公开(公告)号：US20180263934A1

公开(公告)日：2018-09-20

申请号：US15985698

申请日：2018-05-22

Applicant: National Institute of Biological Sciences, Beijing

Inventor： Zhiyuan Zhang ,  Xiaodong Wang ,  Xiaoguang Lei ,  Yaning Su ,  Sudan He ,  Hanying Ruan ,  Liming Sun

IPC: A61K31/165 ,  C07C25/02 ,  C07C233/01 ,  C07C25/13 ,  C07C233/05 ,  A61K31/10

Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US10682319B2

公开(公告)日：2020-06-16

申请号：US15985698

申请日：2018-05-22

Applicant: National Institute of Biological Sciences, Beijing

Inventor： Zhiyuan Zhang ,  Xiaodong Wang ,  Xiaoguang Lei ,  Yaning Su ,  Sudan He ,  Hanying Ruan ,  Liming Sun

IPC: C07C255/60 ,  C07C275/24 ,  C07C311/14 ,  C07C313/06 ,  C07D231/12 ,  C07D217/14 ,  C07D333/20 ,  C07D277/28 ,  C07D211/28 ,  C07D213/40 ,  C07D213/61 ,  C07D213/64 ,  C07D307/14 ,  C07D307/52 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18 ,  C07C233/47 ,  C07C233/59 ,  C07C233/01 ,  C07C235/10 ,  C07C237/06 ,  C07C237/22 ,  C07C25/02 ,  C07C25/13 ,  C07C259/06 ,  A61K31/10 ,  A61K31/165

Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US09974762B2

公开(公告)日：2018-05-22

申请号：US15632412

申请日：2017-06-26

Applicant: National Institute of Biological Sciences, Beijing

Inventor： Zhiyuan Zhang ,  Xiaodong Wang ,  Xiaoguang Lei ,  Yaning Su ,  Sudan He ,  Hanying Ruan ,  Liming Sun

IPC: A61K31/165 ,  A61K31/10 ,  C07C25/13 ,  C07C25/02 ,  C07C233/05 ,  C07C233/01

CPC classification number: A61K31/165 ,  A61K31/10 ,  C07C25/02 ,  C07C25/13 ,  C07C233/01 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18 ,  C07C233/47 ,  C07C233/59 ,  C07C235/10 ,  C07C237/06 ,  C07C237/22 ,  C07C255/60 ,  C07C259/06 ,  C07C275/24 ,  C07C311/14 ,  C07C313/06 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2603/74 ,  C07D211/28 ,  C07D213/40 ,  C07D213/61 ,  C07D213/64 ,  C07D217/14 ,  C07D231/12 ,  C07D277/28 ,  C07D307/14 ,  C07D307/52 ,  C07D333/20

Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US20170290790A1

公开(公告)日：2017-10-12

申请号：US15632412

申请日：2017-06-26

Applicant: National Institute of Biological Sciences, Beijing

Inventor： Zhiyuan Zhang ,  Xiaodong Wang ,  Xiaoguang Lei ,  Yaning Su ,  Sudan He ,  Hanying Ruan ,  Liming Sun

IPC: A61K31/165 ,  C07C25/13 ,  C07C233/05 ,  C07C25/02 ,  A61K31/10 ,  C07C233/01

CPC classification number: A61K31/165 ,  A61K31/10 ,  C07C25/02 ,  C07C25/13 ,  C07C233/01 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18 ,  C07C233/47 ,  C07C233/59 ,  C07C235/10 ,  C07C237/06 ,  C07C237/22 ,  C07C255/60 ,  C07C259/06 ,  C07C275/24 ,  C07C311/14 ,  C07C313/06 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2603/74 ,  C07D211/28 ,  C07D213/40 ,  C07D213/61 ,  C07D213/64 ,  C07D217/14 ,  C07D231/12 ,  C07D277/28 ,  C07D307/14 ,  C07D307/52 ,  C07D333/20

Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.