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    FRACTURE REPAIR PROMOTER
    1.
    发明申请
    FRACTURE REPAIR PROMOTER 审中-公开
    破碎修复促进器

    公开(公告)号：US20120040908A1

    公开(公告)日：2012-02-16

    申请号：US13129613

    申请日：2009-10-19

    申请人： Mizuho Kido ,  Toshiyuki Watanabe ,  Atsushi Danjo ,  Teruo Tanaka ,  Daisuke Uetsuji ,  Aiko Ono ,  Atsushi Serizawa

    发明人： Mizuho Kido ,  Toshiyuki Watanabe ,  Atsushi Danjo ,  Teruo Tanaka ,  Daisuke Uetsuji ,  Aiko Ono ,  Atsushi Serizawa

    IPC分类号： A61K38/17 ,  A61P19/00 ,  A61P19/08

    CPC分类号： A61K35/20 ,  A21D2/263 ,  A23C19/082 ,  A23J1/20 ,  A23K20/147 ,  A23L33/18 ,  A23L33/19 ,  A23V2002/00 ,  A61K38/018 ,  A23V2200/306

    摘要： Disclosed is a substance capable of promoting the repair of a fractured part in a fracture caused by an external force, fatigue or a disease. Also disclosed is a method for producing the substance. Further disclosed is a product capable of promoting the repair of a fracture, such as a food, a beverage and a feed, which comprises the fracture repair promoter. Specifically disclosed is a fracture repair promoter comprising, as an active ingredient, a fraction containing a milk-derived basic protein. In the promoter, the fraction containing the milk-derived basic protein is produced by contacting milk or a milk-derived raw material with a cation exchange resin to cause the adsorption of the basic protein on the cation exchange resin and eluting a fraction adsorbed on the resin by means of an eluent having a salt concentration of 0.1 to 1.0 M.

    摘要翻译： 公开了能够促进由外力，疲劳或疾病引起的骨折部位的修复的物质。 还公开了一种生产该物质的方法。 进一步公开的是能够促进骨折的修复的产品，例如包含骨折修复促进剂的食品，饮料和饲料。 具体公开了一种骨折修复促进剂，其包含含有乳源性碱性蛋白质的级分作为活性成分。 在促进剂中，含有乳衍生的碱性蛋白质的级分通过使乳或乳衍生的原料与阳离子交换树脂接触而产生，以使碱性蛋白质吸附在阳离子交换树脂上并洗脱吸附在 树脂，通过盐浓度为0.1〜1.0M的洗脱液。

    Method for quantification of peptide and protein
    8.
    发明授权
    Method for quantification of peptide and protein 有权
    肽和蛋白质定量方法

    公开(公告)号：US08221967B2

    公开(公告)日：2012-07-17

    申请号：US12521632

    申请日：2007-12-27

    申请人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    发明人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N2030/8831

    摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

    摘要翻译： 测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。 通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列 或感兴趣的肽。

    METHOD FOR QUANTIFICATION OF PEPTIDE AND PROTEIN
    9.
    发明申请
    METHOD FOR QUANTIFICATION OF PEPTIDE AND PROTEIN 有权
    肽和蛋白质的定量方法

    公开(公告)号：US20110039287A1

    公开(公告)日：2011-02-17

    申请号：US12521632

    申请日：2007-12-27

    申请人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    发明人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    IPC分类号： C12Q1/44 ,  C12Q1/28 ,  B01D59/44

    CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N2030/8831

    摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

    摘要翻译： 测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。 通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列 或感兴趣的肽。

    RANKL PRODUCTION INHIBITOR
    10.
    发明申请
    RANKL PRODUCTION INHIBITOR 审中-公开
    RANKL生产抑制剂

    公开(公告)号：US20100099848A1

    公开(公告)日：2010-04-22

    申请号：US12529660

    申请日：2008-02-29

    申请人： Aiko Ono ,  Atsushi Serizawa ,  Yoshikazu Morita ,  Hiroshi Kawakami

    发明人： Aiko Ono ,  Atsushi Serizawa ,  Yoshikazu Morita ,  Hiroshi Kawakami

    IPC分类号： C07K14/00

    CPC分类号： A61K38/018 ,  A23K20/147 ,  A23L33/19 ,  A23V2002/00 ,  A23V2200/306 ,  A23V2200/324 ,  A23V2250/5424

    摘要： The production of RANKL may be inhibited by orally ingesting a milk-derived basic protein. Thus, a RANKL production inhibitor containing a milk-derived basic protein fraction as an active ingredient; a therapeutic agent for a metabolic bone disease and a therapeutic agent for an immune disease each containing the RANKL production inhibitor; and a food/beverage and a feed each containing a specified amount of the RANKL production inhibitor and being characterized by inhibiting the production of RANKL have a remarkable effect of inhibiting the production of RANKL, can be ingested on a daily basis, and exhibit high safety even when being ingested over a long period.

    摘要翻译： 通过口服摄取乳源性碱性蛋白质可以抑制RANKL的产生。 因此，含有乳衍生的碱性蛋白质级分作为活性成分的RANKL产生抑制剂; 每种含有RANKL产生抑制剂的代谢骨疾病治疗剂和免疫疾病治疗剂; 并且每种含有特定量的RANKL产生抑制剂的食品/饮料和饲料，其特征在于抑制RANKL的产生具有显着的抑制RANKL产生的作用，可以每天摄取并显示高安全性 即使长时间摄入也是如此。