基羰基,或者R 1和R 2一起可以形成亚甲二氧基,C 3 -C 5亚烷基或亚丁二烯基(-CH = CH-CH = CH-)环; R3是C2-C4烷基,C2-C4烯基,炔丙基,C3-C6环烷基或环丙基甲基; R4是氢或卤素原子,甲基或乙基; R5是烯丙基,炔丙基,3-丁烯基,3-丁炔基,苯基或苄基; 并且A是氧或硫原子或-CH = CH-基团,其具有各种有用的杀虫和杀螨活性,并且可以通过使下式的取代芳基乙酸反应来制备:其中R1,R2,R3和A是 或其与醇或其卤化物或磺酸盐的反应性衍生物,其分子式如下:其中R 4和R 5各自如上所定义,X为羟基,卤素原子,烷基磺酰氧基或芳基磺酰氧基。
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公开(公告)号:US4091111A
公开(公告)日:1978-05-23
申请号:US728840
申请日:1976-10-01
申请人: Nobuo Ohno , Isao Ohno , Toshio Nishioka , Hisami Takeda , Kiyoshi Kasamatsu
发明人: Nobuo Ohno , Isao Ohno , Toshio Nishioka , Hisami Takeda , Kiyoshi Kasamatsu
IPC分类号: C07C69/612 , A01N37/00 , A01N37/10 , A01N37/38 , A01N37/42 , A01N37/48 , A01N43/06 , A01N43/08 , A01N43/12 , A01N43/30 , A01N43/32 , A01N43/90 , C07C51/00 , C07C59/46 , C07C59/48 , C07C67/00 , C07C69/62 , C07C69/73 , C07C69/76 , C07C69/767 , C07C69/95 , C07C201/00 , C07C205/56 , C07C253/00 , C07C255/50 , C07C255/57 , C07C313/00 , C07C323/62 , C07D307/00 , C07D307/40 , C07D307/54 , C07D307/79 , C07D307/80 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07D333/78 , C08K5/34 , A01N9/24
CPC分类号: C07D307/79 , C07C205/56 , C07C323/00 , C07C67/14 , C07C69/65 , C07D307/54 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60
摘要: A novel substituted-arylacetic acid ester of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or a halogen atom, a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxy, cyano, nitro, methylthio, C.sub.1 -C.sub.4 alkanoyl, C.sub.1 -C.sub.4 alkanoyloxy, or C.sub.1 -C.sub.4 alkoxycarbonyl group, or R.sub.1 and R.sub.2, taken together, may form methylenedioxy, a C.sub.3 -C.sub.5 alkylene or butadienylene (--CH.dbd.CH--CH.dbd.CH--) ring; R.sub.3 is a C.sub.2 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, propargyl, C.sub.3 -C.sub.6 cycloalkyl or cyclopropylmethyl group; R.sub.4 is hydrogen or a halogen atom, methyl or ethyl group; R.sub.5 is allyl, propargyl, 3-butenyl, 3-butynyl, phenyl or benzyl group; and A is oxygen or sulfur atom or --CH.dbd.CH-- group, which possesses various useful insecticidal and acaricidal activities and can be prepared by reacting a substituted-arylacetic acid of the formula; ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and A are each as defined above, or a reactive derivative thereof with an alcohol, or halide or sulfonate thereof of the formula, ##STR3## wherein R.sub.4 and R.sub.5 are each as defined above and X is hydroxy group, a halogen atom, alkylsulfonyloxy or arylsulfonyloxy group.
摘要翻译: 一种新颖的下式的取代芳基乙酸酯,其中R 1和R 2各自为氢或卤原子,C 1 -C 4烷基,C 2 -C 4烯基,C 1 -C 4烷氧基,氰基,硝基,甲硫基 ,C 1 -C 4烷酰基,C 1 -C 4烷酰氧基或C 1 -C 4烷氧基羰基,或者R 1和R 2一起可以形成亚甲二氧基,C 3 -C 5亚烷基或亚丁二烯基(-CH = CH-CH = CH-)环; R3是C2-C4烷基,C2-C4烯基,炔丙基,C3-C6环烷基或环丙基甲基; R4是氢或卤素原子,甲基或乙基; R5是烯丙基,炔丙基,3-丁烯基,3-丁炔基,苯基或苄基; 并且A是氧或硫原子或-CH = CH-基团,其具有各种有用的杀虫和杀螨活性,并且可以通过使式的取代芳基乙酸反应来制备; 其中R 1,R 2,R 3和A各自如上所定义,或其与醇或其下式的卤化物或磺酸盐的反应性衍生物,其中R 4和R 5各自如上所定义,X是 羟基,卤素原子,烷基磺酰氧基或芳基磺酰氧基。
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公开(公告)号:US3981903A
公开(公告)日:1976-09-21
申请号:US491637
申请日:1974-07-25
申请人: Masachika Hirano , Isao Ohno , Yoshitoshi Okuno , Osamu Magara , Nobushige Itaya , Toshio Nishioka , Toshio Mizutani , Nobuo Ohno , Takashi Matsuo , Hisami Takeda
发明人: Masachika Hirano , Isao Ohno , Yoshitoshi Okuno , Osamu Magara , Nobushige Itaya , Toshio Nishioka , Toshio Mizutani , Nobuo Ohno , Takashi Matsuo , Hisami Takeda
IPC分类号: C07C69/747 , A01N53/02 , A01N53/06 , A01N53/10 , A01P7/04 , C07C69/743 , C07C69/74
CPC分类号: A01N53/00 , C07C69/743 , Y10S514/937 , Y10S514/953
摘要: A new pyrethroidal pesticide containing as an active ingredient a pesticidally effective amount of novel cyclopropanecarboxylic acid esters represented by the formula, ##EQU1## wherein R is a hydrogen atom, a halogen atom, a methyl or a methoxy group, and R.sub.1 and R.sub.2 are hydrogen atom, methyl group or a halogen atom, which have a low toxicity to mammals, excellent pesticidal effect on injurious pests in cereal storage, agriculture and forestry and a wide range of uses for prevention of epidemics.
摘要翻译: 一种新的拟除虫菊酯农药,其含有杀虫有效量的由式R 1表示的新型环丙烷羧酸酯作为活性成分,其中C = CH-CH-CH-CO-CH 2 C = C-CH 2 Cl平行|角度角OR2 CH3CH3,其中R是氢原子,卤素原子,甲基或甲氧基,R1和R2是对哺乳动物毒性低的氢原子,甲基或卤素原子,对谷物中有害害虫具有优良的杀虫作用 储存,农业和林业以及预防流行病的广泛用途。
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公开(公告)号:US08691514B2
公开(公告)日:2014-04-08
申请号:US13126140
申请日:2009-10-30
申请人: Jinichi Inokuchi , Masakazu Nagafuku , Isao Ohno , Kaori Okuyama
发明人: Jinichi Inokuchi , Masakazu Nagafuku , Isao Ohno , Kaori Okuyama
IPC分类号: G01N33/53
CPC分类号: A61K31/7032 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0368 , A61K31/7105 , C12N9/1081 , C12N15/8509 , G01N33/505
摘要: The present invention relates to selectively controlling the function of a helper T cell. In the present invention, a mouse lacking a gene involved in ganglioside biosynthesis (ganglioside GM3 synthetase gene) (SAT-I KO) was produced and analyzed. As a result, the present invention provides, for example, a method for screening a substance which induces selective suppression of the function of a helper T cell in an immune response, including control of production of a sphingoglycolipid in the helper T cell, and moderation or suppression of an excessive immune response caused by the suppression of the function, that is, a substance having an immunosuppression activity, an anti-asthmatic action and/or an anti-allergic action.
摘要翻译: 本发明涉及选择性地控制辅助T细胞的功能。 在本发明中,生产并分析了缺乏涉及神经节苷脂生物合成(神经节苷脂GM3合成酶基因)(SAT-1 KO)的基因的小鼠。 结果,本发明提供了例如用于筛选诱导选择性抑制辅助性T细胞在免疫应答中的功能的物质的方法,包括控制辅助T细胞中的鞘糖脂的生产和适度 或抑制由功能的抑制引起的过度的免疫应答,即具有免疫抑制活性的物质,抗哮喘作用和/或抗过敏作用。
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公开(公告)号:US4266074A
公开(公告)日:1981-05-05
申请号:US596332
申请日:1975-07-16
申请人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
发明人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
IPC分类号: C07C67/00 , A01N37/00 , A01N37/04 , A01N37/06 , A01N37/10 , A01N37/32 , A01N37/34 , A01N37/38 , A01N37/42 , A01N37/48 , A01N43/06 , A01N43/16 , A01N43/30 , A01N49/00 , C07C43/29 , C07C51/00 , C07C51/08 , C07C57/30 , C07C57/42 , C07C57/58 , C07C57/60 , C07C59/48 , C07C59/56 , C07C59/64 , C07C69/00 , C07C69/612 , C07C69/614 , C07C69/618 , C07C69/635 , C07C69/66 , C07C69/74 , C07C69/743 , C07C69/76 , C07C255/53 , C07C317/00 , C07D209/48 , C07D227/093 , C07D307/34 , C07D307/40 , C07D307/54 , C07D317/48 , C07D317/60 , C07D333/04 , C07D333/16 , C07D333/24 , C07D333/38 , C07D409/06 , A01N41/02 , C07C79/46 , C07C143/67 , C07C147/107 , C07C149/40
CPC分类号: C07D307/54 , C07C323/00 , C07C51/08 , C07C57/42 , C07C59/64 , C07C69/608 , C07C69/612 , C07C69/618 , C07C69/65 , C07C69/734 , C07C69/738 , C07C2101/16 , C07C2102/08 , C07C2102/10
摘要: Substituted acetate compounds represented by the formula ##STR1## which are useful as pesticides and pesticidal composition containing the substituted acetate compounds as active ingredients, as well as processes for preparing the compounds and the compositions are disclosed.
摘要翻译: 公开了用作农药和由取代的乙酸酯化合物作为活性成分的杀虫组合物的式“IMAGE”代表的取代的乙酸酯化合物,以及制备化合物和组合物的方法。
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公开(公告)号:US4062968A
公开(公告)日:1977-12-13
申请号:US596334
申请日:1975-07-16
申请人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
发明人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
IPC分类号: A01N37/36 , A01N43/06 , C07D307/54 , A01N9/00
CPC分类号: C07D307/54 , C07C323/00
摘要: Substituted acetate compounds represented by the formula ##STR1## which are useful as pesticides and pesticidal composition containing the substituted acetate compounds as active ingredients, as well as processes for preparing the compounds and the compositions are disclosed.
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公开(公告)号:US4058622A
公开(公告)日:1977-11-15
申请号:US557694
申请日:1975-03-12
申请人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
发明人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
IPC分类号: C07C69/612 , C07D307/54 , A01N9/24 , C07C69/76
CPC分类号: C07D307/54 , C07C323/00
摘要: Substituted acetate compounds represented by the formula ##STR1## which are useful as pesticides and pesticidal compositions containing the substituted acetate compounds as active ingredients, as well as processes for preparing the compounds and the compositions are disclosed.
摘要翻译: 公开了用作农药和由取代的乙酸酯化合物作为活性成分的杀虫组合物的式“IMAGE”代表的取代的乙酸酯化合物,以及制备化合物和组合物的方法。
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公开(公告)号:US4039680A
公开(公告)日:1977-08-02
申请号:US596335
申请日:1975-07-16
申请人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
发明人: Keimei Fujimoto , Nobuo Ohno , Yoshitoshi Okuno , Toshio Mizutani , Isao Ohno , Masachika Hirano , Nobushige Itaya , Takashi Matsuo
IPC分类号: A01N37/08 , A01N37/36 , A01N43/06 , C07D307/54 , A01N9/00
CPC分类号: C07D307/54 , C07C323/00
摘要: Substituted acetate compounds represented by the formula ##STR1## which are useful as pesticides and pesticidal composition containing the substituted acetate compounds as active ingredients, as well as processes for preparing the compounds and the compositions are disclosed.
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