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    Protein tyrosine phosphatase PTP20 and related products and methods
    1.
    发明授权
    Protein tyrosine phosphatase PTP20 and related products and methods 失效
    蛋白酪氨酸磷酸酶PTP20及相关产品及方法

    公开(公告)号：US06797501B2

    公开(公告)日：2004-09-28

    申请号：US10243687

    申请日：2002-09-16

    申请人： Naohita Aoki ,  Axel Ullrich

    发明人： Naohita Aoki ,  Axel Ullrich

    IPC分类号： C12N912

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K14/4703 ,  C07K16/18 ,  C07K16/40 ,  C12N9/16

    摘要： The present invention relates to a novel polypeptide, PTP20, and to nucleic acid molecules encoding the polypeptide. The invention also relates to nucleic acid molecules encoding portions of the phosphatase, nucleic acid vectors containing PTP20 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that bind PTP20 or abrogate its interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with PTP20 related molecules or compounds.

    摘要翻译： 本发明涉及新型多肽PTP20，以及编码该多肽的核酸分子。 本发明还涉及编码部分磷酸酶的核酸分子，含有PTP20相关核酸分子的核酸载体，含有此类核酸载体的重组细胞，从这些重组细胞纯化的多肽，对这些多肽的抗体，以及鉴定化合物的方法 结合PTP20或废除其与天然结合配偶体的相互作用。 还公开了用PTP20相关分子或化合物诊断生物体中的异常状况的方法。

    USE OF INHIBITORS FOR THE TREATMENT OF RTK-HYPERFUNCTION-INDUCED DISORDERS, PARTICULARLY CANCER
    6.
    发明申请
    USE OF INHIBITORS FOR THE TREATMENT OF RTK-HYPERFUNCTION-INDUCED DISORDERS, PARTICULARLY CANCER 有权
    使用抑制剂治疗RTK超敏感性疾病，特别是癌症

    公开(公告)号：US20100184686A1

    公开(公告)日：2010-07-22

    申请号：US12689672

    申请日：2010-01-19

    申请人： Axel Ullrich ,  Johannes Bange ,  Pjotr Knyazev

    发明人： Axel Ullrich ,  Johannes Bange ,  Pjotr Knyazev

    IPC分类号： A61K38/17 ,  C07K14/71 ,  C07H21/04 ,  C07K16/28 ,  A61P35/04 ,  A61P35/00 ,  C12Q1/68 ,  C12Q1/48

    CPC分类号： C07K14/71 ,  A61K38/00 ,  G01N33/574

    摘要： The present invention concerns the use of inhibitors for the treatment and/or prophylaxis of diseases which are the consequence of increased receptor tyrosine kinase activity, particularly cancer. The use is particularly directed towards inhibition or lowering of the overexpression and/or altered activity of receptor tyrosine kinases (RTKs). In particular, this altered activity of receptor tyrosine kinase can be triggered by a mutation of FGFR-4, wherein this mutation is in particular a point mutation in the transmembrane domain of FGFR-4 and leads to an exchange of a hydrophobic amino acid for a hydrophilic amino acid. The invention further concerns the use of an inhibitor directed against FGFR-4, for the treatment and/or prophylaxis of cancer. Furthermore, the invention concerns a mutated FGFR-4, which leads to over-expression and/or altered activity in cells. Finally, the invention concerns a DNA and RNA sequence of a mutated FGFR-4 molecule. Finally, in addition the invention concerns a pharmaceutical composition, containing the inhibitor as described above and further a diagnostic and screening procedure.

    摘要翻译： 本发明涉及抑制剂用于治疗和/或预防由于受体酪氨酸激酶活性增加，特别是癌症引起的疾病的用途。 该用途特别涉及抑制或降低受体酪氨酸激酶（RTK）的过表达和/或改变的活性。 特别地，受体酪氨酸激酶的这种改变的活性可以由FGFR-4的突变引发，其中该突变特别是FGFR-4的跨膜结构域中的点突变，并导致疏水性氨基酸的交换 亲水氨基酸。 本发明还涉及使用针对FGFR-4的抑制剂来治疗和/或预防癌症。 此外，本发明涉及突变的FGFR-4，其导致细胞中过度表达和/或改变的活性。 最后，本发明涉及突变的FGFR-4分子的DNA和RNA序列。 最后，本发明还涉及包含如上所述的抑制剂的药物组合物，并进一步进行诊断和筛选程序。

    Use of inhibitors for the treatment of RTK-hyperfunction-induced disorders, particularly cancer
    7.
    发明授权
    Use of inhibitors for the treatment of RTK-hyperfunction-induced disorders, particularly cancer 有权
    使用抑制剂治疗RTK-超功能障碍，特别是癌症

    公开(公告)号：US07297774B2

    公开(公告)日：2007-11-20

    申请号：US10863880

    申请日：2004-06-08

    申请人： Axel Ullrich ,  Johannes Bange ,  Pjotr Knyazev

    发明人： Axel Ullrich ,  Johannes Bange ,  Pjotr Knyazev

    IPC分类号： C07K14/00 ,  C12N15/11 ,  C12P21/06

    CPC分类号： C07K14/71 ,  A61K38/00 ,  G01N33/574

    摘要： The present invention concerns the use of inhibitors for the treatment and/or prophylaxis of diseases which are the consequence of increased receptor tyrosine kinase activity, particularly cancer. The use is particularly directed towards inhibition or lowering of the overexpression and/or altered activity of receptor tyrosine kinases (RTKs). In particular, this altered activity of receptor tyrosine kinase can be triggered by a mutation of FGFR-4, wherein this mutation is in particular a point mutation in the transmembrane domain of FGFR-4 and leads to an exchange of a hydrophobic amino acid for a hydrophilic amino acid. The invention further concerns the use of an inhibitor directed against FGFR-4, for the treatment and/or prophylaxis of cancer. Furthermore, the invention concerns a mutated FGFR-4, which leads to overexpression and/or altered activity in cells. Finally, the invention concerns a DNA and RNA sequence of a mutated FGFR-4 molecule. Finally, in addition the invention concerns a pharmaceutical composition, containing the inhibitor as described above and further a diagnostic and screening procedure.

    摘要翻译： 本发明涉及抑制剂用于治疗和/或预防由于受体酪氨酸激酶活性增加，特别是癌症引起的疾病的用途。 该用途特别涉及抑制或降低受体酪氨酸激酶（RTK）的过表达和/或改变的活性。 特别地，受体酪氨酸激酶的这种改变的活性可以由FGFR-4的突变引发，其中该突变特别是FGFR-4的跨膜结构域中的点突变，并导致疏水性氨基酸的交换 亲水氨基酸。 本发明还涉及使用针对FGFR-4的抑制剂来治疗和/或预防癌症。 此外，本发明涉及突变的FGFR-4，其导致细胞中的过表达和/或改变的活性。 最后，本发明涉及突变的FGFR-4分子的DNA和RNA序列。 最后，本发明还涉及包含如上所述的抑制剂的药物组合物，并进一步进行诊断和筛选程序。

    Methods for diagnosis and treatment of MDK1 signal transduction disorders
    9.
    发明申请
    Methods for diagnosis and treatment of MDK1 signal transduction disorders 审中-公开
    MDK1信号转导障碍的诊断和治疗方法

    公开(公告)号：US20060099708A1

    公开(公告)日：2006-05-11

    申请号：US11303935

    申请日：2005-12-19

    申请人： Thomas Ciossek ,  Axel Ullrich ,  Birgit Millauer

    发明人： Thomas Ciossek ,  Axel Ullrich ,  Birgit Millauer

    IPC分类号： C12N5/06 ,  C07K16/40

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K14/71

    摘要： The present invention relates to MDK1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a MDK1 receptor tyrosine kinase and a receptor for the kinase. The MDK1 receptor tyrosine kinase may be truncated and lack a kinase domain and may be selected from the group consisting of MDK1.T1, MDK1.T2, MDK1.Δ1 and MDK1.Δ2.

    摘要翻译： 本发明涉及MDK1多肽，编码这种多肽的核酸，含有此类核酸的细胞，组织和动物，对这些多肽的抗体，利用这些多肽的测定法，以及与上述所有相关的方法。 提供治疗，诊断和筛查的方法用于以信号转导障碍异常为特征的疾病或病症。 信号转导途径涉及MDK1受体酪氨酸激酶与激酶受体之间的相互作用。 MDK1受体酪氨酸激酶可能被截短并缺少激酶结构域，并且可以选自MDK1.T1，MDK1T2，MDK1Delta1和MDK1Delta2。