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1.发明申请公开(公告)号：US20080009489A1
公开(公告)日：2008-01-10
申请号：US11770586
申请日：2007-06-28
申请人： Nathalie Schlienger , Jan Pawlas , Alma Fejzic , Roger Olsson , Birgitte Lund , Fabrizio Badalassi , Rasmus Lewinsky , Mikkel Thygesen
发明人： Nathalie Schlienger , Jan Pawlas , Alma Fejzic , Roger Olsson , Birgitte Lund , Fabrizio Badalassi , Rasmus Lewinsky , Mikkel Thygesen
IPC分类号： A61K31/439 , A61K31/40 , A61K31/445 , A61K31/5375 , A61P15/00 , A61P21/00 , A61P35/00 , A61P5/00 , C12N5/00
CPC分类号： C07D207/08 , C07C255/58 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D211/22 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/70 , C07D215/20 , C07D215/40 , C07D215/48 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D221/20 , C07D221/22 , C07D237/34 , C07D241/42 , C07D285/14 , C07D295/06 , C07D295/073 , C07D295/096 , C07D295/155 , C07D451/00 , C07D451/02 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D491/10 , C07F9/572 , C07F9/6561
摘要： Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
摘要翻译： 本文公开了式（I）的双环芳基化合物，其选择性调节核受体，优选雄激素受体或其药学上可接受的盐，酯，酰胺或前药，以及治疗疾病的方法，包括给予式（I）化合物至 有需要的患者。
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2.发明申请公开(公告)号：US20060173037A1
公开(公告)日：2006-08-03
申请号：US11348929
申请日：2006-02-06
申请人： Nathalie Schlienger , Mikkel Thygesen , Jan Pawlas , Fabrizio Badalassi , Rasmus Lewinsky , Birgitte Lund , Roger Olsson
发明人： Nathalie Schlienger , Mikkel Thygesen , Jan Pawlas , Fabrizio Badalassi , Rasmus Lewinsky , Birgitte Lund , Roger Olsson
IPC分类号： C07D451/02 , A61K31/46
CPC分类号： C07D451/06 , C07D451/02
摘要： Disclosed herein is a novel class of aminophenyl compounds having the structure: wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
摘要翻译： 本文公开了一类新型的具有以下结构的氨基苯基化合物：其中R 1是氰基或硝基，环A是双环或三环桥连杂环，并且它们用作治疗雄激素受体的调节剂 或预防与此相关的条件。
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公开(公告)号：US20060160845A1
公开(公告)日：2006-07-20
申请号：US11329267
申请日：2006-01-09
申请人： Nathalie Schlienger , Mikkel Thygesen , Jan Pawlas , Fabrizio Badalassi , Rasmus Lewinsky , Birgitte Lund , Roger Olsson
发明人： Nathalie Schlienger , Mikkel Thygesen , Jan Pawlas , Fabrizio Badalassi , Rasmus Lewinsky , Birgitte Lund , Roger Olsson
IPC分类号： C07D451/02 , A61K31/46
CPC分类号： C07D451/02 , C07D451/06
摘要： Disclosed herein is a novel class of aminophenyl compounds having the structure: wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
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4.发明申请Androgen receptor modulators and methods of treating disease using the same 审中-公开雄激素受体调节剂和使用其治疗疾病的方法公开(公告)号：US20070004679A1
公开(公告)日：2007-01-04
申请号：US11348949
申请日：2006-02-06
申请人： Nathalie Schlienger , Jan Pawlas , Alma Fejzic , Roger Olsson , Birgitte Lund , Fabrizio Badalassi , Rasmus Lewinsky , Mikkel Thygesen , Douglas Bonhaus
发明人： Nathalie Schlienger , Jan Pawlas , Alma Fejzic , Roger Olsson , Birgitte Lund , Fabrizio Badalassi , Rasmus Lewinsky , Mikkel Thygesen , Douglas Bonhaus
IPC分类号： A61K31/675 , A61K31/54 , A61K31/5375 , A61K31/445 , A61K31/40 , A61K31/495
CPC分类号： A61K31/40 , A61K31/439 , A61K31/445 , A61K31/504 , A61K31/5375 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/40 , C07D215/48 , C07D217/02 , C07D217/22 , C07D221/20 , C07D221/22 , C07D237/34 , C07D241/42 , C07D285/14 , C07D295/06 , C07D295/155 , C07D451/02 , C07D451/04 , C07D451/06 , C07D471/08 , C07D471/10 , C07D487/08 , C07D491/10
摘要： Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
摘要翻译： 本文公开了式（I）的双环芳基化合物，其选择性调节核受体，优选雄激素受体或其药学上可接受的盐，酯，酰胺或前药，以及治疗疾病的方法，包括给予式（I）化合物至 有需要的患者。
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5.发明申请公开(公告)号：US20060014739A1
公开(公告)日：2006-01-19
申请号：US11130669
申请日：2005-05-16
申请人： Nathalie Schlienger , Jan Pawlas , Alma Fejzic , Roger Olsson , Birgitte Lund , Fabrizio Badalassi , Rasmus Lewinsky , Mikkel Thygesen
发明人： Nathalie Schlienger , Jan Pawlas , Alma Fejzic , Roger Olsson , Birgitte Lund , Fabrizio Badalassi , Rasmus Lewinsky , Mikkel Thygesen
IPC分类号： A61K31/537 , C07D211/06 , C07D265/30 , A61K31/445
CPC分类号： C07D207/08 , C07C255/58 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D211/22 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/70 , C07D215/20 , C07D215/40 , C07D215/48 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D221/20 , C07D221/22 , C07D237/34 , C07D241/42 , C07D285/14 , C07D295/06 , C07D295/073 , C07D295/096 , C07D295/155 , C07D451/00 , C07D451/02 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D491/10 , C07F9/572 , C07F9/6561
摘要： Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
摘要翻译： 本文公开了式（I）的双环芳基化合物，其选择性调节核受体，优选雄激素受体或其药学上可接受的盐，酯，酰胺或前药，以及治疗疾病的方法，包括给予式（I）化合物至 有需要的患者。
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公开(公告)号：US20090176837A1
公开(公告)日：2009-07-09
申请号：US11995528
申请日：2006-07-12
申请人： Roger Olsson , Fabrice Piu , Birgitte Lund
发明人： Roger Olsson , Fabrice Piu , Birgitte Lund
IPC分类号： A61K31/192 , A61K31/443 , A61K31/44 , A61K31/426 , A61K31/4196 , A61K31/4164 , A61K31/34 , C07D405/12 , C07D213/72 , C07D213/55 , C07D277/34 , C07D249/08 , C07D233/18 , C07D307/54 , C07C63/331 , A61P29/00 , A61P25/00 , A61P35/00
CPC分类号： C07C243/38 , C07C63/06 , C07C255/14 , C07C259/10 , C07C311/51 , C07C2601/02 , C07C2601/18 , C07D213/30 , C07D213/40 , C07D213/75 , C07D233/54 , C07D239/26 , C07D277/34 , C07D295/155 , C07D307/42 , C07D307/52
摘要： Disclosed herein are novel compounds with activity at RARβ 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders such as memory deficits and schizophrenia, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, inflammatory disorders such as psoriasis and rheumatoid arthritis, eye disorders and depression.
摘要翻译： 本文公开了在RARβ2受体上具有活性的新化合物。 还公开了这样的化合物用于治疗或缓解癌症症状，神经障碍如记忆缺陷和精神分裂症，神经变性疾病如帕金森病和阿尔茨海默氏病，炎性疾病如牛皮癣和类风湿性关节炎，眼睛疾病和抑郁症的用途。
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7.发明授权Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta 有权二苯基取代的环己烷衍生物，可用作雌激素受体β的调节剂公开(公告)号：US09061981B2
公开(公告)日：2015-06-23
申请号：US14236237
申请日：2012-08-01
申请人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
发明人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
IPC分类号： A61K31/075 , A61K31/045 , C07C43/02 , C07C43/225 , C07C39/42
CPC分类号： C07C43/225 , C07C39/42 , C07C2601/14
摘要： Disclosed herein are novel di-aromatic compounds of the general formula (I). Also pharmaceutical compositions comprising the novel compounds and the use of the novel compounds in treatment and prevention of diseases and disorders related to estrogen receptors are disclosed. Furthermore, methods for treating and preventing diseases and disorders related to estrogen receptors by administration of the novel compounds are disclosed.
摘要翻译： 本文公开了通式（I）的新型二芳族化合物。 还公开了包含新化合物的药物组合物和新化合物在治疗和预防与雌激素受体相关的疾病和病症中的用途。 此外，公开了通过施用新化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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8.发明申请DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA 有权二氢替代环己烷衍生物，有用作为雌激素受体测定的调节剂公开(公告)号：US20140275284A1
公开(公告)日：2014-09-18
申请号：US14236237
申请日：2012-08-01
申请人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
发明人： Roger Olsson , Birgitte Lund , Magnus Gustafsson
IPC分类号： C07C43/225 , C07C39/42
CPC分类号： C07C43/225 , C07C39/42 , C07C2601/14
摘要： Disclosed herein are novel di-aromatic compounds of the general formula (I). Also pharmaceutical compositions comprising the novel compounds and the use of the novel compounds in treatment and prevention of diseases and disorders related to estrogen receptors are disclosed. Furthermore, methods for treating and preventing diseases and disorders related to estrogen receptors by administration of the novel compounds are disclosed.
摘要翻译： 本文公开了通式（I）的新型二芳族化合物。 还公开了包含新化合物的药物组合物和新化合物在治疗和预防与雌激素受体相关的疾病和病症中的用途。 此外，公开了通过施用新化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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