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公开(公告)号：US06572839B2
公开(公告)日：2003-06-03
申请号：US09801844
申请日：2001-03-09
IPC分类号： A61B800
CPC分类号： A61K31/353 , A61B8/4444 , A61N7/00 , C07D311/86
摘要： A sensitizer for tumor treatment has a structure such that a lipophilic group and a hydrophilic group are bound to one and the same carbon atom in a compound containing a xanthene dye structure. It is important that the lipophilic group and hydrophilic group are bound to one and the same carbon atom; if they are separated from each other, no sufficient effect is obtained. Thus, the sensitizer possesses both lipophilicity and hydrophilicity. This sensitizer has a function of promoting acoustic cavitation and a function of revealing an antitumor effect and is an agent highly accumulable in tumor tissues. Thus, this sensitizer is highly selective for tumor tissues and enables the treatment of malignant tumor using ultrasound.
摘要翻译： 用于肿瘤治疗的敏化剂具有使亲油基团和亲水基团与含有呫吨染料结构的化合物中的同一个碳原子结合的结构。 重要的是亲脂基团和亲水基团与同一个碳原子结合; 如果它们彼此分离，则不能获得足够的效果。 因此，敏化剂具有亲油性和亲水性。 这种敏化剂具有促进声孔的功能和显示抗肿瘤作用的功能，并且是在肿瘤组织中高度累积的药剂。 因此，这种敏化剂对于肿瘤组织是高度选择性的并且能够使用超声治疗恶性肿瘤。
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公开(公告)号：US08460191B2
公开(公告)日：2013-06-11
申请号：US11914962
申请日：2006-05-18
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译： 一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。
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3.发明授权公开(公告)号：US07074427B2
公开(公告)日：2006-07-11
申请号：US10198178
申请日：2002-07-19
CPC分类号： A61K41/0033
摘要： A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is to be used in combination with ultrasonic irradiation, comprises a shell within the internal space of which a gas is enclosed and which contains or retains a substance capable of generating active oxygen species upon ultrasonic irradiation of the shell.
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公开(公告)号：US06511428B1
公开(公告)日：2003-01-28
申请号：US09830423
申请日：2001-04-26
申请人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
发明人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B8/12 , A61B2017/00154 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , A61B2090/3782
摘要： An ultrasound therapy apparatus delivers focused ultrasound for therapeutical purposes which can be correctly targeted to a target region, and also, a positional shift from the target region under irradiation of ultrasound can be effectively avoided. An ultrasound transducer is inside an applicator with an imaging ultrasonic probe. Another ultrasound transducer monitors a position of a target and a positional shift is inside a catheter which is inserted into a urethral tube. An imaging system drives the ultrasound probe to display an ultrasound tomographic image of a region in the vicinity of a target region. The ultrasound transducer is driven in a pulse-shaped mode at the same frequency as the imaging ultrasound and also at such timing when the imaging ultrasound is reached. As a result, a point-shaped sound source image is superimposed and displayed on an ultrasound tomographic image.
摘要翻译： 超声治疗装置将聚焦超声波提供给治疗目的，可以正确地瞄准目标区域，并且可以有效地避免从超声照射下的目标区域的位置偏移。 超声波换能器在具有成像超声波探头的施加器内部。 另一个超声波传感器监测目标的位置，位置偏移在插入尿道管内的导管内。 成像系统驱动超声波探头以显示目标区域附近的区域的超声断层图像。 超声波换能器以与成像超声相同的频率以及在达到成像超声的这种定时以脉冲模式驱动。 结果，点状声源图像被叠加并显示在超声断层图像上。
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公开(公告)号：US20090048516A1
公开(公告)日：2009-02-19
申请号：US11914962
申请日：2006-05-18
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译： 一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。
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公开(公告)号：US06224826B1
公开(公告)日：2001-05-01
申请号：US09270846
申请日：1999-03-18
申请人： Kageyoshi Katakura , Masahiro Kurihara , Kazuo Takei , Shinichiro Umemura , Kenichi Kawabata , Hiroshi Masuzawa
发明人： Kageyoshi Katakura , Masahiro Kurihara , Kazuo Takei , Shinichiro Umemura , Kenichi Kawabata , Hiroshi Masuzawa
IPC分类号： A61L200
CPC分类号： A61L2/025 , C02F1/36 , C02F1/48 , C02F2303/04 , Y10S261/48
摘要： A method and apparatus for sterilizing water containing pathogen protozoa having shells in a simple manner without negative influencing the environment is disclosed. Ultrasonic waves are applied to drinking water to form fine cavitation bubbles which are used to destroy the shells of pathogenic protozoa. The residual chlorine in the drinking water along with an oxidizing action and effect of the ultrasonic wave, permit not only sterilization but also deodorization and decolorization.
摘要翻译： 公开了以简单的方式对含有病原体原生动物的水灭菌的方法和装置，而不会对环境产生不利影响。 超声波应用于饮用水，形成细小的气泡，用于破坏致病原生动物的壳。 饮用水中的残留氯以及超声波的氧化作用和作用，不但能消毒灭菌，而且除臭脱色。
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公开(公告)号：US5523058A
公开(公告)日：1996-06-04
申请号：US240733
申请日：1994-05-12
申请人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
发明人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
CPC分类号： A61N7/02 , A61B17/22004 , A61N2007/006 , A61N2007/0078 , A61N2007/0095
摘要： By providing an ultrasonic irradiation apparatus for generating acoustic cavitation efficiently, it is intended to realize an ultrasonic therapeutic apparatus for generating the action of cavitation on a living body suitable for medical treatment of malignant tumors and medical treatment of thrombi and calculi, an ultrasonic diagnostic apparatus for generating cavitation for emphasizing an ultrasonic echo image such as a blood flow and utilizing the reflection capability of the cavitation, an ultrasonic chemical reaction accelerating apparatus, an ultrasonic cleaning apparatus or an ultrasonic sterilizing apparatus. Irradiation focus/code signals for defining irradiated acoustic fields of a fundamental wave and a second harmonic wave as well as focus positions/acoustic pressure distribution forms of the respective waves are applied from an irradiation unit main control circuit to drive phase generating circuits. Generated drive phases are applied to drive signal generating circuits, generated drive signals are applied to element drive circuits and a group of fundamental frequency elements and a group of second harmonic elements are driven. The drive phases are controlled such that the fundamental wave and second harmonic wave are superimposed on each other in a medium near a focal point, thus generating acoustic caviation locally and efficiently.
摘要翻译： PCT No.PCT / JP93 / 01310 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年9月14日PCT公布。 公开号WO94 / 06380 日期为1994年3月31日。通过提供用于有效产生声孔的超声波照射装置，旨在实现用于产生适于恶性肿瘤治疗的生物体上的空化作用的超声波治疗装置和血栓的治疗 和结石，用于产生用于强调超声波回波图像如血流并利用空化反射能力的超声波诊断装置，超声波化学反应加速装置，超声波清洗装置或超声波消毒装置。 用于定义基波和二次谐波的辐射声场以及各波的聚焦位置/声压分布形式的照射焦点/码信号从照射单元主控制电路施加到驱动相位产生电路。 产生的驱动相位被施加到驱动信号发生电路，所产生的驱动信号被施加到元件驱动电路，并且一组基频元件和一组二次谐波元件被驱动。 控制驱动相位使得基波和二次谐波在焦点附近的介质中彼此叠加，从而局部且有效地产生声空化。
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公开(公告)号：US5435311A
公开(公告)日：1995-07-25
申请号：US243321
申请日：1994-05-16
CPC分类号： A61B8/0833 , A61B17/2256
摘要： In an ultrasound therapeutic system provided with an ultrasound transmitter having a focusing mechanism and a plurality of groups of ultrasound transmitters/receivers, each of which has a controllable directivity, each of the transmitters/receivers is constructed so as to be able to receive both echo of pulse-shaped ultrasound transmitted by itself and even order harmonic signals of the ultrasound transmitted by the transmitter, and a plurality of two-dimensional pulse echographical images constructed by ultrasound signals obtained by transmitting/receiving beams, while controlling the directivity of the beam emitted by each of the plurality of groups of ultrasound transmitters/receivers and a plurality of images indicating orientation and intensity, in which an even order harmonic wave signal due to the ultrasound transmitted by the transmitter is received by each of the plurality of groups of ultrasound transmitters/receivers, are displayed, superimposed on each other.
摘要翻译： 在具有超声波发射器的超声波治疗系统中，每个发射器/接收器具有聚焦机构和多组超声波发射器/接收器，每个发射器/接收器具有可控的方向性，每个发射器/接收器被构造成能够接收两个回波 其自身发射的脉冲型超声波和由发射器发射的超声波的均匀次谐波信号，以及由通过发射/接收光束获得的超声信号构成的多个二维脉冲回波图像，同时控制发射的光束的方向性 通过多组超声波发射器/接收器中的每一个以及指示取向和强度的多个图像，其中由发射器发送的超声波引起的偶次谐波信号被多个超声发射器组中的每一个接收 /接收器，被显示，彼此叠加。
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公开(公告)号：US07824336B2
公开(公告)日：2010-11-02
申请号：US11336849
申请日：2006-01-23
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/481 , A61B2090/378 , A61N7/02
摘要： An ultrasonic apparatus for diagnosis and therapy is provided with plural ultrasound probes for generating ultrasound waves for phase shift, diagnosis, and therapy. A first control part causes phase shift in a nano droplet ultrasound contrast agent, while a second control part detects the phase shift of the nano droplet ultrasound contrast agent using ultrasound echo detected by an echo detection device. A difference calculation device calculates a difference of the detected phase shift over time, and a positioning device determines a target position where the difference is produced. A third control part is also provided for exposing a decided target area to the ultrasound waves for therapy.
摘要翻译： 用于诊断和治疗的超声波装置设置有用于产生用于相移，诊断和治疗的超声波的多个超声波探头。 第一控制部分引起纳米液滴超声造影剂中的相移，而第二控制部分使用由回波检测装置检测的超声回波来检测纳米液滴超声造影剂的相移。 差分计算装置计算检测到的相移随时间的差异，并且定位装置确定产生差异的目标位置。 还提供了第三控制部件，用于将决定的目标区域暴露于用于治疗的超声波。
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公开(公告)号：US07404797B2
公开(公告)日：2008-07-29
申请号：US10621762
申请日：2003-07-18
IPC分类号： A61B8/00
CPC分类号： A61B8/461 , A61B8/08 , A61B8/464 , A61B8/467 , G01S7/52034 , G01S7/52036 , G01S7/5206 , G06T5/003 , G06T5/20 , G06T2207/10132 , G06T2207/30004
摘要： The present invention provides an ultrasonic imaging system capable of extracting structure-emphasized image data in which the structure of a tissue in a living body is emphasized and texture-emphasized image data in which a texture pattern coming from properties of a tissue in a living body is emphasized from B-mode image data, and obtaining a synthesized image obtained by weighting and combining the two extracted image data pieces. An ultrasonic imaging system has: a structure extractor for extracting structure-emphasized image data in which a structure of a tissue in the living body is emphasized from B-mode image data of the living body; a texture pattern extractor for extracting texture-emphasized image data in which a texture pattern coming from properties of a tissue in the living body is emphasized; an image synthesizer for obtaining a synthesized image by weighting and combining the structure-emphasized image data and the texture-emphasized image data; and a display for displaying at least one of the structure-emphasized image data, the texture-emphasized image data, and the synthesized image.
摘要翻译： 本发明提供一种超声波成像系统，其能够提取结构强调图像数据，其中生物体中的组织的结构被强调，并且纹理强调图像数据，其中来自生物体中组织的性质的纹理图案 从B模式图像数据中强调，并获得通过对两个提取的图像数据进行加权和组合而获得的合成图像。 一种超声波成像系统具有：结构提取器，用于从生物体的B模式图像数据中提取结构强调图像数据，其中生物体中的组织的结构被强调; 用于提取纹理强调图像数据的纹理图案提取器，其中强调来自生物体中的组织的特性的纹理图案; 图像合成器，用于通过加权并组合结构强调图像数据和纹理强调图像数据来获得合成图像; 以及用于显示结构强调图像数据，纹理强调图像数据和合成图像中的至少一个的显示器。
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