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15 条记录 (耗时 0.018 秒)

    Method of production of 9-cis-retinoic acid
    3.
    发明授权
    Method of production of 9-cis-retinoic acid 有权
    9-顺 - 视黄酸的生产方法

    公开(公告)号：US08536373B2

    公开(公告)日：2013-09-17

    申请号：US12442162

    申请日：2007-09-27

    申请人： Michael Stanek ,  Stefan Essl ,  Monika Knopp ,  Erwin Kübel

    发明人： Michael Stanek ,  Stefan Essl ,  Monika Knopp ,  Erwin Kübel

    IPC分类号： C07C61/00

    CPC分类号： C07C403/20 ,  C07B2200/09 ,  C07C2601/16 ,  C07F9/5442

    摘要： Improved method of production of 9-(Z)-retinoic acid, in which a) a β-formyl-crotonic acid C1-C10 alkyl or phenyl ester is reacted with an isolated 9-(Z)—C15-triarylphosphonium salt by the Wittig reaction in the presence of a base to the corresponding 9-(Z)-retinoic acid ester; which b) is then saponified with a base to the corresponding 9-(Z)-retinoic acid carboxylate and then, following protonation with an acid, the desired 9-(Z)-retinoic acid is obtained, and improved method for the enrichment and isolation of the 9-(Z)—C15-triarylphosphonium salt.

    摘要翻译： 改进的9-（Z） - 视黄酸的制备方法，其中a）β-甲酰基 - 巴豆酸C1-C10烷基或苯基酯与Wittig与分离的9-（Z）-C15-三芳基鏻盐反应 在碱存在下与相应的9-（Z） - 视黄酸酯反应; 然后将b）用碱皂化成相应的9-（Z） - 视黄酸羧酸酯，然后在用酸质子化后，得到所需的9-（Z） - 视黄酸，并且改进了富集和 分离9-（Z）-C 15 - 三芳基鏻盐。

    Method for producing 4-cyano-2-aminomethylthiazole
    4.
    发明授权
    Method for producing 4-cyano-2-aminomethylthiazole 有权
    4-氰基-2-氨基甲基噻唑的制备方法

    公开(公告)号：US06639081B1

    公开(公告)日：2003-10-28

    申请号：US10031703

    申请日：2002-04-30

    申请人： Monika Knopp ,  Stefan Koser ,  Bernd Schaefer

    发明人： Monika Knopp ,  Stefan Koser ,  Bernd Schaefer

    IPC分类号： C07D27704

    CPC分类号： C07D277/56

    摘要： The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ib in which n=1 or 2 and for n=1, X is chloride, bromide, triflate and hydrogen sulfate and for n=2, X is sulfate, which comprises the process step where the aminonitrile of the formula II is stirred with a cysteine ester of the formula III, in which R1 is branched or linear C1-10-alkyl or where n=0, 1 or 2 and R2 is branched or linear C1-C10C10-alkyl or C1-C4-alkoxy or C1-C4-dialkylamino in an inert solvent in the presence of a base at from 0° C. to 80° C. until the reaction has essentially proceeded to completion, and to the compounds of the formulae Ia and Ib.

    摘要翻译： 本发明涉及制备2-氨基甲基-4-氰基噻唑及其盐，其中n = 1或2，n = 1，X为氯化物，溴化物，三氟甲磺酸酯和硫酸氢盐，n = 2，X为 硫酸盐，其包括其中式II的氨基腈与式III的半胱氨酸酯一起搅拌的方法步骤，其中R 1是支链或直链的C 1-10 - 烷基或其中n = 0,1或2， 2>是在0℃至80℃的碱存在下，在惰性溶剂中的支链或直链C 1 -C 10 C 10 - 烷基或C 1 -C 4 - 烷氧基或C 1 -C 4 - 二烷基氨基，直到反应基本上进行 以及式Ia和Ib的化合物。

    Substituted amides, their production and their use
    8.
    发明授权
    Substituted amides, their production and their use 失效
    取代酰胺，其生产和使用

    公开(公告)号：US06448254B1

    公开(公告)日：2002-09-10

    申请号：US09647677

    申请日：2000-10-03

    申请人： Wilfried Lubisch ,  Achim Möller ,  Hans-Jörg Treiber ,  Monika Knopp

    发明人： Wilfried Lubisch ,  Achim Möller ,  Hans-Jörg Treiber ,  Monika Knopp

    IPC分类号： C07C31121

    CPC分类号： C07D213/56 ,  C07C311/21 ,  C07D215/36 ,  C07D239/70 ,  C07D239/96

    摘要： Amides of the general formula I and their tautomeric and isomeric forms, possible enantiomeric and diastereomeric forms, as well as possible physiologically tolerable salts, in which the variables have the following meanings: R1 [sic] can be C1-C6-alkyl, phenyl, naphthyl, quinolyl, pyridyl, pyrimidyl, pyridazyl, quinazolyl and quinoxalyl, where the rings can additionally be substituted by up to 2 radicals R4 [sic], and R2 [sic] is —(CH2)m—R8 [sic], where R8 [sic] can be phenyl, cyclohexyl- or indolyl and m=1 to 6, and X is a bond, —CH2—, —CH2CH2—, —CH═CH—, —C≡C—, —CONH—, —SO2NH— [sic], and and [sic] R1—X [sic] together are also  and R3 [sic] is hydrogen and CO—NR6R7 [sic], R4 [sic] is hydrogen, C1-C4-alkyl [sic], which is branched and unbranched, and —O—C1-C4-alkyl [sic]; R5 [sic] is hydrogen, C1-C4-alkyl [sic], which is branched or unbranched, and —O—C1-C4-alkyl [sic]; R6 [sic] is hydrogen, C1-C6-alkyl, which is branched and unbranched, and R7 [sic] is hydrogen, C1-C6-alkyl, which is branched or unbranched, and n is is [sic] a number 0, 1 or 2.

    摘要翻译： 通式I的酰胺及其互变异构体和异构体形式，可能的对映异构体和非对映体形式，以及可能的生理上可耐受的盐，其中变量具有以下含义：R 1 [C 1-6]可以是C 1 -C 6 - 烷基，苯基，萘基 ，喹啉基，吡啶基，嘧啶基，哒嗪基，喹唑啉基和喹喔啉基，其中环可以另外被至多2个基团R 4 [sic]取代，并且R 2是 - （CH 2）m -R 8 [sic]，其中R 8 [ ]可以是苯基，环己基或吲哚基并且m = 1至6，X是键，-CH 2 - ， - CH 2 CH 2 - ， - CH = CH - ， - C≡C - ， - CONH - ， - SO 2 NH- ]，并且R 1-X [sic]一起也是且R 3 [sic]是氢且CO-NR 6 R 7 [sic]，R 4 [sic]是氢，C 1 -C 4 - 烷基[ 非支链和-O-C 1 -C 4 - 烷基[sic]; R 5 [sic]是氢，C 1 -C 4 - 烷基[sic]，其是支链或非支链的，和-O-C 1 -C 4 - 烷基[ R 6是氢，C 1 -C 6 - 烷基，其是支链和非支链的，并且R 7 [sic]是氢，C 1 -C 6 - 烷基，其是支链或 不分支，而且是数字0，1或2。

    Substituted amides, their preparation and use
    9.
    发明授权
    Substituted amides, their preparation and use 失效
    取代酰胺，其制备和使用

    公开(公告)号：US06753327B1

    公开(公告)日：2004-06-22

    申请号：US09673089

    申请日：2000-10-11

    申请人： Wilfried Lubisch ,  Achim Möller ,  Hans-Jörg Treiber ,  Monika Knopp

    发明人： Wilfried Lubisch ,  Achim Möller ,  Hans-Jörg Treiber ,  Monika Knopp

    IPC分类号： A61K3116

    CPC分类号： C07D213/82 ,  A61K31/195 ,  A61K31/5375 ,  C07C229/38 ,  C07C237/22 ,  C07C237/32 ,  C07C2601/14 ,  C07D295/155

    摘要： An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: A —(CH2)p—R1, where R1 can be pyrrolidine, morpholine, piperidine, —NR5R6 and  and R5, R6 and R7 can, independently of one another, be hydrogen, C1-C4-alkyl, CH2Ph, Ph, CH2CH2Ph, it also being possible for the phenyl rings to be substituted by R6, and p can be 1 and 2, and B can be phenyl, pyridyl, pyrimidyl and pyridazyl, it also being possible for the rings to be substituted by up to 2 R8 radicals, and D can be a bond, —(CH2)m, —CH═CH—, —C≡C—, and Y is phenyl, pyridine, pyrimidine and pyrazine and n is a number 0, 1 or 2, and m,q are, independently of one another, a number 0, 1, 2, 3 or 4.

    摘要翻译： 式I的酰胺及其互变异构形式，可能的对映异构体和非对映体形式，E和Z形式以及可能的生理学耐受盐，其中变量具有以下含义：A - （CH 2）p R 1，其中R 1 可以是吡咯烷，吗啉，哌啶，-NR 5 R 6和R 5，R 6和R 7可以彼此独立地是氢，C 1 -C 4 - 烷基，CH 2 Ph ，Ph，CH2CH2Ph，苯环可被R 6取代，p可以是1和2，B可以是苯基，吡啶基，嘧啶基和哒嗪基，环也可以是 被至多2个R 8基团取代，并且D可以是键， - （CH 2）m，-CH = CH-，-C = C-，Y是苯基，吡啶，嘧啶和吡嗪，n是0， 1或2，且m，q彼此独立地为0,1,2,3或4。