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公开(公告)号：US06572839B2
公开(公告)日：2003-06-03
申请号：US09801844
申请日：2001-03-09
IPC分类号： A61B800
CPC分类号： A61K31/353 , A61B8/4444 , A61N7/00 , C07D311/86
摘要： A sensitizer for tumor treatment has a structure such that a lipophilic group and a hydrophilic group are bound to one and the same carbon atom in a compound containing a xanthene dye structure. It is important that the lipophilic group and hydrophilic group are bound to one and the same carbon atom; if they are separated from each other, no sufficient effect is obtained. Thus, the sensitizer possesses both lipophilicity and hydrophilicity. This sensitizer has a function of promoting acoustic cavitation and a function of revealing an antitumor effect and is an agent highly accumulable in tumor tissues. Thus, this sensitizer is highly selective for tumor tissues and enables the treatment of malignant tumor using ultrasound.
摘要翻译： 用于肿瘤治疗的敏化剂具有使亲油基团和亲水基团与含有呫吨染料结构的化合物中的同一个碳原子结合的结构。 重要的是亲脂基团和亲水基团与同一个碳原子结合; 如果它们彼此分离，则不能获得足够的效果。 因此，敏化剂具有亲油性和亲水性。 这种敏化剂具有促进声孔的功能和显示抗肿瘤作用的功能，并且是在肿瘤组织中高度累积的药剂。 因此，这种敏化剂对于肿瘤组织是高度选择性的并且能够使用超声治疗恶性肿瘤。
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公开(公告)号：US07824336B2
公开(公告)日：2010-11-02
申请号：US11336849
申请日：2006-01-23
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/481 , A61B2090/378 , A61N7/02
摘要： An ultrasonic apparatus for diagnosis and therapy is provided with plural ultrasound probes for generating ultrasound waves for phase shift, diagnosis, and therapy. A first control part causes phase shift in a nano droplet ultrasound contrast agent, while a second control part detects the phase shift of the nano droplet ultrasound contrast agent using ultrasound echo detected by an echo detection device. A difference calculation device calculates a difference of the detected phase shift over time, and a positioning device determines a target position where the difference is produced. A third control part is also provided for exposing a decided target area to the ultrasound waves for therapy.
摘要翻译： 用于诊断和治疗的超声波装置设置有用于产生用于相移，诊断和治疗的超声波的多个超声波探头。 第一控制部分引起纳米液滴超声造影剂中的相移，而第二控制部分使用由回波检测装置检测的超声回波来检测纳米液滴超声造影剂的相移。 差分计算装置计算检测到的相移随时间的差异，并且定位装置确定产生差异的目标位置。 还提供了第三控制部件，用于将决定的目标区域暴露于用于治疗的超声波。
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公开(公告)号：US07125387B2
公开(公告)日：2006-10-24
申请号：US10368436
申请日：2003-02-20
CPC分类号： A61N7/00 , A61N2007/0078
摘要： According to the invention, an ultrasonic apparatus for therapeutical use suitable for remedy by the irradiation of an ultrasonic wave low in the degree of convergence using medicine that stays in a disease region, reduces the threshold of cavitation caused by an ultrasonic wave and secondarily generates active oxygen by the acoustic cavitation caused by the ultrasonic wave is provided. The ultrasonic apparatus for therapeutical use is provided with a belt wearable in a position (on the abdomen of a patient) that surrounds a diseased part and unit ultrasonic radiators can be mounted in an arbitrary position of the belt.
摘要翻译： 根据本发明，适用于通过使用滞留在疾病区域中的药物的收敛度低的超声波的照射来治疗的超声波装置降低了由超声波引起的空穴阈值，并且二次生成活动 提供了由超声波引起的声空化的氧。 用于治疗用的超声波设备设置有可佩戴在患者部分周围的位置（患者的腹部）的皮带，并且单元超声波辐射器可以安装在皮带的任意位置。
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公开(公告)号：US20070016042A1
公开(公告)日：2007-01-18
申请号：US11336849
申请日：2006-01-23
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/481 , A61B2090/378 , A61N7/02
摘要： The ultrasonic apparatus for a diagnosis and therapy includes: a first ultrasound probe, a second ultrasound probe, and an ultrasound exposure apparatus for exposing ultrasounds for a phase shift, diagnosis, and therapy, respectively; an echo detection device for detecting an ultrasound echo; control parts for the phase shift for causing the shift in an ultrasound contrast agent by exposing the ultrasound for the shift through the first device, and for the diagnosis for detecting the shift of the agent, using the echo detected by the detection device, corresponding to an exposure of the ultrasound for the diagnosis by the second device; a difference calculation device for calculating a difference over time of the shift detected by the control part for the diagnosis; a device for positioning for deciding a target position where the difference is produced; and a control part for the therapy for exposing the ultrasound for the therapy to the decided target position through the exposure apparatus.
摘要翻译： 用于诊断和治疗的超声波装置分别包括：第一超声波探头，第二超声波探头和用于分别暴露超声波用于相移，诊断和治疗的超声波曝光装置; 用于检测超声回波的回波检测装置; 用于通过使超声波暴露于第一装置的移位而引起超声造影剂移位的相移的控制部件，以及使用由检测装置检测到的回波来检测试剂的移位的诊断，对应于 超声波对第二装置进行诊断的曝光; 差分计算装置，用于计算由用于诊断的控制部分检测到的位移的时间差; 用于确定产生差异的目标位置的定位装置; 以及用于通过曝光装置将用于治疗的超声波暴露于所确定的目标位置的治疗的控制部分。
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公开(公告)号：US08460191B2
公开(公告)日：2013-06-11
申请号：US11914962
申请日：2006-05-18
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译： 一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。
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6.发明授权公开(公告)号：US07074427B2
公开(公告)日：2006-07-11
申请号：US10198178
申请日：2002-07-19
CPC分类号： A61K41/0033
摘要： A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is to be used in combination with ultrasonic irradiation, comprises a shell within the internal space of which a gas is enclosed and which contains or retains a substance capable of generating active oxygen species upon ultrasonic irradiation of the shell.
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公开(公告)号：US06511428B1
公开(公告)日：2003-01-28
申请号：US09830423
申请日：2001-04-26
申请人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
发明人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B8/12 , A61B2017/00154 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , A61B2090/3782
摘要： An ultrasound therapy apparatus delivers focused ultrasound for therapeutical purposes which can be correctly targeted to a target region, and also, a positional shift from the target region under irradiation of ultrasound can be effectively avoided. An ultrasound transducer is inside an applicator with an imaging ultrasonic probe. Another ultrasound transducer monitors a position of a target and a positional shift is inside a catheter which is inserted into a urethral tube. An imaging system drives the ultrasound probe to display an ultrasound tomographic image of a region in the vicinity of a target region. The ultrasound transducer is driven in a pulse-shaped mode at the same frequency as the imaging ultrasound and also at such timing when the imaging ultrasound is reached. As a result, a point-shaped sound source image is superimposed and displayed on an ultrasound tomographic image.
摘要翻译： 超声治疗装置将聚焦超声波提供给治疗目的，可以正确地瞄准目标区域，并且可以有效地避免从超声照射下的目标区域的位置偏移。 超声波换能器在具有成像超声波探头的施加器内部。 另一个超声波传感器监测目标的位置，位置偏移在插入尿道管内的导管内。 成像系统驱动超声波探头以显示目标区域附近的区域的超声断层图像。 超声波换能器以与成像超声相同的频率以及在达到成像超声的这种定时以脉冲模式驱动。 结果，点状声源图像被叠加并显示在超声断层图像上。
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公开(公告)号：US20090048516A1
公开(公告)日：2009-02-19
申请号：US11914962
申请日：2006-05-18
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译： 一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。
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公开(公告)号：US20080311046A1
公开(公告)日：2008-12-18
申请号：US11658591
申请日：2005-08-04
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe.
摘要翻译： 由至少一种低沸点水不溶性物质（沸点低于37℃）和至少一种高沸点水不溶性物质（沸点高于 37℃）。 前者在施加超声波时蒸发以吸收超声能量，从而使后者二次蒸发，产生的回波图像产生气泡。 它不太容易碰撞，因此安全。
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公开(公告)号：US08323620B2
公开(公告)日：2012-12-04
申请号：US11658591
申请日：2005-08-04
IPC分类号： A61B8/00
CPC分类号： A61K49/223
摘要： An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe.
摘要翻译： 由至少一种低沸点水不溶性物质（沸点低于37℃）和至少一种高沸点水不溶性物质（沸点高于 37℃）。 前者在施加超声波时蒸发以吸收超声能量，从而使后者二次蒸发，产生的回波图像产生气泡。 它不太容易碰撞，因此安全。
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