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公开(公告)号：US07129063B2
公开(公告)日：2006-10-31
申请号：US10298417
申请日：2002-11-15
申请人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
发明人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
CPC分类号： C07K14/47 , C07K14/705
摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
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公开(公告)号：US07824676B2
公开(公告)日：2010-11-02
申请号：US11522043
申请日：2006-09-15
申请人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
发明人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , C07K14/705
摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
摘要翻译： 通过技术可视化蛋白质的定位技术筛选编码在细胞连接处定位的蛋白质的蛋白质的基因片段的小鼠cDNA文库，以鉴定连接蛋白和相关蛋白JEAP。 GenBank同源性检索是根据序列进行的。 基于获得的序列，筛选小鼠cDNA文库以鉴定JEAP-2。 通过使用针对这些蛋白质的制备的抗体，显示这些蛋白质在紧密连接处特别是在外分泌腺中的紧密连接处特异性表达。
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公开(公告)号：US20080119641A1
公开(公告)日：2008-05-22
申请号：US11522043
申请日：2006-09-15
申请人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
发明人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , C07K14/705
摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell—cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
摘要翻译： 通过技术可视化蛋白质的定位技术筛选编码在细胞连接处定位的蛋白质的蛋白质的基因片段的小鼠cDNA文库，以鉴定连接蛋白和相关蛋白JEAP。 GenBank同源性检索是根据序列进行的。 基于获得的序列，筛选小鼠cDNA文库以鉴定JEAP-2。 通过使用针对这些蛋白质的制备的抗体，显示这些蛋白质在紧密连接处特别是在外分泌腺中的紧密连接处特异性表达。
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公开(公告)号：US20140045215A1
公开(公告)日：2014-02-13
申请号：US13924433
申请日：2013-06-21
申请人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
发明人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
IPC分类号： C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
摘要翻译： 本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。 本发明还涉及所述抗体的重链和轻链。 本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。 本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。
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5.发明授权Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine 有权使用抗CX3CR1抗体，抗分解蛋白抗体和fractalkine公开(公告)号：US07390490B1
公开(公告)日：2008-06-24
申请号：US11225829
申请日：2005-09-13
申请人： Toshio Imai , Miyuki Nishimura , Kenzo Muramoto , Yoshikazu Kuboi
发明人： Toshio Imai , Miyuki Nishimura , Kenzo Muramoto , Yoshikazu Kuboi
IPC分类号： A61K39/395 , C07K16/24 , C07K16/28
CPC分类号： G01N33/56972 , A61K2039/505 , C07K16/24 , C07K16/2866 , Y10S424/81
摘要： There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotoxic activity of killer lymphocytes by suppressing an interaction between CX3CR1 and fractalkine.
摘要翻译： 提供了针对CX3CR1和fractalkine的抗体的用途。 通过使用抗CX3CR1抗体可以容易地鉴定，消除和分离杀伤淋巴细胞。 此外，可以提供通过抑制CX3CR1与fractalkine之间的相互作用来抑制杀伤淋巴细胞的趋化性和细胞毒性的抗体药物。
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公开(公告)号：US20140193421A1
公开(公告)日：2014-07-10
申请号：US14240090
申请日：2012-08-30
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2319/55
摘要： An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.
摘要翻译： 本发明的目的是提供与人XCR1结合的单克隆抗体，其中所述抗体结合至包含至少三个氨基酸的线性或不连续表位，所述氨基酸选自第8,11,12,13,13和14， 16位，17位，22位，23位，第176位和第177位氨基酸。
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7.发明授权Treating inflammatory diseases with antibodies that inhibit fractalkine-CXCR1 interaction 有权用抑制fractalkine-CXCR1相互作用的抗体治疗炎性疾病公开(公告)号：US08518401B1
公开(公告)日：2013-08-27
申请号：US11718246
申请日：2005-10-31
申请人： Yoshikazu Kuboi , Toshio Imai , Miyuki Nishimura , Keiko Mizuno
发明人： Yoshikazu Kuboi , Toshio Imai , Miyuki Nishimura , Keiko Mizuno
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A61K31/00 , A61K2039/505 , C07K2317/76
摘要： A therapeutic agent for an inflammatory disease comprising an antibody or a CX3CR1 antagonist that inhibits an interaction of fractalkine and CX3CR1 is provided.
摘要翻译： 提供一种炎症性疾病的治疗剂，其包含抑制分解素与CX3CR1相互作用的抗体或CX3CR1拮抗剂。
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公开(公告)号：US20120213799A1
公开(公告)日：2012-08-23
申请号：US13504742
申请日：2010-10-28
IPC分类号： A61K39/395 , C12N15/13 , A61P29/00 , A61P1/04 , A61P19/02 , C12N1/00 , A61P1/16 , A61P25/00 , C12N15/63 , C12N5/10 , C12P21/02 , C07K16/24 , A61P37/00
CPC分类号： C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/76 , Y10S514/894
摘要： The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
摘要翻译： 本发明的特征在于与人源化抗体相关的组合物和方法，其结合分子链的FKN结合片段。
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公开(公告)号：US08932592B2
公开(公告)日：2015-01-13
申请号：US13504742
申请日：2010-10-28
IPC分类号： A61K39/395 , C07K16/24 , C12N15/13 , C12N5/10 , C12P21/02
CPC分类号： C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/76 , Y10S514/894
摘要： The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
摘要翻译： 本发明的特征在于与人源化抗体相关的组合物和方法，其结合分子链的FKN结合片段。
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公开(公告)号：US09371389B2
公开(公告)日：2016-06-21
申请号：US14240090
申请日：2012-08-30
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2319/55
摘要： An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.
摘要翻译： 本发明的目的是提供与人XCR1结合的单克隆抗体，其中所述抗体结合至包含至少三个氨基酸的线性或不连续表位，所述氨基酸选自第8,11,12,13,13和14， 16位，17位，22位，23位，第176位和第177位氨基酸。
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