公开(公告)号：US07824676B2

公开(公告)日：2010-11-02

申请号：US11522043

申请日：2006-09-15

申请人： Miyuki Nishimura ,  Mayumi Asano ,  Yuichi Ono ,  Koji Morimoto ,  Masakazu Takeuchi ,  Yoko Inoue ,  Toshio Imai ,  Yoshimi Takai

发明人： Miyuki Nishimura ,  Mayumi Asano ,  Yuichi Ono ,  Koji Morimoto ,  Masakazu Takeuchi ,  Yoko Inoue ,  Toshio Imai ,  Yoshimi Takai

IPC分类号： C07K16/18

CPC分类号： C07K14/47 ,  C07K14/705

摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.

摘要翻译： 通过技术可视化蛋白质的定位技术筛选编码在细胞连接处定位的蛋白质的蛋白质的基因片段的小鼠cDNA文库，以鉴定连接蛋白和相关蛋白JEAP。 GenBank同源性检索是根据序列进行的。 基于获得的序列，筛选小鼠cDNA文库以鉴定JEAP-2。 通过使用针对这些蛋白质的制备的抗体，显示这些蛋白质在紧密连接处特别是在外分泌腺中的紧密连接处特异性表达。

公开(公告)号：US07129063B2

公开(公告)日：2006-10-31

申请号：US10298417

申请日：2002-11-15

申请人： Miyuki Nishimura ,  Mayumi Asano ,  Yuichi Ono ,  Koji Morimoto ,  Masakazu Takeuchi ,  Yoko Inoue ,  Toshio Imai ,  Yoshimi Takai

发明人： Miyuki Nishimura ,  Mayumi Asano ,  Yuichi Ono ,  Koji Morimoto ,  Masakazu Takeuchi ,  Yoko Inoue ,  Toshio Imai ,  Yoshimi Takai

IPC分类号： C12P21/02 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  C07H21/04

CPC分类号： C07K14/47 ,  C07K14/705

摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.

公开(公告)号：US20080119641A1

公开(公告)日：2008-05-22

申请号：US11522043

申请日：2006-09-15

申请人： Miyuki Nishimura ,  Mayumi Asano ,  Yuichi Ono ,  Koji Morimoto ,  Masakazu Takeuchi ,  Yoko Inoue ,  Toshio Imai ,  Yoshimi Takai

发明人： Miyuki Nishimura ,  Mayumi Asano ,  Yuichi Ono ,  Koji Morimoto ,  Masakazu Takeuchi ,  Yoko Inoue ,  Toshio Imai ,  Yoshimi Takai

IPC分类号： C07K16/18

CPC分类号： C07K14/47 ,  C07K14/705

摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell—cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.

摘要翻译： 通过技术可视化蛋白质的定位技术筛选编码在细胞连接处定位的蛋白质的蛋白质的基因片段的小鼠cDNA文库，以鉴定连接蛋白和相关蛋白JEAP。 GenBank同源性检索是根据序列进行的。 基于获得的序列，筛选小鼠cDNA文库以鉴定JEAP-2。 通过使用针对这些蛋白质的制备的抗体，显示这些蛋白质在紧密连接处特别是在外分泌腺中的紧密连接处特异性表达。

公开(公告)号：US07153831B2

公开(公告)日：2006-12-26

申请号：US11257883

申请日：2005-10-25

申请人： Masakazu Takeuchi ,  Yoshimi Takai

发明人： Masakazu Takeuchi ,  Yoshimi Takai

IPC分类号： A61K38/00

CPC分类号： C07K16/18 ,  C07K14/4702 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/68 ,  G01N2500/00

摘要： A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.

公开(公告)号：US20060246502A1

公开(公告)日：2006-11-02

申请号：US11483356

申请日：2006-07-07

申请人： Masakazu Takeuchi ,  Yoshimi Takai

发明人： Masakazu Takeuchi ,  Yoshimi Takai

IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K16/18 ,  C07K14/4702 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/68 ,  G01N2500/00

摘要： A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.

摘要翻译： 可用于澄清Ca 2+依赖性胞吐作用的调节机制的蛋白质，特别是Rab3A的活化和失活，以及筛选用于调节Ca 2+， / SUP>依赖性胞吐，特别是使用上述蛋白质激活和失活Rab3A。 通过使用抗Rab3A GEP抗体的共免疫沉淀，测定参与Rab3A的激活或失活调节的蛋白质。 当蛋白质与rabconnectin-3和GDP / GTP交换蛋白结合时，它可用于筛选增加或减少结合的材料。

公开(公告)号：US07279461B2

公开(公告)日：2007-10-09

申请号：US11483356

申请日：2006-07-07

申请人： Masakazu Takeuchi ,  Yoshimi Takai

发明人： Masakazu Takeuchi ,  Yoshimi Takai

IPC分类号： A61K38/00

CPC分类号： C07K16/18 ,  C07K14/4702 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/68 ,  G01N2500/00

摘要： A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.

摘要翻译： 可用于澄清Ca 2+依赖性胞吐作用的调节机制的蛋白质，特别是Rab3A的活化和失活，以及筛选用于调节Ca 2+， / SUP>依赖性胞吐，特别是使用上述蛋白质激活和失活Rab3A。 通过使用抗Rab3A GEP抗体的共免疫沉淀，测定参与Rab3A的激活或失活调节的蛋白质。 当蛋白质与rabconnectin-3和GDP / GTP交换蛋白结合时，它可用于筛选增加或减少结合的材料。

公开(公告)号：US20060040328A1

公开(公告)日：2006-02-23

申请号：US11257883

申请日：2005-10-25

申请人： Masakazu Takeuchi ,  Yoshimi Takai

发明人： Masakazu Takeuchi ,  Yoshimi Takai

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K16/18 ,  C07K14/4702 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/68 ,  G01N2500/00

摘要： A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.

公开(公告)号：US20050064430A1

公开(公告)日：2005-03-24

申请号：US10645335

申请日：2003-08-21

申请人： Masakazu Takeuchi ,  Yoshimi Takai

发明人： Masakazu Takeuchi ,  Yoshimi Takai

IPC分类号： C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/705 ,  C12N9/10

CPC分类号： C07K16/18 ,  C07K14/4702 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/68 ,  G01N2500/00

摘要： A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.

摘要翻译： 一种可用于澄清Ca 2+依赖性胞吐作用的调节机制的蛋白质，特别是Rab3A的活化和失活，以及筛选适用于调节Ca 2+依赖性胞吐作用的材料的方法，特别是 使用上述蛋白激活和灭活Rab3A。 通过使用抗Rab3A GEP抗体的共免疫沉淀，测定参与Rab3A的激活或失活调节的蛋白质。 当蛋白质与rabconnectin-3和GDP / GTP交换蛋白结合时，它可用于筛选增加或减少结合的材料。

公开(公告)号：US20140085278A1

公开(公告)日：2014-03-27

申请号：US14116178

申请日：2012-05-01

申请人： Masakazu Takeuchi ,  Chihiro Watanabe ,  Yasuki Mori ,  Akihisa Iwamoto

发明人： Masakazu Takeuchi ,  Chihiro Watanabe ,  Yasuki Mori ,  Akihisa Iwamoto

IPC分类号： G09G3/00

CPC分类号： G09G3/00 ,  G09G5/003 ,  G09G5/006 ,  G09G2370/042 ,  G09G2370/047

摘要： In order to reduce the number of components forming a display device, a control IC 102 and a PC 104 are connected to an EEPROM 103 via an I2CBUS 106. The EEPROM 103 stores EDID data, and data stored in an LCD, which is used for control processing by the control IC 102.

摘要翻译： 为了减少形成显示装置的部件的数量，控制IC 102和PC104通过I2CBUS 106连接到EEPROM 103. EEPROM 103存储EDID数据和存储在LCD中的数据，其用于 由控制IC102进行控制处理。

公开(公告)号：US08390548B2

公开(公告)日：2013-03-05

申请号：US12078153

申请日：2008-03-27

申请人： Masakazu Takeuchi ,  Takashi Morimoto ,  Yasuki Mori

发明人： Masakazu Takeuchi ,  Takashi Morimoto ,  Yasuki Mori

IPC分类号： G09G3/36

CPC分类号： G02F1/136213

摘要： A liquid crystal display device includes a group of first signal lines ( . . . , Sm−1, Sm, Sm+1, . . . ) arranged in parallel, a group of second signal lines ( . . . , Gn−1, Gn, Gn+1, . . . ) and a group of auxiliary capacity wirings ( . . . , Csn−1, Csn, Csn+1, . . . ) alternately arranged one by one in parallel so as to intersect with the group of the first signal lines, a plurality of pixel electrodes arranged in a pixel region, an auxiliary electrode connected to each of the pixel electrodes, and a TFT element corresponding to each of the pixel electrodes. The auxiliary electrode has a portion forming a capacitor by overlapping with auxiliary capacity wiring Csn and a portion forming a capacitor by overlapping with second signal line Gn−1.

摘要翻译： 一种液晶显示装置，包括并排布置的一组第一信号线（...，Sm-1，Sm，Sm + 1 ...），一组第二信号线（...，Gn-1， Gn，Gn + 1，...）和一组并行交替排列的辅助容量布线（...，Csn-1，Csn，Csn + 1，...） 的第一信号线，排列在像素区域中的多个像素电极，连接到每个像素电极的辅助电极以及与每个像素电极相对应的TFT元件。 辅助电极具有通过与辅助电容布线Csn和形成电容器的部分与第二信号线Gn-1重叠而形成电容器的部分。