公开(公告)号：US20150352209A1

公开(公告)日：2015-12-10

申请号：US14759758

申请日：2014-01-10

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Mitsuhiro EBARA ,  Takao AOYAGI ,  Koichiro UTO

IPC: A61K41/00 ,  D01D5/00 ,  A61K47/32 ,  D04H1/728 ,  A61K9/70

CPC classification number: A61K41/0052 ,  A61K9/7007 ,  A61K9/7061 ,  A61K33/00 ,  A61K33/26 ,  A61K33/44 ,  A61K47/32 ,  C08F220/56 ,  C08L33/24 ,  D01D5/0007 ,  D01D5/003 ,  D01F1/10 ,  D01F6/28 ,  D01F6/30 ,  D04H1/413 ,  D04H1/728 ,  D10B2321/10 ,  D10B2401/10 ,  D10B2509/00 ,  C08F220/54 ,  C08F220/58

Abstract: The invention aims to provide a nanofiber having self-heating properties and biologically active substance release properties, which can release a drug at the same time as self-heating, and can be safely used on a human body without diffusing self-heating nanoparticles, a production method for the same, and a nonwoven fabric having self-heating properties and biologically active substance release capabilities. A fiber is provided having a diameter in a range of 50 nm to 50 μm, and a length of 100 times the diameter or more, the fiber including: self-heating particles that generate heat in response to stimulation from outside; a stimulation-responsive polymer of which physical properties change by directly or indirectly reacting due to the stimulation; and a biologically active substance that is held by the stimulation-responsive polymer, in which the biologically active substance is released to the outside in response to the changes in the physical properties of the stimulation-responsive polymer, a production method for the same, and a nonwoven fabric having self-heating properties and biologically active substance release capabilities.

Abstract translation: 本发明的目的在于提供具有自热特性和生物活性物质释放性质的纳米纤维，其能够在自加热的同时释放药物，并且可以安全地使用在人体上而不扩散自加热纳米颗粒， 以及具有自热性和生物活性物质释放能力的无纺布。 提供的纤维的直径在50nm至50μm的范围内，长度为直径或以上的100倍，纤维包括：响应于来自外部的刺激产生热量的自加热颗粒; 刺激响应性聚合物，其物理性质由于刺激而直接或间接反应而改变; 以及由刺激响应性聚合物保持的生物活性物质，其中响应于刺激响应性聚合物的物理性质的变化而将生物活性物质释放到外部，其生产方法和 具有自热特性和生物活性物质释放能力的无纺织物。

公开(公告)号：US20210140081A1

公开(公告)日：2021-05-13

申请号：US17257043

申请日：2019-07-09

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Koichiro UTO ,  Mitsuhiro EBARA ,  Mitsuru NAIKI ,  Takafumi KONISHI ,  Hitoshi YAMAMOTO

IPC: D04H1/728 ,  D04H1/55

Abstract: A non-woven fabric including fibers including an aliphatic polyester that has at least two maximum values in a molecular weight distribution thereof, wherein the fibers have a fiber diameter falling within the range of 100 to 3000 nm. The non-woven fabric of the present invention has excellent biodegradability.

公开(公告)号：US20160199789A1

公开(公告)日：2016-07-14

申请号：US14913698

申请日：2014-08-25

Applicant: National Institute for Materials Science

Inventor： Mitsuhiro EBARA ,  Koki NAMEKAWA ,  Takao AOYAGI

IPC: B01D69/14 ,  B29C47/00 ,  B01D61/24 ,  B01D71/38 ,  A61M1/16 ,  B01D63/04 ,  B01D71/02

CPC classification number: B01D69/148 ,  A61K35/14 ,  A61M1/16 ,  B01D61/243 ,  B01D63/02 ,  B01D63/04 ,  B01D67/0004 ,  B01D67/0079 ,  B01D69/04 ,  B01D69/08 ,  B01D71/028 ,  B01D71/26 ,  B01D71/38 ,  B01D71/76 ,  B01D2323/39 ,  B01D2325/12 ,  B29C47/0014 ,  B29K2029/04 ,  B29K2031/04 ,  B29L2031/14 ,  B29L2031/731

Abstract: A blood purification membrane capable of adsorbing creatinine which is a uremic toxin in the blood and purifying the blood, the blood purification membrane including fibers and particles adhered to the aforementioned fibers, wherein the aforementioned fibers are composed of a polymer insoluble in water, the aforementioned particles contain SiO2 and Al2O3, and pores capable of incorporating at least a portion of the aforementioned uremic toxin are provided in the aforementioned particles.

Abstract translation: 一种血液净化膜，其能够吸附作为血液中的尿毒症毒素的肌酸酐，并且对血液进行净化，所述血液净化膜包括附着在上述纤维上的纤维和粒子，上述纤维由不溶于水的聚合物构成，上述 颗粒含有SiO 2和Al 2 O 3，并且在上述颗粒中提供能够引入至少一部分上述尿毒症毒素的孔。

公开(公告)号：US20240168017A1

公开(公告)日：2024-05-23

申请号：US18272097

申请日：2022-03-07

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Mitsuhiro EBARA ,  Ahmed Nabil Ahmed Elsayed TOLBA

IPC: G01N33/569 ,  C07K14/165 ,  C07K16/10 ,  C08F220/56 ,  C08F220/60 ,  G01N33/536

CPC classification number: G01N33/56983 ,  C07K14/165 ,  C07K16/1003 ,  C08F220/56 ,  C08F220/60 ,  G01N33/536 ,  G01N2333/165

Abstract: A copolymer of the present invention includes a repeating unit 1 represented by the following formula (1) and a repeating unit 2 represented by the following formula (2) and can be used for concentrating an antigen by immobilizing an antibody thereto.

公开(公告)号：US20210205234A1

公开(公告)日：2021-07-08

申请号：US17163871

申请日：2021-02-01

Applicant: OSAKA UNIVERSITY ,  NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Hiroyuki TANAKA ,  Kiyoshi OKADA ,  Hideki YOSHIKAWA ,  Koji SUZUKI ,  Mitsuhiro EBARA

IPC: A61K9/70 ,  A61K47/34 ,  A61K47/36 ,  A61K31/714 ,  A61K35/36 ,  A61K45/00 ,  A61K38/18 ,  A61P25/02 ,  A61K47/32

Abstract: A sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet including a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.

公开(公告)号：US20190083415A1

公开(公告)日：2019-03-21

申请号：US16082594

申请日：2017-03-06

Applicant: OSAKA UNIVERSITY ,  NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Hiroyuki TANAKA ,  Kiyoshi OKADA ,  Hideki YOSHIKAWA ,  Koji SUZUKI ,  Mitsuhiro EBARA

IPC: A61K9/70 ,  A61K31/714 ,  A61K35/36 ,  A61K38/18 ,  A61K47/34 ,  A61K47/32 ,  A61K47/36 ,  A61P25/02

Abstract: Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.