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    BIOERODIBLE WRAPS AND USES THEREFOR
    1.
    发明申请
    BIOERODIBLE WRAPS AND USES THEREFOR 有权
    生物不便的威胁及其用途

    公开(公告)号：US20120330437A1

    公开(公告)日：2012-12-27

    申请号：US13502759

    申请日：2010-10-28

    申请人： Mohammed El-Kurdi ,  J. Christopher Flaherty ,  Yi Hong ,  Jonathan McGrath ,  Lorenzo Soletti ,  John Stankus ,  David Vorp ,  William Wagner

    发明人： Mohammed El-Kurdi ,  J. Christopher Flaherty ,  Yi Hong ,  Jonathan McGrath ,  Lorenzo Soletti ,  John Stankus ,  David Vorp ,  William Wagner

    IPC分类号： A61F2/04

    CPC分类号： A61F2/06 ,  A61F2/04 ,  A61F2/062 ,  A61F2002/072

    摘要： A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. 5 Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

    摘要翻译： 提供了一种管状组织移植装置，其包括围绕管状组织的圆周的生物可蚀解聚合物的管状构件和限制性纤维基质。 基质可以电纺到管状组织上。 在一个实施例中，管状组织来自静脉，例如隐静脉，可用作动脉移植物，例如但不限于冠状动脉旁路手术。 还提供了制备管状移植物的方法，其包括围绕管状组织的周边沉积生物可蚀解聚合物的纤维基质以产生管状组织移植装置。 还提供了一种包括绕管冠状动脉的心脏旁路方法，所述管状组织移植装置包括围绕静脉周围的静脉和生物可蚀解聚合物的限制性纤维基质。

    Sustained release of Apo A-I mimetic peptides and methods of treatment
    4.
    发明授权
    Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
    持续释放Apo A-I模拟肽和治疗方法

    公开(公告)号：US09173890B2

    公开(公告)日：2015-11-03

    申请号：US11946028

    申请日：2007-11-27

    申请人： Katsuyuki Murase ,  Jinping Wan ,  John Stankus ,  Dariush Davalian ,  Florian Ludwig

    发明人： Katsuyuki Murase ,  Jinping Wan ,  John Stankus ,  Dariush Davalian ,  Florian Ludwig

    IPC分类号： A61K38/00 ,  A61K31/661 ,  A61K9/14 ,  A61K38/10 ,  A61K38/17 ,  A61P3/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/16 ,  A61K9/51

    CPC分类号： A61K31/661 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/127 ,  A61K9/1647 ,  A61K9/5153 ,  A61K38/17

    摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

    摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

    Drug-Coated Balloon With Location-Specific Plasma Treatment
    9.
    发明申请
    Drug-Coated Balloon With Location-Specific Plasma Treatment 有权
    具有位置特异性等离子体处理的药物涂层气球

    公开(公告)号：US20120064141A1

    公开(公告)日：2012-03-15

    申请号：US12883024

    申请日：2010-09-15

    申请人： Anthony S. Andreacchi ,  Stephen D. Pacetti ,  John Stankus ,  Victoria M. Gong ,  Michael J. Leonard ,  Binh Nguyen

    发明人： Anthony S. Andreacchi ,  Stephen D. Pacetti ,  John Stankus ,  Victoria M. Gong ,  Michael J. Leonard ,  Binh Nguyen

    IPC分类号： A61F2/00 ,  B05D3/06 ,  C23C14/02

    CPC分类号： B05D3/144 ,  A61F2/82 ,  B05D7/02 ,  C08J7/123

    摘要： Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.

    摘要翻译： 涂覆可膨胀构件的方法，例如 气囊，所述方法包括提供具有外表面的可扩张构件。 该方法包括在可扩张构件的外表面的至少一部分上进行气体供应的等离子体处理。 在执行等离子体处理之后，至少在可膨胀构件的外表面的等离子体处理部分上施加治疗剂。 等离子体处理可以降低治疗剂对可扩张构件表面的粘附。 还提供了通过所公开的方法制造的医疗装置。

    Impact Resistant Lagging, Method For Designing Impact Resistant Lagging, and Apparatus for Testing Impact Resistant Lagging
    10.
    发明申请
    Impact Resistant Lagging, Method For Designing Impact Resistant Lagging, and Apparatus for Testing Impact Resistant Lagging 有权
    抗冲击滞后设计方法，耐冲击阻尼设计方法，耐冲击阻尼试验装置

    公开(公告)号：US20100266349A1

    公开(公告)日：2010-10-21

    申请号：US12714139

    申请日：2010-02-26

    申请人： Kevin Jinrong Ma ,  John Stankus ,  Robert McGinnis ,  Dakota Faulkner ,  Demrey Brandon ,  John Feyrer

    发明人： Kevin Jinrong Ma ,  John Stankus ,  Robert McGinnis ,  Dakota Faulkner ,  Demrey Brandon ,  John Feyrer

    IPC分类号： E21D23/04 ,  E21D5/00 ,  G01N3/30

    CPC分类号： G01N3/30 ,  E21D11/18 ,  E21D11/28

    摘要： A steel set assembly includes a first pair of legs and a second pair of legs with the first pair of legs being spaced from and positioned opposite the second pair of legs. First and second beams are provided with the first beam being secured to one leg of the first pair of legs and one leg of the second pair of legs. The second beam is secured to the other leg of the first pair of legs and the other leg of the second pair of legs. A panel is secured to the first and second beams and includes a base having a top surface and a bottom surface, a block having a top surface and a bottom surface, and a pad. The block is secured to the base and the pad is positioned between the top surface of the base and the bottom surface of the block.

    摘要翻译： 钢组件包括第一对腿和第二对腿，其中第一对腿与第二对腿分开并与第二对腿相对定位。 第一和第二梁设置有第一梁被固定到第一对腿的一条腿和第二对腿的一条腿。 第二梁被固定到第一对腿的另一条腿和第二对腿的另一条腿。 面板被固定到第一和第二梁上并且包括具有顶表面和底表面的基部，具有顶表面和底表面的块以及垫。 块被固定到基部，并且垫位于基部的顶表面和块的底表面之间。