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公开(公告)号：US5844099A
公开(公告)日：1998-12-01
申请号：US563105
申请日：1995-11-27
IPC分类号： C12N15/09 , A61K38/00 , A61P3/02 , A61P19/10 , A61P35/02 , A61P43/00 , C07K7/06 , C07K14/475 , C07K14/52 , C07K14/54 , C07K14/715 , C12N15/19 , C12N15/24 , C12P21/02 , C07K14/495 , C07K14/71
CPC分类号： C07K14/715 , C07K14/475 , C07K14/5412 , A61K38/00
摘要： Heteromeric proteins comprising a soluble .alpha. specificity determining cytokine receptor component and the extracellular domain of a .beta. receptor component function as cytokine antagonists.
摘要翻译： 包含可溶性α特异性测定细胞因子受体组分和β受体组分的细胞外结构域的异源蛋白质作为细胞因子拮抗剂起作用。
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公开(公告)号：US07927583B2
公开(公告)日：2011-04-19
申请号：US12177185
申请日：2008-07-22
申请人： Neil Stahl , George D. Yancopoulos
发明人： Neil Stahl , George D. Yancopoulos
CPC分类号： C07H21/04 , A61K38/00 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： The present invention provides a fusion polypeptide capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.
摘要翻译： 本发明提供能够结合细胞因子以形成非功能性复合物的融合多肽。 它还提供编码融合多肽的核酸序列以及制备和用于融合多肽的方法。
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公开(公告)号：US07531172B2
公开(公告)日：2009-05-12
申请号：US11502736
申请日：2006-08-11
CPC分类号： A61K38/179
摘要： A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition treatable with a VEGF antagonist in which is it desirable to reduce or prevent hypertension. The method is particularly useful for treatment of patients unresponsive to treatment with a VEGF inhibitor administered intravenously.
摘要翻译： 在患有可用VEGF拮抗剂治疗的疾病或病症的人类受试者中降低或预防与血管内皮生长因子（VEGF）拮抗剂的给药相关的高血压的方法，其中希望减少或预防高血压。 该方法对于治疗对用静脉内施用的VEGF抑制剂治疗无反应的患者特别有用。
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公开(公告)号：US07435553B2
公开(公告)日：2008-10-14
申请号：US11434403
申请日：2006-05-15
申请人： James P Fandl , Neil Stahl , Gang Chen , George D. Yancopoulos
发明人： James P Fandl , Neil Stahl , Gang Chen , George D. Yancopoulos
CPC分类号： C40B30/04 , A01K2217/05 , A01K2267/01 , C07K14/315 , C07K14/52 , C07K16/2863 , C07K2317/77 , C07K2319/00 , C12N15/1051 , G01N33/56966 , G01N33/6845 , G01N2500/10
摘要： A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.
摘要翻译： 一种检测和分离产生任何分泌的感兴趣蛋白质（POI）的细胞的方法，包括：a）通过用核酸转染细胞系来构建瞬时或稳定表达结合POI的细胞表面捕获分子的细胞系 编码这种细胞表面捕获分子; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。
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公开(公告)号：US07285532B2
公开(公告)日：2007-10-23
申请号：US10735345
申请日：2003-12-12
IPC分类号： A61K38/16
CPC分类号： C07K16/22 , A61K38/00 , A61K39/00 , C07K14/475
摘要： Methods of treating and/or inhibiting a bone morphogenetic protein (BMP)-related disorder or condition by administering a BMP antagonist to a subject suffering from a BMP-related disorder or condition such that the BMP-related disorder or condition is treated. The method is carried out with a human noggin or a human noggin deletion mutant.
摘要翻译： 通过向患有BMP相关病症或病症的受试者施用BMP拮抗剂以治疗和/或抑制骨形态发生蛋白（BMP）相关障碍或病症，使得与BMP相关的病症或病症得到治疗。 该方法用人noggin或人noggin缺失突变体进行。
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6.发明授权公开(公告)号：US07083950B2
公开(公告)日：2006-08-01
申请号：US10610452
申请日：2003-06-30
CPC分类号： C12N15/62 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/248 , C07K16/468 , C07K2317/622 , C07K2317/92 , C07K2318/10 , C07K2318/20 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： High affinity fusion proteins (“trapbodies”), capable of binding and inhibiting the activity of soluble, interacting proteins (“SIPs”) are described. The trapbodies are multimers, preferably dimers, of SIP-specific fusion polypeptides which comprise SIP binding domains derived from SIP targets and/or anti-SIP immunoglobulins, as well as multimerizing components.
摘要翻译： 描述了能够结合和抑制可溶性相互作用蛋白（“SIP”）活性的高亲和力融合蛋白（“陷阱”）。 所述捕获体是SIP特异性融合多肽的多聚体，优选二聚体，其包含衍生自SIP靶标和/或抗-Iss免疫球蛋白的SIP结合结构域，以及多聚化组分。
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公开(公告)号：US06472179B2
公开(公告)日：2002-10-29
申请号：US09313942
申请日：1999-05-19
申请人： Neil Stahl , George D. Yancopoulos
发明人： Neil Stahl , George D. Yancopoulos
IPC分类号： C12P2104
CPC分类号： C07K14/715 , C07K2319/02
摘要： The present invention provides a fusion polypeptide capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.
摘要翻译： 本发明提供能够结合细胞因子以形成非功能性复合物的融合多肽。 它还提供编码融合多肽的核酸序列以及制备和用于融合多肽的方法。
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8.发明授权Methods of screening competitors of OB-R binding to SHP-2-SH2 peptides 失效筛选OB-R与SHP-2-SH2肽结合的竞争者的方法公开(公告)号：US06270981B1
公开(公告)日：2001-08-07
申请号：US09093814
申请日：1998-06-09
IPC分类号： G01N33567
CPC分类号： G01N33/6842 , G01N33/68 , G01N33/74 , G01N2500/00
摘要： The present invention relates to methods for identifying therapeutic agents that enhance the effect of leptin, an adipocyte-derived cytokine that regulates food intake and body weight. The invention further provides for use of agents identified using this assay system to enhance the interaction between leptin and its receptor, OB-R, thereby boosting leptin's weight-reducing effects in obese individuals.
摘要翻译： 本发明涉及用于鉴定增强瘦素效应的治疗剂的方法，该瘦素是调节食物摄入和体重的脂肪细胞来源的细胞因子。 本发明进一步提供了使用该测定系统鉴定的试剂来增强瘦素与其受体OB-R之间的相互作用，从而提高瘦素在肥胖个体中的减肥作用。
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公开(公告)号：US07083949B2
公开(公告)日：2006-08-01
申请号：US10287035
申请日：2002-11-01
申请人： Neil Stahl , George D. Yancopoulos
发明人： Neil Stahl , George D. Yancopoulos
CPC分类号： C07K14/715 , C07K2319/02
摘要： The present invention provides a fusion polypeptide that forms a multimer that is capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.
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公开(公告)号：US07008781B1
公开(公告)日：2006-03-07
申请号：US09868677
申请日：1999-12-23
CPC分类号： C07K14/515 , A61K38/00 , C07K14/52 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/73 , C07K2319/75 , C12N15/62
摘要： Novel fusion polypeptide ligands that bind Eph family receptors or the Tie-2 receptor are identified, and methods for making the fusion polypeptide ligands in biologically active form are described. Nucleic acids encoding these novel fusion polypeptide ligands enable production of the fusion polypeptide ligands. The method of making the nucleic acids and the fusion polypeptide ligands is broadly applicable to the production of polypeptide ligands in general, resulting in improved affinity and/or increased activity of the ligand when compared to its native form.
摘要翻译： 鉴定了结合Eph家族受体或Tie-2受体的新型融合多肽配体，描述了制备具有生物活性形式的融合多肽配体的方法。 编码这些新型融合多肽配体的核酸能够产生融合多肽配体。 制备核酸和融合多肽配体的方法通常广泛地适用于多肽配体的产生，当与其天然形式相比时，导致配体的亲和力和/或增加的活性。
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