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公开(公告)号：US20100256226A1
公开(公告)日：2010-10-07
申请号：US12760354
申请日：2010-04-14
CPC分类号： A61K39/3955 , A61K38/00 , A61K38/1808 , C07K14/52 , C07K16/22 , C07K2317/76 , G01N33/74 , G01N2500/00
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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公开(公告)号：US20100254999A1
公开(公告)日：2010-10-07
申请号：US12724964
申请日：2010-03-16
IPC分类号： A61K39/395 , A61K38/18 , A61P35/00 , A61P5/00
CPC分类号： C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
摘要翻译： 本发明涉及本文称为EG-VEGF的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了筛选EG-VEGF调节剂的方法。 此外，本文描述了涉及调节细胞增殖和趋化性的方法和相关的治疗方法。
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公开(公告)号：US20070122412A1
公开(公告)日：2007-05-31
申请号：US11537382
申请日：2006-09-29
申请人： NAPOLEONE FERRARA , Colin Watanabe , William Wood
发明人： NAPOLEONE FERRARA , Colin Watanabe , William Wood
IPC分类号： A61K39/395 , A61K38/18 , A61K48/00
CPC分类号： C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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公开(公告)号：US20070244063A1
公开(公告)日：2007-10-18
申请号：US11536880
申请日：2006-09-29
IPC分类号： A61K31/711 , A61K31/00 , A61P15/00 , C12N5/08 , C12Q1/18 , C12N5/06 , A61K31/7105
CPC分类号： G01N33/5064 , A61K38/00 , C07K14/475 , G01N2500/00
摘要： The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.
摘要翻译： 本发明提供使用Bv8多肽诱导内皮细胞增殖并增强内皮细胞存活的方法。 本文还提供筛选Bv8活性调节剂的方法。 此外，提供了使用Bv8多肽的治疗方法。
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5.发明申请VEGF-SPECIFIC ANTAGONISTS FOR ADJUVANT AND NEOADJUVANT THERAPY AND THE TREATMENT OF EARLY STAGE TUMORS 审中-公开VEGF特异性拮抗剂用于治疗和治疗早期治疗和早期阶段肿瘤公开(公告)号：US20110052576A1
公开(公告)日：2011-03-03
申请号：US12826001
申请日：2010-06-29
IPC分类号： A61K39/395 , A61K31/7088 , A61K31/713 , A61K39/00 , A61P35/00
CPC分类号： C07K16/22 , A61K38/179 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Disclosed herein are methods of treating benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating a subject at risk of developing benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating or preventing recurrence of a tumor using an anti-VEGF-specific antagonist as well as use of VEGF-specific antagonists in neoadjuvant and adjuvant cancer therapy.
摘要翻译： 本文公开了使用抗VEGF特异性拮抗剂治疗良性，癌前或非转移性肿瘤的方法。 还公开了使用抗VEGF特异性拮抗剂治疗患有发展良性，癌前或非转移性肿瘤的风险的受试者的方法。 还公开了使用抗VEGF特异性拮抗剂治疗或预防肿瘤复发以及在新辅助和辅助癌症治疗中使用VEGF特异性拮抗剂的方法。
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公开(公告)号：US20100310555A1
公开(公告)日：2010-12-09
申请号：US12611397
申请日：2009-11-03
IPC分类号： A61K39/395 , A61K38/17 , A61K31/713 , A61P3/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/12 , A61P35/02
CPC分类号： A61K39/3955 , A61K38/02 , A61K38/1866 , A61K38/1891 , C12N5/0669
摘要： The present invention provides methods of using Bv8 and EG-VEGF polypeptides and nucleic acids to promote hematopoiesis. Also provided herein are methods of screening for modulators of Bv8 and EG-VEGF activity. Furthermore, methods of treatment using Bv8 and EG-VEGF polypeptides or Bv8 and EG-VEGF antagonists are provided.
摘要翻译： 本发明提供使用Bv8和EG-VEGF多肽和核酸促进造血作用的方法。 本文还提供筛选Bv8和EG-VEGF活性调节剂的方法。 此外，提供了使用Bv8和EG-VEGF多肽或Bv8和EG-VEGF拮抗剂的治疗方法。
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