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公开(公告)号：US20190290671A1
公开(公告)日：2019-09-26
申请号：US16361457
申请日：2019-03-22
IPC分类号： A61K31/7034 , A61P3/06 , A61K31/05
摘要： Disclosed are the hypolipidemic effects of a composition comprising at least 10% w/w or above of 1-O-galloyl-β-D-glucose (β-glucogallin). The composition is effective in reducing the circulating levels of total cholesterol, triglycerides, LDL, cholesterol:HDL ratio and increasing HDL levels. The invention also discloses a method for reducing absorption and bio-accessibility of lipids in mammals using the abovementioned composition.
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公开(公告)号：US20180344627A1
公开(公告)日：2018-12-06
申请号：US15996725
申请日：2018-06-04
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Shaheen Majeed , Lakshmi Mundkur
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Shaheen Majeed , Lakshmi Mundkur
摘要： Disclosed are the skin care applications of a composition containing the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856. More specifically, the invention discloses the ability of the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856 to confer protection to the skin fibroblasts against UV induced cell damage and apoptosis, oxidative stress and inflammation.
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公开(公告)号：US20190328798A1
公开(公告)日：2019-10-31
申请号：US16396876
申请日：2019-04-29
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Furqan Ali , Sivakumar Arumugam , Shaheen Majeed , Lakshmi Mundkur , Anurag Pande
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Furqan Ali , Sivakumar Arumugam , Shaheen Majeed , Lakshmi Mundkur , Anurag Pande
IPC分类号： A61K35/742 , C12N1/20
摘要： The present invention discloses a composition comprising heat inactivated spores and/or comprising heat inactivated vegetative cells of probiotic bacteria Bacillus coagulans, and a process for preparing the same. The invention also discloses a method of modulating immune function in mammals by activating macrophages, using a composition comprising Bacillus coagulans in the form of live or heat inactivated spore and/or vegetative cells.
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公开(公告)号：US20190060216A1
公开(公告)日：2019-02-28
申请号：US16117146
申请日：2018-08-30
IPC分类号： A61K8/99 , A61Q19/08 , A61Q17/04 , A61K35/742 , A61P39/06
摘要： Disclosed are the anti-pollution effects of probiotic bacteria Bacillus coagulans MTCC 5856. More specifically the invention discloses the use of probiotic bacteria Bacillus coagulans MTCC 5856 in protecting mammalian skin against the harmful effects of UV and different environmental pollutants. The use of Bacillus coagulans MTCC 5856, as an antioxidant, skin rejuvenating and cleansing agent is also disclosed.
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5.发明授权公开(公告)号：US11123382B2
公开(公告)日：2021-09-21
申请号：US15995454
申请日：2018-06-01
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Shaheen Majeed , Lakshmi Mundkur
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Shaheen Majeed , Lakshmi Mundkur
IPC分类号： A61K35/742 , A61K9/00 , A61P17/08 , A61P17/14 , A61Q7/00 , A61K8/99 , A61K47/32 , A61K47/18 , A61K47/44
摘要： Disclosed are hair care compositions containing partially purified extracellular metabolite preparation from strains of Bacillus coagulans. Specifically, the uses of compositions containing extracellular metabolite preparation from a strain of Bacillus coagulans for increasing hair growth, inhibition of 5α-reductase and proliferation of follicle dermal papilla cells and in the management of androgenic alopecia, are disclosed.
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6.发明授权公开(公告)号：US10668115B2
公开(公告)日：2020-06-02
申请号：US15805394
申请日：2017-11-07
IPC分类号： G01N15/14 , A61K35/742 , C12N1/20 , G01N1/30 , C12Q1/02 , C12N1/04 , A61K35/741 , A61K35/745 , A61K35/747 , C12Q1/06 , G01N15/10
摘要： Disclosed is a stable probiotic composition containing Bacillus coagulans MTCC 5856 exhibiting increased viability over wide range of pH and the use of flow cytometry method to enumerate the viable count of Bacillus coagulans MTCC 5856 under various environmental conditions.
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7.发明授权公开(公告)号：US10966919B2
公开(公告)日：2021-04-06
申请号：US15996791
申请日：2018-06-04
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Lakshmi Mundkur , Shaheen Majeed
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Lakshmi Mundkur , Shaheen Majeed
摘要： Disclosed is the use of partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856 to prevent skin aging. More specifically the invention discloses the anti-collagenase, anti-elastase, anti-glycation activity and enhancement of TGF-β, epidermal growth factor and hyaluronic acid expression in human dermal fibroblasts, of extracellular metabolites isolated from Bacillus coagulans MTCC 5856.
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8.发明申请公开(公告)号：US20180344781A1
公开(公告)日：2018-12-06
申请号：US15995454
申请日：2018-06-01
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Shaheen Majeed , Lakshmi Mundkur
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivakumar Arumugam , Furqan Ali , Shaheen Majeed , Lakshmi Mundkur
摘要： Disclosed are hair care compositions containing partially purified extracellular metabolite preparation from strains of Bacillus coagulans. Specifically, the uses of compositions containing extracellular metabolite preparation from a strain of Bacillus coagulans for increasing hair growth, inhibition of 5α-reductase and proliferation of follicle dermal papilla cells and in the management of androgenic alopecia, are disclosed.
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9.发明申请公开(公告)号：US20180318362A1
公开(公告)日：2018-11-08
申请号：US15805394
申请日：2017-11-07
IPC分类号： A61K35/742 , A61K35/745 , A61K35/747 , C12Q1/06 , G01N15/14
摘要： Disclosed is a stable probiotic composition containing Bacillus coagulans MTCC 5856 exhibiting increased viability over wide range of pH and the use of flow cytometry method to enumerate the viable count of Bacillus coagulans MTCC 5856 under various environmental conditions.
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公开(公告)号：US11298381B2
公开(公告)日：2022-04-12
申请号：US16396876
申请日：2019-04-29
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Furqan Ali , Sivakumar Arumugam , Shaheen Majeed , Lakshmi Mundkur , Anurag Pande
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Furqan Ali , Sivakumar Arumugam , Shaheen Majeed , Lakshmi Mundkur , Anurag Pande
IPC分类号： A01N63/00 , A61K35/742 , C12N1/20
摘要： The present invention discloses a composition comprising heat inactivated spores and/or comprising heat inactivated vegetative cells of probiotic bacteria Bacillus coagulans, and a process for preparing the same. The invention also discloses a method of modulating immune function in mammals by activating macrophages, using a composition comprising Bacillus coagulans in the form of live or heat inactivated spore and/or vegetative cells.
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