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公开(公告)号：US06572839B2
公开(公告)日：2003-06-03
申请号：US09801844
申请日：2001-03-09
IPC分类号： A61B800
CPC分类号： A61K31/353 , A61B8/4444 , A61N7/00 , C07D311/86
摘要： A sensitizer for tumor treatment has a structure such that a lipophilic group and a hydrophilic group are bound to one and the same carbon atom in a compound containing a xanthene dye structure. It is important that the lipophilic group and hydrophilic group are bound to one and the same carbon atom; if they are separated from each other, no sufficient effect is obtained. Thus, the sensitizer possesses both lipophilicity and hydrophilicity. This sensitizer has a function of promoting acoustic cavitation and a function of revealing an antitumor effect and is an agent highly accumulable in tumor tissues. Thus, this sensitizer is highly selective for tumor tissues and enables the treatment of malignant tumor using ultrasound.
摘要翻译： 用于肿瘤治疗的敏化剂具有使亲油基团和亲水基团与含有呫吨染料结构的化合物中的同一个碳原子结合的结构。 重要的是亲脂基团和亲水基团与同一个碳原子结合; 如果它们彼此分离，则不能获得足够的效果。 因此，敏化剂具有亲油性和亲水性。 这种敏化剂具有促进声孔的功能和显示抗肿瘤作用的功能，并且是在肿瘤组织中高度累积的药剂。 因此，这种敏化剂对于肿瘤组织是高度选择性的并且能够使用超声治疗恶性肿瘤。
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公开(公告)号：US20070016042A1
公开(公告)日：2007-01-18
申请号：US11336849
申请日：2006-01-23
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/481 , A61B2090/378 , A61N7/02
摘要： The ultrasonic apparatus for a diagnosis and therapy includes: a first ultrasound probe, a second ultrasound probe, and an ultrasound exposure apparatus for exposing ultrasounds for a phase shift, diagnosis, and therapy, respectively; an echo detection device for detecting an ultrasound echo; control parts for the phase shift for causing the shift in an ultrasound contrast agent by exposing the ultrasound for the shift through the first device, and for the diagnosis for detecting the shift of the agent, using the echo detected by the detection device, corresponding to an exposure of the ultrasound for the diagnosis by the second device; a difference calculation device for calculating a difference over time of the shift detected by the control part for the diagnosis; a device for positioning for deciding a target position where the difference is produced; and a control part for the therapy for exposing the ultrasound for the therapy to the decided target position through the exposure apparatus.
摘要翻译： 用于诊断和治疗的超声波装置分别包括：第一超声波探头，第二超声波探头和用于分别暴露超声波用于相移，诊断和治疗的超声波曝光装置; 用于检测超声回波的回波检测装置; 用于通过使超声波暴露于第一装置的移位而引起超声造影剂移位的相移的控制部件，以及使用由检测装置检测到的回波来检测试剂的移位的诊断，对应于 超声波对第二装置进行诊断的曝光; 差分计算装置，用于计算由用于诊断的控制部分检测到的位移的时间差; 用于确定产生差异的目标位置的定位装置; 以及用于通过曝光装置将用于治疗的超声波暴露于所确定的目标位置的治疗的控制部分。
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公开(公告)号：US07824336B2
公开(公告)日：2010-11-02
申请号：US11336849
申请日：2006-01-23
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/481 , A61B2090/378 , A61N7/02
摘要： An ultrasonic apparatus for diagnosis and therapy is provided with plural ultrasound probes for generating ultrasound waves for phase shift, diagnosis, and therapy. A first control part causes phase shift in a nano droplet ultrasound contrast agent, while a second control part detects the phase shift of the nano droplet ultrasound contrast agent using ultrasound echo detected by an echo detection device. A difference calculation device calculates a difference of the detected phase shift over time, and a positioning device determines a target position where the difference is produced. A third control part is also provided for exposing a decided target area to the ultrasound waves for therapy.
摘要翻译： 用于诊断和治疗的超声波装置设置有用于产生用于相移，诊断和治疗的超声波的多个超声波探头。 第一控制部分引起纳米液滴超声造影剂中的相移，而第二控制部分使用由回波检测装置检测的超声回波来检测纳米液滴超声造影剂的相移。 差分计算装置计算检测到的相移随时间的差异，并且定位装置确定产生差异的目标位置。 还提供了第三控制部件，用于将决定的目标区域暴露于用于治疗的超声波。
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公开(公告)号：US07125387B2
公开(公告)日：2006-10-24
申请号：US10368436
申请日：2003-02-20
CPC分类号： A61N7/00 , A61N2007/0078
摘要： According to the invention, an ultrasonic apparatus for therapeutical use suitable for remedy by the irradiation of an ultrasonic wave low in the degree of convergence using medicine that stays in a disease region, reduces the threshold of cavitation caused by an ultrasonic wave and secondarily generates active oxygen by the acoustic cavitation caused by the ultrasonic wave is provided. The ultrasonic apparatus for therapeutical use is provided with a belt wearable in a position (on the abdomen of a patient) that surrounds a diseased part and unit ultrasonic radiators can be mounted in an arbitrary position of the belt.
摘要翻译： 根据本发明，适用于通过使用滞留在疾病区域中的药物的收敛度低的超声波的照射来治疗的超声波装置降低了由超声波引起的空穴阈值，并且二次生成活动 提供了由超声波引起的声空化的氧。 用于治疗用的超声波设备设置有可佩戴在患者部分周围的位置（患者的腹部）的皮带，并且单元超声波辐射器可以安装在皮带的任意位置。
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公开(公告)号：US20080311046A1
公开(公告)日：2008-12-18
申请号：US11658591
申请日：2005-08-04
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe.
摘要翻译： 由至少一种低沸点水不溶性物质（沸点低于37℃）和至少一种高沸点水不溶性物质（沸点高于 37℃）。 前者在施加超声波时蒸发以吸收超声能量，从而使后者二次蒸发，产生的回波图像产生气泡。 它不太容易碰撞，因此安全。
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公开(公告)号：US08323620B2
公开(公告)日：2012-12-04
申请号：US11658591
申请日：2005-08-04
IPC分类号： A61B8/00
CPC分类号： A61K49/223
摘要： An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe.
摘要翻译： 由至少一种低沸点水不溶性物质（沸点低于37℃）和至少一种高沸点水不溶性物质（沸点高于 37℃）。 前者在施加超声波时蒸发以吸收超声能量，从而使后者二次蒸发，产生的回波图像产生气泡。 它不太容易碰撞，因此安全。
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公开(公告)号：US07993581B2
公开(公告)日：2011-08-09
申请号：US11006757
申请日：2004-12-08
申请人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
发明人： Yusuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
IPC分类号： G01N1/36 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.
摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。
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公开(公告)号：US20050202572A1
公开(公告)日：2005-09-15
申请号：US11006757
申请日：2004-12-08
申请人： Yasuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
发明人： Yasuke Seki , Akira Tsukamoto , Daisuke Suzuki , Masahiro Yamaoka , Nami Sugita , Akihiko Kandori , Kazuo Saitoh
IPC分类号： G01N33/53 , G01N27/72 , G01N33/542 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.
摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。
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公开(公告)号：US07780598B2
公开(公告)日：2010-08-24
申请号：US11476866
申请日：2006-06-29
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61M37/0092 , A61N7/00
摘要： In a sonodynamic treatment apparatus including: a first ultrasound radiating unit for radiating diagnostic ultrasound; a second ultrasound radiating unit for radiating treatment ultrasound; an echo detection unit for detecting an ultrasound echo; a diagnostic controller for radiating the diagnostic ultrasound with the first ultrasound radiating unit and detecting the ultrasound echo corresponding the diagnostic ultrasound; an echographic controller for processing an echographic image on the basis of the detected ultrasound echo; and a treatment controller for radiating the treatment ultrasound with the second ultrasound radiating unit, radiation of the treatment ultrasound with the second ultrasound radiating unit is controlled to have a predetermined exposure duration and a predetermined pause duration of the treatment ultrasound, and the echographic image is generated on the basis of the ultrasound echo during the pause duration of the treatment ultrasound exposure with the diagnostic image generator. The treatment ultrasound may be weakened after detection of a bubble generated by the treatment ultrasound.
摘要翻译： 一种声动治疗装置，包括：用于放射诊断超声的第一超声波辐射单元; 用于放射治疗超声波的第二超声波辐射单元; 用于检测超声回波的回波检测单元; 诊断控制器，用于利用所述第一超声波辐射单元辐射所述诊断超声波，并且检测对应于所述诊断超声的超声回波; 基于检测到的超声回波来处理回波图像的回波记录控制器; 以及处理控制器，用于利用所述第二超声波辐射单元照射所述处理超声波，将所述处理超声波与所述第二超声波辐射单元的放射线控制为具有预定的曝光持续时间和所述治疗超声波的预定暂停持续时间，并且所述回波图像为 在诊断图像生成器的处理超声波曝光的暂停时间期间，基于超声回波生成。 检测到由治疗超声波产生的气泡后，治疗超声可能会减弱。
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10.发明申请公开(公告)号：US20090054722A1
公开(公告)日：2009-02-26
申请号：US12186545
申请日：2008-08-06
申请人： Ryoko Sugano , Nami Sugita , Teruo Kohashi , Keiji Takata , Chiharu Mitsumata , Shigeo Fujii
发明人： Ryoko Sugano , Nami Sugita , Teruo Kohashi , Keiji Takata , Chiharu Mitsumata , Shigeo Fujii
CPC分类号： A61N1/406 , A61K9/0009 , A61K9/127
摘要： The present invention provides drug carriers having high heating efficiency by high-frequency dielectric heating in a state of being selectively accumulated in a target site. The drug carriers each consist of a drug, magnetic fine particles, and a shell containing the drug and the magnetic fine particles. The shell has an outer diameter in a range from 10 nm to 200 nm. The magnetic fine particles having an average particle diameter of d has a standard deviation σ of particle diameter distribution satisfying 0.8d>σ>0.4d. The magnetic fine particles contained in the individual drug carriers generate hysteresis heat due to high-frequency dielectric heating by irradiation of a high-frequency magnetic field.
摘要翻译： 本发明通过选择性地积聚在目标部位的状态提供通过高频电介质加热具有高加热效率的药物载体。 药物载体各自由药物，磁性细颗粒和含有药物和磁性细颗粒的壳组成。 外壳的外径在10nm〜200nm的范围内。 平均粒径为d的磁性微粒的粒径分布的标准偏差σ为0.8d> s> 0.4d。 包含在各个药物载体中的磁性微粒由于高频磁场的照射而产生高频介电加热而产生滞后热。
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