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公开(公告)号：US20060062821A1
公开(公告)日：2006-03-23
申请号：US11218654
申请日：2005-09-02
Applicant: Murthy Simhambhatla , Ni Ding , Stephen Pacetti
Inventor： Murthy Simhambhatla , Ni Ding , Stephen Pacetti
IPC: A61F13/00
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/606 , A61L2300/622 , A61L2300/626 , C08L77/04
Abstract: Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.
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公开(公告)号：US08747385B2
公开(公告)日：2014-06-10
申请号：US13468956
申请日：2012-05-10
Applicant: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
Inventor： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC: A61M31/00
CPC classification number: A61K9/0019 , A61K9/0024 , A61K31/7088
Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
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公开(公告)号：US08821473B2
公开(公告)日：2014-09-02
申请号：US12632612
申请日：2009-12-07
Applicant: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
Inventor： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC: A61M31/00 , A61K31/7088 , A61K9/00
CPC classification number: A61K9/0019 , A61K9/0024 , A61K31/7088
Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US08383158B2
公开(公告)日：2013-02-26
申请号：US10414602
申请日：2003-04-15
Applicant: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
Inventor： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC: A61K9/14
CPC classification number: A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.
Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些试剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US20100144635A1
公开(公告)日：2010-06-10
申请号：US12632612
申请日：2009-12-07
Applicant: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
Inventor： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
CPC classification number: A61K9/0019 , A61K9/0024 , A61K31/7088
Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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Patent Agency Ranking
公开(公告)号：US20070298354A1
公开(公告)日：2007-12-27
申请号：US11820560
申请日：2007-06-19
Applicant: Ni Ding , Gene Michal , Stephen Pacetti
Inventor： Ni Ding , Gene Michal , Stephen Pacetti
CPC classification number: A61L31/16 , A61L31/084 , A61L2300/606
Abstract: A carbon coating on a stent having a bioactive agent covalently attached thereto and methods of making the same are described.
Abstract translation: 描述了具有共价连接于其上的生物活性剂的支架上的碳涂层及其制备方法。
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公开(公告)号：US20060198897A1
公开(公告)日：2006-09-07
申请号：US11213288
申请日：2005-08-26
Applicant: Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
Inventor： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
CPC classification number: A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
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公开(公告)号：US20060018944A1
公开(公告)日：2006-01-26
申请号：US11213290
申请日：2005-08-26
Applicant: Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
Inventor： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
IPC: A61K31/727 , A61F13/00
CPC classification number: A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
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9.发明授权公开(公告)号：US07989018B2
公开(公告)日：2011-08-02
申请号：US11395014
申请日：2006-03-31
Applicant: Andrew F. McNiven , Thomas D. Esbeck , Ni Ding , Stephen Pacetti , Syed F. A. Hossainy
Inventor： Andrew F. McNiven , Thomas D. Esbeck , Ni Ding , Stephen Pacetti , Syed F. A. Hossainy
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/602 , B05D3/107
Abstract: A method for modifying a polymeric coating on an implantable medical device, such as a stent, is disclosed. The method includes application of a fluid to a wet or dry polymeric coating with and without drugs.
Abstract translation: 公开了一种用于修改可植入医疗装置（例如支架）上的聚合物涂层的方法。 该方法包括将液体施用于具有和不具有药物的湿或干燥聚合物涂层。
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公开(公告)号：US20070059434A1
公开(公告)日：2007-03-15
申请号：US11592632
申请日：2006-11-02
Applicant: Wouter Roorda , Syed Hossainy , Ni Ding , Fuh-Wei Tang , Stephen Pacetti
Inventor： Wouter Roorda , Syed Hossainy , Ni Ding , Fuh-Wei Tang , Stephen Pacetti
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08
Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
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