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    Sensitizer for tumor treatment
    1.
    发明授权
    Sensitizer for tumor treatment 有权
    敏化剂用于肿瘤治疗

    公开(公告)号：US06572839B2

    公开(公告)日：2003-06-03

    申请号：US09801844

    申请日：2001-03-09

    申请人： Nami Sugita ,  Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki ,  Isao Sakata

    发明人： Nami Sugita ,  Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki ,  Isao Sakata

    IPC分类号： A61B800

    CPC分类号： A61K31/353 ,  A61B8/4444 ,  A61N7/00 ,  C07D311/86

    摘要： A sensitizer for tumor treatment has a structure such that a lipophilic group and a hydrophilic group are bound to one and the same carbon atom in a compound containing a xanthene dye structure. It is important that the lipophilic group and hydrophilic group are bound to one and the same carbon atom; if they are separated from each other, no sufficient effect is obtained. Thus, the sensitizer possesses both lipophilicity and hydrophilicity. This sensitizer has a function of promoting acoustic cavitation and a function of revealing an antitumor effect and is an agent highly accumulable in tumor tissues. Thus, this sensitizer is highly selective for tumor tissues and enables the treatment of malignant tumor using ultrasound.

    摘要翻译： 用于肿瘤治疗的敏化剂具有使亲油基团和亲水基团与含有呫吨染料结构的化合物中的同一个碳原子结合的结构。 重要的是亲脂基团和亲水基团与同一个碳原子结合; 如果它们彼此分离，则不能获得足够的效果。 因此，敏化剂具有亲油性和亲水性。 这种敏化剂具有促进声孔的功能和显示抗肿瘤作用的功能，并且是在肿瘤组织中高度累积的药剂。 因此，这种敏化剂对于肿瘤组织是高度选择性的并且能够使用超声治疗恶性肿瘤。

    METHOD FOR FABRICATING SUBSTRATE FOR SOLAR CELL AND SOLAR CELL
    2.
    发明申请
    METHOD FOR FABRICATING SUBSTRATE FOR SOLAR CELL AND SOLAR CELL 审中-公开
    用于制造太阳能电池和太阳能电池基板的方法

    公开(公告)号：US20130306148A1

    公开(公告)日：2013-11-21

    申请号：US13982104

    申请日：2012-01-27

    申请人： Hidetaka Takato ,  Isao Sakata ,  Keiji Mase ,  Shozo Ishibashi ,  Takayuki Harada ,  Yoichi Kondo ,  Hideyuki Asai

    发明人： Hidetaka Takato ,  Isao Sakata ,  Keiji Mase ,  Shozo Ishibashi ,  Takayuki Harada ,  Yoichi Kondo ,  Hideyuki Asai

    IPC分类号： H01L31/0236

    CPC分类号： H01L31/02363 ,  B28D5/045 ,  H01L21/02381 ,  H01L21/02658 ,  Y02E10/50

    摘要： The problem addressed by the present invention is providing a technique for fabricating, by a method simpler than conventional methods, a silicon substrate that is effective for light trapping, one surface of which has a textured structure and the other surface of which has higher reflectivity than the surface having the textured structure. The fabrication method for this semiconductor substrate comprises: a sandblasting step in which a first surface of a silicon substrate in an as-sliced state, fabricated by slicing a silicon ingot, is surface treated by sandblasting and, after the sandblasting step, a step for carrying out surface treatment using an etching solution that contains either or both of hydrofluoric acid and nitric acid on the silicon substrate.

    摘要翻译： 本发明所解决的问题是提供一种通过比传统方法简单的方法制造对于光捕获有效的硅衬底的技术，其一个表面具有纹理结构，另一个表面的反射率比 该表面具有纹理结构。 该半导体衬底的制造方法包括：喷砂步骤，通过喷砂表面处理以硅锭切片制成的切片状态的硅衬底的第一表面，并且在喷砂步骤之后， 使用在硅衬底上含有氢氟酸和硝酸中的任一种或两者的蚀刻溶液进行表面处理。

    Nitroimidazole substituted porphyrin complex
    4.
    发明授权
    Nitroimidazole substituted porphyrin complex 失效
    硝基咪唑取代卟啉络合物

    公开(公告)号：US06548045B2

    公开(公告)日：2003-04-15

    申请号：US09889778

    申请日：2001-07-20

    申请人： Isao Sakata ,  Susumu Nakajima ,  Yoshinori Nakae

    发明人： Isao Sakata ,  Susumu Nakajima ,  Yoshinori Nakae

    IPC分类号： C07D48722

    CPC分类号： C07D487/22 ,  A61K41/0038 ,  A61K49/06 ,  A61K49/085 ,  A61K49/10

    摘要： The present invention provides the porphyrin compound having nitroimidazole in the molecule, which is used for diagnosis and/or treatment of cancer in magnetic resonance imaging (MRI) and/or radiotherapy as well as for DDS therapy. The porphyrin compound of the present invention shows no phototoxicity, and represented by the following formula: [wherein, R1 and R2 are —CH═CH2 or —CH(CH3)—OH, —CH(CH3)—O—(CH2)n—NH—Ra; R3 is hydrogen atom or —CO—(CH2)m—COOH; and M is transition metal of Mn, Fe, Co or Cu], (in which, Ra is hydrogen atom or the group represented by the following formula: n and m are the integer 2 or 3), or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了在分子中具有硝基咪唑的卟啉化合物，其用于诊断和/或治疗磁共振成像（MRI）和/或放射治疗以及DDS治疗中的癌症。 本发明的卟啉化合物不显示光毒性，由下式表示：[其中，R 1和R 2为-CH = CH 2或-CH（CH 3）-OH，-CH（CH 3）-O-（CH 2）n -NH-R a; R 3是氢原子或-CO-（CH 2）m -COOH; 和Mn是Mn，Fe，Co或Cu的过渡金属]（其中，Ra是氢原子或由下式表示的基团：n和m是整数2或3）或其药学上可接受的盐。

    Process for manufacturing high-resilient flexible urethan foams
    5.
    发明授权
    Process for manufacturing high-resilient flexible urethan foams 失效
    制造高弹性柔性聚氨酯泡沫的方法

    公开(公告)号：US4119582A

    公开(公告)日：1978-10-10

    申请号：US656979

    申请日：1976-02-10

    申请人： Kiyoshi Matsubara ,  Yuichi Nomura ,  Tadashi Yatomi ,  Tadashi Hamamura ,  Isao Noda ,  Terumi Watanabe ,  Takao Nomura ,  Isao Sakata

    发明人： Kiyoshi Matsubara ,  Yuichi Nomura ,  Tadashi Yatomi ,  Tadashi Hamamura ,  Isao Noda ,  Terumi Watanabe ,  Takao Nomura ,  Isao Sakata

    IPC分类号： C08G18/00 ,  C08G18/63 ,  C08G18/76 ,  C08K5/54

    CPC分类号： C08G18/632 ,  C08G18/7607 ,  Y10S521/904

    摘要： A process for manufacturing high-resilient flexible urethan foams characterized by, reacting and foaming polyalkylene ether polyol and an organic polyisocyanate in the presence of a blowing agent, a surfactant and catalyst, (1) using as said polyalkylene ether polyol one which contains 2 to 10% by weight of a vinyl type polymer and in which its hydroxyl number ranges from 25 to 60 mg KOH/g, of its hydroxyl groups 20 to 70 mol% are primary hydroxyl groups and the remaining hydroxyl groups are secondary hydroxyl groups; (2) using as said organic polyisocyanate a mixture of tolylene diisocyanate with diphenylmethane diisocyanate or a crude diphenylmethane diisocyanate; and (3) using as said surfactant a mixture of a high-molecular-weight siloxane-oxyalkylene copolymer with a low-molecular-weight siloxane-oxyalkylene copolymer.

    摘要翻译： 其特征在于在发泡剂，表面活性剂和催化剂的存在下使聚亚烷基醚多元醇和有机多异氰酸酯反应并发泡，（1）使用含有2〜2个碳原子的聚亚烷基醚多元醇， 10重量％的乙烯基型聚合物，其羟值范围为25至60mg KOH / g，其羟基为20至70mol％为伯羟基，剩余的羟基为仲羟基; （2）使用甲苯二异氰酸酯与二苯基甲烷二异氰酸酯或粗二苯基甲烷二异氰酸酯的混合物作为有机多异氰酸酯; 和（3）使用高分子量硅氧烷 - 氧化烯共聚物与低分子量硅氧烷 - 氧化烯共聚物的混合物作为表面活性剂。

    Method for Treating Body Fluid
    7.
    发明申请
    Method for Treating Body Fluid 审中-公开
    治疗体液的方法

    公开(公告)号：US20090280549A1

    公开(公告)日：2009-11-12

    申请号：US11919247

    申请日：2006-04-26

    申请人： Hiroshi Takei ,  Sumio Minematsu ,  Sueo Miyaki ,  Shinichi Fujisaka ,  Isao Sakata ,  Yoshinori Nakae

    发明人： Hiroshi Takei ,  Sumio Minematsu ,  Sueo Miyaki ,  Shinichi Fujisaka ,  Isao Sakata ,  Yoshinori Nakae

    IPC分类号： C12N13/00

    CPC分类号： A61K41/0019 ,  A61K31/409 ,  A61K41/0071

    摘要： The invention provides a body fluid treatment method for selective ex vivo killing of malignant lymphoma cells, leukemia cells or activated macrophages in a body fluid, the body fluid treatment method comprising: an addition step wherein a compound represented by formula (I) below is added to a body fluid containing malignant lymphoma cells, leukemia cells or activated macrophages that has been removed from the body, to yield an addition mixture; and an excitation step wherein the addition mixture is irradiated with excitation light to excite the compound. According to the invention, there is provided a method for selective ex vivo killing of malignant lymphoma cells, leukemia cells or activated macrophages in a body fluid while avoiding adverse effects on normal cells.

    摘要翻译： 本发明提供了一种体液治疗方法，其用于选择性地体外杀死体液中的恶性淋巴瘤细胞，白血病细胞或活化的巨噬细胞，所述体液治疗方法包括：添加步骤，其中加入由下式（I）表示的化合物 包含已经从体内除去的恶性淋巴瘤细胞，白血病细胞或活化的巨噬细胞的体液，以产生加成混合物; 和激发步骤，其中加入的混合物用激发光照射以激发该化合物。 根据本发明，提供了选择性地离体杀死体液中的恶性淋巴瘤细胞，白血病细胞或活化的巨噬细胞的方法，同时避免对正常细胞的不利影响。

    Motorcycle
    8.
    外观设计
    Motorcycle 有权

    公开(公告)号：USD559155S1

    公开(公告)日：2008-01-08

    申请号：US29273627

    申请日：2007-03-09

    申请人： Isao Sakata

    设计人： Isao Sakata

    Motorcycle
    10.
    外观设计
    Motorcycle 有权

    公开(公告)号：USD755084S1

    公开(公告)日：2016-05-03

    申请号：US29512484

    申请日：2014-12-19

    申请人： Isao Sakata

    设计人： Isao Sakata