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1.发明授权Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cyclodextrins 失效使用包含环糊精的培养基培养幽门螺杆菌，弯曲杆菌和弧菌属微生物的方法
公开(公告)号：US5866375A
公开(公告)日：1999-02-02
申请号：US468372
申请日：1995-06-06
CPC分类号： C12N1/20 , Y10S435/822 , Y10S530/825
摘要： Method for the culture of microorganisms of the genera Helicobacter, Campylobacter and Arcobacter, wherein culture media are employed, which comprise, in place of blood or its derivative, cyclodextrins.
摘要翻译： 幽门螺杆菌属，弯曲杆菌属和弓形杆菌属微生物培养方法，其中使用培养基，代替血液或其衍生物，包括环糊精。
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2.发明授权Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cycodextrin 失效使用包含环糊精的培养基来培养幽门螺杆菌，弯曲杆菌和杆菌属微生物的方法
公开(公告)号：US5900372A
公开(公告)日：1999-05-04
申请号：US295081
申请日：1994-08-24
CPC分类号： C12N1/20
摘要： Method for the culture of microorganisms of the genera Helicobacter, Campylobacter and Arcobacter, wherein culture media are employed, which comprise, in place of blood or its derivative, cyclodextrins, methylcellulose or mixtures thereof.
摘要翻译： 用于培养幽门螺杆菌，弯曲杆菌属和弓形杆菌属的微生物的方法，其中使用培养基，代替血液或其衍生物，环糊精，甲基纤维素或其混合物。
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公开(公告)号：US6090611A
公开(公告)日：2000-07-18
申请号：US471491
申请日：1995-06-06
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/106 , A61P1/04 , A61P31/04 , C07K14/195 , C07K14/205 , C12N1/21 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C07K14/205 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/975
摘要： A cytotoxin associated immunodominant antigen and the nucleic acid encoding the antigen from Helicobacter pylori are described. This antigen was identified from the cytotoxin positive CCUG 17874 Helicobacter pylori strain, and both the antigen and the DNA encoding it have been sequenced. The antigen is a hydrophilic, surface-exposed protein having a molecular weight of 120-132 kDa. The nucleic acid encoding the antigen may be incorporated into a vector for transformation of host cells for expression of the antigen. Both the DNA and the antigen can be used in assays for detection of disease or infection by Helicobacter pylori, and may find use in treating and preventing infection by Helicobacter pylori and the diseases associated with such infection.
摘要翻译： 描述了细胞毒素相关免疫显性抗原和编码幽门螺旋杆菌抗原的核酸。 从细胞毒素阳性CCUG 17874幽门螺杆菌菌株鉴定出该抗原，并且对抗原和编码它的DNA进行了测序。 抗原是亲水性，表面暴露的蛋白质，其分子量为120-132kDa。 编码抗原的核酸可以并入用于转化宿主细胞用于表达抗原的载体中。 DNA和抗原都可用于检测幽门螺杆菌疾病或感染的检测中，可用于治疗和预防幽门螺杆菌感染以及与此类感染有关的疾病。
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公开(公告)号：US6077706A
公开(公告)日：2000-06-20
申请号：US470260
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/106 , A61K39/39 , A61K48/00 , A61P1/04 , A61P31/04 , A61P35/00 , C07H21/00 , C07H21/04 , C07K7/06 , C07K14/195 , C07K14/205 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/80 , C12N15/09 , C12N15/31 , C12N15/62 , C12N15/66 , C12N15/74 , C12P19/34 , C12P21/02 , C12Q1/68 , C12R1/01 , C12R1/19 , G01N33/569 , C12N1/20
CPC分类号： C07K14/195 , C07K14/205 , C12Q1/689 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/35 , C07K2319/40
摘要： Helicobacter pylori known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected with this bacterium. The present invention relates generally to certain H. pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. Specifically, molecular cloning, nucleotide, and amino add sequences for the H. pylori cytotoxin (CT), the "Cytotoxin Associated Immunodominant" (CAI) antigen, and the heat shock protein (hsp60) are described herein.
摘要翻译： 幽门螺杆菌已知会导致或成为B型胃炎，消化性溃疡和胃肿瘤中的辅因子。 在发达国家和发展中国家，很高比例的人感染了这种细菌。 本发明一般涉及某些幽门螺杆菌蛋白质，表达这些蛋白质的基因，以及这些蛋白质用于诊断和疫苗应用的用途。 具体地，本文描述了幽门螺杆菌细胞毒素（CT），“细胞毒素相关免疫显性”（CAI）抗原和热休克蛋白（hsp60）的分子克隆，核苷酸和氨基酸序列。
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公开(公告)号：US20070243204A1
公开(公告)日：2007-10-18
申请号：US11580632
申请日：2006-10-12
CPC分类号： A61K39/105 , A61K39/00 , C07K14/195 , C07K14/205 , Y10S530/825
摘要： This invention provides polypeptides of Helicobacter Pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising polypeptides of Helicobacter pylori CAI antigen, and methods for preparation. The invention also provides methods of treatment of Helicobacter pylori infection using these vaccines.
摘要翻译： 本发明提供幽门螺杆菌细胞毒素相关免疫显性（CAI）抗原的多肽。 本发明还提供包含幽门螺杆菌CAI抗原多肽的预防和治疗疫苗及其制备方法。 本发明还提供使用这些疫苗治疗幽门螺杆菌感染的方法。
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公开(公告)号：US6130059A
公开(公告)日：2000-10-10
申请号：US466662
申请日：1995-06-06
IPC分类号： A61P31/04 , C12N1/21 , C12Q1/68 , A61K39/106 , C07H21/04 , C07K14/205
CPC分类号： C12Q1/689 , Y10S435/975
摘要： Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected with this bacterium. The present invention relates generally to certain H. pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. Specifically, molecular cloning, nucteotide, and amino acid sequences for the H. pylori cytotoxin (CT), the "Cytotoxin Associated Immunodominant" (CAI) antigen, and the heat shock protein (hsp60). are described herein.
摘要翻译： 已知幽门螺杆菌可引起或成为B型胃炎，消化性溃疡和胃肿瘤中的辅因子。 在发达国家和发展中国家，很高比例的人感染了这种细菌。 本发明一般涉及某些幽门螺杆菌蛋白质，表达这些蛋白质的基因，以及这些蛋白质用于诊断和疫苗应用的用途。 具体地，幽门螺杆菌细胞毒素（CT），“细胞毒素相关免疫显性”（CAI）抗原和热休克蛋白（hsp60）的分子克隆，核苷酸和氨基酸序列。 在此描述。
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公开(公告)号：US07700755B2
公开(公告)日：2010-04-20
申请号：US10615668
申请日：2003-07-08
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , C07K14/205 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12Q1/689
摘要： This invention provides polynucleotides encoding Helicobacter pylori cytotoxin associated immunodominant antigen. The polynucleotides can be used as probes to identify the presence of complementary target nucleotide sequences. The invention also provides kits and vectors containing the polynucleotides of the invention.
摘要翻译： 本发明提供编码幽门螺杆菌细胞毒素相关免疫显性抗原的多核苷酸。 多核苷酸可用作探针以鉴定互补靶核苷酸序列的存在。 本发明还提供了含有本发明的多核苷酸的试剂盒和载体。
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公开(公告)号：US07141244B1
公开(公告)日：2006-11-28
申请号：US09360685
申请日：1999-07-26
CPC分类号： A61K39/105 , A61K39/00 , C07K14/195 , C07K14/205 , Y10S530/825
摘要： This invention provides polypeptides of Helicobacter pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising polypeptides of Helicobacter pylori CAI antigen, and methods for their preparation. The invention also provides methods of treatment of Helicobactor pylori infection using these vaccines.
摘要翻译： 本发明提供幽门螺杆菌细胞毒素相关免疫显性（CAI）抗原的多肽。 本发明还提供包含幽门螺杆菌CAI抗原多肽的预防和治疗疫苗及其制备方法。 本发明还提供使用这些疫苗治疗幽门螺杆菌感染幽门螺杆菌感染的方法。
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公开(公告)号：US20050276819A1
公开(公告)日：2005-12-15
申请号：US10615668
申请日：2003-07-08
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/106 , A61K39/39 , A61K48/00 , A61P1/04 , A61P31/04 , A61P35/00 , C07H21/00 , C07H21/04 , C07K7/06 , C07K14/195 , C07K14/205 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/80 , C12N15/09 , C12N15/31 , C12N15/62 , C12N15/66 , C12N15/74 , C12P19/34 , C12P21/02 , C12Q1/68 , C12R1/01 , C12R1/19 , G01N33/569
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , C07K14/205 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12Q1/689
摘要： This invention provides polynucleotides encoding Helicobacter pylori cytotoxin associated immunodominant antigen. The polynucleotides can be used as probes to identify the presence of complementary target nucleotide sequences. The invention also provides kits and vectors containing the polynucleotides of the invention.
摘要翻译： 本发明提供编码幽门螺杆菌细胞毒素相关免疫显性抗原的多核苷酸。 多核苷酸可用作探针以鉴定互补靶核苷酸序列的存在。 本发明还提供了含有本发明的多核苷酸的试剂盒和载体。
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10.发明申请Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin 有权培养基用酵母或大豆提取物作为氨基酸来源，不含动物来源的蛋白质复合物公开(公告)号：US20050089968A1
公开(公告)日：2005-04-28
申请号：US10979758
申请日：2004-11-03
申请人： Roberto Olivieri , Fabio Sabbatini , Maria Kontakou , Lucia Tagliaferri , Antonella Giglioli , Rino Rappuoli
发明人： Roberto Olivieri , Fabio Sabbatini , Maria Kontakou , Lucia Tagliaferri , Antonella Giglioli , Rino Rappuoli
IPC分类号： A61K39/00 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/095 , A61K39/10 , A61P31/04 , C12N1/20 , C12N1/21 , C12N5/02 , C12R1/01 , C12N9/88
摘要： The present invention relates to a medium containing non-animal derived proteinaceous material for cultivating patheogenic bacteria to produce an immunogenic factor and processes employing such medium.
摘要翻译： 本发明涉及含有非动物来源的蛋白质物质的培养基以产生免疫原性因子并使用这种培养基的方法。
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