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公开(公告)号：US20180043030A1
公开(公告)日：2018-02-15
申请号：US15549787
申请日：2016-02-09
CPC分类号： A61K47/60 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/39 , C07K1/1077 , C07K14/78 , C08B37/0069 , C08B37/0075 , C08G65/3342 , C08G75/045 , C08G75/12 , C08G81/00 , C08G2210/00 , C08G2650/04 , C08G2650/16 , C08G2650/20 , C08H1/00 , C08J3/075 , C08J3/246 , C08J2300/16 , C08J2371/02 , C08J2389/00 , C08L101/16 , C12N9/2462 , C12Y302/01017
摘要： Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.
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公开(公告)号：US20220241466A1
公开(公告)日：2022-08-04
申请号：US17611111
申请日：2020-05-14
摘要： The present disclosure relates generally to degradable polymeric scaffolds, methods of making them, and their use in the biomedical field.
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公开(公告)号：US20210154306A1
公开(公告)日：2021-05-27
申请号：US17085798
申请日：2020-10-30
IPC分类号： A61K47/60 , C08G75/12 , C08G75/045 , C08J3/24 , C08G81/00 , C08H1/00 , C07K1/107 , C12N9/36 , C08B37/00 , C07K14/78 , C08J3/075 , C08L101/16 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/39 , C08G65/334
摘要： Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.
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4.发明申请公开(公告)号：US20130243878A1
公开(公告)日：2013-09-19
申请号：US13758942
申请日：2013-02-04
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , A61K35/14 , A61L27/3616 , A61L27/52 , A61L27/54 , A61L27/58 , C08L71/02 , A61K2300/00
摘要： The disclosure provides biomaterials including scaffolds that include blood products including blood fractions and products including platelets for administration to subjects in need thereof. More specifically, the scaffolds based on step growth polymers are enriched with blood extracts that contain platelet rich plasma (PRP) and/or extracts of platelets. Compositions comprising a biomaterial or precursor thereof and a blood extract are provided, as are methods of making and using the biopolymers or precursors thereof. Kits and articles of manufacture comprising the biopolymers or precursors thereof are also described.
摘要翻译： 本公开提供生物材料，包括支架，其包括血液制品，包括血液级分和产品，包括用于给予有需要的受试者的血小板。 更具体地，基于步进生长聚合物的支架富含含有血小板富集血浆（PRP）和/或血小板提取物的血液提取物。 提供了包含其生物材料或其前体和血液提取物的组合物，以及制备和使用生物聚合物或其前体的方法。 还描述了包含生物聚合物或其前体的试剂盒和制品。
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公开(公告)号：US20220227838A1
公开(公告)日：2022-07-21
申请号：US17458075
申请日：2021-08-26
摘要： The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of disclosed methods. The covalently modified biological macromolecules may be further crosslinked to form a scaffold.
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公开(公告)号：US20180360970A1
公开(公告)日：2018-12-20
申请号：US15973163
申请日：2018-05-07
摘要： The disclosure provides biomaterials including scaffolds that include blood products including blood fractions and products including platelets for administration to subjects in need thereof. More specifically, the scaffolds based on step growth polymers are enriched with blood extracts that contain platelet rich plasma (PRP) and/or extracts of platelets. Compositions comprising a biomaterial or precursor thereof and a blood extract are provided, as are methods of making and using the biopolymers or precursors thereof. Kits and articles of manufacture comprising the biopolymers or precursors thereof are also described.
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公开(公告)号：US20180355019A1
公开(公告)日：2018-12-13
申请号：US15971700
申请日：2018-05-04
CPC分类号： C07K14/75 , A61K47/557 , A61K47/60 , C07K1/1077 , C12N9/63 , C12N9/96 , C12Y304/22006
摘要： The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods. The covalently modified biological macromolecules may be further crosslinked to form a scaffold.
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公开(公告)号：US20140273153A1
公开(公告)日：2014-09-18
申请号：US14210106
申请日：2014-03-13
CPC分类号： C07K14/75 , A61K47/557 , A61K47/60 , C07K1/1077 , C12N9/63 , C12N9/96 , C12Y304/22006
摘要： The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods. The covalently modified biological macromolecules may be further crosslinked to form a scaffold.
摘要翻译： 本公开提供共价修饰生物大分子的方法，所述方法包括使包含以下物质的反应混合物：（a）包含一个或多个硫醇基的生物大分子; 和（b）在足以产生共价修饰的生物大分子的条件下，包含一个或多个烯烃或炔部分至自由基反应的分子。 本公开还提供共价修饰生物大分子的方法，该方法包括使包含以下物质的反应混合物：（a）包含一个或多个硫醇基团的分子; 和（b）在足以产生共价修饰的生物大分子的条件下，在自由基反应中含有一个或多个烯烃或炔部分的生物大分子。 本公开进一步提供了通过任何所公开的方法制备的共价修饰的生物大分子。 共价修饰的生物大分子可进一步交联以形成支架。
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