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公开(公告)号:US4468560A
公开(公告)日:1984-08-28
申请号:US348018
申请日:1982-02-11
CPC分类号: H01J37/224 , G01B11/02 , G01B9/04
摘要: Electron microscope imparted with measuring functions comprises an electron microscope system for forming an electron-microscopic image, a fluorescent screen for displaying the electron-microscopic image, and an optical microscope for observing the electron-microscopic image on the fluorescent screen. A pattern which provides convenience for measurements of the electron-microscopic image is imaged on an object plane of an eyepiece of the optical microscope.
摘要翻译: 具有测量功能的电子显微镜包括用于形成电子显微图像的电子显微镜系统,用于显示电子显微图像的荧光屏和用于观察荧光屏上的电子显微镜图像的光学显微镜。 为电子显微图像的测量提供便利的图案被成像在光学显微镜的目镜的物平面上。
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公开(公告)号:US4212297A
公开(公告)日:1980-07-15
申请号:US951422
申请日:1978-10-16
申请人: Robert A. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Frosch , John E. Johnson, Jr. , Paul F. Swartz
发明人: Robert A. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Frosch , John E. Johnson, Jr. , Paul F. Swartz
CPC分类号: A61M16/0465 , A61M2250/00 , Y10S128/06 , Y10S128/12 , Y10S128/26
摘要: In a micro-fluid exchange apparatus for exchanging fluid with an organ, such as the trachea or a blood vessel of a small animal, such as a rat or a mouse, a hollow needle, such as a syringe needle, is provided for penetrating the fluid conduit of the animal. The syringe needle is coupled to a plenum chamber having an inlet and outlet port. The plenum chamber is coupled to the syringe needle via the intermediary of a standard quick disconnect coupling fitting. The plenum chamber is carried at the end of a drive rod which is coupled to a micrometer drive head. The micrometer drive head is slidably and pivotably coupled to a pedestal for adjusting the height and angle of inclination of the needle relative to a reference base support. The needle is positioned adjacent to the incised trachea or a blood vessel of a small animal and the micrometer drive head is operated for penetrating the fluid conduit of the animal. In the case of a micro-respirator, an oxygen respirator pump is coupled in gaseous communication with the input and output ports of the plenum chamber for supplying oxygen and withdrawing exhaled gas from the small animal.
摘要翻译: 在用于与诸如大鼠或小鼠等小动物的气管或血管的器官交换流体的微流体交换装置中,提供中空针,例如注射器针,用于穿透 动物的流体导管。 注射器针联接到具有入口和出口的增压室。 通气室通过标准快速断开联接配件的中间联接到注射器针头。 增压室在与千分尺驱动头连接的驱动杆的末端承载。 千分尺驱动头可滑动地和可枢转地联接到基座,用于调节针头相对于参考基座支架的高度和倾斜角度。 针位于切开的气管或小动物的血管附近,并且千分尺驱动头被操作以穿透动物的流体导管。 在微呼吸器的情况下,氧气呼吸器泵与充气室的输入和输出端口气体连通地联接,用于供应氧气并从小动物中抽取呼出气体。
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公开(公告)号:USD404760S
公开(公告)日:1999-01-26
申请号:US83595
申请日:1998-02-12
申请人: John E. Johnson, Jr.
设计人: John E. Johnson, Jr.
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公开(公告)号:US09296699B2
公开(公告)日:2016-03-29
申请号:US13491676
申请日:2012-06-08
IPC分类号: C07D221/22 , C07D221/28 , A61K31/44 , C07D471/08
CPC分类号: C07D221/28 , C07D471/08
摘要: The present invention provides compositions of 6-amino morphinan compounds and process for their synthesis. In particular, the processes provide for the reductive amination of 6-keto morphinans by catalytic transfer hydrogenation, to produce 6-amino morphinan compounds, which are epimerically and/or diastereomerically enriched.
摘要翻译: 本发明提供6-氨基吗啡喃化合物的组合物及其合成方法。 特别地,该方法通过催化转移氢化来提供6-酮基吗啡烷的还原胺化,以产生6-氨基吗啡喃化合物,其是差向异构的和/或非对映异构的富集的。
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公开(公告)号:US08314237B2
公开(公告)日:2012-11-20
申请号:US12876284
申请日:2010-09-07
申请人: Hang Sun , John E. Johnson, Jr. , Ricky L. Fenton , Sarah M. Dorn
发明人: Hang Sun , John E. Johnson, Jr. , Ricky L. Fenton , Sarah M. Dorn
IPC分类号: C07D489/08 , C07D489/02
CPC分类号: C07D489/02 , C07D489/08
摘要: The present invention provides processes for the preparation of 10-keto and/or 10-hydroxy morphinans. In particular, the invention provides to processes for preparing a 10-keto morphinan by chromium-catalyzed benzylic oxidation of a morphinan with a periodic acid.
摘要翻译: 本发明提供了制备10-酮和/或10-羟基吗啡喃的方法。 特别地,本发明提供了通过铬 - 催化苄氧化吗啡喃与高碘酸制备10-酮吗啡喃的方法。
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