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1.发明授权Peptides modified with triterpenoids and small organic molecules: synthesis and use in cosmeceuticals 有权用三萜类化合物和小有机分子修饰的肽：合成和用于药妆品公开(公告)号：US08383594B2
公开(公告)日：2013-02-26
申请号：US11835165
申请日：2007-08-07
Applicant: Muhammed Majeed , Renukeshwar H Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
Inventor： Muhammed Majeed , Renukeshwar H Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
Abstract: The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
Abstract translation: 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。
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2.发明授权Non-cytotoxic synthetic analogues of (1E, 6E)-1, 7-Bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-Dione and therapeutic applications thereof in cystic fibrosis 有权（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮的非细胞毒性合成类似物及其在囊性纤维化中的治疗应用公开(公告)号：US07521580B1
公开(公告)日：2009-04-21
申请号：US12032955
申请日：2008-02-18
Applicant: Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Subbalakshmi Prakash , Kalyanam Nagabhushanam , Samuel Manoharan Thomas , Susmitha Anand , Geetha Kanhangad-Gangadharan
Inventor： Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Subbalakshmi Prakash , Kalyanam Nagabhushanam , Samuel Manoharan Thomas , Susmitha Anand , Geetha Kanhangad-Gangadharan
IPC: C07C49/203 , C07C49/215 , A61K31/12
CPC classification number: C07C49/248 , A61K31/12 , C07C45/74
Abstract: Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered CFTR trafficking and the associated impaired chloride (Cl−) ion transport. Introduction of branched-alkyl groups ortho to the phenolic groups gave rise to clinical compounds with vastly improved trafficking of delF508CFTR and with no cytotoxicity.
Abstract translation: 公开了（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮的新型合成类似物，以及用于其改变的囊性纤维化的治疗应用 CFTR贩运和相关的氯化物（Cl - ）离子迁移。 引入酚基团邻位的支链烷基产生临床化合物，其具有大大改善的delF508CFTR的运输并且没有细胞毒性。
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公开(公告)号：US08987212B2
公开(公告)日：2015-03-24
申请号：US12979667
申请日：2010-12-28
Applicant: Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
Inventor： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
CPC classification number: A61K8/64 , A61K2800/57 , A61K2800/78 , A61Q19/00 , A61Q19/007 , A61Q19/04 , A61Q19/08 , C07K7/06
Abstract: The present invention relates to a composition containing peptide of SEQ ID NO: 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.
Abstract translation: 本发明涉及与齐墩果酸连接的含有SEQ ID NO：1的肽的组合物和治疗皮肤老化的方法。 该组合物有效地减少由于氧化，胶原蛋白不足和丝氨酸蛋白酶如弹性蛋白酶和胶原酶的过度活动导致皮肤皱纹，细纹，减少皮肤厚度，色素沉着过度，眼睛黑眼圈和过早老化等现象。
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4.发明申请Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceutical 审中-公开用三萜类化合物和小有机分子修饰的肽：合成和用于药妆公开(公告)号：US20140206842A1
公开(公告)日：2014-07-24
申请号：US13746633
申请日：2013-01-22
Applicant: Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
Inventor： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
IPC: C07K1/107
CPC classification number: C07K1/1077 , C07K7/06
Abstract: The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the Synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
Abstract translation: 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上出现细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。
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公开(公告)号：US20110033565A1
公开(公告)日：2011-02-10
申请号：US12537843
申请日：2009-08-07
Applicant: Muhammed Majeed , Kalyanam Nagabhushanam , Beena Bhat , Geetha Kanhangad-Gangadharan , Susmitha Anand-Tathapudi , Pritee Paliwal
Inventor： Muhammed Majeed , Kalyanam Nagabhushanam , Beena Bhat , Geetha Kanhangad-Gangadharan , Susmitha Anand-Tathapudi , Pritee Paliwal
CPC classification number: A61Q7/00 , A61K8/37 , A61K8/4973 , A61K8/60 , A61K8/97 , A61K9/0014 , A61K9/08 , A61K31/235 , A61K31/365 , A61K31/366 , A61K31/7024 , A61K36/889 , A61K47/10 , A61K2800/592 , A61K2300/00
Abstract: Disclosed are novel protective compositions for dermal papilla cells. In an embodiment the protective compositions of the present invention comprise 0.25% w/w or above of compositions comprising at least 10% w/w and above of 1-O-galloyl-β-D-glucose (β-glucogallin). In an embodiment, the said protective composition additionally comprises 50% to greater than 50% gallates including mucic acid 1,4-lactone 5-O-gallate, mucic acid 2-O-gallate, mucic acid 6-Methyl ester 2-O-gallate, mucic acid 1-Methyl ester 2-O-gallate and ellagic acid. In another embodiment the invention also encompasses synergistic protective compositions comprising the said protective compositions and 0.5% concentrate of liquid endosperm of Cocos nucifera, for dermal papilla directed towards helping the dermal papilla cells to form sufficient numbers and to retain a healthy morphology conducive for hair growth.
Abstract translation: 公开了用于真皮乳头细胞的新型保护性组合物。 在一个实施方案中，本发明的保护性组合物包含0.25％w / w或更高含量的至少10％w / w及以上的1-O--酰基-β-葡萄糖（葡萄糖 - 葡糖苷）的组合物。 在一个实施方案中，所述保护性组合物另外包含50％至大于50％的没食子酸酯，包括粘酸1,4-内酯5-O-没食子酸酯，粘酸2-邻氯乙酸酯，粘酸6-甲酯2-O- 没食子酸酯，粘酸1-甲酯2-O-没食子酸酯和鞣花酸。 在另一个实施方案中，本发明还包括协同保护组合物，其包含所述保护性组合物和0.5％的Cocos Nucifera的液体胚乳浓缩液，用于促成真皮乳头细胞形成足够数量并保持有利于毛发生长的健康形态的真皮乳头 。
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Patent Agency Ranking
6.发明申请Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceuticals 有权用三萜类化合物和小有机分子修饰的肽：在化妆品中的合成和应用公开(公告)号：US20100034758A1
公开(公告)日：2010-02-11
申请号：US11835165
申请日：2007-08-07
Applicant: Muhammed Majeed , Renukeshwar H. Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
Inventor： Muhammed Majeed , Renukeshwar H. Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
Abstract: The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
Abstract translation: 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。
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7.发明申请Standardized method for recovering enriched Indian date extract (IDE), properties of IDE and applications thereof 审中-公开用于恢复富集的印度日期提取物（IDE）的标准化方法，IDE的属性及其应用公开(公告)号：US20080286387A1
公开(公告)日：2008-11-20
申请号：US11751033
申请日：2007-05-20
Applicant: Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Subbafakshmi Prakash , Susmitha Anand , Geetha Kanhangad Gangadharan
Inventor： Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Subbafakshmi Prakash , Susmitha Anand , Geetha Kanhangad Gangadharan
IPC: A61K36/889 , A61K131/00 , A61P13/08 , A61P35/00 , A61Q19/00 , C07H1/08
CPC classification number: A61K36/889 , A61K8/97 , A61K2800/92 , A61Q7/00 , A61Q19/008 , A61Q19/08
Abstract: Disclosed are (i) a standardized method for the recovery of the polyphenolic contents from the seed coats of Tamarindus indica L. (ii) a standardized polyphenolic extract (10%-90%) from the seed coat of Tamarindus indica L. (standardized Indian date extract) and uses thereof as oral/topical, “skin care” and “hair care” nutra-cosmetic formulations. The standardized Indian Date extract of the present invention exhibits anti-collagenase, anti-elastase, anti-5-alpha-reductase and anti-hyaluronidase activities. The standardized Indian date extract of the present invention is suitable for oral/topical, “skin care” and “hair care” nutra-cosmetic formulations either singly or as “cosmetic blends” with other carefully chosen natural plant actives.
Abstract translation: 公开的是（i）从罗望子the的种皮回收多酚含量的标准化方法。（ii）来自罗望子the的种皮的标准化多酚提取物（10％-90％）（标准印度 日期提取物）及其作为口服/局部用途的“护肤品”和“护发品”营养配方。 本发明的标准印度日本提取物显示抗胶原酶，抗弹性蛋白酶，抗5-α-还原酶和抗透明质酸酶活性。 本发明的标准印度日期提取物适合于单独的口服/局部，“护肤品”和“头发护理”营养配方，或与其他精心挑选的天然植物活性成分的“化妆品混合物”。
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公开(公告)号：US08247003B2
公开(公告)日：2012-08-21
申请号：US12537843
申请日：2009-08-07
Applicant: Muhammed Majeed , Kalyanam Nagabhushanam , Beena Bhat , Geetha Kanhangad-Gangadharan , Susmitha Anand-Tathapudi , Pritee Paliwal
Inventor： Muhammed Majeed , Kalyanam Nagabhushanam , Beena Bhat , Geetha Kanhangad-Gangadharan , Susmitha Anand-Tathapudi , Pritee Paliwal
IPC: A61K36/00
CPC classification number: A61Q7/00 , A61K8/37 , A61K8/4973 , A61K8/60 , A61K8/97 , A61K9/0014 , A61K9/08 , A61K31/235 , A61K31/365 , A61K31/366 , A61K31/7024 , A61K36/889 , A61K47/10 , A61K2800/592 , A61K2300/00
Abstract: Disclosed are novel protective compositions for dermal papilla cells. In an embodiment the protective compositions of the present invention comprise 0.25% w/w or above of compositions comprising at least 10% w/w and above of 1-O-galloyl-β-D-glucose (β-glucogallin). In an embodiment, the said protective composition additionally comprises 50% to greater than 50% gallates including mucic acid 1,4-lactone 5-O-gallate, mucic acid 2-O-gallate, mucic acid 6-Methyl ester 2-O-gallate, mucic acid 1-Methyl ester 2-O-gallate and ellagic acid. In another embodiment the invention also encompasses synergistic protective compositions comprising the said protective compositions and 0.5% concentrate of liquid endosperm of Cocos nucifera, for dermal papilla directed towards helping the dermal papilla cells to form sufficient numbers and to retain a healthy morphology conducive for hair growth.
Abstract translation: 公开了用于真皮乳头细胞的新型保护性组合物。 在一个实施方案中，本发明的保护性组合物包含0.25％w / w或更高含量的至少10％w / w及以上的1-O--酰基-β-葡萄糖（葡萄糖 - 葡糖苷）的组合物。 在一个实施方案中，所述保护性组合物另外包含50％至大于50％的没食子酸酯，包括粘酸1,4-内酯5-O-没食子酸酯，粘酸2-邻氯乙酸酯，粘酸6-甲酯2-O- 没食子酸酯，粘酸1-甲酯2-O-没食子酸酯和鞣花酸。 在另一个实施方案中，本发明还包括协同保护组合物，其包含所述保护性组合物和0.5％的Cocos Nucifera的液体胚乳浓缩液，用于促成真皮乳头细胞形成足够数量并保持有利于毛发生长的健康形态的真皮乳头 。
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9.发明申请COMPOSITION AND A METHOD OF TREATING CNS DISORDERS AND HYPERPIGMENTATION 审中-公开组合物和治疗中枢神经系统疾病和高血压的方法公开(公告)号：US20120088841A1
公开(公告)日：2012-04-12
申请号：US12900727
申请日：2010-10-08
Applicant: Muhammed Majeed , Sarang Bani , Anjali Pandey , Susmitha Anand-Tathapudi
Inventor： Muhammed Majeed , Sarang Bani , Anjali Pandey , Susmitha Anand-Tathapudi
Abstract: The present invention relates to a method of treating CNS disorders, particularly Alzheimer's disease. The method comprise step of administering to a subject in need thereof a therapeutically effective amount of hydroxychavicol and/or its derivatives or a composition comprising hydroxychavicol and/or its derivatives optionally along with pharmaceutically acceptable excipients. The invention also relates to use of hydroxychavicol and/or its derivatives for treating hyperpigmentation.
Abstract translation: 本发明涉及一种治疗CNS病症，特别是阿尔茨海默氏病的方法。 该方法包括向有需要的受试者施用治疗有效量的羟基查考唑和/或其衍生物或包含任选地与药学上可接受的赋形剂的包含羟基查韦可和/或其衍生物的组合物的步骤。 本发明还涉及羟基茶多酚和/或其衍生物用于治疗色素沉着过度的用途。
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10.发明申请OLEANOYL PEPTIDE COMPOSITION AND A METHOD OF TREATING SKIN AGING 有权OLEANOYL PEPTIDE COMPOSITION和一种治疗皮肤老化的方法公开(公告)号：US20110091398A1
公开(公告)日：2011-04-21
申请号：US12979667
申请日：2010-12-28
Applicant: Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
Inventor： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
CPC classification number: A61K8/64 , A61K2800/57 , A61K2800/78 , A61Q19/00 , A61Q19/007 , A61Q19/04 , A61Q19/08 , C07K7/06
Abstract: The present invention relates to a composition containing peptide of SEQ ID No. 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.
Abstract translation: 本发明涉及与齐墩果酸连接的含有SEQ ID No.1的肽的组合物和治疗皮肤老化的方法。 该组合物有效地减少由于氧化，胶原蛋白不足和丝氨酸蛋白酶如弹性蛋白酶和胶原酶的过度活动导致皮肤皱纹，细纹，减少皮肤厚度，色素沉着过度，眼睛黑眼圈和过早老化等现象。
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